Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1053 | 0.1053 |
Leishmania major | trypanothione reductase | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Onchocerca volvulus | 0.0023 | 0.0952 | 1 | |
Echinococcus granulosus | defective proboscis extension response | 0.0018 | 0.0518 | 0.0518 |
Schistosoma mansoni | nephrin | 0.0023 | 0.0937 | 0.0937 |
Echinococcus granulosus | neuroglian | 0.0023 | 0.0937 | 0.0937 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0518 | 0.0518 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0023 | 0.0952 | 0.0952 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0018 | 0.0518 | 0.0518 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0042 | 0.2731 | 0.5 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0518 | 0.0518 |
Onchocerca volvulus | 0.0023 | 0.0952 | 1 | |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0123 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0123 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0123 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0123 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0042 | 0.2731 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0042 | 0.2731 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0018 | 0.0518 | 0.0518 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0518 | 0.0518 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0023 | 0.0952 | 0.0952 |
Schistosoma mansoni | vesicular amine transporter | 0.0018 | 0.0518 | 0.0518 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0042 | 0.2731 | 0.1966 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0042 | 0.2731 | 0.2731 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0018 | 0.0518 | 0.0518 |
Onchocerca volvulus | 0.0023 | 0.0952 | 1 | |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0042 | 0.2731 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.2075 | 0.2075 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1184 | 0.1184 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0042 | 0.2731 | 0.2731 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0023 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | glutathione reductase | 0.0123 | 1 | 1 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0023 | 0.0952 | 0.0952 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0042 | 0.2731 | 0.2731 |
Onchocerca volvulus | 0.0023 | 0.0952 | 1 | |
Onchocerca volvulus | 0.0023 | 0.0952 | 1 | |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0042 | 0.2731 | 0.1966 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0042 | 0.2731 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1472 | 0.1472 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0023 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1472 | 0.1472 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0018 | 0.0518 | 0.0518 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0042 | 0.2731 | 0.2731 |
Trypanosoma brucei | trypanothione reductase | 0.0123 | 1 | 1 |
Echinococcus granulosus | Immunoglobulin | 0.0018 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0042 | 0.2731 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0123 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0123 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Plasmodium falciparum | glutathione reductase | 0.0123 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0042 | 0.2731 | 0.5 |
Onchocerca volvulus | 0.0023 | 0.0952 | 1 | |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0023 | 0.0952 | 0.0952 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0042 | 0.2731 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0518 | 0.0518 |
Echinococcus multilocularis | Immunoglobulin | 0.0018 | 0.0518 | 0.0518 |
Echinococcus multilocularis | neuroglian | 0.0023 | 0.0937 | 0.0937 |
Echinococcus multilocularis | roundabout 2 | 0.0029 | 0.1472 | 0.1472 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0035 | 0.2075 | 0.2075 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Schistosoma mansoni | cell adhesion molecule | 0.0024 | 0.1053 | 0.1053 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0031 | 0.1708 | 0.1708 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0018 | 0.0518 | 0.0518 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0023 | 0.0952 | 0.0952 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0023 | 0.0952 | 0.0952 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0024 | 0.1053 | 0.1053 |
Treponema pallidum | NADH oxidase | 0.0042 | 0.2731 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0042 | 0.2731 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0123 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0042 | 0.2731 | 0.1966 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0024 | 0.1053 | 0.1053 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0018 | 0.0518 | 0.0518 |
Echinococcus granulosus | roundabout 2 | 0.0029 | 0.1472 | 0.1472 |
Brugia malayi | Sushi domain | 0.0023 | 0.0952 | 0.0952 |
Onchocerca volvulus | 0.0023 | 0.0952 | 1 | |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0031 | 0.1708 | 0.1708 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0042 | 0.2731 | 0.1966 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0042 | 0.2731 | 0.2731 |
Onchocerca volvulus | 0.0023 | 0.0952 | 1 | |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0024 | 0.1053 | 0.1053 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0023 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0518 | 0.0518 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0042 | 0.2731 | 0.2731 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Onchocerca volvulus | 0.0023 | 0.0952 | 1 | |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0042 | 0.2731 | 0.5 |
Onchocerca volvulus | 0.0023 | 0.0952 | 1 | |
Plasmodium falciparum | glutathione reductase | 0.0042 | 0.2731 | 0.1966 |
Echinococcus granulosus | twitchin | 0.0024 | 0.1024 | 0.1024 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0952 | 0.0952 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0042 | 0.2731 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.