Detailed information for compound 1805780

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 494.748 | Formula: C33H50O3
  • H donors: 1 H acceptors: 2 LogP: 7.78 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CCOC(=O)[C@@]12CC[C@H]([C@@H]([C@H]2C2=CC[C@H]3[C@@]([C@@]2(CC1)C)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C)C
  • InChi: 1S/C33H50O3/c1-9-20-36-28(35)33-17-12-21(2)22(3)27(33)23-10-11-25-30(6)15-14-26(34)29(4,5)24(30)13-16-32(25,8)31(23,7)18-19-33/h1,10,21-22,24-27,34H,11-20H2,2-8H3/t21-,22+,24+,25-,26+,27+,30+,31-,32-,33+/m1/s1
  • InChiKey: YPJZTZJGWLTHSA-ABODYXKQSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Schistosoma mansoni ephrin receptor 0.0425 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Brugia malayi hypothetical protein 0.0425 1 1
Schistosoma mansoni protein kinase 0.0425 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0166 0.2939 0.2796
Echinococcus granulosus retinal guanylyl cyclase 2 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.2939 0.2939
Echinococcus multilocularis carbonic anhydrase 0.0166 0.2939 0.2796
Echinococcus multilocularis protein KINase family member (kin 25) 0.0425 1 1
Schistosoma mansoni protein kinase 0.0425 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0425 1 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0425 1 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0425 1 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0425 1 1
Leishmania major protein kinase, putative 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0425 1 1
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Loa Loa (eye worm) TK/RYK protein kinase 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0425 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Schistosoma mansoni protein kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0166 0.2939 0.2939
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0425 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0425 1 1
Brugia malayi SH2 domain containing protein 0.0425 1 1
Onchocerca volvulus 0.0425 1 0.5
Brugia malayi protein-tyrosine kinase 0.0425 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.0425 1 1
Echinococcus multilocularis protein tyrosine kinase 0.0425 1 1
Loa Loa (eye worm) SRC-1 0.0425 1 1
Entamoeba histolytica tyrosin kinase, putative 0.0425 1 0.5
Entamoeba histolytica hypothetical protein 0.0425 1 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0425 1 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Echinococcus granulosus carbonic anhydrase 0.0166 0.2939 0.2796
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Schistosoma mansoni serine/threonine RGC 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Trypanosoma brucei Pseudokinase, putative 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0425 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Echinococcus multilocularis c src tyrosine kinase 0.0425 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Toxoplasma gondii protein kinase domain-containing protein 0.0425 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0425 1 1
Brugia malayi hypothetical protein 0.0425 1 1
Entamoeba histolytica cysteine surface protein, putative 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Onchocerca volvulus Tyrosine kinase homolog 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Schistosoma mansoni protein kinase 0.0425 1 1
Onchocerca volvulus 0.0425 1 0.5
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0425 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0425 1 0.5
Schistosoma mansoni lipoxygenase 0.0132 0.2012 0.185
Schistosoma mansoni protein kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Giardia lamblia Kinase 0.0425 1 0.5
Brugia malayi integrin-linked kinase 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0425 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0425 1 0.5
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Loa Loa (eye worm) protein kinase domain-containing protein 0.0425 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Echinococcus multilocularis protein kinase 0.0425 1 1
Plasmodium falciparum protein kinase, putative 0.0425 1 1
Loa Loa (eye worm) TK protein kinase 0.0425 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0425 1 0.5
Onchocerca volvulus 0.0425 1 0.5
Echinococcus granulosus tyrosine kinase 0.0425 1 1
Brugia malayi hypothetical protein 0.0425 1 1
Echinococcus granulosus carbonic anhydrase 0.0166 0.2939 0.2796
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0166 0.2939 0.2939
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0425 1 1
Plasmodium falciparum protein kinase, putative 0.0425 1 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0425 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0166 0.2939 0.2939
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0132 0.2012 0.185
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Entamoeba histolytica hypothetical protein 0.0425 1 0.5
Echinococcus granulosus tyrosine protein kinase Srms 0.0425 1 1
Echinococcus multilocularis FL cytokine receptor 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0425 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0425 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0166 0.2939 0.2796
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0425 1 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0425 1 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0425 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Echinococcus granulosus tyrosine kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0425 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0425 1 1
Plasmodium falciparum protein kinase, putative 0.0425 1 1
Schistosoma mansoni tyrosine protein kinase 0.0425 1 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0425 1 1
Brugia malayi Guanylyl cyclase protein 23 0.0425 1 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0425 1 1
Echinococcus multilocularis activated cdc42 kinase 1 0.0425 1 1
Entamoeba histolytica tyrosin kinase, putative 0.0425 1 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0425 1 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0425 1 1
Brugia malayi jmjC domain containing protein 0.0066 0.0199 0.0199
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0425 1 1
Trichomonas vaginalis STE family protein kinase 0.0425 1 0.5
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0425 1 1
Echinococcus multilocularis insulin receptor 0.0425 1 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0425 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0425 1 1
Echinococcus multilocularis integrin linked protein kinase 0.0425 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Onchocerca volvulus 0.0425 1 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0425 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0425 1 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0425 1 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Toxoplasma gondii protein kinase 0.0425 1 1
Entamoeba histolytica receptor protein kinase, putative 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0354 0.8068 0.8029
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0425 1 1
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0425 1 0.5
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.2939 0.2939
Onchocerca volvulus 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Onchocerca volvulus 0.0425 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Schistosoma mansoni protein kinase 0.0425 1 1
Schistosoma mansoni protein tyrosine kinase 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0425 1 1
Schistosoma mansoni ephrin receptor 0.0425 1 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0425 1 1
Brugia malayi Receptor family ligand binding region containing protein 0.0425 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0425 1 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0425 1 1
Echinococcus granulosus integrin linked protein kinase 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Echinococcus granulosus carbonic anhydrase II 0.0354 0.8068 0.8029
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0425 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0425 1 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Trypanosoma cruzi protein kinase, putative 0.0425 1 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0425 1 0.5
Leishmania major hypothetical protein, conserved 0.0425 1 1
Echinococcus multilocularis protein kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Brugia malayi jmjC domain containing protein 0.0066 0.0199 0.0199
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Echinococcus granulosus c src tyrosine kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0425 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Schistosoma mansoni protein kinase 0.0425 1 1
Brugia malayi Raf kinase 0.0425 1 1
Entamoeba histolytica hypothetical protein 0.0425 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0425 1 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0425 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Trichomonas vaginalis TK family protein kinase 0.0425 1 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0199 0.0199
Plasmodium falciparum tyrosine kinase-like protein 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Schistosoma mansoni hypothetical protein 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Plasmodium vivax protein kinase, putative 0.0425 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0425 1 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0425 1 1
Echinococcus granulosus protein tyrosine kinase 0.0425 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0425 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Loa Loa (eye worm) TK protein kinase 0.0425 1 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0425 1 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase shark 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0354 0.8068 0.8068
Schistosoma mansoni hypothetical protein 0.0166 0.2939 0.2796
Echinococcus granulosus tyrosine protein kinase Src42A 0.0425 1 1
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0425 1 0.5
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0166 0.2939 0.2939
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0425 1 1
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0425 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0425 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Entamoeba histolytica hypothetical protein 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Brugia malayi SH2 domain containing protein 0.0425 1 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Schistosoma mansoni carbonic anhydrase 0.0166 0.2939 0.2796
Schistosoma mansoni protein kinase 0.0425 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0354 0.8068 0.8029
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0166 0.2939 0.2939
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Loa Loa (eye worm) TK/FAK protein kinase 0.0425 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Echinococcus granulosus tyrosine protein kinase 0.0425 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0425 1 1
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase HCK 0.0425 1 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0425 1 0.5
Giardia lamblia Kinase, NEK 0.0425 1 0.5
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0425 1 1
Schistosoma mansoni protein kinase 0.0425 1 1
Echinococcus multilocularis transfer RNA-Thr 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Echinococcus granulosus insulin receptor 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trypanosoma brucei protein kinase, putative 0.0425 1 1
Onchocerca volvulus 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis AGC family protein kinase 0.0425 1 0.5
Echinococcus granulosus ephrin type A receptor 4 A 0.0425 1 1
Schistosoma mansoni protein kinase 0.0425 1 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0425 1 1
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0425 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Echinococcus multilocularis ephrin type A receptor 4 A 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0425 1 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0425 1 1
Onchocerca volvulus 0.0425 1 0.5
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0425 1 1
Loa Loa (eye worm) TK protein kinase 0.0425 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Loa Loa (eye worm) TK/Met protein kinase 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Echinococcus granulosus carbonic anhydrase 0.0166 0.2939 0.2796
Onchocerca volvulus 0.0425 1 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Entamoeba histolytica hypothetical protein 0.0425 1 0.5
Entamoeba histolytica ankyrin repeat protein 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Onchocerca volvulus 0.0425 1 0.5
Onchocerca volvulus 0.0425 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Echinococcus granulosus protein kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica hypothetical protein 0.0425 1 0.5
Trypanosoma cruzi protein kinase, putative 0.0425 1 1
Leishmania major protein kinase, putative 0.0425 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0425 1 0.5
Echinococcus granulosus kinase suppressor of Ras 1 0.0425 1 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0425 1 1
Onchocerca volvulus 0.0425 1 0.5
Entamoeba histolytica receptor protein kinase, putative 0.0425 1 0.5
Echinococcus multilocularis carbonic anhydrase II 0.0354 0.8068 0.8029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0425 1 1
Brugia malayi Furin-like cysteine rich region family protein 0.0425 1 1
Entamoeba histolytica tyrosin kinase, putative 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Giardia lamblia Kinase, NEK 0.0425 1 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.0425 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Echinococcus granulosus tyrosine kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0425 1 1
Brugia malayi C-terminal src kinase protein 1 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Loa Loa (eye worm) carbonic anhydrase 3 0.0354 0.8068 0.8068
Loa Loa (eye worm) RGC/RGC protein kinase 0.0425 1 1
Echinococcus multilocularis heat shock protein 70 0.0425 1 1
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0425 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.2939 0.2939
Brugia malayi Tyrosine-protein kinase PR2 0.0425 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0354 0.8068 0.8068
Echinococcus granulosus tyrosine protein kinase shark 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Echinococcus multilocularis tyrosine kinase 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0425 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0425 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0425 1 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0425 1 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0425 1 0.5
Entamoeba histolytica ankyrin repeat protein 0.0425 1 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0425 1 0.5
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0425 1 0.5
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0132 0.2012 0.185
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0425 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0425 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Echinococcus multilocularis activin receptor type 0.0425 1 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0425 1 0.5
Echinococcus multilocularis carbonic anhydrase 0.0166 0.2939 0.2796
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0425 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0425 1 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Brugia malayi SRC-1 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0425 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Toxoplasma gondii STE kinase 0.0425 1 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0425 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0425 1 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0425 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Schistosoma mansoni protein kinase 0.0425 1 1
Trichomonas vaginalis protein kinase atn1, putative 0.0425 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0425 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0166 0.2939 0.2939
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0425 1 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0425 1 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Loa Loa (eye worm) TK/ACK protein kinase 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0425 1 0.5
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0425 1 1
Entamoeba histolytica hypothetical protein 0.0425 1 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0425 1 0.5
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Echinococcus granulosus activated cdc42 kinase 1 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0425 1 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0425 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0425 1 1
Onchocerca volvulus 0.0425 1 0.5
Entamoeba histolytica protein kinase, putative 0.0425 1 0.5
Echinococcus granulosus activin receptor type 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Loa Loa (eye worm) serine/threonine protein kinase 0.0425 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0425 1 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0425 1 1
Entamoeba histolytica hypothetical protein 0.0425 1 0.5
Schistosoma mansoni lipoxygenase 0.0093 0.0924 0.0739
Entamoeba histolytica hypothetical protein 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0425 1 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0425 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0425 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0425 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0425 1 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0425 1 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0425 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0425 1 1
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase pr2 0.0425 1 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0425 1 1
Entamoeba histolytica hypothetical protein 0.0425 1 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0425 1 1
Echinococcus multilocularis carbonic anhydrase 0.0166 0.2939 0.2796
Brugia malayi ephrin receptor 1 precursor 0.0425 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0425 1 1
Entamoeba histolytica hypothetical protein 0.0425 1 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Giardia lamblia Protein 21.1 0.0425 1 0.5
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0354 0.8068 0.8068
Echinococcus granulosus tyrosine protein kinase Fyn 0.0425 1 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Loa Loa (eye worm) TK protein kinase 0.0425 1 1
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Brugia malayi bone morphogenetic protein type 1 receptor 0.0425 1 1
Schistosoma mansoni tyrosine kinase 0.0425 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0425 1 1
Onchocerca volvulus 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0425 1 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0425 1 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0425 1 0.5
Schistosoma mansoni carbonic anhydrase-related 0.0166 0.2939 0.2796
Brugia malayi Protein kinase domain containing protein 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0425 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0425 1 0.5
Onchocerca volvulus 0.0425 1 0.5
Echinococcus multilocularis tyrosine kinase 0.0425 1 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0425 1 1
Trichomonas vaginalis TKL family protein kinase 0.0425 1 0.5
Echinococcus multilocularis tyrosine protein kinase 0.0425 1 1

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 11 % Growth inhibition of Homo sapiens (human) IMR32 cells at 10 uM after 48 hr by SRB assay ChEMBL. No reference
IC50 (functional) = 38 uM Cytotoxicity against human KB cells ChEMBL. 25442310

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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