Detailed information for compound 1806049

Basic information

Technical information
  • TDR Targets ID: 1806049
  • Name: N,4-dimethyl-6-(trichloromethyl)-1,3,5-triazi n-2-amine
  • MW: 241.506 | Formula: C6H7Cl3N4
  • H donors: 1 H acceptors: 3 LogP: 2.35 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1nc(C)nc(n1)C(Cl)(Cl)Cl
  • InChi: 1S/C6H7Cl3N4/c1-3-11-4(6(7,8)9)13-5(10-2)12-3/h1-2H3,(H,10,11,12,13)
  • InChiKey: SBOWLPJZUMTCMH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl-[4-methyl-6-(trichloromethyl)-s-triazin-2-yl]amine
  • 24830-33-9
  • 2-METHYL-4-METHYLAMINO-6-TRICHLOROMETHYL-S-TRIA*

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.1616 0.7834
Onchocerca volvulus Fatty acid synthase homolog 0.0049 0.0258 0.124
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0132 0.0628
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0118 0.0559
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0008 0.0026
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0085 0.0102
Brugia malayi Blistered cuticle protein 3 0.0027 0.0097 0.0461
Brugia malayi Cytochrome P450 family protein 0.0019 0.0036 0.0163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0628
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0118 0.0499
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0008 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Brugia malayi hypothetical protein 0.0016 0.0015 0.006
Leishmania major protein kinase, putative 0.0016 0.0016 0.0038
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0342 0.1658
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0036 0.0132
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0937 0.4447
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0092 0.0112
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0986 0.7153 1
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0118 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0218 0.1041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0118 0.0559
Brugia malayi steroid hormone receptor 0.003 0.0118 0.0559
Echinococcus multilocularis tumor protein p63 0.0328 0.2309 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0036 0.0163
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0087
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Schistosoma mansoni thyroid hormone receptor 0.003 0.0118 0.1034
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0118 0.0499
Echinococcus multilocularis 0.007 0.0416 0.1793
Loa Loa (eye worm) hypothetical protein 0.003 0.0118 0.0559
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0118 0.0559
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0015 0.0111
Brugia malayi hypothetical protein 0.0294 0.2062 1
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0218 0.0934
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0118 0.0559
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0208 0.0957
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0118 0.0559
Loa Loa (eye worm) hypothetical protein 0.0043 0.0215 0.1032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0024
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0218 0.1934
Leishmania major protein kinase, putative 0.0071 0.0424 0.1995
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0118 0.0499
Echinococcus multilocularis lamin 0.0032 0.0132 0.056
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0092 0.0112
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0041 0.0046
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0016 0.0038
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0097 0.0461
Echinococcus multilocularis musashi 0.0032 0.0132 0.056
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0118 0.1034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0118 0.0559
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0178 0.0232
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0118 0.0559
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0255 0.1227
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0045
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1373 1 0.5
Onchocerca volvulus 0.0047 0.0245 0.118
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0342 0.1658
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2021 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0118 0.0559
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0087
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.2091 1
Brugia malayi nuclear hormone receptor 0.003 0.0118 0.0559
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2021 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0008 0.0026
Brugia malayi intermediate filament protein 0.0032 0.0132 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0118 0.0559
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0118 0.1034
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0118 0.0559
Brugia malayi Protein kinase domain containing protein 0.0071 0.0424 0.2046
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0065 0.0053
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0218 0.1934
Brugia malayi nuclear receptor RXR 0.0016 0.0015 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.2091 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0387 0.2747 0.2738
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.006
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0097 0.0461
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0342 0.1472
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.006
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0071 0.0424 0.1995
Echinococcus granulosus single minded 2 0.0042 0.0209 0.0897
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0209 0.0197
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.0318 0.2836
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0118 0.1034
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1373 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0218 0.1046
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0049 0.0258 0.124
Brugia malayi isocitrate dehydrogenase 0.0015 0.0012 0.0048
Loa Loa (eye worm) hypothetical protein 0.003 0.0118 0.0559
Schistosoma mansoni peroxidasin 0.0027 0.0097 0.0853
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0012 0.0088
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.006
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0092 0.0336
Onchocerca volvulus 0.0027 0.0097 0.0461
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.008 0.0095
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0047
Mycobacterium ulcerans polyketide synthase 0.0026 0.0092 0.008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0029
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0681
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0118 0.0559
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2021 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0024 0.0104
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0071 0.0424 0.198
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1054 0.1459
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0936 0.1298
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0218 0.0989
Brugia malayi MAP kinase sur-1 0.006 0.0342 0.1649
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0015 0.0053
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0218 0.0934
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0255 0.1227
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0012 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0424 0.3785
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0118 0.0559
Echinococcus granulosus hypothetical protein 0.007 0.0416 0.1793
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0092 0.008
Loa Loa (eye worm) hypothetical protein 0.003 0.0118 0.0559
Onchocerca volvulus 0.0042 0.0209 0.1005
Brugia malayi hypoxia-induced factor 1 0.0176 0.1195 0.5791
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0118 0.0559
Echinococcus granulosus tumor protein p63 0.0328 0.2309 1
Onchocerca volvulus 0.0032 0.0132 0.0628
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0016 0.0038
Onchocerca volvulus 0.0032 0.0132 0.0628
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0042 0.0042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0012 0.0042
Leishmania major protein kinase, putative 0.0071 0.0424 0.1995
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0041 0.0149
Echinococcus multilocularis geminin 0.0165 0.1116 0.4828
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.008 0.0095
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0209 0.1005
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0012 0.0019
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0986 0.7153 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0342 0.1602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0118 0.0559
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0118 0.0499
Onchocerca volvulus 0.0027 0.0097 0.0461
Schistosoma mansoni lamin 0.0032 0.0132 0.116
Schistosoma mansoni nuclear hormone receptor 0.003 0.0118 0.1034
Brugia malayi hypothetical protein 0.0027 0.0097 0.0461
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0097 0.0461
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2021 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0218 0.0934
Loa Loa (eye worm) hypothetical protein 0.003 0.0118 0.0559
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0342 0.305
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2021 1
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0071 0.0424 0.198
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0208 0.094
Schistosoma mansoni hypothetical protein 0.0165 0.1116 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0118 0.0559
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0218 0.1006
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0118 0.0559
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Echinococcus granulosus intermediate filament protein 0.0032 0.0132 0.056
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.2021 1
Toxoplasma gondii hypothetical protein 0.0048 0.0253 0.0921
Schistosoma mansoni hypothetical protein 0.0033 0.0143 0.1259
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0342 0.1245
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0118 0.0499
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0118 0.0559
Onchocerca volvulus 0.0027 0.0097 0.0461
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0936 0.1293
Brugia malayi PAS domain containing protein 0.0057 0.0318 0.1533
Echinococcus granulosus FTZ F1 alpha 0.003 0.0118 0.0499
Schistosoma mansoni coup transcription factor 0.003 0.0118 0.1034
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0218 0.1041
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0209 0.0897
Leishmania major protein kinase, putative 0.0016 0.0016 0.0038
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0218 0.1041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0024
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0342 0.1602
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.006
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0118 0.0499
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0118 0.0499
Echinococcus multilocularis GPCR, family 2 0.0015 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0118 0.0559
Mycobacterium ulcerans polyketide synthase 0.0025 0.008 0.0067
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0036 0.0023
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0087
Onchocerca volvulus Peroxidase homolog 0.0027 0.0097 0.0461
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0065 0.0079
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.008 0.0067
Loa Loa (eye worm) hypoxia-induced factor 1 0.0176 0.1195 0.5791
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0071 0.0424 0.1995
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0178 0.0166
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0012 0.0043
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0342 0.1602
Loa Loa (eye worm) hypothetical protein 0.003 0.0118 0.0559
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0012 0.0019
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.2091 1
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.0424 0.2065
Brugia malayi ecdysteroid receptor 0.003 0.0118 0.0559
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0218 0.1006
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0012 0.0043
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0218 0.0934
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0012 0.0047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0015 0.006
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0065 0.0074
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0097 0.0461
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0012 0.0043
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0096 0.0453
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0015 0.0053
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0097 0.0461
Schistosoma mansoni peroxidasin 0.0027 0.0097 0.0853
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.008 0.0095
Brugia malayi hypothetical protein 0.0191 0.1304 0.632
Onchocerca volvulus 0.0015 0.0008 0.0029
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0275 0.1281
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0012 0.0043
Loa Loa (eye worm) hypothetical protein 0.007 0.0416 0.2008
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0071 0.0424 0.1995
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0936 0.0924
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0342 0.1472
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0012 0.0048
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0342 0.1586
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0342 0.1649
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0118 0.0499
Loa Loa (eye worm) hypothetical protein 0.0294 0.2062 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0015 0.006
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0012 0.0045
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0178 0.0232
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.008 0.0067
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0118 0.1034
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0028 0.0104
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0255 0.1227
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2021 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0118 0.0499
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0097 0.0461
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0118 0.0499
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0097 0.0461
Echinococcus multilocularis dual specificity protein kinase clk2 0.0071 0.0424 0.1827
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0118 0.1034
Schistosoma mansoni lamin 0.0032 0.0132 0.116
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0342 0.1472
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0092 0.0117
Brugia malayi nuclear receptor NHR-88 0.003 0.0118 0.0559
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0036 0.0132
Loa Loa (eye worm) hypothetical protein 0.0043 0.0218 0.1046
Mycobacterium ulcerans hypothetical protein 0.0157 0.1054 0.1043
Echinococcus granulosus lamin 0.0032 0.0132 0.056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0118 0.0559
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.008 0.01
Brugia malayi hypothetical protein 0.0016 0.0015 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2021 1
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0071 0.0424 0.2046
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0118 0.0499
Loa Loa (eye worm) hypothetical protein 0.003 0.0118 0.0559
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0118 0.0499
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0012 0.004
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0036 0.0114
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0132 0.0628
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0097 0.0461
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0085 0.0402
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0208 0.0957
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0036 0.0163
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0118 0.0559
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0118 0.0559
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0016 0.0038
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2021 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0012 0.0048
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.008 0.0067
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0092 0.0112
Schistosoma mansoni hypothetical protein 0.0165 0.1116 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0118 0.0499
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0342 0.1658
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0012 0.0043
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0118 0.1034
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0118 0.1034
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0178 0.0238
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0015 0.006
Onchocerca volvulus 0.0025 0.0085 0.0402
Schistosoma mansoni thyroid hormone receptor 0.003 0.0118 0.1034
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0036 0.0163
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.006
Echinococcus granulosus dual specificity protein kinase clk2 0.0071 0.0424 0.1827
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0218 0.1006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Brugia malayi Cytochrome P450 family protein 0.0019 0.0036 0.0163
Echinococcus multilocularis peroxidasin 0.0027 0.0097 0.0412
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0092 0.0117
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1373 1 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0015 0.0013 0.0006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.2091 1
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0097 0.0461
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0218 0.0934
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0012 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0424 0.3785
Echinococcus granulosus lamin dm0 0.0032 0.0132 0.056
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0041 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0118 0.0499
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Loa Loa (eye worm) hypothetical protein 0.0048 0.0255 0.1227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0118 0.0559
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0092 0.0117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0118 0.0499
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0252 0.2244
Giardia lamblia Kinase, CMGC CLK 0.0071 0.0424 0.1143
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0012 0.0043
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0118 0.1034
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0012 0.0047
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0208 0.0957
Trypanosoma brucei protein kinase, putative 0.006 0.0342 0.1586
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.008 0.01
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2021 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0342 0.1602
Schistosoma mansoni intermediate filament proteins 0.0032 0.0132 0.116
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0071 0.0424 0.1995
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0044 0.0044
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0012 0.0045
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0937 0.4458
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0092 0.008
Brugia malayi Peroxidasin 0.0027 0.0097 0.0461
Onchocerca volvulus 0.0048 0.0252 0.1213
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0118 0.0499
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.008 0.0376
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0118 0.1034
Plasmodium vivax serine/threonine kinase-1, putative 0.0071 0.0424 1
Leishmania major cytochrome p450-like protein 0.0019 0.0036 0.0132
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0342 0.1658
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0008 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0118 0.0559
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0342 0.0689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0118 0.0559
Onchocerca volvulus 0.0233 0.1616 0.7834
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0012 0.0019
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2021 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0342 0.1602
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0118 0.0559
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0015 0.0111
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0387 0.2747 0.2741
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0087
Echinococcus multilocularis lamin dm0 0.0032 0.0132 0.056
Plasmodium falciparum protein serine/threonine kinase-1 0.0071 0.0424 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0252 0.1213
Brugia malayi Pax transcription factor protein 2 0.0233 0.1616 0.7834
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0024 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0118 0.0559
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0342 0.1602
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0387 0.2747 0.3833
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0097 0.0461
Onchocerca volvulus 0.0294 0.2062 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.1304 0.632
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0461
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0092 0.0112
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0008 0.0026
Onchocerca volvulus 0.003 0.0118 0.0559
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0342 0.1472
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0016 0.0038
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0071 0.0424 0.1543
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0118 0.0499
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0092 0.0112
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0012 0.0042
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0097 0.0461
Mycobacterium ulcerans thioesterase 0.0023 0.0065 0.0053
Echinococcus granulosus geminin 0.0165 0.1116 0.4828
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0041 0.0029
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0218 0.0934
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0118 0.0559
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0143 0.0681
Schistosoma mansoni single-minded 0.0057 0.0318 0.2836
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0937 0.4458
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.008 0.0067
Onchocerca volvulus Peroxidase homolog 0.0027 0.0097 0.0461
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0097 0.0461
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0085 0.0402
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0097 0.0461
Loa Loa (eye worm) hypothetical protein 0.0031 0.0127 0.0607
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0012 0.0047
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0387 0.2747 1
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0097 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0118 0.0559
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0132 0.0628
Echinococcus granulosus GPCR family 2 0.0015 0.0012 0.0042
Echinococcus granulosus peroxidasin 0.0027 0.0097 0.0412

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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