Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | musashi | 0.0031 | 0.0929 | 0.2912 |
Brugia malayi | bHLH-PAS transcription factor | 0.0042 | 0.1531 | 0.1449 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0071 | 0.319 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.006 | 0.2557 | 0.7991 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.3129 | 0.3129 |
Brugia malayi | MAP kinase sur-1 | 0.006 | 0.2557 | 0.2485 |
Echinococcus granulosus | mitogen activated protein kinase | 0.006 | 0.2557 | 0.8015 |
Echinococcus granulosus | lamin | 0.0031 | 0.0929 | 0.2912 |
Echinococcus granulosus | hypothetical protein | 0.007 | 0.3129 | 0.9808 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0929 | 0.0929 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0929 | 0.2912 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0071 | 0.319 | 1 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0071 | 0.319 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.006 | 0.2557 | 0.7991 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0071 | 0.319 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.006 | 0.2557 | 0.8015 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0929 | 0.2912 |
Echinococcus multilocularis | 0.007 | 0.3129 | 0.9808 | |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0071 | 0.319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0896 | 0.0896 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.0071 | 0.319 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0095 | 0.0095 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.006 | 0.2557 | 0.8015 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.006 | 0.2557 | 0.7991 |
Brugia malayi | PAS domain containing protein | 0.0057 | 0.2372 | 0.2299 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0071 | 0.319 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0042 | 0.1531 | 0.5 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0057 | 0.2372 | 0.6384 |
Leishmania major | protein kinase, putative | 0.0071 | 0.319 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.006 | 0.2557 | 0.7991 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0071 | 0.319 | 0.319 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.006 | 0.2557 | 0.8015 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0071 | 0.319 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.006 | 0.2557 | 0.2557 |
Brugia malayi | hypoxia-induced factor 1 | 0.0175 | 0.9158 | 0.915 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0071 | 0.319 | 0.5 |
Echinococcus granulosus | single minded 2 | 0.0042 | 0.1531 | 0.4798 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.006 | 0.2557 | 0.7991 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0929 | 0.2912 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0929 | 0.2912 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0071 | 0.319 | 1 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0042 | 0.1531 | 0.4798 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0071 | 0.319 | 1 |
Schistosoma mansoni | single-minded | 0.0057 | 0.2372 | 0.6384 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0929 | 0.0929 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0071 | 0.319 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.006 | 0.2557 | 0.7199 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0929 | 0.0842 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0071 | 0.319 | 1 |
Giardia lamblia | Kinase, CMGC CLK | 0.0071 | 0.319 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0071 | 0.319 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0071 | 0.319 | 0.3125 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.006 | 0.2557 | 0.7991 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0071 | 0.319 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0929 | 0.0842 |
Onchocerca volvulus | 0.0042 | 0.1531 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0929 | 0.0929 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0175 | 0.9158 | 0.9158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.