Detailed information for compound 1805934

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.442 | Formula: C27H18N2O6
  • H donors: 1 H acceptors: 5 LogP: 6.08 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(c1oc2c(c1)cc(cc2)c1cccc(c1)[N+](=O)[O-])c1ccc(cc1)c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C27H18N2O6/c30-27(18-9-7-17(8-10-18)19-3-1-5-23(14-19)28(31)32)26-16-22-13-21(11-12-25(22)35-26)20-4-2-6-24(15-20)29(33)34/h1-16,27,30H
  • InChiKey: ZVBBXKIXLYIHIW-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0207
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0103 0.0077
Echinococcus granulosus geminin 0.0186 0.1188 0.5432
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.007 0.0339
Schistosoma mansoni zinc finger protein 0.0019 0.007 0.0468
Brugia malayi conserved hypotetical protein 0.0019 0.007 0.0339
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0215 0.1044
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.0068
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0085 0.06
Plasmodium falciparum thioredoxin reductase 0.0037 0.019 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0415
Onchocerca volvulus 0.0019 0.007 0.0339
Loa Loa (eye worm) hypothetical protein 0.0049 0.0269 0.1308
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0215 0.1044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Brugia malayi MH2 domain containing protein 0.0117 0.0726 0.3528
Trichomonas vaginalis C-MYB, putative 0.002 0.0074 0.0259
Brugia malayi hypothetical protein 0.0019 0.007 0.0339
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0114 0.0088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0272 0.1321
Brugia malayi Nuclear hormone receptor E75 0.0019 0.007 0.0339
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1855 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.007 0.0319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1855 1
Loa Loa (eye worm) DR-78 0.0019 0.007 0.0339
Echinococcus granulosus cpg binding protein 0.003 0.0141 0.0643
Trichomonas vaginalis C-MYB, putative 0.002 0.0074 0.0259
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0215 0.1044
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0118
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.009 0.0067
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0075 0.0262
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0207
Brugia malayi nuclear receptor RXR 0.0022 0.0085 0.0415
Loa Loa (eye worm) hypothetical protein 0.0034 0.0167 0.0811
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.019 0.0922
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.013 0.063
Echinococcus granulosus tumor protein p63 0.0335 0.2187 1
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0215 0.0982
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0215 0.0982
Trichomonas vaginalis MYB72, putative 0.002 0.0074 0.0259
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1919 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0215 0.1704
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0258
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0518
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0069 0.0079
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0215 0.0982
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0114 0.0101
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.019 0.0247
Onchocerca volvulus 0.0028 0.0125 0.0608
Brugia malayi CXXC zinc finger family protein 0.0028 0.013 0.063
Plasmodium vivax glutathione reductase, putative 0.0037 0.019 1
Brugia malayi nuclear hormone receptor 0.0041 0.0215 0.1044
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0114 0.0142
Brugia malayi Thioredoxin reductase 0.0037 0.019 0.0922
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0045 0.026
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0019 0.007 0.008
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0004 0.0019
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0068 0.0041
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0015 0.0068
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0877 0.4492
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0074 0.0259
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0219 0.1013
Brugia malayi nuclear receptor RXR 0.0019 0.007 0.0339
Leishmania major trypanothione reductase 0.0037 0.019 0.0862
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0125 0.0608
Onchocerca volvulus Peroxidase homolog 0.0028 0.0125 0.0608
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0215 0.1704
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1317 0.6401
Onchocerca volvulus 0.0028 0.0125 0.0608
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0215 0.1704
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.007 0.0319
Loa Loa (eye worm) glutathione reductase 0.0037 0.019 0.0922
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0045 0.114
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0045 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0215 0.1044
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0192 0.0165
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0103 0.0126
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.009 0.0108
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0726 0.3528
Onchocerca volvulus 0.0025 0.0108 0.0524
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.1855 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0247 0.1131
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0085 0.0415
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0068 0.0036
Onchocerca volvulus 0.0049 0.0269 0.1308
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.007 0.0339
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0107 0.4894
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0042 0.0041
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0215 0.1044
Brugia malayi nuclear receptor NHR-67 0.0019 0.007 0.0339
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1507 0.8095
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0103 0.0126
Onchocerca volvulus 0.0019 0.007 0.0339
Brugia malayi hypothetical protein 0.0016 0.0048 0.0232
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0125 0.0608
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0108 0.0524
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0215 0.1044
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0074 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0247 0.1131
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.007 0.0468
Leishmania major hypothetical protein, conserved 0.0025 0.0107 0.0422
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.15 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.007 0.0319
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0006 0.0028
Onchocerca volvulus 0.0239 0.1541 0.7487
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0114 0.0142
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0215 0.0982
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0045 0.022
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0057 0.0109
Trypanosoma brucei trypanothione reductase 0.0037 0.019 0.0862
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1919 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0074 0.0259
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0108 0.0133
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0125 0.0608
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0027 0.013
Brugia malayi Pre-SET motif family protein 0.0205 0.1317 0.6401
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0103 0.0126
Giardia lamblia Myb 1-like protein 0.002 0.0075 0.0262
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0074 0.0259
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0215 0.1704
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0258
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.15 1 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0005 0.0026
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0045 0.0207
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0215 0.1704
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.007 0.0339
Echinococcus granulosus GPCR family 2 0.0016 0.0045 0.0207
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0573 0.0783
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0141 0.1078
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0509 0.0694
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0074 0.0259
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0215 0.0982
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0215 0.0982
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0192 0.025
Echinococcus multilocularis geminin 0.0186 0.1188 0.5432
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0045 0.0098
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0207
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0215 0.0982
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0215 0.1044
Loa Loa (eye worm) hypothetical protein 0.0041 0.0215 0.1044
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0509 0.0694
Brugia malayi ecdysone receptor 0.0019 0.007 0.0339
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0107 0.0422
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0207
Echinococcus multilocularis GPCR, family 2 0.0016 0.0045 0.0207
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0876 0.117
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0215 0.1044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0247 0.1131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0215 0.0982
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0192 0.025
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0423 0.2776 0.3839
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Loa Loa (eye worm) hypothetical protein 0.0041 0.0215 0.1044
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.007 0.0468
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0219 0.1013
Loa Loa (eye worm) fatty acid synthase 0.0026 0.0117 0.057
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0045 0.0098
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.007 0.0319
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0103 0.0077
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0258
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0074 0.0259
Loa Loa (eye worm) hypothetical protein 0.0042 0.0225 0.1094
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1919 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0509 0.0694
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1077 0.7164 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1855 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.007 0.0339
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0085 0.06
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0045 0.0207
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0193 0.0883
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0272 0.1321
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0215 0.0982
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0125 0.0608
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0085 0.039
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0114 0.0101
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0877 0.4492
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0215 0.0982
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0215 0.0982
Onchocerca volvulus 0.0028 0.013 0.063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0215 0.0982
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0103 0.0077
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0573 0.0783
Trichomonas vaginalis MYB3r3, putative 0.002 0.0074 0.0259
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0068 0.015
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0103 0.0085
Loa Loa (eye worm) histone methyltransferase 0.001 0.0006 0.003
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0125 0.0608
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.019 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0509 0.0656
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0219 0.1013
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.1855 0.1833
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0272 0.1321
Brugia malayi tailless protein 0.0019 0.007 0.0339
Schistosoma mansoni cpg binding protein 0.003 0.0141 0.1071
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0074 0.0259
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0107 0.0422
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0107 0.4894
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0207
Brugia malayi hypothetical protein 0.0022 0.0085 0.0415
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Loa Loa (eye worm) hypothetical protein 0.0041 0.0215 0.1044
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0141 0.0646
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.0068
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0215 0.1044
Mycobacterium ulcerans polyketide synthase Pks9 0.0015 0.0042 0.0016
Loa Loa (eye worm) hypothetical protein 0.0041 0.0215 0.1044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0215 0.0982
Onchocerca volvulus 0.0316 0.2058 1
Mycobacterium ulcerans thioesterase 0.0022 0.009 0.0063
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0877 0.4492
Brugia malayi nuclear receptor NHR-88 0.0019 0.007 0.0339
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0027 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0107 0.4894
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.007 0.0319
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.15 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1855 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0167 0.0811
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Schistosoma mansoni peroxidasin 0.0028 0.0125 0.0939
Loa Loa (eye worm) hypothetical protein 0.0041 0.0215 0.1044
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0215 0.1704
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Loa Loa (eye worm) pax transcription factor protein 2 0.0239 0.1541 0.7487
Brugia malayi Nuclear hormone receptor E75 0.0019 0.007 0.0339
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0006 0.0028
Onchocerca volvulus 0.0047 0.0253 0.1227
Schistosoma mansoni cpg binding protein 0.003 0.0141 0.1071
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0103 0.0085
Brugia malayi hypothetical protein 0.0022 0.0085 0.0415
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0098
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0125 0.0608
Schistosoma mansoni hypothetical protein 0.0186 0.1188 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0247 0.1981
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0726 0.3528
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0247 0.1202
Echinococcus multilocularis cpg binding protein 0.003 0.0141 0.0643
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0215 0.1704
Mycobacterium ulcerans hypothetical protein 0.0155 0.0983 0.0958
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.007 0.0339
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0114 0.0088
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0114 0.0318
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0509 0.0694
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0074 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0247 0.1131
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0219 0.1013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0215 0.1044
Loa Loa (eye worm) hypothetical protein 0.0041 0.0215 0.1044
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1919 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0573 0.0783
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0114 0.0142
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0027 0.0122
Schistosoma mansoni peroxidasin 0.0028 0.0125 0.0939
Onchocerca volvulus Dual oxidase homolog 0.0028 0.0125 0.0608
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0027 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0215 0.1044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0415
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0687
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.007 0.0319
Onchocerca volvulus Peroxidasin homolog 0.0028 0.0125 0.0608
Plasmodium falciparum glutathione reductase 0.0037 0.019 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.1855 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0215 0.1044
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0215 0.1044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1855 1
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0125 0.0608
Brugia malayi hypothetical protein 0.0316 0.2058 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0215 0.1704
Schistosoma mansoni nuclear hormone receptor 0.0019 0.007 0.0468
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0247 0.1202
Mycobacterium ulcerans polyketide synthase 0.0026 0.0114 0.0088
Brugia malayi hypothetical protein 0.0028 0.0125 0.0608
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0573 0.0745
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0045 0.0045
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0423 0.2776 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.019 0.0862
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1855 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0215 0.0982
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0114 0.0101
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0349 0.2851
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0193 0.0883
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0215 0.0982
Schistosoma mansoni nuclear hormone receptor 0.0019 0.007 0.0468
Schistosoma mansoni hypothetical protein 0.0034 0.0167 0.1296
Onchocerca volvulus 0.003 0.0141 0.0687
Brugia malayi Blistered cuticle protein 3 0.0028 0.0125 0.0608
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0141 0.1078
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0215 0.1044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0215 0.1044
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0015 0.0042 0.0016
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0098
Schistosoma mansoni nuclear receptor 0.0019 0.007 0.0468
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0264 0.1282
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0085 0.0415
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.007 0.0319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0247 0.1981
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0215 0.1044
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0215 0.1044
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0269 0.2167
Schistosoma mansoni coup transcription factor 0.0041 0.0215 0.1704
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0103 0.0077
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.002 0.0075 0.0174
Schistosoma mansoni cpg binding protein 0.0028 0.013 0.0979
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0876 0.0851
Brugia malayi glutathione reductase 0.0037 0.019 0.0922
Loa Loa (eye worm) hypothetical protein 0.0041 0.0215 0.1044
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0027 0.0122
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0125 0.0608
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0141 0.1078
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0075 0.0262
Onchocerca volvulus 0.0234 0.1507 0.7323
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.007 0.0319
Onchocerca volvulus Chorion peroxidase homolog 0.0028 0.0125 0.0608
Mycobacterium ulcerans thioesterase TesA 0.0022 0.009 0.0063
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.007 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0215 0.1044
Brugia malayi nuclear receptor NHR-88 0.0041 0.0215 0.1044
Toxoplasma gondii thioredoxin reductase 0.0037 0.019 0.0593
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0215 0.1704
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0141 0.0646
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.007 0.0339
Echinococcus granulosus peroxidasin 0.0028 0.0125 0.0572
Brugia malayi isocitrate dehydrogenase 0.0016 0.0045 0.022
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0423 0.2776 0.2757
Echinococcus multilocularis tumor protein p63 0.0335 0.2187 1
Brugia malayi hypothetical protein 0.0019 0.007 0.0339
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0215 0.0982
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1855 1
Schistosoma mansoni nuclear receptor 0.0019 0.007 0.0468
Schistosoma mansoni hypothetical protein 0.0186 0.1188 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0085 0.039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0215 0.1044
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0192 0.021
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0068 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0108 0.0524
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0141 0.1078
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.007 0.0319
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0215 0.1044
Onchocerca volvulus Fatty acid synthase homolog 0.0048 0.0264 0.1282
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0215 0.1044
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0107 0.0422
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0215 0.1704
Toxoplasma gondii hypothetical protein 0.0048 0.0259 0.0846
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.007 0.0339
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0207
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0215 0.1044
Plasmodium vivax SET domain protein, putative 0.003 0.0141 0.7027
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.007 0.0339
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0098
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0107 0.029
Brugia malayi Pre-SET motif family protein 0.003 0.0141 0.0687
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0015 0.0068
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0215 0.1704
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0215 0.1044
Brugia malayi nuclear hormone receptor 0.0019 0.007 0.0339
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0215 0.0982
Brugia malayi hypothetical protein 0.0025 0.0107 0.0518
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0423 0.2776 0.2757
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1077 0.7164 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.013 0.0594
Onchocerca volvulus 0.0028 0.0125 0.0608
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.007 0.0319
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0103 0.0501
Trichomonas vaginalis MYB, putative 0.002 0.0075 0.0262
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0279 0.1335
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0215 0.1044
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0045 0.022
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0031 0.0015
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0114 0.0142
Brugia malayi steroid hormone receptor 0.0041 0.0215 0.1044
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0085 0.0415
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0215 0.1044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0608
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.007 0.0468
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0509 0.0694
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0114 0.0142
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.1855 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0004 0.0019
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.007 0.0319
Brugia malayi ecdysteroid receptor 0.0041 0.0215 0.1044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0207
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0876 0.1207
Onchocerca volvulus 0.0041 0.0215 0.1044
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0215 0.0982
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0306 0.1017
Loa Loa (eye worm) hypothetical protein 0.0316 0.2058 1
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0023 0.0111
Loa Loa (eye worm) hypothetical protein 0.0041 0.0215 0.1044
Loa Loa (eye worm) hypothetical protein 0.0049 0.0272 0.1321
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0045 0.022
Onchocerca volvulus Peroxidasin homolog 0.0028 0.0125 0.0608
Loa Loa (eye worm) blistered cuticle protein 3 0.0028 0.0125 0.0608
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0125 0.0608
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Mycobacterium tuberculosis Probable reductase 0.0085 0.0509 0.0694
Brugia malayi Pax transcription factor protein 2 0.0239 0.1541 0.7487
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0045 0.022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0247 0.1981
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1855 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0339
Brugia malayi Peroxidasin 0.0028 0.0125 0.0608
Echinococcus multilocularis peroxidasin 0.0028 0.0125 0.0572
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0141 0.0646
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.007 0.0319
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0215 0.1704
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0983 0.1356
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0215 0.1044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0415
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0207
Onchocerca volvulus Peroxidase homolog 0.0028 0.0125 0.0608
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0141 0.0417
Mycobacterium ulcerans polyketide synthase 0.0024 0.0103 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0215 0.1044
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0045 0.114

Activities

Activity type Activity value Assay description Source Reference
GI (functional) Antibacterial activity against Escherichia coli NCTC 12923 assessed as growth inhibition at 1 to 50 mg/mL after 24 hr ChEMBL. No reference
IZ (functional) = 0 mm Antifungal activity against Candida albicans NCPF 3179 assessed as growth inhibition at 50 mg/mL after 3 days ChEMBL. No reference
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli NCTC 12923 assessed as growth inhibition at 50 mg/mL after 24 hr ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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