Detailed information for compound 1804959

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.403 | Formula: C13H22N4O5S
  • H donors: 0 H acceptors: 6 LogP: 1.41 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(S(=O)(=O)c1ncn(n1)C(=O)N(CC)CC)C(=O)OC
  • InChi: 1S/C13H22N4O5S/c1-5-8-10(11(18)22-4)23(20,21)12-14-9-17(15-12)13(19)16(6-2)7-3/h9-10H,5-8H2,1-4H3
  • InChiKey: UFFFNHXLVMMKAK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.1034 0.3905
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1034 0.2078
Brugia malayi Calcitonin receptor-like protein seb-1 0.025 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.1034 0.1034
Brugia malayi hypothetical protein 0.0009 0.0103 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0128 0.4978 0.7369
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0314 0.0314
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1034 0.2078
Leishmania major pentamidine resistance protein 1 0.0014 0.0314 0.0502
Onchocerca volvulus 0.0032 0.1034 0.147
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0314 0.0781
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.1034 0.3905
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0032 0.1034 0.2348
Schistosoma mansoni smad1 5 8 and 0.0017 0.0422 0.0624
Loa Loa (eye worm) hypothetical protein 0.0014 0.0314 0.0314
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0014 0.0314 0.0314
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.6755 0.6755
Schistosoma mansoni Smad4 0.0017 0.0422 0.0624
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.4978 0.4978
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0103 0.0103
Loa Loa (eye worm) TAR-binding protein 0.0128 0.4978 0.4978
Brugia malayi N-terminal motif family protein 0.0178 0.7036 0.7036
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.1044 0.2096
Brugia malayi Protein kinase domain containing protein 0.0071 0.2649 0.2649
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0071 0.2649 0.6588
Echinococcus multilocularis voltage gated potassium channel subunit 0.0009 0.0118 0.0237
Echinococcus granulosus aldo keto reductase 0.0032 0.1034 0.2078
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1034 0.2078
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.1044 0.2096
Loa Loa (eye worm) pigment dispersing factor receptor c 0.025 1 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.1044 1
Brugia malayi MH2 domain containing protein 0.0017 0.0422 0.0422
Loa Loa (eye worm) oxidoreductase 0.0032 0.1034 0.1034
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0661 0.5922
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0103 0.0207
Toxoplasma gondii aldo-keto reductase 0.0009 0.0118 0.0058
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.1034 0.1034
Entamoeba histolytica ABC transporter, putative 0.0014 0.0314 0.0781
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.4021 0.5953
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1034 0.2078
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0032 0.1034 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0241 0.0241
Brugia malayi hypothetical protein 0.0009 0.0103 0.0103
Brugia malayi MH1 domain containing protein 0.0017 0.0422 0.0422
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1034 0.2078
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.9687 0.9687
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0014 0.0314 0.0502
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1034 0.2078
Echinococcus granulosus hypothetical protein 0.0032 0.1034 0.2078
Entamoeba histolytica multidrug resistance protein, putative 0.0014 0.0314 0.0781
Brugia malayi DIX domain containing protein 0.0009 0.0103 0.0103
Entamoeba histolytica aldose reductase, putative 0.0032 0.1034 0.2572
Trypanosoma brucei multidrug resistance protein E 0.0014 0.0314 0.0502
Echinococcus multilocularis mothers against decapentaplegic 2 0.0007 0.0047 0.0094
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0103 0.0207
Brugia malayi Latrophilin receptor protein 2 0.0079 0.2989 0.2989
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1034 0.2078
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.1044 0.3694
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1034 0.2078
Schistosoma mansoni smad 0.0017 0.0422 0.0624
Brugia malayi multidrug resistance related protein 1 0.0014 0.0314 0.0314
Schistosoma mansoni multidrug resistance protein 0.0014 0.0314 0.0465
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0241 0.0599
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0007 0.0047 0.0067
Schistosoma mansoni hypothetical protein 0.0171 0.6755 1
Brugia malayi TAR-binding protein 0.0128 0.4978 0.4978
Echinococcus multilocularis multidrug resistance associated protein 1 0.0014 0.0314 0.0631
Echinococcus multilocularis Smad4 0.0017 0.0422 0.0847
Plasmodium vivax serine/threonine kinase-1, putative 0.0071 0.2649 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0009 0.0118 0.0445
Leishmania major prostaglandin f synthase, putative 0.0032 0.1034 0.2348
Schistosoma mansoni dishevelled 0.0009 0.0103 0.0153
Loa Loa (eye worm) oxidoreductase 0.0032 0.1034 0.1034
Echinococcus multilocularis dual specificity protein kinase clk2 0.0071 0.2649 0.5322
Leishmania major p-glycoprotein e 0.0014 0.0314 0.0502
Loa Loa (eye worm) oxidoreductase 0.0032 0.1034 0.1034
Echinococcus granulosus aldo keto reductase 0.0032 0.1034 0.2078
Brugia malayi Protein kinase domain containing protein 0.0104 0.4021 0.4021
Trypanosoma cruzi aldo-keto reductase 0.0032 0.1034 0.2572
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1034 0.2078
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0071 0.2649 0.2649
Trypanosoma brucei aldo-keto reductase, putative 0.0032 0.1034 0.2348
Loa Loa (eye worm) hypothetical protein 0.0103 0.3977 0.3977
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.2989 0.2989
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0104 0.4021 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0241 0.0241
Leishmania major cytochrome p450-like protein 0.0012 0.0241 0.0315
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1034 0.2078
Loa Loa (eye worm) RNA binding protein 0.0128 0.4978 0.4978
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Onchocerca volvulus 0.0032 0.1034 0.147
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0422 0.0624
Loa Loa (eye worm) multidrug resistance-associated protein 0.0011 0.0186 0.0186
Onchocerca volvulus 0.0032 0.1034 0.147
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1034 0.2078
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1034 0.2078
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Giardia lamblia Aldose reductase 0.0032 0.1034 0.3099
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.1044 0.2096
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.2989 0.6005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.1044 0.2096
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0314 0.002
Loa Loa (eye worm) Smad1 0.0017 0.0422 0.0422
Echinococcus multilocularis multidrug resistance associated protein 7 0.0014 0.0314 0.0631
Loa Loa (eye worm) hypothetical protein 0.0014 0.0309 0.0309
Loa Loa (eye worm) oxidoreductase 0.0032 0.1034 0.1034
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0314 0.0828
Trypanosoma brucei p-glycoprotein 0.0014 0.0314 0.0502
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0103 0.0153
Brugia malayi MH2 domain containing protein 0.0017 0.0422 0.0422
Trypanosoma brucei prostaglandin f synthase 0.0032 0.1034 0.2348
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0118 0.0293
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0009 0.0118 0.0118
Trypanosoma cruzi aldo/keto reductase, putative 0.0009 0.0118 0.0293
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0241 0.0599
Loa Loa (eye worm) hypothetical protein 0.0007 0.0047 0.0047
Trypanosoma cruzi aldo/keto reductase, putative 0.0032 0.1034 0.2572
Entamoeba histolytica aldose reductase, putative 0.0032 0.1034 0.2572
Echinococcus granulosus GPCR family 2 0.0079 0.2989 0.6005
Schistosoma mansoni hypothetical protein 0.0079 0.2989 0.4425
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.1044 0.2595
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.1034 0.3905
Schistosoma mansoni tar DNA-binding protein 0.0128 0.4978 0.7369
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.2989 0.6005
Schistosoma mansoni Smad4 0.0007 0.0047 0.007
Leishmania major aldo-keto reductase-like protein 0.0032 0.1034 0.2348
Brugia malayi MH1 domain containing protein 0.0017 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0171 0.6755 0.6755
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0104 0.4021 1
Echinococcus multilocularis aldo keto reductase 0.0032 0.1034 0.2078
Leishmania major protein kinase, putative 0.0071 0.2649 0.6485
Schistosoma mansoni Smad4 0.0007 0.0047 0.007
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 0.1034 0.9901
Schistosoma mansoni hypothetical protein 0.0079 0.2989 0.4425
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.2649 0.3921
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0118 0.0445
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.1044 0.3657
Echinococcus granulosus Smad4 0.0017 0.0422 0.0847
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.1044 0.3694
Echinococcus granulosus hypothetical protein 0.007 0.2605 0.5233
Brugia malayi MH2 domain containing protein 0.0243 0.9687 0.9687
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0314 0.0502
Schistosoma mansoni aldo-keto reductase 0.0032 0.1034 0.1531
Schistosoma mansoni smad1 5 8 and 0.0017 0.0422 0.0624
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0422 0.0422
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0104 0.4021 0.4021
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0103 0.0103
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.1044 0.2595
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0103 0.0146
Echinococcus granulosus smad 0.0017 0.0422 0.0847
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0071 0.2649 0.6588
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0241 0.134
Onchocerca volvulus 0.0009 0.0118 0.0168
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Onchocerca volvulus 0.0032 0.1034 0.147
Echinococcus multilocularis tar DNA binding protein 0.0128 0.4978 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Brugia malayi mothers against decapentaplegic homolog 3 0.0007 0.0047 0.0047
Echinococcus multilocularis aldo keto reductase 0.0032 0.1034 0.2078
Giardia lamblia ABC transporter, putative 0.0014 0.0314 0.002
Toxoplasma gondii aldose reductase, putative 0.0032 0.1034 0.3658
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0314 0.0781
Plasmodium falciparum protein serine/threonine kinase-1 0.0071 0.2649 1
Echinococcus multilocularis aldo keto reductase 0.0032 0.1034 0.2078
Schistosoma mansoni multidrug resistance protein 0.0014 0.0314 0.0465
Brugia malayi MH2 domain containing protein 0.0007 0.0047 0.0047
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0422 0.0847
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.1044 0.3657
Echinococcus multilocularis GPCR, family 2 0.0079 0.2989 0.6005
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1034 0.2078
Loa Loa (eye worm) hypothetical protein 0.0009 0.0098 0.0098
Schistosoma mansoni smad1 5 8 and 0.0017 0.0422 0.0624
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0104 0.4021 1
Loa Loa (eye worm) nuclear factor I 0.0009 0.0119 0.0119
Entamoeba histolytica protein kinase, putative 0.0104 0.4021 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0103 0.0207
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0103 0.0207
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0422 0.0847
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0314 0.002
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.1044 0.1545
Loa Loa (eye worm) oxidoreductase 0.0032 0.1034 0.1034
Trypanosoma cruzi multidrug resistance protein E, putative 0.0014 0.0314 0.0781
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0047 0.0047
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1034 0.2078
Brugia malayi Smad1 0.0017 0.0422 0.0422
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0103 0.0153
Echinococcus granulosus multidrug resistance associated protein 7 0.0014 0.0314 0.0631
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.1044 0.2371
Schistosoma mansoni tar DNA-binding protein 0.0128 0.4978 0.7369
Echinococcus granulosus multidrug resistance associated protein 4 0.0011 0.0182 0.0365
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0103 0.0207
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0014 0.0314 0.0502
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1034 0.2078
Loa Loa (eye worm) hypothetical protein 0.025 1 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0009 0.0118 0.0118
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0314 0.0781
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0103 0.0153
Onchocerca volvulus 0.0032 0.1034 0.147
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.2649 1
Brugia malayi MH1 domain containing protein 0.0009 0.0119 0.0119
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0032 0.1034 0.1034
Echinococcus granulosus aldo keto reductase 0.0032 0.1034 0.2078
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0032 0.1034 0.2348
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.2649 0.3921
Entamoeba histolytica protein kinase, putative 0.0104 0.4021 1
Brugia malayi NADH-dependent xylose reductase 0.0009 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0009 0.0103 0.0103
Echinococcus multilocularis aldehyde reductase 0.0022 0.0661 0.1327
Schistosoma mansoni multidrug resistance protein 0.0014 0.0314 0.0465
Echinococcus multilocularis mothers against decapentaplegic 6 0.0007 0.0047 0.0094
Schistosoma mansoni dishevelled 0.0009 0.0103 0.0153
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0014 0.0314 0.0502
Echinococcus multilocularis multidrug resistance associated protein 4 0.0011 0.0182 0.0365
Leishmania major ABC-thiol transporter 0.0014 0.0314 0.0502
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.2989 0.2989
Schistosoma mansoni tar DNA-binding protein 0.0128 0.4978 0.7369
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1034 0.2078
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1034 0.2078
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0014 0.0314 0.0502
Giardia lamblia Kinase, CMGC CLK 0.0071 0.2649 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Entamoeba histolytica hypothetical protein 0.0104 0.4021 1
Schistosoma mansoni hypothetical protein 0.0079 0.2989 0.4425
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0071 0.2649 0.6485
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0241 0.0315
Echinococcus granulosus mothers against decapentaplegic 6 0.0007 0.0047 0.0094
Loa Loa (eye worm) hypothetical protein 0.0009 0.0103 0.0103
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0009 0.0118 0.0058
Echinococcus multilocularis aldo keto reductase 0.0032 0.1034 0.2078
Schistosoma mansoni tar DNA-binding protein 0.0128 0.4978 0.7369
Echinococcus granulosus aldehyde reductase 0.0022 0.0661 0.1327
Echinococcus multilocularis 0.007 0.2605 0.5233
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0422 0.0847
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0103 0.0103
Entamoeba histolytica aldose reductase, putative 0.0032 0.1034 0.2572
Schistosoma mansoni dep domain containing protein 0.0009 0.0103 0.0153
Giardia lamblia Aldose reductase 0.0032 0.1034 0.3099
Loa Loa (eye worm) hypothetical protein 0.0014 0.0314 0.0314
Schistosoma mansoni smad 0.0007 0.0047 0.007
Echinococcus multilocularis dual specificity 0.0104 0.4021 0.8078
Echinococcus granulosus multidrug resistance associated protein 1 0.0014 0.0314 0.0631
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.1034 0.3905
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.7036 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0071 0.2649 0.6588
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0314 0.0502
Schistosoma mansoni potassium channel beta 0.0009 0.0118 0.0175
Brugia malayi Cytochrome P450 family protein 0.0012 0.0241 0.0241
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0118 0.0445
Schistosoma mansoni pol-related 0.0032 0.1034 0.1531
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.2989 0.6005
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.1044 0.1044
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.1034 0.3905
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0103 0.0207
Entamoeba histolytica protein kinase domain containing protein 0.0104 0.4021 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.4978 0.4978
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0079 0.2989 0.4425
Schistosoma mansoni aldo-keto reductase 0.0032 0.1034 0.1531
Onchocerca volvulus 0.0032 0.1034 0.147
Loa Loa (eye worm) hypothetical protein 0.0103 0.3977 0.3977
Brugia malayi MH1 domain containing protein 0.0009 0.0119 0.0119
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1034 0.2078
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.0314 0.0781
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.9687 0.9687
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0118 0.0445
Trypanosoma cruzi hypothetical protein 0.0011 0.0182 0.0452
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.1044 0.2371
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.0314 0.0781
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0009 0.0103 0.0103
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0103 0.0207
Brugia malayi Cytochrome P450 family protein 0.0012 0.0241 0.0241
Mycobacterium ulcerans oxidoreductase 0.0032 0.1034 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.1044 0.2371
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.2989 0.6005
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.1044 0.2096
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0103 0.0207
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0009 0.0118 0.0058
Schistosoma mansoni multidrug resistance protein 0.0014 0.0314 0.0465
Loa Loa (eye worm) hypothetical protein 0.0009 0.0119 0.0119
Echinococcus granulosus tar DNA binding protein 0.0128 0.4978 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.1034 0.1034
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0314 0.0781
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0071 0.2649 1
Brugia malayi Isocitrate dehydrogenase 0.0032 0.1044 0.1044
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0009 0.0118 0.0237
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Echinococcus granulosus dual specificity 0.0104 0.4021 0.8078
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0118 0.0445
Onchocerca volvulus 0.0009 0.0103 0.0146
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0422 0.0847
Echinococcus granulosus voltage gated potassium channel subunit 0.0009 0.0118 0.0237
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.1034 0.3905
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0071 0.2649 0.6485
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.1034 0.3905
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.1034 0.2078
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0103 0.0207
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.1044 0.2096
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.1034 0.2078
Echinococcus granulosus dual specificity protein kinase clk2 0.0071 0.2649 0.5322
Entamoeba histolytica hypothetical protein 0.0014 0.0314 0.0781
Giardia lamblia MRP-like ABC transporter 0.0014 0.0314 0.002
Loa Loa (eye worm) hypothetical protein 0.0079 0.2989 0.2989
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0118 0.0293
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0103 0.0207
Loa Loa (eye worm) hypothetical protein 0.007 0.2605 0.2605
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.1034 0.1034
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0178 0.7036 0.7036
Echinococcus multilocularis smad 0.0017 0.0422 0.0847
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0422 0.0422
Leishmania major protein kinase, putative 0.0071 0.2649 0.6485
Echinococcus granulosus mothers against decapentaplegic 2 0.0007 0.0047 0.0094
Brugia malayi RNA binding protein 0.0128 0.4978 0.4978
Brugia malayi isocitrate dehydrogenase 0.0032 0.1044 0.1044
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0104 0.4021 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0071 0.2649 0.6588

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 10 % Toxicity in Oryza sativa (rice) assessed as injury at 50 g/ha pre-emergence application under paddy conditions by crop safety assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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