Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | protein kinase, putative | 0.0001 | 0 | 0.5 |
Leishmania major | serine-threonine protein kinase-like protein | 0.0001 | 0 | 0.5 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.007 | 0.1293 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0153 | 0.2861 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0153 | 0.2861 | 1 |
Mycobacterium leprae | Shikimate kinase AroK (SK) | 0.0532 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.0001 | 0 | 0.5 |
Mycobacterium tuberculosis | Shikimate kinase AroK (SK) | 0.0532 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.1293 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0153 | 0.286 | 0.9993 |
Entamoeba histolytica | protein kinase, putative | 0.0153 | 0.2861 | 1 |
Trypanosoma brucei | Forkhead Kinase, putative | 0.0001 | 0 | 0.5 |
Trypanosoma cruzi | carbohydrate kinase, thermoresistant glucokinase, putative | 0.007 | 0.1293 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0153 | 0.2861 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0153 | 0.2861 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0153 | 0.286 | 0.9993 |
Leishmania major | protein kinase, putative | 0.0001 | 0 | 0.5 |
Mycobacterium ulcerans | shikimate kinase | 0.0532 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | Antifungal activity against Candida albicans assessed as growth inhibition after 96 hr by agar dilution method | ChEMBL. | No reference | |
MIC (functional) | Antifungal activity against Cryptococcus neoformans assessed as growth inhibition after 96 hr by agar dilution method | ChEMBL. | No reference | |
MIC (functional) | Antibacterial activity against Escherichia coli 319 assessed as growth inhibition after 24 hr by agar dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.