Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0057 | 0.0079 | 0.0064 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0128 | 0.0255 | 0.4481 |
Echinococcus multilocularis | 0.0031 | 0.0015 | 0.0014 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0322 | 0.0736 | 0.0722 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0337 | 0.0773 | 0.0772 |
Echinococcus multilocularis | caspase 3 | 0.021 | 0.0458 | 0.0457 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0056 | 0.0077 | 0.0077 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0056 | 0.0077 | 0.0137 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0322 | 0.0736 | 0.0722 |
Brugia malayi | cytochrome P450 | 0.0031 | 0.0015 | 0.0014 |
Loa Loa (eye worm) | thymidylate synthase | 0.0322 | 0.0736 | 0.0736 |
Trypanosoma cruzi | metacaspase, putative | 0.0128 | 0.0255 | 0.0525 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0057 | 0.0079 | 0.0064 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0128 | 0.0255 | 0.0525 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0057 | 0.0079 | 0.0064 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0337 | 0.0773 | 0.0772 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.0077 | 0.0077 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0034 | 0.0022 | 0.0021 |
Trypanosoma brucei | metacaspase MCA2 | 0.0128 | 0.0255 | 0.0525 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0057 | 0.0079 | 0.0064 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0107 | 0.0203 | 0.0412 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.407 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.407 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.407 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.407 | 1 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0128 | 0.0255 | 0.0525 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0107 | 0.0203 | 0.0412 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0128 | 0.0255 | 0.4481 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1879 | 0.4583 | 1 |
Echinococcus multilocularis | caspase 8 | 0.0128 | 0.0255 | 0.0253 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0128 | 0.0255 | 0.0525 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0107 | 0.0203 | 0.0202 |
Echinococcus granulosus | caspase 8 | 0.0128 | 0.0255 | 0.0253 |
Schistosoma mansoni | hypothetical protein | 0.0119 | 0.0233 | 0.0232 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.014 | 0.0285 | 0.0285 |
Trypanosoma brucei | metacaspase MCA3 | 0.0128 | 0.0255 | 0.0525 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0057 | 0.0079 | 0.014 |
Echinococcus multilocularis | caspase | 0.0337 | 0.0773 | 0.0772 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0128 | 0.0255 | 0.4481 |
Trypanosoma brucei | Metacaspase-4 | 0.0128 | 0.0255 | 0.0525 |
Mycobacterium ulcerans | thymidylate synthase | 0.0322 | 0.0736 | 0.0722 |
Echinococcus granulosus | caspase 3 | 0.021 | 0.0458 | 0.0457 |
Echinococcus granulosus | thymidylate synthase | 0.0322 | 0.0736 | 0.0735 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0128 | 0.0255 | 0.4481 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1879 | 0.4583 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0203 | 0.0203 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0153 | 0.0318 | 0.0304 |
Brugia malayi | PAS domain containing protein | 0.0045 | 0.0051 | 0.005 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0128 | 0.0255 | 0.0525 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0128 | 0.0255 | 0.4481 |
Brugia malayi | hypothetical protein | 0.0153 | 0.0318 | 0.0317 |
Trypanosoma cruzi | metacaspase, putative | 0.0128 | 0.0255 | 0.0525 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.0077 | 0.0077 |
Schistosoma mansoni | dihydrofolate reductase | 0.407 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0128 | 0.0255 | 0.4481 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0128 | 0.0255 | 0.0525 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0235 | 0.0519 | 0.0519 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.0077 | 0.0076 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0057 | 0.0079 | 0.0078 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1879 | 0.4583 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1879 | 0.4583 | 1 |
Echinococcus granulosus | caspase | 0.0337 | 0.0773 | 0.0772 |
Leishmania major | cytochrome p450-like protein | 0.0056 | 0.0077 | 0.0137 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0128 | 0.0255 | 0.4481 |
Leishmania major | metacaspase, putative | 0.0128 | 0.0255 | 0.0525 |
Echinococcus multilocularis | caspase 2 | 0.0246 | 0.0548 | 0.0547 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0119 | 0.0233 | 0.0232 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0119 | 0.0233 | 0.0232 |
Echinococcus multilocularis | thymidylate synthase | 0.0322 | 0.0736 | 0.0735 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.407 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1879 | 0.4583 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0337 | 0.0773 | 0.0772 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0128 | 0.0255 | 0.4481 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0337 | 0.0773 | 0.0772 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0128 | 0.0255 | 0.4481 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0002 | 0.0002 |
Echinococcus granulosus | caspase 2 | 0.0246 | 0.0548 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0315 | 0.0315 |
Echinococcus granulosus | single minded 2 | 0.0034 | 0.0022 | 0.0021 |
Chlamydia trachomatis | dihydrofolate reductase | 0.407 | 1 | 0.5 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0128 | 0.0255 | 0.0253 |
Schistosoma mansoni | single-minded | 0.0045 | 0.0051 | 0.005 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0128 | 0.0255 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0001 | 0.0001 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0107 | 0.0203 | 0.0202 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0057 | 0.0079 | 0.0078 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0107 | 0.0203 | 0.0202 |
Onchocerca volvulus | 0.0119 | 0.0233 | 0.3153 | |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0107 | 0.0203 | 0.0412 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0057 | 0.0079 | 0.0078 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0107 | 0.0203 | 0.0202 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0107 | 0.0203 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0235 | 0.0519 | 0.0518 |
Trypanosoma cruzi | metacaspase, putative | 0.0128 | 0.0255 | 0.0525 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0057 | 0.0079 | 0.0078 |
Brugia malayi | Dihydrofolate reductase | 0.407 | 1 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0045 | 0.0051 | 0.005 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0031 | 0.0015 | 0.0014 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0107 | 0.0203 | 0.0412 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0057 | 0.0079 | 0.014 |
Brugia malayi | Cell death protein 3 precursor | 0.0246 | 0.0548 | 0.0547 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0086 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | cytochrome P450 | 0.0031 | 0.0015 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0015 | 0.0014 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0128 | 0.0255 | 0.4481 |
Brugia malayi | hypoxia-induced factor 1 | 0.014 | 0.0285 | 0.0284 |
Brugia malayi | hypothetical protein | 0.0119 | 0.0233 | 0.0232 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0107 | 0.0203 | 0.0202 |
Brugia malayi | thymidylate synthase | 0.0322 | 0.0736 | 0.0735 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0056 | 0.0077 | 0.0137 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0107 | 0.0203 | 0.0202 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0128 | 0.0255 | 0.4481 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0246 | 0.0548 | 0.0547 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0128 | 0.0255 | 0.4481 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0015 | 0.0014 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0128 | 0.0255 | 0.4481 |
Brugia malayi | bHLH-PAS transcription factor | 0.0034 | 0.0022 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0233 | 0.0233 |
Onchocerca volvulus | 0.0034 | 0.0022 | 0.0283 | |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.0077 | 0.0076 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1879 | 0.4583 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0025 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.0548 | 0.0548 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0246 | 0.0548 | 0.7445 |
Schistosoma mansoni | cytochrome P450 | 0.0031 | 0.0015 | 0.0014 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0128 | 0.0255 | 0.4481 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0322 | 0.0736 | 0.0735 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0025 | 0.0001 | 0.0001 |
Trypanosoma brucei | cytochrome P450, putative | 0.0056 | 0.0077 | 0.0137 |
Brugia malayi | Cytochrome P450 family protein | 0.0086 | 0.0151 | 0.015 |
Trypanosoma brucei | metacaspase 5, putative | 0.0128 | 0.0255 | 0.0525 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0128 | 0.0255 | 0.4481 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0107 | 0.0203 | 0.0202 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0056 | 0.0077 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0255 | 0.0255 |
Brugia malayi | hypothetical protein | 0.0152 | 0.0315 | 0.0313 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.407 | 1 | 1 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0107 | 0.0203 | 0.0202 |
Mycobacterium ulcerans | putative regulatory protein | 0.0034 | 0.0022 | 0.0007 |
Trypanosoma brucei | metacaspase | 0.0128 | 0.0255 | 0.0525 |
Onchocerca volvulus | 0.0322 | 0.0736 | 1 | |
Trypanosoma cruzi | metacaspase 5, putative | 0.0128 | 0.0255 | 0.0525 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0153 | 0.0318 | 0.0664 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0107 | 0.0203 | 0.0202 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0153 | 0.0318 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0107 | 0.0203 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 83 % | Compound was evaluated in vitro for the inhibition of Fucosyltransferase 6 | ChEMBL. | No reference |
Inhibition (binding) | = 96 % | Compound was evaluated in vitro for the inhibition of Fucosyltransferase 3 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.