TDR Targets

Basic information

Technical information

TDR Targets ID: 1806450
Name: (2E)-2-[2-[(2-fluorophenoxy)methyl]phenyl]-2- methoxyimino-N-methylacetamide
MW: 316.327 | Formula: C17H17FN2O3
H donors: 1 H acceptors: 1 LogP: 3.23 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CO/N=C(\c1ccccc1COc1ccccc1F)/C(=O)NC
InChi: 1S/C17H17FN2O3/c1-19-17(21)16(20-22-2)13-8-4-3-7-12(13)11-23-15-10-6-5-9-14(15)18/h3-10H,11H2,1-2H3,(H,19,21)/b20-16+
InChiKey: PDZQMFVCGHSBCH-CAPFRKAQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2E)-2-[2-[(2-fluorophenoxy)methyl]phenyl]-2-methoxyimino-N-methyl-acetamide
(2E)-2-[2-[(2-fluorophenoxy)methyl]phenyl]-2-methoxyimino-N-methyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0149	0.5231	1
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.1592	0.3043
Loa Loa (eye worm)	hypothetical protein	0.0173	0.6213	1
Brugia malayi	beta-lactamase family protein	0.0042	0.089	0.1317
Echinococcus granulosus	proteasome prosome macropain	0.0149	0.5231	0.8419
Loa Loa (eye worm)	hypothetical protein	0.0042	0.089	0.1432
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.089	0.0814
Mycobacterium ulcerans	lipase LipD	0.0042	0.089	0.1568
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0059	0.1592	0.2932
Mycobacterium tuberculosis	Conserved protein	0.0042	0.089	0.0814
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0082	0.0133
Echinococcus granulosus	mitogen activated protein kinase 3	0.0059	0.1592	0.2562
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0149	0.5231	0.8419
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0082	0.0133
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.0168	0.0271
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0082	0.5
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0059	0.1592	0.2932
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0149	0.5231	1
Mycobacterium ulcerans	hypothetical protein	0.0042	0.089	0.1568
Loa Loa (eye worm)	hypothetical protein	0.005	0.1202	0.1934
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.089	0.1568
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0258	0.0493
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0059	0.1592	0.2932
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.007	0.205	0.3822
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.0029	0.0046
Echinococcus granulosus	zinc finger protein	0.0023	0.0118	0.0191
Brugia malayi	Bromodomain containing protein	0.0044	0.0998	0.1493
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0149	0.5231	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.252	0.4056
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0059	0.1592	0.2562
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0149	0.5231	1
Loa Loa (eye worm)	beta-lactamase	0.0042	0.089	0.1432
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.089	0.0814
Mycobacterium ulcerans	proteasome PrcB	0.0149	0.5231	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.089	0.1568
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0042	0.0886	0.1427
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.089	0.0814
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.205	0.392
Brugia malayi	beta-lactamase family protein	0.0042	0.089	0.1317
Mycobacterium tuberculosis	Conserved protein	0.0042	0.089	0.0814
Schistosoma mansoni	ap endonuclease	0.0022	0.0082	0.0157
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0149	0.5231	0.8419
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0059	0.1592	0.2932
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.1592	0.2932
Toxoplasma gondii	proteasome subunit beta type, putative	0.0149	0.5231	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.007	0.205	0.33
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1001	0.1611
Echinococcus multilocularis	mitogen activated protein kinase	0.0059	0.1592	0.2562
Mycobacterium tuberculosis	Conserved protein	0.0042	0.089	0.0814
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0082	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.089	0.1568
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.089	0.1701
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.1592	0.2932
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.1592	0.2932
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.089	0.1568
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.205	0.3822
Mycobacterium ulcerans	beta-lactamase	0.0042	0.089	0.1568
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0258	0.0415
Toxoplasma gondii	ABC1 family protein	0.0042	0.089	0.1568
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0149	0.5231	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.089	0.1568
Schistosoma mansoni	zinc finger protein	0.0023	0.0118	0.0226
Trichomonas vaginalis	esterase, putative	0.0042	0.089	0.1568
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.089	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0173	0.6213	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.205	0.3822
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0149	0.5231	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0059	0.1592	0.2932
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.205	0.3822
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.089	0.0814
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0149	0.5231	0.5191
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.089	0.0814
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0069	0.2002	0.3223
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.007	0.205	0.1984
Echinococcus granulosus	mitogen activated protein kinase	0.0059	0.1592	0.2562
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.089	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0042	0.089	0.1432
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.089	0.1432
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.089	0.1568
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.089	0.1701
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0082	0.0133
Brugia malayi	Proteasome A-type and B-type family protein	0.0149	0.5231	0.8398
Echinococcus multilocularis	muscleblind protein	0.0173	0.6213	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0059	0.1592	0.2562
Loa Loa (eye worm)	hypothetical protein	0.0042	0.089	0.1432
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0149	0.5231	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.089	0.0814
Echinococcus multilocularis	muscleblind protein 1	0.0173	0.6213	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.089	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0042	0.089	0.1432
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0069	0.2002	0.3223
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0059	0.1592	0.2932
Brugia malayi	Muscleblind-like protein	0.0173	0.6213	1
Leishmania major	hypothetical protein, conserved	0.0042	0.089	0.1568
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.089	0.0814
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.089	0.1432
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.089	0.1317
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.089	0.1568
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0042	0.0886	0.1427
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0059	0.1592	0.2932
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.007	0.205	0.33
Onchocerca volvulus		0.0042	0.089	0.5
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0258	0.0415
Schistosoma mansoni	bromodomain containing protein	0.0073	0.2171	0.4149
Toxoplasma gondii	aldehyde dehydrogenase	0.007	0.205	0.3822
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1112	0.179
Giardia lamblia	Kinase, CMGC MAPK	0.0059	0.1592	0.2932
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0059	0.1592	0.2932
Schistosoma mansoni	hypothetical protein	0.0024	0.0168	0.0321
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.089	0.1432
Echinococcus granulosus	muscleblind protein	0.0173	0.6213	1
Onchocerca volvulus		0.0042	0.089	0.5
Onchocerca volvulus		0.0042	0.089	0.5
Brugia malayi	beta-lactamase	0.0042	0.089	0.1317
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0149	0.5231	1
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.1592	0.2932
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.205	0.392
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0149	0.5231	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.089	0.1432
Leishmania major	proteasome beta 5 subunit, putative	0.0149	0.5231	1
Plasmodium falciparum	proteasome subunit beta type-5	0.0149	0.5231	1
Brugia malayi	PHD-finger family protein	0.0029	0.0369	0.0467
Brugia malayi	MAP kinase sur-1	0.0059	0.1592	0.2462
Trypanosoma brucei	protein kinase, putative	0.0059	0.1592	0.2932
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.089	0.1568
Brugia malayi	Bromodomain containing protein	0.0087	0.2721	0.4304
Schistosoma mansoni	ap endonuclease	0.0022	0.0082	0.0157
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.089	0.1568
Echinococcus multilocularis	zinc finger protein	0.0023	0.0118	0.0191

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2287429

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1806450