TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 438.317 | Formula: C22H20BrN3O2
H donors: 0 H acceptors: 1 LogP: 4.83 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(cc1)C1OC(=NN1C(=O)C)c1ccc(cc1)n1c(C)ccc1C
InChi: 1S/C22H20BrN3O2/c1-14-4-5-15(2)25(14)20-12-8-17(9-13-20)21-24-26(16(3)27)22(28-21)18-6-10-19(23)11-7-18/h4-13,22H,1-3H3
InChiKey: IJMJCBCRKMPZLD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0728	0.2842	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0392	0.109	0.109
Echinococcus granulosus	neurogenic locus notch protein	0.0212	0.0153	0.01
Schistosoma mansoni	notch	0.0212	0.0153	0.01
Entamoeba histolytica	cyclin C, putative	0.0549	0.1908	1
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.031	0.0662	0.0612
Brugia malayi	Cadherin domain containing protein	0.0212	0.0153	0.01
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0541	0.1867	0.1824
Schistosoma mansoni	hypothetical protein	0.0212	0.0153	0.01
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0728	0.2842	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0728	0.2842	0.2803
Echinococcus multilocularis	c4b binding protein beta chain	0.0392	0.109	0.1042
Schistosoma mansoni	hypothetical protein	0.0212	0.0153	0.01
Brugia malayi	Thioredoxin reductase	0.21	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0728	0.2842	0.2803
Trypanosoma cruzi	trypanothione reductase, putative	0.0728	0.2842	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0728	0.2842	0.2803
Brugia malayi	hypothetical protein	0.0392	0.109	0.1042
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0212	0.0153	0.01
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0193	0.0053	0.0053
Trypanosoma cruzi	trypanothione reductase, putative	0.21	1	1
Brugia malayi	pregnancy-associated plasma protein-A	0.0392	0.109	0.1042
Echinococcus granulosus	c4b binding protein beta chain	0.0392	0.109	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Echinococcus multilocularis	cyclin dependent kinase 19	0.0689	0.2641	0.2602
Echinococcus granulosus	thioredoxin glutathione reductase	0.21	1	1
Echinococcus granulosus	defective proboscis extension response	0.031	0.0662	0.0612
Schistosoma mansoni	serine/threonine protein kinase	0.0689	0.2641	0.2602
Echinococcus multilocularis	neurogenic locus notch protein	0.0212	0.0153	0.01
Echinococcus granulosus	Immunoglobulin	0.031	0.0662	0.0612
Loa Loa (eye worm)	glutathione reductase	0.21	1	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0534	0.1834	0.179
Loa Loa (eye worm)	Notch2	0.0212	0.0153	0.0153
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0728	0.2842	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0392	0.109	0.109
Loa Loa (eye worm)	hypothetical protein	0.031	0.0662	0.0662
Schistosoma mansoni	nephrin	0.0389	0.1075	0.1027
Echinococcus multilocularis	neurogenic locus protein delta	0.0212	0.0153	0.01
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0212	0.0153	0.01
Onchocerca volvulus		0.0392	0.109	1
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Loa Loa (eye worm)	thioredoxin reductase	0.21	1	1
Schistosoma mansoni	hypothetical protein	0.0212	0.0153	0.01
Schistosoma mansoni	notch	0.0212	0.0153	0.01
Toxoplasma gondii	thioredoxin reductase	0.21	1	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0411	0.1189	0.1189
Schistosoma mansoni	laminin gamma-3 chain	0.0212	0.0153	0.01
Onchocerca volvulus		0.0212	0.0153	0.0957
Echinococcus granulosus	protein jagged 2	0.0212	0.0153	0.01
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0541	0.1867	0.1824
Schistosoma mansoni	notch	0.0212	0.0153	0.01
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.031	0.0662	0.0612
Brugia malayi	Cyclin C	0.1083	0.4694	0.4666
Echinococcus granulosus	delta-like protein 1	0.0212	0.0153	0.01
Brugia malayi	Sushi domain	0.0392	0.109	0.1042
Plasmodium vivax	glutathione reductase, putative	0.21	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Brugia malayi	hypothetical protein	0.0392	0.109	0.1042
Loa Loa (eye worm)	hypothetical protein	0.031	0.0662	0.0662
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0541	0.1867	0.1824
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0728	0.2842	0.2803
Plasmodium vivax	apical sushi protein, putative	0.0392	0.109	0.1042
Schistosoma mansoni	hypothetical protein	0.0212	0.0153	0.01
Echinococcus granulosus	neuroglian	0.0389	0.1075	0.1027
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.031	0.0662	0.0612
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0728	0.2842	1
Echinococcus granulosus	slit 2 protein	0.0212	0.0153	0.01
Onchocerca volvulus		0.0392	0.109	1
Brugia malayi	EGF-like domain containing protein	0.0212	0.0153	0.01
Echinococcus granulosus	twitchin	0.0392	0.109	0.1042
Schistosoma mansoni	hypothetical protein	0.0212	0.0153	0.01
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0411	0.1189	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Echinococcus granulosus	neural cadherin	0.0212	0.0153	0.01
Schistosoma mansoni	hypothetical protein	0.0212	0.0153	0.01
Onchocerca volvulus		0.0212	0.0153	0.0957
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0728	0.2842	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0728	0.2842	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Brugia malayi	EGF-like domain containing protein	0.0212	0.0153	0.01
Brugia malayi	Calcium binding EGF domain containing protein	0.0212	0.0153	0.01
Loa Loa (eye worm)	hypothetical protein	0.031	0.0662	0.0662
Schistosoma mansoni	notch	0.0212	0.0153	0.01
Schistosoma mansoni	cell adhesion molecule	0.0411	0.1189	0.1142
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0728	0.2842	0.2803
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0728	0.2842	0.2803
Trypanosoma brucei	trypanothione reductase	0.21	1	1
Plasmodium falciparum	apical sushi protein	0.0392	0.109	0.1042
Onchocerca volvulus	Slit protein homolog	0.0212	0.0153	0.0957
Brugia malayi	hypothetical protein	0.0392	0.109	0.1042
Brugia malayi	Calcium binding EGF domain containing protein	0.0212	0.0153	0.01
Toxoplasma gondii	rhoptry neck protein RON9	0.0392	0.109	0.1042
Brugia malayi	Delta serrate ligand family protein	0.0212	0.0153	0.01
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Loa Loa (eye worm)	gastrulation defective protein 1	0.0686	0.2627	0.2627
Brugia malayi	EGF-like domain containing protein	0.0212	0.0153	0.01
Brugia malayi	GCC2 and GCC3 family protein	0.0604	0.2196	0.2154
Loa Loa (eye worm)	hypothetical protein	0.0604	0.2196	0.2196
Trichomonas vaginalis	glutathione reductase, putative	0.0728	0.2842	1
Loa Loa (eye worm)	hypothetical protein	0.0392	0.109	0.109
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0728	0.2842	0.2803
Onchocerca volvulus		0.0212	0.0153	0.0957
Brugia malayi	Fibronectin type III domain containing protein	0.031	0.0662	0.0612
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0728	0.2842	0.2803
Brugia malayi	Immunoglobulin I-set domain containing protein	0.031	0.0662	0.0612
Echinococcus multilocularis	Immunoglobulin	0.031	0.0662	0.0612
Leishmania major	trypanothione reductase	0.21	1	1
Giardia lamblia	High cysteine protein	0.0212	0.0153	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0436	0.1319	0.1319
Brugia malayi	EGF-like domain containing protein	0.0212	0.0153	0.01
Brugia malayi	hypothetical protein	0.0392	0.109	0.1042
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0212	0.0153	0.01
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Brugia malayi	EGF-like domain containing protein	0.0212	0.0153	0.01
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0728	0.2842	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0728	0.2842	1
Echinococcus granulosus	fibropellin Ia	0.0212	0.0153	0.01
Schistosoma mansoni	hypothetical protein	0.0212	0.0153	0.01
Plasmodium falciparum	thioredoxin reductase	0.0728	0.2842	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0392	0.109	0.109
Echinococcus granulosus	protein jagged 2	0.0212	0.0153	0.01
Echinococcus granulosus	roundabout 2	0.049	0.1602	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0053	0.0053
Brugia malayi	hypothetical protein	0.0392	0.109	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Onchocerca volvulus	Putative cubilin	0.0212	0.0153	0.0957
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0728	0.2842	0.2803
Brugia malayi	notch-like transmembrane receptor	0.0212	0.0153	0.01
Loa Loa (eye worm)	cyclin C	0.1083	0.4694	0.4694
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0728	0.2842	0.2803
Echinococcus granulosus	neurogenic locus notch protein 4	0.0212	0.0153	0.01
Onchocerca volvulus		0.0392	0.109	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.21	1	1
Loa Loa (eye worm)	programmed cell death 8	0.0193	0.0053	0.0053
Schistosoma mansoni	c4b-binding protein beta chain	0.0392	0.109	0.1042
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0728	0.2842	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Echinococcus multilocularis	protein jagged 2	0.0212	0.0153	0.01
Trichomonas vaginalis	mercuric reductase, putative	0.0728	0.2842	1
Brugia malayi	Protein kinase domain containing protein	0.0689	0.2641	0.2602
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.0392	0.109	0.109
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0728	0.2842	1
Onchocerca volvulus		0.0392	0.109	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0728	0.2842	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Plasmodium falciparum	glutathione reductase	0.21	1	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0728	0.2842	0.2803
Echinococcus multilocularis	protein jagged 1	0.0212	0.0153	0.01
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0411	0.1189	0.1142
Echinococcus granulosus	notch	0.0212	0.0153	0.01
Brugia malayi	hypothetical protein	0.0392	0.109	0.1042
Echinococcus multilocularis	Immunoglobulin	0.031	0.0662	0.0612
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0728	0.2842	0.2803
Treponema pallidum	NADH oxidase	0.0728	0.2842	1
Echinococcus granulosus	protein jagged 1	0.0212	0.0153	0.01
Echinococcus multilocularis	slit 2 protein	0.0212	0.0153	0.01
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0728	0.2842	0.2803
Plasmodium falciparum	thioredoxin reductase	0.21	1	1
Brugia malayi	Muscle positioning protein 4	0.0212	0.0153	0.01
Onchocerca volvulus	Neurogenic locus notch homolog	0.0212	0.0153	0.0957
Echinococcus granulosus	cyclin dependent kinase 19	0.0689	0.2641	0.2602
Echinococcus multilocularis	protein jagged 1	0.0212	0.0153	0.01
Loa Loa (eye worm)	hypothetical protein	0.031	0.0662	0.0662
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0728	0.2842	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Toxoplasma gondii	rhoptry neck protein RON1	0.0392	0.109	0.1042
Onchocerca volvulus		0.0212	0.0153	0.0957
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0728	0.2842	0.2803
Echinococcus multilocularis	notch	0.0212	0.0153	0.01
Echinococcus multilocularis	roundabout 2	0.049	0.1602	0.1557
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0728	0.2842	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0728	0.2842	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0728	0.2842	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Echinococcus multilocularis	neural cadherin	0.0212	0.0153	0.01
Brugia malayi	Calcium binding EGF domain containing protein	0.0212	0.0153	0.01
Loa Loa (eye worm)	hypothetical protein	0.0268	0.0442	0.0442
Loa Loa (eye worm)	CMGC/CDK/CDK8 protein kinase	0.0689	0.2641	0.2641
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0728	0.2842	0.2803
Echinococcus granulosus	neurogenic locus protein delta	0.0212	0.0153	0.01
Echinococcus granulosus	C type lectin domian containing protein	0.0392	0.109	0.1042
Schistosoma mansoni	vesicular amine transporter	0.031	0.0662	0.0612
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0728	0.2842	1
Echinococcus granulosus	neurogenic locus notch protein	0.0212	0.0153	0.01
Plasmodium falciparum	glutathione reductase	0.0728	0.2842	0.2803
Schistosoma mansoni	notch	0.0212	0.0153	0.01
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0728	0.2842	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1189	0.1189
Onchocerca volvulus		0.0392	0.109	1
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0534	0.1834	0.179
Echinococcus multilocularis	fibropellin Ia	0.0212	0.0153	0.01
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Toxoplasma gondii	EGF family domain-containing protein	0.0212	0.0153	0.01
Brugia malayi	hypothetical protein	0.0392	0.109	0.1042
Echinococcus multilocularis	C type lectin domian containing protein	0.0392	0.109	0.1042
Echinococcus multilocularis	neuroglian	0.0389	0.1075	0.1027
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0212	0.0153	0.01
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0728	0.2842	0.2803
Schistosoma mansoni	slit	0.0212	0.0153	0.01
Loa Loa (eye worm)	hypothetical protein	0.0392	0.109	0.109
Echinococcus granulosus	cyclin	0.0541	0.1867	0.1824
Echinococcus granulosus	protein jagged 1	0.0212	0.0153	0.01
Schistosoma mansoni	cell polarity protein	0.0212	0.0153	0.01
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0212	0.0153	0.0957
Onchocerca volvulus		0.0392	0.109	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.0662	0.0662
Echinococcus multilocularis	cyclin	0.0541	0.1867	0.1824
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Onchocerca volvulus		0.0392	0.109	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.0662	0.0662
Loa Loa (eye worm)	hypothetical protein	0.049	0.1602	0.1602
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0728	0.2842	0.2803
Plasmodium vivax	thioredoxin reductase, putative	0.21	1	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0728	0.2842	1
Schistosoma mansoni	g1/s-specific cyclin C	0.1083	0.4694	0.4666
Onchocerca volvulus		0.0212	0.0153	0.0957
Schistosoma mansoni	notch	0.0212	0.0153	0.01
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0153	0.0153
Brugia malayi	hypothetical protein	0.031	0.0662	0.0612
Echinococcus multilocularis	thioredoxin glutathione reductase	0.21	1	1
Brugia malayi	Cadherin domain containing protein	0.0212	0.0153	0.01
Onchocerca volvulus		0.0392	0.109	1
Onchocerca volvulus		0.0392	0.109	1
Brugia malayi	EGF-like domain containing protein	0.0212	0.0153	0.01
Schistosoma mansoni	septate junction protein	0.0212	0.0153	0.01
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0728	0.2842	0.2803
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0728	0.2842	0.2803
Brugia malayi	EGF-like domain containing protein	0.0212	0.0153	0.01
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0728	0.2842	0.2803
Echinococcus multilocularis	neurogenic locus notch protein	0.0212	0.0153	0.01
Echinococcus multilocularis	neurogenic locus protein delta	0.0212	0.0153	0.01
Loa Loa (eye worm)	cyclin domain-containing protein	0.0541	0.1867	0.1867
Onchocerca volvulus		0.0392	0.109	1
Loa Loa (eye worm)	notch protein	0.0212	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0392	0.109	0.109
Loa Loa (eye worm)	hypothetical protein	0.0392	0.109	0.109
Loa Loa (eye worm)	hypothetical protein	0.049	0.1602	0.1602

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (ADMET)	= 195 uM	Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay	ChEMBL.	No reference
MIC (functional)	= 8 ug ml-1	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 21 days by broth dilution method	ChEMBL.	No reference
MIC (functional)	= 31.25 ug ml-1	Antifungal activity against Saccharomyces cerevisiae after 18 hr by broth microdilution technique	ChEMBL.	No reference
MIC (functional)	= 500 ug ml-1	Antibacterial activity against Escherichia coli after 18 hr by broth microdilution technique	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2281701

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1806084