Detailed information for compound 1805935

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 532.627 | Formula: C29H24O6S2
  • H donors: 1 H acceptors: 5 LogP: 4.9 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(c1oc2c(c1)cc(cc2)c1cccc(c1)S(=O)(=O)C)c1ccc(cc1)c1cccc(c1)S(=O)(=O)C
  • InChi: 1S/C29H24O6S2/c1-36(31,32)25-7-3-5-21(16-25)19-9-11-20(12-10-19)29(30)28-18-24-15-23(13-14-27(24)35-28)22-6-4-8-26(17-22)37(2,33)34/h3-18,29-30H,1-2H3
  • InChiKey: RCZUOYDVQFFHDY-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0142 0.1616
Leishmania major protein kinase, putative 0.0025 0.0071 0.0772
Onchocerca volvulus Peroxidase homolog 0.0027 0.0083 0.0171
Schistosoma mansoni coup transcription factor 0.002 0.0032 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0211 0.0423
Onchocerca volvulus Alhambra homolog 0.0029 0.0101 0.0229
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0032 0.0105
Trypanosoma cruzi ISWI complex protein 0.0033 0.0129 0.1459
Mycobacterium ulcerans beta-lactamase 0.0035 0.0142 0.0135
Brugia malayi acetyltransferase, GNAT family protein 0.0172 0.1156 0.3802
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.04 0.1317
Echinococcus multilocularis transcription factor btf3 0.0035 0.0144 0.0254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0156 0.0314
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0235 0.0773
Echinococcus multilocularis RUN 0.0062 0.0339 0.0599
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.002 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0101 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0069 0.108
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0071 0.0772
Brugia malayi ecdysteroid receptor 0.002 0.0032 0.0105
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0153 0.101 0.3322
Trypanosoma brucei trypanothione reductase 0.0047 0.0235 0.2729
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.002 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0032 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0032 0.0105
Echinococcus granulosus RUN 0.0062 0.0339 0.068
Brugia malayi beta-NAC-like protein 0.0035 0.0144 0.0473
Mycobacterium tuberculosis Conserved protein 0.0035 0.0142 0.0189
Onchocerca volvulus 0.0035 0.0142 0.0365
Loa Loa (eye worm) hypothetical protein 0.0322 0.2254 0.7416
Brugia malayi hypoxia-induced factor 1 0.0297 0.2071 0.6812
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0019 0.0013
Leishmania major hypothetical protein, conserved 0.0033 0.0129 0.1459
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0069 0.0745
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0142 0.0466
Giardia lamblia Kinase, PLK 0.0095 0.0584 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0032 0.0057
Trichomonas vaginalis esterase, putative 0.0035 0.0142 0.2343
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0196 0.3283
Brugia malayi hypothetical protein 0.0062 0.0339 0.1116
Brugia malayi mbt repeat family protein 0.0103 0.0644 0.2118
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0156 0.0276
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0584 0.6896
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.002 0.0019
Schistosoma mansoni hypothetical protein 0.0033 0.0129 0.0258
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0032 0.0057
Loa Loa (eye worm) hypothetical protein 0.0074 0.0427 0.1405
Brugia malayi Peroxidasin 0.0027 0.0083 0.0275
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0136 0.024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0032 0.0057
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0032 0.0057
Echinococcus multilocularis Polycystic kidney disease protein 0.0062 0.0339 0.0599
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.0035
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.002 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0032 0.0105
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0142 0.0189
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0019 0.0063
Brugia malayi MH2 domain containing protein 0.012 0.0768 0.2527
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0142 0.0284
Schistosoma mansoni kinase 0.0048 0.024 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0032 0.0105
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0133 0.0865 0.1734
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0185 0.0372
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0019 0.0018
Echinococcus granulosus transcription factor btf3 0.0035 0.0144 0.0288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0032 0.0105
Onchocerca volvulus 0.0152 0.1006 0.3237
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0177 0.0354
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0446 0.0895
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.0844 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0231 0.389
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0032 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0354 0.0709
Onchocerca volvulus 0.0062 0.0339 0.1021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0032 0.0057
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0069 0.108
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0273
Entamoeba histolytica hypothetical protein 0.0036 0.0151 0.1602
Mycobacterium tuberculosis Conserved protein 0.0035 0.0142 0.0189
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0156 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0069 0.108
Schistosoma mansoni rab6-interacting 0.0062 0.0339 0.068
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0144 0.1511
Echinococcus granulosus zinc finger protein 0.0046 0.0227 0.0455
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0584 0.117
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.4987 0.8811
Loa Loa (eye worm) RNA binding protein 0.0064 0.0354 0.1163
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0083 0.0171
Brugia malayi beta-lactamase 0.0035 0.0142 0.0466
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0083 0.0171
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0032 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0032 0.0105
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0142 0.0189
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0369 0.26 0.4594
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0772 0.1072
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0387 0.2737 0.3768
Echinococcus granulosus SAM and MBT domain containing protein 0.0103 0.0644 0.1291
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0142 0.2343
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0019 0.0063
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0136 0.0448
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0354 0.0709
Loa Loa (eye worm) hypothetical protein 0.0103 0.0644 0.2118
Echinococcus multilocularis polycomb protein SCMH1 0.0103 0.0644 0.1137
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.0844 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0032 0.0064
Schistosoma mansoni loxhd1 0.0062 0.0339 0.068
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0584 0.6896
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0142 0.4065
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0683 0.0947
Loa Loa (eye worm) hypothetical protein 0.0152 0.1006 0.3308
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0032 0.0064
Trypanosoma cruzi ISWI complex protein 0.0033 0.0129 0.1459
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0156 0.0314
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0032 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0032 0.0057
Schistosoma mansoni ap endonuclease 0.0018 0.0019 0.0039
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0235 0.032
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1524 0.2124
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0584 0.1834
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0339 0.0599
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0231 0.389
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0156 0.0314
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0071 0.0772
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0144 0.0473
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0069 0.0122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0032 0.0105
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0591 0.1186
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0142 0.2343
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0032 0.0057
Leishmania major hypothetical protein, conserved 0.0035 0.0142 0.1616
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0144 0.1641
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0172 0.1156 0.2042
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0083 0.0275
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1373 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0032 0.0105
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0387 0.2737 0.2732
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.002 0.0035
Schistosoma mansoni hypothetical protein 0.0062 0.0339 0.068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0211 0.0423
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0019 0.0384
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0772 0.0993
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.0285 0.4834
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0218 0.3658
Brugia malayi RNA binding protein 0.0064 0.0354 0.1163
Echinococcus multilocularis peroxidasin 0.0027 0.0083 0.0147
Schistosoma mansoni ap endonuclease 0.0018 0.0019 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0032 0.0064
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0354 0.1163
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.013 0.0844 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0177 0.0354
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0409 0.2901 0.5125
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0591 0.1045
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0213 0.0702
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0069 0.108
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0185 0.0327
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0142 0.2343
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0032 0.0064
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0032 0.0105
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0387 0.2737 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0339 0.068
Onchocerca volvulus 0.0428 0.304 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0032 0.0105
Mycobacterium tuberculosis Probable reductase 0.0108 0.0683 0.0947
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.0457 0.0916
Schistosoma mansoni lipoxygenase 0.0258 0.1783 0.3576
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0032 0.0105
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0069 0.0138
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0069 0.108
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0101 0.0202
Brugia malayi hypothetical protein 0.0036 0.0151 0.0498
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.0285 0.8386
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0144 0.1641
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.0844 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.0035
Schistosoma mansoni hypothetical protein 0.0171 0.1142 0.2289
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.009 0.1443
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0678 0.223
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0584 0.6848
Schistosoma mansoni hypothetical protein 0.0056 0.0296 0.0593
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0142 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Onchocerca volvulus 0.0027 0.0083 0.0171
Schistosoma mansoni aryl hydrocarbon receptor 0.0096 0.0591 0.1186
Brugia malayi Thioredoxin reductase 0.0047 0.0235 0.0773
Brugia malayi Bromodomain containing protein 0.0087 0.0524 0.1725
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0142 0.2343
Loa Loa (eye worm) hypothetical protein 0.0428 0.304 1
Brugia malayi hypothetical protein 0.0152 0.1006 0.3308
Schistosoma mansoni thyroid hormone receptor 0.002 0.0032 0.0064
Brugia malayi PHD-finger family protein 0.0029 0.0101 0.0332
Onchocerca volvulus 0.0031 0.0112 0.0265
Schistosoma mansoni lipoxygenase 0.0369 0.26 0.5214
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.0035
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0032 0.0057
Brugia malayi Isocitrate dehydrogenase 0.0018 0.002 0.0065
Schistosoma mansoni peroxidasin 0.0027 0.0083 0.0167
Brugia malayi glutathione reductase 0.0047 0.0235 0.0773
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0101 0.0346
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0019 0.0153
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0683 0.0947
Plasmodium falciparum LCCL domain-containing protein 0.0062 0.0339 1
Loa Loa (eye worm) bromodomain containing protein 0.0042 0.0196 0.0646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0211 0.0423
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0235 0.0471
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0142 0.0103
Brugia malayi PAS domain containing protein 0.0096 0.0591 0.1946
Onchocerca volvulus 0.0071 0.0408 0.125
Leishmania major basic transcription factor 3a, putative 0.0035 0.0144 0.1641
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0032 0.0105
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0019 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Schistosoma mansoni hypothetical protein 0.0036 0.0151 0.0303
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0142 0.0189
Mycobacterium ulcerans hypothetical protein 0.0035 0.0142 0.0135
Loa Loa (eye worm) hypothetical protein 0.005 0.0255 0.0838
Plasmodium vivax glutathione reductase, putative 0.0047 0.0235 0.6866
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0986 0.7149 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0142 0.1616
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0083 0.0275
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0768 0.2527
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0354 0.0625
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0083 0.0275
Trypanosoma brucei ISWI complex protein 0.0033 0.0129 0.1459
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0019 0.0153
Echinococcus granulosus tar DNA binding protein 0.0064 0.0354 0.0709
Brugia malayi hypothetical protein 0.0027 0.0083 0.0275
Brugia malayi hypothetical protein 0.0273 0.1897 0.624
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.0226
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0772 0.1072
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0354 0.0709
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0071 0.0772
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0367
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0354 0.1163
Schistosoma mansoni bromodomain containing protein 0.0141 0.0922 0.1848
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0069 0.108
Brugia malayi hypothetical protein 0.0428 0.304 1
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0768 0.2527
Brugia malayi beta-lactamase family protein 0.0035 0.0142 0.0466
Echinococcus granulosus Polycystic kidney disease protein 0.0062 0.0339 0.068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0156 0.0314
Echinococcus multilocularis GPCR, family 2 0.0034 0.0136 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0144 0.2379
Echinococcus granulosus polycomb protein SCMH1 0.0103 0.0644 0.1291
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0032 0.0064
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0142 0.025
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.0457 0.0807
Mycobacterium ulcerans lipase LipD 0.0035 0.0142 0.0135
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0117 0.0749 0.1501
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0678 0.223
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0083 0.0275
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0032 0.0064
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0142 0.0189
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0083 0.0275
Plasmodium falciparum phd finger protein, putative 0.0029 0.0101 0.2837
Echinococcus multilocularis Protein lozenge 0.0054 0.0281 0.0496
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.0285 0.4834
Echinococcus granulosus transcription factor Dp 1 0.0075 0.044 0.0882
Toxoplasma gondii ABC1 family protein 0.0035 0.0142 0.0495
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0142 0.0284
Echinococcus granulosus histone acetyltransferase MYST2 0.0117 0.0749 0.1501
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0142 0.0189
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0584 0.6896
Echinococcus multilocularis chromobox protein 1 0.007 0.04 0.0707
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0032 0.0105
Brugia malayi Heterochromatin protein 1 0.007 0.04 0.1317
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0339 0.0599
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0211 0.0694
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0019 0.0153
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0019 0.0034
Loa Loa (eye worm) mbt repeat family protein 0.0103 0.0644 0.2118
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0142 0.1616
Loa Loa (eye worm) acetyltransferase 0.0172 0.1156 0.3802
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.0285 0.0572
Echinococcus multilocularis chromobox protein 1 0.007 0.04 0.0707
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0101 0.0178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Schistosoma mansoni zinc finger protein 0.0033 0.0129 0.0258
Schistosoma mansoni hypothetical protein 0.0045 0.0213 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0032 0.0105
Schistosoma mansoni chromobox protein 0.007 0.04 0.0803
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0019 0.0222
Schistosoma mansoni lozenge 0.0054 0.0281 0.0563
Loa Loa (eye worm) hypothetical protein 0.0096 0.0594 0.1953
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0032 0.0064
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.4987 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0156 0.0515
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.013 0.0844 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0142 0.0103
Loa Loa (eye worm) hypothetical protein 0.0062 0.0339 0.1116
Brugia malayi mbt repeat family protein 0.0103 0.0644 0.2118
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0683 0.0947
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0369 0.26 0.5214
Schistosoma mansoni transcription factor btf3 0.0035 0.0144 0.0288
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0156 0.0314
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0117 0.0749 0.1323
Echinococcus granulosus GPCR family 2 0.0034 0.0136 0.0273
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0032 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0032 0.0105
Mycobacterium ulcerans putative regulatory protein 0.0071 0.0408 0.0402
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0151 0.0303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0032 0.0105
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0101 0.0346
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0083 0.0275
Echinococcus granulosus chromobox protein 1 0.007 0.04 0.0803
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0211 0.0423
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0235 0.0415
Schistosoma mansoni polycystin 1-related 0.0062 0.0339 0.068
Echinococcus multilocularis peregrin 0.0038 0.0169 0.0298
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0142 0.0189
Schistosoma mansoni rab6-interacting 0.0062 0.0339 0.068
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0136 0.0448
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0354 0.0709
Plasmodium falciparum thioredoxin reductase 0.0047 0.0235 0.6866
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.004
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0172 0.1156 0.2317
Schistosoma mansoni zinc finger protein 0.0046 0.0227 0.0455
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0103 0.0644 0.1291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0032 0.0105
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0032 0.0064
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0144 0.4128
Brugia malayi Doublecortin family protein 0.0062 0.0339 0.1116
Onchocerca volvulus 0.0062 0.0339 0.1021
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0142 0.2343
Schistosoma mansoni hypothetical protein 0.0629 0.4523 0.9068
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0387 0.2737 0.2732
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Onchocerca volvulus 0.0035 0.0142 0.0365
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0584 0.117
Onchocerca volvulus 0.0035 0.0142 0.0365
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0177 0.0581
Loa Loa (eye worm) hypothetical protein 0.0062 0.0339 0.1116
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Loa Loa (eye worm) hypothetical protein 0.0034 0.0136 0.0448
Entamoeba histolytica hypothetical protein 0.0036 0.0151 0.1602
Echinococcus multilocularis geminin 0.0171 0.1142 0.2017
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0144 0.2379
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Brugia malayi isocitrate dehydrogenase 0.0018 0.002 0.0065
Brugia malayi bHLH-PAS transcription factor 0.0071 0.0408 0.1342
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0136 0.0273
Loa Loa (eye worm) MBCTL1 0.0117 0.0749 0.2463
Loa Loa (eye worm) glutathione reductase 0.0047 0.0235 0.0773
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0144 0.2379
Loa Loa (eye worm) hypothetical protein 0.0092 0.0563 0.1853
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0584 0.192
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0069 0.0745
Entamoeba histolytica hypothetical protein 0.0036 0.0151 0.1602
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0235 0.2729
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0196 0.3283
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0144 0.0503
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0136 0.0273
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0142 0.0466
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.013 0.0844 0.1691
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.0244 0.0489
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0296 0.0972
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0144 0.4128
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0117 0.0749 0.2463
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0032 0.0105
Loa Loa (eye worm) hypoxia-induced factor 1 0.0297 0.2071 0.6812
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0103 0.0644 0.2034
Echinococcus multilocularis zinc finger protein 0.0046 0.0227 0.0401
Brugia malayi Blistered cuticle protein 3 0.0027 0.0083 0.0275
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0032 0.0064
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.002 0.0158
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.002 0.0398
Entamoeba histolytica hypothetical protein 0.0036 0.0151 0.1602
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0573
Schistosoma mansoni hypothetical protein 0.0029 0.0101 0.0202
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0986 0.7149 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0019 0.0222
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0083 0.0275
Trypanosoma brucei polo-like protein kinase 0.0095 0.0584 0.6896
Loa Loa (eye worm) hypothetical protein 0.0117 0.0749 0.2463
Onchocerca volvulus 0.0027 0.0083 0.0171
Brugia malayi beta-lactamase family protein 0.0035 0.0142 0.0466
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0142 0.0135
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.013 0.0844 0.149
Loa Loa (eye worm) runx1 0.0054 0.0281 0.0924
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0071 0.0772
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0069 0.108
Schistosoma mansoni hypothetical protein 0.0171 0.1142 0.2289
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0083 0.0171
Echinococcus multilocularis transcription factor Dp 1 0.0075 0.044 0.0777
Brugia malayi jmjC domain containing protein 0.0096 0.0591 0.1945
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0772 0.1072
Trichomonas vaginalis chromobox protein, putative 0.007 0.04 0.6825
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0083 0.0275
Brugia malayi Bromodomain containing protein 0.0038 0.0169 0.0555
Leishmania major protein kinase, putative 0.0025 0.0071 0.0772
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1373 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0273
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0683 0.0947
Schistosoma mansoni nuclear hormone receptor 0.002 0.0032 0.0064
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.002 0.004
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0177 0.0354
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0409 0.2901 0.5816
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0083 0.0275
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.002 0.0158
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0032 0.0064
Onchocerca volvulus 0.0025 0.0069 0.0122
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0069 0.108
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0069 0.108
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.566 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0174 0.0472
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0584 0.1031
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0069 0.0745
Brugia malayi nuclear receptor NHR-88 0.002 0.0032 0.0105
Mycobacterium tuberculosis Conserved protein 0.0035 0.0142 0.0189
Brugia malayi hypothetical protein 0.0062 0.0339 0.1116
Brugia malayi PHD-finger family protein 0.0058 0.0312 0.1025
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0032 0.0064
Brugia malayi TAR-binding protein 0.0064 0.0354 0.1163
Schistosoma mansoni thyroid hormone receptor 0.002 0.0032 0.0064
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0584 0.192
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0211 0.0694
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0032 0.0064
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0019 0.0039
Schistosoma mansoni peroxidasin 0.0027 0.0083 0.0167
Echinococcus granulosus chromobox protein 1 0.007 0.04 0.0803
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0146 0.0258
Echinococcus multilocularis histone acetyltransferase MYST2 0.0117 0.0749 0.1323
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0273
Loa Loa (eye worm) hypothetical protein 0.0108 0.0678 0.223
Entamoeba histolytica hypothetical protein 0.0035 0.0144 0.1511
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0144 0.1641
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0683 0.0867
Brugia malayi chromobox protein homolog 3 0.0039 0.0174 0.0573
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0019 0.0384
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0275
Schistosoma mansoni hypothetical protein 0.0074 0.0427 0.0856
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0218 0.2407
Brugia malayi nuclear hormone receptor 0.002 0.0032 0.0105
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.013 0.0844 0.2775
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.0285 0.1022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0211 0.0373
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0142 0.0284
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.033 0.1087
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0069 0.108
Brugia malayi hypothetical protein 0.0322 0.2254 0.7416
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0354 0.1163
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0354 0.0709
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0032 0.0105
Toxoplasma gondii thioredoxin reductase 0.0047 0.0235 0.0837
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.013 0.0844 0.1691
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.0285 0.1022
Brugia malayi jmjC domain containing protein 0.004 0.0177 0.0581
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0136 0.0448
Echinococcus multilocularis SAM and MBT domain containing protein 0.0103 0.0644 0.1137
Plasmodium falciparum glutathione reductase 0.0047 0.0235 0.6866
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0678 0.223
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0032 0.0105
Onchocerca volvulus Peroxidase homolog 0.0027 0.0083 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0032 0.0105
Leishmania major trypanothione reductase 0.0047 0.0235 0.2729
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0683 0.0947
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.002 0.0158
Echinococcus granulosus histone acetyltransferase KAT2B 0.0163 0.1084 0.2173
Plasmodium vivax multidomain scavenger receptor, putative 0.0062 0.0339 1
Brugia malayi steroid hormone receptor 0.002 0.0032 0.0105
Toxoplasma gondii exonuclease III APE 0.0018 0.0019 0.0047
Schistosoma mansoni chromobox protein 0.007 0.04 0.0803
Loa Loa (eye worm) hypothetical protein 0.0029 0.0101 0.0332
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0151 0.0303
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1373 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0136 0.024
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0069 0.0122
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0019 0.0222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0211 0.0373
Loa Loa (eye worm) doublecortin family protein 0.0062 0.0339 0.1116
Loa Loa (eye worm) hypothetical protein 0.0083 0.0495 0.163
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0013
Schistosoma mansoni myelin transcription factor 1 myt1 0.0117 0.0749 0.1501
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0644 0.1291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0211 0.0423
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.013 0.0844 0.2775
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0032 0.0064
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0218 0.6347
Giardia lamblia PHD finger protein 15 0.0029 0.0101 0.1635
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.1897 0.3803
Loa Loa (eye worm) hypothetical protein 0.0273 0.1897 0.624
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0083 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.009 0.1443
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0083 0.0275
Trichomonas vaginalis chromobox protein, putative 0.007 0.04 0.6825
Brugia malayi Bromodomain containing protein 0.0166 0.1108 0.3645
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0142 0.0189
Onchocerca volvulus 0.0027 0.0083 0.0171
Schistosoma mansoni survival motor neuron protein 0.0056 0.0296 0.0593
Echinococcus granulosus microtubule associated protein 2 0.0693 0.4987 1
Onchocerca volvulus 0.0103 0.0644 0.2034
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0069 0.0138
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0032 0.0064
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.0466
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0151 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0174 0.2903
Echinococcus granulosus FTZ F1 alpha 0.002 0.0032 0.0064
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0196 0.0545
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.0244 0.0431
Loa Loa (eye worm) beta-lactamase 0.0035 0.0142 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0174 0.2903
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0032 0.0064
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0644 0.1291
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.002 0.0158
Echinococcus granulosus geminin 0.0171 0.1142 0.2289
Echinococcus granulosus peregrin 0.0038 0.0169 0.0338
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.0408 0.0721
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0427 0.1405
Onchocerca volvulus 0.0056 0.0296 0.0876
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0019 0.0013
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0006 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0101 0.2837
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Echinococcus granulosus single minded 2 0.0071 0.0408 0.0818
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0019 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0156 0.0314
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.002 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0584 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0032 0.0105
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.0069 0.0062
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0013
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0133 0.0865 0.1528
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.002 0.0035
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0069 0.108
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.002 0.0048
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0235 0.6866
Schistosoma mansoni single-minded 0.0096 0.0591 0.1186
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0339 0.068
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0105
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0069 0.0226
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0244 0.0489
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0101 0.0202
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.1897 0.3351
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0273
Loa Loa (eye worm) hypothetical protein 0.0428 0.304 1
Echinococcus granulosus peroxidasin 0.0027 0.0083 0.0167

Activities

Activity type Activity value Assay description Source Reference
GI (functional) Antibacterial activity against Escherichia coli NCTC 12923 assessed as growth inhibition at 1 to 50 mg/mL after 24 hr ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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