Detailed information for compound 1805935

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 532.627 | Formula: C29H24O6S2
  • H donors: 1 H acceptors: 5 LogP: 4.9 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(c1oc2c(c1)cc(cc2)c1cccc(c1)S(=O)(=O)C)c1ccc(cc1)c1cccc(c1)S(=O)(=O)C
  • InChi: 1S/C29H24O6S2/c1-36(31,32)25-7-3-5-21(16-25)19-9-11-20(12-10-19)29(30)28-18-24-15-23(13-14-27(24)35-28)22-6-4-8-26(17-22)37(2,33)34/h3-18,29-30H,1-2H3
  • InChiKey: RCZUOYDVQFFHDY-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0032 0.0105
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0133 0.0865 0.1734
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0032 0.0057
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0144 0.0503
Brugia malayi hypothetical protein 0.0273 0.1897 0.624
Echinococcus granulosus peroxidasin 0.0027 0.0083 0.0167
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0101 0.0346
Schistosoma mansoni ap endonuclease 0.0018 0.0019 0.0039
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0986 0.7149 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0032 0.0064
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0177 0.0581
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0069 0.0122
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0032 0.0064
Brugia malayi PAS domain containing protein 0.0096 0.0591 0.1946
Onchocerca volvulus 0.0035 0.0142 0.0365
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Loa Loa (eye worm) acetyltransferase 0.0172 0.1156 0.3802
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0101 0.2837
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0185 0.0327
Echinococcus granulosus geminin 0.0171 0.1142 0.2289
Mycobacterium ulcerans putative regulatory protein 0.0071 0.0408 0.0402
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0339 0.068
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0032 0.0105
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0071 0.0772
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0174 0.2903
Brugia malayi TAR-binding protein 0.0064 0.0354 0.1163
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0101 0.0202
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0032 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0032 0.0064
Schistosoma mansoni chromobox protein 0.007 0.04 0.0803
Loa Loa (eye worm) hypothetical protein 0.0062 0.0339 0.1116
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0032 0.0105
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.0035
Schistosoma mansoni polycystin 1-related 0.0062 0.0339 0.068
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0083 0.0275
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0339 0.0599
Brugia malayi PHD-finger family protein 0.0029 0.0101 0.0332
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0211 0.0373
Schistosoma mansoni chromobox protein 0.007 0.04 0.0803
Mycobacterium ulcerans hypothetical protein 0.0035 0.0142 0.0135
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0019 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0369 0.26 0.5214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0032 0.0105
Schistosoma mansoni coup transcription factor 0.002 0.0032 0.0064
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0032 0.0064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.0035
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.0844 1
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.4987 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.013 0.0844 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0032 0.0105
Brugia malayi hypothetical protein 0.0027 0.0083 0.0275
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0185 0.0372
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0142 0.0189
Echinococcus granulosus GPCR family 2 0.0034 0.0136 0.0273
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.0844 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0136 0.0448
Schistosoma mansoni hypothetical protein 0.0036 0.0151 0.0303
Schistosoma mansoni rab6-interacting 0.0062 0.0339 0.068
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0032 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0032 0.0105
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0772 0.0993
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.002 0.004
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Loa Loa (eye worm) beta-lactamase 0.0035 0.0142 0.0466
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0339 0.068
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0032 0.0064
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0069 0.0745
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0177 0.0354
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0071 0.0772
Onchocerca volvulus 0.0062 0.0339 0.1021
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0069 0.108
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0142 0.2343
Brugia malayi nuclear hormone receptor 0.002 0.0032 0.0105
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0387 0.2737 0.2732
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0101 0.0178
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.002 0.0048
Brugia malayi jmjC domain containing protein 0.004 0.0177 0.0581
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0069 0.0122
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0032 0.0064
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0032 0.0057
Echinococcus multilocularis transcription factor Dp 1 0.0075 0.044 0.0777
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0584 0.6896
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0142 0.0189
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0235 0.032
Schistosoma mansoni survival motor neuron protein 0.0056 0.0296 0.0593
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0387 0.2737 1
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0083 0.0275
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0071 0.0772
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0446 0.0895
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.002 0.0035
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0032 0.0064
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.002 0.0158
Echinococcus granulosus peregrin 0.0038 0.0169 0.0338
Trichomonas vaginalis chromobox protein, putative 0.007 0.04 0.6825
Leishmania major basic transcription factor 3a, putative 0.0035 0.0144 0.1641
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0069 0.108
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0032 0.0064
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0142 0.0135
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0584 0.192
Echinococcus multilocularis SAM and MBT domain containing protein 0.0103 0.0644 0.1137
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.0285 0.4834
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.0408 0.0721
Plasmodium vivax glutathione reductase, putative 0.0047 0.0235 0.6866
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0142 0.0284
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0083 0.0171
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0142 0.0189
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.1897 0.3351
Loa Loa (eye worm) runx1 0.0054 0.0281 0.0924
Onchocerca volvulus 0.0027 0.0083 0.0171
Echinococcus multilocularis peroxidasin 0.0027 0.0083 0.0147
Schistosoma mansoni zinc finger protein 0.0046 0.0227 0.0455
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.0457 0.0807
Onchocerca volvulus 0.0031 0.0112 0.0265
Loa Loa (eye worm) MBCTL1 0.0117 0.0749 0.2463
Echinococcus multilocularis RUN 0.0062 0.0339 0.0599
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0069 0.0226
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0032 0.0057
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0339 0.0599
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0354 0.0709
Plasmodium vivax multidomain scavenger receptor, putative 0.0062 0.0339 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0584 0.6848
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.0457 0.0916
Loa Loa (eye worm) hypothetical protein 0.0273 0.1897 0.624
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0144 0.2379
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0142 0.1616
Entamoeba histolytica hypothetical protein 0.0036 0.0151 0.1602
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0142 0.0189
Entamoeba histolytica hypothetical protein 0.0036 0.0151 0.1602
Loa Loa (eye worm) hypothetical protein 0.0108 0.0678 0.223
Brugia malayi beta-lactamase family protein 0.0035 0.0142 0.0466
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0211 0.0423
Trypanosoma brucei polo-like protein kinase 0.0095 0.0584 0.6896
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1524 0.2124
Giardia lamblia Kinase, PLK 0.0095 0.0584 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0172 0.1156 0.2317
Echinococcus multilocularis chromobox protein 1 0.007 0.04 0.0707
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0083 0.0275
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0142 0.2343
Brugia malayi hypothetical protein 0.0062 0.0339 0.1116
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0142 0.0284
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0032 0.0105
Mycobacterium ulcerans beta-lactamase 0.0035 0.0142 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0354 0.0709
Echinococcus granulosus tar DNA binding protein 0.0064 0.0354 0.0709
Brugia malayi beta-NAC-like protein 0.0035 0.0144 0.0473
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0019 0.0222
Echinococcus granulosus microtubule associated protein 2 0.0693 0.4987 1
Brugia malayi mbt repeat family protein 0.0103 0.0644 0.2118
Brugia malayi hypothetical protein 0.0152 0.1006 0.3308
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0151 0.0303
Loa Loa (eye worm) hypothetical protein 0.0037 0.0156 0.0515
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0218 0.2407
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0196 0.3283
Trypanosoma brucei ISWI complex protein 0.0033 0.0129 0.1459
Loa Loa (eye worm) hypothetical protein 0.0153 0.101 0.3322
Toxoplasma gondii thioredoxin reductase 0.0047 0.0235 0.0837
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0678 0.223
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0103 0.0644 0.2034
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0083 0.0275
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.013 0.0844 0.2775
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0032 0.0064
Schistosoma mansoni ap endonuclease 0.0018 0.0019 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0069 0.108
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0177 0.0354
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0591 0.1186
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0142 0.0284
Brugia malayi bHLH-PAS transcription factor 0.0071 0.0408 0.1342
Loa Loa (eye worm) hypothetical protein 0.0029 0.0101 0.0332
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0142 0.2343
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0211 0.0423
Loa Loa (eye worm) hypothetical protein 0.005 0.0255 0.0838
Echinococcus granulosus chromobox protein 1 0.007 0.04 0.0803
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0032 0.0105
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.002 0.0158
Plasmodium falciparum LCCL domain-containing protein 0.0062 0.0339 1
Onchocerca volvulus 0.0027 0.0083 0.0171
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.013 0.0844 0.149
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0231 0.389
Leishmania major hypothetical protein, conserved 0.0033 0.0129 0.1459
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0032 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Onchocerca volvulus 0.0035 0.0142 0.0365
Schistosoma mansoni hypothetical protein 0.0171 0.1142 0.2289
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0032 0.0057
Loa Loa (eye worm) hypothetical protein 0.0074 0.0427 0.1405
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Brugia malayi hypothetical protein 0.0428 0.304 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0096 0.0591 0.1186
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0013
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0144 0.1641
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0069 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0032 0.0105
Plasmodium falciparum thioredoxin reductase 0.0047 0.0235 0.6866
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0142 0.025
Entamoeba histolytica hypothetical protein 0.0036 0.0151 0.1602
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0174 0.0472
Brugia malayi RNA binding protein 0.0064 0.0354 0.1163
Schistosoma mansoni thyroid hormone receptor 0.002 0.0032 0.0064
Loa Loa (eye worm) hypothetical protein 0.0322 0.2254 0.7416
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0218 0.3658
Onchocerca volvulus Alhambra homolog 0.0029 0.0101 0.0229
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0144 0.1511
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0069 0.0138
Echinococcus granulosus transcription factor Dp 1 0.0075 0.044 0.0882
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0427 0.1405
Schistosoma mansoni hypothetical protein 0.0045 0.0213 0.0428
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0101 0.0202
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0273
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0142 0.0466
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0142 0.0189
Trichomonas vaginalis esterase, putative 0.0035 0.0142 0.2343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0211 0.0423
Brugia malayi jmjC domain containing protein 0.0096 0.0591 0.1945
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0142 0.1616
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0218 0.6347
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0584 0.117
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0083 0.0275
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0213 0.0702
Schistosoma mansoni bromodomain containing protein 0.0141 0.0922 0.1848
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0156 0.0314
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0019 0.0063
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0354 0.1163
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0144 0.0473
Schistosoma mansoni lipoxygenase 0.0258 0.1783 0.3576
Schistosoma mansoni hypothetical protein 0.0056 0.0296 0.0593
Onchocerca volvulus 0.0056 0.0296 0.0876
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0156 0.0314
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0032 0.0057
Echinococcus granulosus Polycystic kidney disease protein 0.0062 0.0339 0.068
Mycobacterium tuberculosis Conserved protein 0.0035 0.0142 0.0189
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.0844 1
Brugia malayi Isocitrate dehydrogenase 0.0018 0.002 0.0065
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.002 0.0158
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0235 0.0415
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0136 0.0273
Brugia malayi Heterochromatin protein 1 0.007 0.04 0.1317
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0019 0.0013
Echinococcus multilocularis GPCR, family 2 0.0034 0.0136 0.024
Schistosoma mansoni single-minded 0.0096 0.0591 0.1186
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0069 0.108
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.0285 0.4834
Brugia malayi hypothetical protein 0.0322 0.2254 0.7416
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0142 0.2343
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.013 0.0844 0.2775
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0273
Brugia malayi hypothetical protein 0.0036 0.0151 0.0498
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0019 0.0384
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0151 0.0303
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0019 0.0153
Loa Loa (eye worm) hypothetical protein 0.0083 0.0495 0.163
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0032 0.0105
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.013 0.0844 0.1691
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0156 0.0314
Loa Loa (eye worm) glutathione reductase 0.0047 0.0235 0.0773
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0019 0.0153
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0142 0.2343
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0032 0.0105
Echinococcus multilocularis Protein lozenge 0.0054 0.0281 0.0496
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0354 0.1163
Brugia malayi Bromodomain containing protein 0.0166 0.1108 0.3645
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0986 0.7149 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0573
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0069 0.108
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Onchocerca volvulus 0.0035 0.0142 0.0365
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Schistosoma mansoni hypothetical protein 0.0033 0.0129 0.0258
Mycobacterium ulcerans lipase LipD 0.0035 0.0142 0.0135
Brugia malayi mbt repeat family protein 0.0103 0.0644 0.2118
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0211 0.0423
Leishmania major trypanothione reductase 0.0047 0.0235 0.2729
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0083 0.0275
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0768 0.2527
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0101 0.0332
Echinococcus granulosus histone acetyltransferase KAT2B 0.0163 0.1084 0.2173
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0156 0.0276
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0644 0.1291
Mycobacterium tuberculosis Probable reductase 0.0108 0.0683 0.0947
Echinococcus multilocularis peregrin 0.0038 0.0169 0.0298
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.0285 0.0572
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0683 0.0947
Trichomonas vaginalis chromobox protein, putative 0.007 0.04 0.6825
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0083 0.0275
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0235 0.6866
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0032 0.0105
Schistosoma mansoni thyroid hormone receptor 0.002 0.0032 0.0064
Echinococcus granulosus polycomb protein SCMH1 0.0103 0.0644 0.1291
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0144 0.2379
Brugia malayi nuclear receptor NHR-88 0.002 0.0032 0.0105
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0772 0.1072
Echinococcus granulosus transcription factor btf3 0.0035 0.0144 0.0288
Mycobacterium leprae Probable lipase LipE 0.0035 0.0142 0.0103
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0678 0.223
Giardia lamblia PHD finger protein 15 0.0029 0.0101 0.1635
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0019 0.0153
Entamoeba histolytica hypothetical protein 0.0036 0.0151 0.1602
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0071 0.0772
Echinococcus multilocularis polycomb protein SCMH1 0.0103 0.0644 0.1137
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0083 0.0275
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0235 0.0471
Echinococcus granulosus single minded 2 0.0071 0.0408 0.0818
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0032 0.0057
Loa Loa (eye worm) mbt repeat family protein 0.0103 0.0644 0.2118
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0409 0.2901 0.5816
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0032 0.0064
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0101 0.0346
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0146 0.0258
Loa Loa (eye worm) RNA binding protein 0.0064 0.0354 0.1163
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.04 0.1317
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0133 0.0865 0.1528
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.0244 0.0431
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.4987 0.8811
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0069 0.108
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0156 0.0276
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.002 0.0398
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0117 0.0749 0.1501
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.002 0.0065
Loa Loa (eye worm) doublecortin family protein 0.0062 0.0339 0.1116
Plasmodium falciparum glutathione reductase 0.0047 0.0235 0.6866
Onchocerca volvulus 0.0027 0.0083 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0354 0.0709
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0019 0.0034
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0142 0.0189
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0683 0.0947
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0032 0.0057
Schistosoma mansoni kinase 0.0048 0.024 0.0482
Onchocerca volvulus 0.0152 0.1006 0.3237
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0584 0.1834
Brugia malayi Bromodomain containing protein 0.0038 0.0169 0.0555
Brugia malayi Thioredoxin reductase 0.0047 0.0235 0.0773
Loa Loa (eye worm) hypoxia-induced factor 1 0.0297 0.2071 0.6812
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0142 0.0189
Schistosoma mansoni myelin transcription factor 1 myt1 0.0117 0.0749 0.1501
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0083 0.0171
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0367
Schistosoma mansoni hypothetical protein 0.0074 0.0427 0.0856
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0069 0.108
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Onchocerca volvulus 0.0062 0.0339 0.1021
Schistosoma mansoni nuclear hormone receptor 0.002 0.0032 0.0064
Brugia malayi acetyltransferase, GNAT family protein 0.0172 0.1156 0.3802
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Brugia malayi isocitrate dehydrogenase 0.0018 0.002 0.0065
Brugia malayi Peroxidasin 0.0027 0.0083 0.0275
Brugia malayi chromobox protein homolog 3 0.0039 0.0174 0.0573
Brugia malayi hypoxia-induced factor 1 0.0297 0.2071 0.6812
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0032 0.0105
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0032 0.0064
Echinococcus multilocularis Polycystic kidney disease protein 0.0062 0.0339 0.0599
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0156 0.0314
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0231 0.389
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0196 0.3283
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0144 0.4128
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0083 0.0275
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.0285 0.1022
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0584 0.1031
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1373 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0211 0.0694
Brugia malayi beta-lactamase 0.0035 0.0142 0.0466
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.002 0.0158
Loa Loa (eye worm) bromodomain containing protein 0.0042 0.0196 0.0646
Schistosoma mansoni transcription factor btf3 0.0035 0.0144 0.0288
Onchocerca volvulus 0.0071 0.0408 0.125
Mycobacterium tuberculosis Conserved protein 0.0035 0.0142 0.0189
Brugia malayi Doublecortin family protein 0.0062 0.0339 0.1116
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0144 0.1641
Entamoeba histolytica hypothetical protein 0.0035 0.0144 0.1511
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0211 0.0694
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0142 0.0103
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0032 0.0105
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.0069 0.0062
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.1897 0.3803
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0584 0.6896
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0584 0.6896
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0354 0.0709
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0069 0.0745
Onchocerca volvulus 0.0025 0.0069 0.0122
Onchocerca volvulus 0.0103 0.0644 0.2034
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.013 0.0844 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0296 0.0972
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.566 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0117 0.0749 0.1501
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.033 0.1087
Onchocerca volvulus 0.0428 0.304 1
Loa Loa (eye worm) hypothetical protein 0.0428 0.304 1
Leishmania major protein kinase, putative 0.0025 0.0071 0.0772
Echinococcus multilocularis histone acetyltransferase MYST2 0.0117 0.0749 0.1323
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0354 0.0625
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0032 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0354 0.0709
Schistosoma mansoni lipoxygenase 0.0369 0.26 0.5214
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0032 0.0064
Schistosoma mansoni loxhd1 0.0062 0.0339 0.068
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1373 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0142 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0032 0.0064
Schistosoma mansoni hypothetical protein 0.0062 0.0339 0.068
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0032 0.0064
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0644 0.1291
Onchocerca volvulus Peroxidase homolog 0.0027 0.0083 0.0171
Onchocerca volvulus Peroxidase homolog 0.0027 0.0083 0.0171
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.004
Toxoplasma gondii ABC1 family protein 0.0035 0.0142 0.0495
Loa Loa (eye worm) hypothetical protein 0.0062 0.0339 0.1116
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0683 0.0947
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0683 0.0947
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0156 0.0314
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0772 0.1072
Brugia malayi Bromodomain containing protein 0.0087 0.0524 0.1725
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0235 0.0773
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.0035
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0144 0.1641
Brugia malayi PHD-finger family protein 0.0058 0.0312 0.1025
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0144 0.2379
Leishmania major protein kinase, putative 0.0025 0.0071 0.0772
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0069 0.108
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.0285 0.1022
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0019 0.0013
Schistosoma mansoni hypothetical protein 0.0629 0.4523 0.9068
Schistosoma mansoni peroxidasin 0.0027 0.0083 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.009 0.1443
Trypanosoma cruzi ISWI complex protein 0.0033 0.0129 0.1459
Brugia malayi MH2 domain containing protein 0.012 0.0768 0.2527
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0019 0.0063
Echinococcus granulosus RUN 0.0062 0.0339 0.068
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.013 0.0844 0.1691
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.0226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0678 0.223
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0142 0.1616
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0032 0.0064
Loa Loa (eye worm) hypothetical protein 0.0092 0.0563 0.1853
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0032 0.0064
Echinococcus granulosus SAM and MBT domain containing protein 0.0103 0.0644 0.1291
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0151 0.0267
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0069 0.108
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Brugia malayi glutathione reductase 0.0047 0.0235 0.0773
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0096 0.0594 0.1953
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0235 0.2729
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0683 0.0947
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0136 0.024
Schistosoma mansoni zinc finger protein 0.0033 0.0129 0.0258
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0387 0.2737 0.3768
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0768 0.2527
Schistosoma mansoni hypothetical protein 0.0029 0.0101 0.0202
Loa Loa (eye worm) hypothetical protein 0.0152 0.1006 0.3308
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0032 0.0105
Loa Loa (eye worm) hypothetical protein 0.0103 0.0644 0.2118
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.0244 0.0489
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1373 1 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0069 0.0745
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0083 0.0171
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0019 0.0384
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.002 0.0019
Trypanosoma cruzi ISWI complex protein 0.0033 0.0129 0.1459
Brugia malayi ecdysteroid receptor 0.002 0.0032 0.0105
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0142 0.4065
Loa Loa (eye worm) hypothetical protein 0.0117 0.0749 0.2463
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.0285 0.8386
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0019 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0369 0.26 0.4594
Leishmania major hypothetical protein, conserved 0.0035 0.0142 0.1616
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0083 0.0275
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0019 0.0013
Echinococcus granulosus zinc finger protein 0.0046 0.0227 0.0455
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Echinococcus granulosus FTZ F1 alpha 0.002 0.0032 0.0064
Schistosoma mansoni peroxidasin 0.0027 0.0083 0.0167
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.002 0.0048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0136 0.024
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.002 0.0035
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0772 0.1072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0019 0.0153
Trypanosoma brucei trypanothione reductase 0.0047 0.0235 0.2729
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0032 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0211 0.0373
Plasmodium falciparum phd finger protein, putative 0.0029 0.0101 0.2837
Echinococcus multilocularis chromobox protein 1 0.007 0.04 0.0707
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0584 0.192
Schistosoma mansoni lozenge 0.0054 0.0281 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0032 0.0105
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0136 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0032 0.0105
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0142 0.0466
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0032 0.0064
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0103 0.0644 0.1291
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0032 0.0105
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0117 0.0749 0.1323
Mycobacterium tuberculosis Conserved protein 0.0035 0.0142 0.0189
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0172 0.1156 0.2042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0136 0.0273
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0136 0.0448
Brugia malayi steroid hormone receptor 0.002 0.0032 0.0105
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0144 0.4128
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.009 0.1443
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0584 0.117
Toxoplasma gondii exonuclease III APE 0.0018 0.0019 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0032 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0032 0.0105
Echinococcus multilocularis transcription factor btf3 0.0035 0.0144 0.0254
Brugia malayi hypothetical protein 0.0062 0.0339 0.1116
Schistosoma mansoni hypothetical protein 0.0171 0.1142 0.2289
Echinococcus multilocularis zinc finger protein 0.0046 0.0227 0.0401
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0019 0.0222
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0273
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0019 0.0222
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.002 0.0398
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0156 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0174 0.2903
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0177 0.0354
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0683 0.0867
Brugia malayi Blistered cuticle protein 3 0.0027 0.0083 0.0275
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0136 0.0448
Brugia malayi beta-lactamase family protein 0.0035 0.0142 0.0466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0211 0.0423
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0117 0.0749 0.2463
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0196 0.0545
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0354 0.1163
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0591 0.1045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0032 0.0105
Schistosoma mansoni rab6-interacting 0.0062 0.0339 0.068
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0409 0.2901 0.5125
Echinococcus multilocularis geminin 0.0171 0.1142 0.2017
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0083 0.0171
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0013
Echinococcus granulosus chromobox protein 1 0.007 0.04 0.0803
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0069 0.108
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0069 0.108
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0244 0.0489
Loa Loa (eye worm) hypothetical protein 0.0428 0.304 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0387 0.2737 0.2732
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.002 0.0158

Activities

Activity type Activity value Assay description Source Reference
GI (functional) Antibacterial activity against Escherichia coli NCTC 12923 assessed as growth inhibition at 1 to 50 mg/mL after 24 hr ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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