TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 395.28 | Formula: C19H20Cl2N2O3
H donors: 1 H acceptors: 1 LogP: 4.14 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CNC(=O)C(c1ccccc1CO/N=C(/c1ccc(cc1Cl)Cl)\C)OC
InChi: 1S/C19H20Cl2N2O3/c1-12(15-9-8-14(20)10-17(15)21)23-26-11-13-6-4-5-7-16(13)18(25-3)19(24)22-2/h4-10,18H,11H2,1-3H3,(H,22,24)/b23-12+
InChiKey: PRAAQCXARDMQPA-FSJBWODESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0072	0.0276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Onchocerca volvulus		0.0012	0.0072	0.019
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0202	0.0774
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.0202	0.1146
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.1404	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0046	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0046	0.0177
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0046	0.0154
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0046	0.0177
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0046	0.0154
Schistosoma mansoni	coup transcription factor	0.0011	0.0046	0.0154
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0046	0.0177
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0046	0.0177
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0202	0.1366
Mycobacterium leprae	conserved hypothetical protein	0.0075	0.1404	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0202	0.0774
Brugia malayi	MH2 domain containing protein	0.0132	0.2608	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0202	0.1366
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0072	0.0276
Trypanosoma brucei	hypothetical protein, conserved	0.0075	0.1404	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0012	0.0038
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.0202	0.0774
Onchocerca volvulus		0.0019	0.0202	0.1146
Echinococcus multilocularis	cysteine protease	0.0019	0.0202	0.0673
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0202	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0046	0.0154
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0151	0.2997	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1404	0.5385
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0202	0.1366
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.1404	0.4686
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0012	0.0044
Mycobacterium leprae	Probable lipase LipE	0.0075	0.1404	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0046	0.0177
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0046	0.0167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0202	0.1146
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0202	0.0774
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0046	0.0154
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.1305	0.9284
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0202	0.1366
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0075	0.1404	0.5385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0046	0.0177
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0046	0.0154
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.1305	0.9284
Onchocerca volvulus		0.0019	0.0202	0.1146
Loa Loa (eye worm)	cysteine protease	0.0019	0.0202	0.0774
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0202	0.1366
Plasmodium vivax	vivapain-2	0.0019	0.0202	0.1366
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.0202	0.0731
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.1305	0.9284
Echinococcus granulosus	cathepsin L	0.001	0.0012	0.0042
Leishmania major	cathepsin L-like protease	0.0071	0.1305	0.9171
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0202	0.1366
Loa Loa (eye worm)	fibroinase	0.0019	0.0202	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0046	0.0177
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0202	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0202	0.0673
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.1404	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0046	0.0154
Trichomonas vaginalis	esterase, putative	0.0075	0.1404	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0046	0.0177
Brugia malayi	nuclear hormone receptor	0.0011	0.0046	0.0177
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0046	0.0177
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0019	0.0202	1
Toxoplasma gondii	ABC1 family protein	0.0075	0.1404	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0046	0.0177
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.2608	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0072	0.0435
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0202	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0046	0.0177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Leishmania major	hypothetical protein, conserved	0.0075	0.1404	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0046	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0046	0.0177
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0202	0.1146
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0012	0.0038
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.1404	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0202	0.0673
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0012	0.0038
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.1305	0.9284
Onchocerca volvulus		0.0019	0.0202	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0046	0.0177
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0046	0.0154
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0072	0.0276
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.1305	0.9284
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0202	0.1366
Brugia malayi	cathepsin L-like precursor	0.0012	0.0072	0.0276
Echinococcus granulosus	beta LACTamase domain containing family member	0.0075	0.1404	0.5088
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0072	0.0276
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.0202	0.0774
Mycobacterium ulcerans	lipase LipD	0.0075	0.1404	0.5
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0075	0.1404	0.4686
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0046	0.0154
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0046	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0046	0.0177
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0046	0.0154
Onchocerca volvulus		0.0075	0.1404	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.1305	0.9284
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0046	0.0154
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0202	0.1366
Plasmodium vivax	vivapain-2	0.0019	0.0202	0.1366
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0046	0.0167
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.1404	0.4686
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0046	0.0154
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0072	0.3182
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0046	0.0167
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0046	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0046	0.0177
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0046	0.0154
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.1305	0.9284
Trypanosoma cruzi	major cysteine proteinase, putative	0.0056	0.0985	0.6986
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0046	0.0154
Onchocerca volvulus		0.0019	0.0202	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1404	0.5385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.1305	0.9284
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0046	0.0177
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0202	0.0673
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0046	0.0154
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0202	0.1366
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0019	0.0202	1
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0046	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1404	0.5385
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0046	0.0167
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0046	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0046	0.0177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0072	0.0435
Echinococcus multilocularis	cathepsin L	0.001	0.0012	0.0038
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.1404	1
Schistosoma mansoni	hypothetical protein	0.014	0.276	0.921
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.1305	0.9284
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0046	0.0154
Echinococcus granulosus	cysteine protease	0.001	0.0012	0.0042
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Brugia malayi	beta-lactamase family protein	0.0075	0.1404	0.5385
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.014	0.276	0.921
Loa Loa (eye worm)	beta-lactamase	0.0075	0.1404	0.5385
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0075	0.1404	0.5385
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1404	0.5385
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0046	0.0167
Echinococcus multilocularis	cysteine protease	0.0019	0.0202	0.0673
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0046	0.0167
Leishmania major	cathepsin L-like protease	0.0071	0.1305	0.9171
Echinococcus granulosus	cathepsin l1	0.0012	0.0072	0.0261
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.0202	0.0731
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.1305	0.9284
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0046	0.0177
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0046	0.0167
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0065	0.1175	0.8353
Onchocerca volvulus		0.0019	0.0202	0.1146
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0202	0.0673
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.014	0.276	1
Leishmania major	cathepsin L-like protease	0.0071	0.1305	0.9171
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0202	0.0774
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0046	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0072	0.0276
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0046	0.0177
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0012	0.0044
Schistosoma mansoni	thyroid hormone receptor	0.0151	0.2997	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0072	0.0276
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0075	0.1404	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0046	0.0177
Plasmodium vivax	hypothetical protein, conserved	0.0075	0.1404	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.1305	0.9284
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0202	0.1366
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.1305	0.9284
Loa Loa (eye worm)	ctsf protein	0.0019	0.0202	0.0774
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0046	0.0167
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.1404	1
Echinococcus granulosus	cathepsin L cysteine protease	0.001	0.0012	0.0042
Onchocerca volvulus		0.0019	0.0202	0.1146
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0046	0.0177
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0046	0.0154
Onchocerca volvulus		0.0075	0.1404	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0046	0.0154
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.1305	0.9284
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.1404	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0202	0.1366
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.1404	1
Brugia malayi	beta-lactamase	0.0075	0.1404	0.5385
Echinococcus granulosus	cathepsin l1	0.0019	0.0202	0.0731
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0202	0.0774
Brugia malayi	ecdysteroid receptor	0.0011	0.0046	0.0177
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0202	0.0673
Brugia malayi	beta-lactamase family protein	0.0075	0.1404	0.5385
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1404	0.5385
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0202	0.0774
Schistosoma mansoni	thyroid hormone receptor	0.0151	0.2997	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0046	0.0177
Mycobacterium ulcerans	beta-lactamase	0.0075	0.1404	0.5
Onchocerca volvulus		0.0075	0.1404	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0046	0.0177
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0202	0.0774
Trypanosoma cruzi	cruzipain precursor, putative	0.0071	0.1305	0.9284
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0019	0.0202	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.1305	0.9284
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.2608	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0046	0.0154
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0046	0.0177
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0046	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1404	0.5385
Brugia malayi	steroid hormone receptor	0.0011	0.0046	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0046	0.0177
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0202	0.0673
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0202	0.1366
Mycobacterium ulcerans	esterase/lipase LipP	0.0075	0.1404	0.5
Mycobacterium ulcerans	hypothetical protein	0.0075	0.1404	0.5
Onchocerca volvulus		0.0019	0.0202	0.1146
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0072	0.024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0046	0.0177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0202	0.1366
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0202	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2271932

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1806556