Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0687 | 0.9094 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0394 | 0.3299 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.039 | 0.3217 | 0.3117 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0234 | 0.0145 | 0.0145 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0394 | 0.3299 | 0.32 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0687 | 0.9094 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0687 | 0.9094 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0687 | 0.9094 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.039 | 0.3217 | 0.3117 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0687 | 0.9094 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0394 | 0.3299 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0733 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0687 | 0.9094 | 0.908 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0394 | 0.3299 | 0.3299 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0687 | 0.9094 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0234 | 0.0145 | 0.0145 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0687 | 0.9094 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0394 | 0.3299 | 0.32 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0687 | 0.9094 | 0.5 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0687 | 0.9094 | 0.9094 |
Schistosoma mansoni | tyrosine kinase | 0.039 | 0.3217 | 0.3117 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0733 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0687 | 0.9094 | 0.908 |
Mycobacterium ulcerans | proteasome PrcB | 0.0687 | 0.9094 | 0.5 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0687 | 0.9094 | 0.5 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0687 | 0.9094 | 0.908 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0687 | 0.9094 | 0.5 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0687 | 0.9094 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain | 0.0687 | 0.9094 | 0.908 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0687 | 0.9094 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0733 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0733 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.