Detailed information for compound 1806934

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 506.545 | Formula: C25H34N2O9
  • H donors: 6 H acceptors: 7 LogP: 0.61 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 3
  • SMILES: O/N=C\1/[C@H](OC(=O)c2[nH]ccc2)[C@](O)(C(C)C)[C@@]2([C@@]3(C[C@@]1(C)[C@@]1(O)CC[C@@H]([C@H]([C@@]1(C2=O)O3)O)C)O)C
  • InChi: 1S/C25H34N2O9/c1-12(2)24(33)17(35-18(29)14-7-6-10-26-14)15(27-34)20(4)11-23(32)21(24,5)19(30)25(36-23)16(28)13(3)8-9-22(20,25)31/h6-7,10,12-13,16-17,26,28,31-34H,8-9,11H2,1-5H3/b27-15-/t13-,16+,17-,20+,21-,22-,23-,24+,25-/m0/s1
  • InChiKey: YBPJBZDRLKDVGB-JWCJVRTKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei aurora B kinase 0.0137 0.0884 0.3429
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0288
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0005 0.0008
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.008 0.0456 0.3439
Giardia lamblia DNA repair protein RAD52 0.0343 0.2423 0.5831
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0004 0.0004
Mycobacterium ulcerans DNA gyrase subunit B 0.008 0.0456 0.2173
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Trypanosoma cruzi aurora B kinase, putative 0.0137 0.0884 0.3429
Onchocerca volvulus 0.002 0.0005 0.0011
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Schistosoma mansoni amine GPCR 0.002 0.0005 0.0004
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0005 0.0004
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.002 0.0005 0.0011
Schistosoma mansoni neuroligin 3 (S09 family) 0.0101 0.0617 0.0615
Loa Loa (eye worm) hypothetical protein 0.0041 0.0165 0.038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Onchocerca volvulus 0.0023 0.0034 0.0192
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.0345 0.1511
Schistosoma mansoni nuclear receptor 0.0019 0.0004 0.0002
Brugia malayi ORL1-like opioid receptor 0.002 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0288
Plasmodium vivax DNA gyrase subunit B, putative 0.008 0.0456 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0165 0.0376
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0005 0.0012
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0005 0.0008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0165 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0005 0.0004
Plasmodium falciparum DNA topoisomerase 2 0.0137 0.0883 0.2269
Brugia malayi hypothetical protein 0.0035 0.0125 0.0283
Brugia malayi serine/threonine protein kinase 6 0.0137 0.0884 0.2032
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0005 0.0004
Echinococcus granulosus neuropeptide receptor 0.002 0.0005 0.0004
Plasmodium vivax ubiquitin activating enzyme, putative 0.0048 0.0215 0.0446
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.008 0.0456 0.1871
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0002 0.0004
Brugia malayi serine/threonine-protein kinase 6 0.0137 0.0884 0.2032
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0165 0.0163
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0004 0.0002
Brugia malayi hypothetical protein 0.0019 0.0004 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0165 0.0163
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0227 0.0519
Onchocerca volvulus 0.002 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0048
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0227 0.0519
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0034 0.0078
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0005 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0005 0.0004
Echinococcus multilocularis sex peptide receptor 0.002 0.0005 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0005 0.0004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0005 0.0004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0197 0.0449
Brugia malayi nuclear receptor NHR-88 0.0041 0.0165 0.0376
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0281 0.1957 0.9354
Schistosoma mansoni amine GPCR 0.002 0.0005 0.0004
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0093 0.0552 0.127
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0004 0.0002
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0125 0.0589
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0021 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0197 0.0453
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0051 0.0193
Echinococcus multilocularis survival motor neuron protein 1 0.0465 0.3334 0.3333
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0005 0.0004
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0564 0.0563
Loa Loa (eye worm) carboxylesterase 0.0101 0.0617 0.1421
Echinococcus multilocularis conserved hypothetical protein 0.0681 0.4949 0.4948
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0137 0.0884 0.2125
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Echinococcus multilocularis lamin 0.0027 0.0058 0.0057
Schistosoma mansoni adenoreceptor 0.002 0.0005 0.0004
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0066 0.0349 0.0837
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1606 0.3864
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0066 0.0349 0.0837
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0031 0.0093 0.0092
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0101 0.0617 0.2943
Loa Loa (eye worm) hypothetical protein 0.0041 0.0165 0.038
Plasmodium falciparum telomerase reverse transcriptase 0.0516 0.3714 1
Brugia malayi G protein-coupled receptor 0.002 0.0005 0.0008
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0004 0.0008
Onchocerca volvulus 0.002 0.0005 0.0011
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0098 0.0589 0.1414
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0004
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0005 0.0012
Brugia malayi neuropeptide F receptor 0.002 0.0005 0.0008
Entamoeba histolytica hypothetical protein 0.0098 0.0589 0.1414
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0165 0.0376
Schistosoma mansoni protein kinase 0.0137 0.0884 0.0883
Entamoeba histolytica hypothetical protein 0.0035 0.0125 0.0296
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0564 0.2187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 0.4154 1
Brugia malayi nuclear receptor NHR-67 0.0019 0.0004 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0005 0.0004
Mycobacterium tuberculosis Cell division protein FtsZ 0.0299 0.2093 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0021 0.0019
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0034 0.0156
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0093 0.0551 0.3415
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0165 0.0376
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0101 0.0617 0.1421
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0005 0.0004
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0004 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0125 0.0297
Trichomonas vaginalis esterase, putative 0.0036 0.0125 0.0297
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0281 0.1957 0.9344
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.008 0.0078
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0051 0.012
Brugia malayi Serotonin receptor 0.002 0.0005 0.0008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0034 0.0078
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0137 0.0883 0.2029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0165 0.0163
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0005 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0005 0.0004
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0137 0.0884 0.2273
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Brugia malayi nuclear hormone receptor 0.0041 0.0165 0.0376
Echinococcus multilocularis neuropeptide receptor 0.002 0.0005 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0165 0.0376
Onchocerca volvulus 0.002 0.0005 0.0011
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0004 0.0002
Mycobacterium leprae Probable lipase LipE 0.0036 0.0125 0.0441
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0402 0.1556
Toxoplasma gondii ThiF family protein 0.0031 0.0093 0.0356
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0165 0.0163
Brugia malayi neuropeptide F receptor 0.002 0.0005 0.0008
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0051 0.0193
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0165 0.0163
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0101 0.0617 0.2943
Trichomonas vaginalis spcc417.12 protein, putative 0.0101 0.0617 0.1482
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0075
Echinococcus multilocularis acetylcholinesterase 0.06 0.4344 0.4343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0165 0.038
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.0962 0.2214
Echinococcus multilocularis g protein coupled receptor 0.002 0.0005 0.0004
Trypanosoma cruzi DNA topoisomerase II, putative 0.013 0.0827 0.3208
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Brugia malayi larval opioid receptor 0.002 0.0005 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0125 0.0297
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0101 0.0617 0.0615
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0165 0.038
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.008 0.0456 0.2173
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0402 0.2981
Brugia malayi ecdysteroid receptor 0.0041 0.0165 0.0376
Trypanosoma brucei C-8 sterol isomerase, putative 0.0363 0.2575 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0083 0.0482 0.1866
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Schistosoma mansoni DNA topoisomerase type I 0.0183 0.1228 0.1226
Loa Loa (eye worm) AUR protein kinase 0.0137 0.0884 0.2035
Brugia malayi nuclear hormone receptor 0.0019 0.0004 0.0004
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0363 0.2575 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0056 0.0276 0.0634
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0004 0.0002
Loa Loa (eye worm) Ulp1 protease 0.0066 0.0349 0.0804
Schistosoma mansoni biogenic amine receptor 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0288
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0137 0.0884 0.2125
Loa Loa (eye worm) hypothetical protein 0.06 0.4344 1
Echinococcus granulosus aurora kinase A 0.0137 0.0884 0.0883
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Onchocerca volvulus 0.002 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0495
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.008 0.0078
Trypanosoma brucei cytochrome P450, putative 0.0035 0.0118 0.0452
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0195
Onchocerca volvulus 0.002 0.0005 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0005 0.0004
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0004 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0165 0.038
Schistosoma mansoni neuropeptide receptor 0.002 0.0005 0.0004
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0005 0.0004
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0031 0.0093 0.0092
Brugia malayi follicle stimulating hormone receptor 0.0472 0.3386 0.7793
Echinococcus granulosus lamin dm0 0.0027 0.0058 0.0057
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0575 0.4154 1
Plasmodium falciparum DNA gyrase subunit B 0.008 0.0456 0.1105
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0125 0.0297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0165 0.038
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0004 0.0008
Brugia malayi AKH receptor 0.002 0.0005 0.0008
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0564 0.1296
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0165 0.0163
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0069 0.0372 0.0371
Schistosoma mansoni tsg101-related 0.0057 0.0286 0.0285
Brugia malayi Carboxylesterase family protein 0.0101 0.0617 0.1417
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0004 0.0002
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0004 0.0002
Trypanosoma brucei polo-like protein kinase 0.0094 0.0564 0.2187
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0071 0.007
Trypanosoma cruzi DNA topoisomerase II, putative 0.013 0.0827 0.3208
Loa Loa (eye worm) hypothetical protein 0.0101 0.0617 0.1421
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0021 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0288
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0197 0.0195
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0005 0.0004
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0004 0.0004
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0402 0.0964
Echinococcus granulosus neuropeptide receptor 0.002 0.0005 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0165 0.0376
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0031 0.0093 0.0114
Echinococcus multilocularis orexin receptor type 2 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Loa Loa (eye worm) DR-78 0.0019 0.0004 0.0008
Giardia lamblia Telomerase catalytic subunit 0.0083 0.0482 0.1156
Onchocerca volvulus 0.0234 0.1606 1
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0118 0.0272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.008 0.0078
Brugia malayi tailless protein 0.0019 0.0004 0.0004
Entamoeba histolytica protein kinase , putative 0.0137 0.0884 0.2125
Trichomonas vaginalis hypothetical protein 0.0033 0.0109 0.0259
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0884 0.2125
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0005 0.0008
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0575 0.4154 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0005 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0165 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0402 0.0964
Leishmania major hypothetical protein, conserved 0.0022 0.0023 0.0084
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 0.4154 1
Schistosoma mansoni hypothetical protein 0.0095 0.0568 0.0567
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0005 0.0004
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0005 0.0004
Onchocerca volvulus 0.0036 0.0125 0.0757
Schistosoma mansoni hypothetical protein 0.0035 0.0125 0.0123
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0125 0.0123
Onchocerca volvulus Neuropeptide F receptor homolog 0.002 0.0005 0.0011
Chlamydia trachomatis DNA gyrase subunit A 0.0029 0.0079 0.1646
Schistosoma mansoni serine/threonine protein kinase 0.0137 0.0884 0.0883
Brugia malayi hypothetical protein 0.0022 0.0021 0.0044
Schistosoma mansoni lamin 0.0027 0.0058 0.0057
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0005 0.0004
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0005 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0048 0.0215 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0564 0.1355
Echinococcus granulosus g protein coupled receptor 0.002 0.0005 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0197 0.0195
Loa Loa (eye worm) hypothetical protein 0.0101 0.0617 0.1421
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0051 0.012
Brugia malayi Dopamine receptor protein 1 0.002 0.0005 0.0008
Echinococcus granulosus single minded 2 0.0035 0.0123 0.0121
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0069 0.0372 0.0371
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0118 0.0272
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0005 0.0004
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0005 0.0004
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0005 0.0004
Toxoplasma gondii DNA topoisomerase I, putative 0.0183 0.1228 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0213 0.0508
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 0.0156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0134
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0004 0.0002
Echinococcus multilocularis neuroligin 0.0101 0.0617 0.0615
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0255
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0165 0.1007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0058 0.0134
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0101 0.0617 0.1421
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0101 0.0617 0.1482
Schistosoma mansoni BC026374 protein (S09 family) 0.0101 0.0617 0.0615
Entamoeba histolytica protein kinase, putative 0.0137 0.0884 0.2125
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0165 0.0376
Brugia malayi DNA topoisomerase I 0.0183 0.1228 0.2824
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0005 0.0004
Echinococcus granulosus neuroligin 0.0101 0.0617 0.0615
Brugia malayi Cytochrome P450 family protein 0.0035 0.0118 0.0268
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0005 0.0004
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0111 0.0251
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0165 0.0163
Schistosoma mansoni hypothetical protein 0.0051 0.0238 0.0236
Echinococcus granulosus geminin 0.0167 0.1109 0.1108
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0165 0.0163
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0402 0.1556
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0137 0.0883 0.0881
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.3398 0.3397
Echinococcus multilocularis aurora kinase A 0.0137 0.0884 0.0883
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.3398 0.3397
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0005 0.0004
Trichomonas vaginalis DNA topoisomerase II, putative 0.0137 0.0883 0.2121
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Entamoeba histolytica protein kinase domain containing protein 0.0137 0.0884 0.2125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 0.4154 1
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0197 0.0195
Loa Loa (eye worm) hypothetical protein 0.0041 0.0165 0.038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0227 0.0523
Schistosoma mansoni single-minded 0.0048 0.0215 0.0214
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.0118 0.0556
Schistosoma mansoni hypothetical protein 0.0034 0.0111 0.0109
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0005 0.0004
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0165 0.1007
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Brugia malayi Cell division protein ftsZ 0.0147 0.0962 0.2211
Brugia malayi serine/threonine kinase 12 0.0137 0.0884 0.2032
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0005 0.0012
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0005 0.0004
Echinococcus granulosus sentrin specific protease 8 0.0066 0.0349 0.0347
Brugia malayi hypothetical protein 0.0121 0.0763 0.1753
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Echinococcus multilocularis g protein coupled receptor 0.002 0.0005 0.0004
Treponema pallidum fructose-bisphosphate aldolase 0.0575 0.4154 1
Schistosoma mansoni survival motor neuron protein 0.0095 0.0568 0.0567
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0125 0.0479
Schistosoma mansoni histamine h1 receptor 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Onchocerca volvulus 0.0036 0.0125 0.0757
Toxoplasma gondii RNA-directed DNA polymerase 0.0083 0.0482 0.366
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0564 0.1355
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0005 0.0004
Trypanosoma brucei DNA topoisomerase II beta, putative 0.013 0.0827 0.3208
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Trypanosoma brucei telomerase reverse transcriptase 0.0083 0.0482 0.1866
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0004 0.0002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0165 0.1007
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0125 0.0589
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0005 0.0008
Schistosoma mansoni coup transcription factor 0.0041 0.0165 0.0163
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.3398 0.3397
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0165 0.0376
Giardia lamblia DNA topoisomerase II 0.013 0.0829 0.1993
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0402 0.0401
Loa Loa (eye worm) hypothetical protein 0.0465 0.3334 0.7676
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.008 0.0239
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0402 0.1915
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0004 0.0002
Brugia malayi Cytochrome P450 family protein 0.0035 0.0118 0.0268
Echinococcus granulosus intermediate filament protein 0.0027 0.0058 0.0057
Schistosoma mansoni biogenic amine receptor 0.002 0.0005 0.0004
Entamoeba histolytica protein kinase, putative 0.0137 0.0884 0.2125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0165 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0125 0.0201
Schistosoma mansoni lamin 0.0027 0.0058 0.0057
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0005 0.0004
Brugia malayi G-protein coupled receptor 0.002 0.0005 0.0008
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.013 0.0827 0.3208
Brugia malayi Carboxylesterase family protein 0.0101 0.0617 0.1417
Echinococcus multilocularis para nitrobenzyl esterase 0.0101 0.0617 0.0615
Onchocerca volvulus 0.0035 0.0123 0.0745
Mycobacterium ulcerans DNA gyrase subunit A 0.0029 0.0079 0.0372
Echinococcus granulosus g protein coupled receptor 0.002 0.0005 0.0004
Brugia malayi hypothetical protein 0.0069 0.0372 0.0853
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0004 0.0004
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0101 0.0617 0.0615
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0005 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0125 0.0297
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.008 0.0078
Mycobacterium leprae cell division protein FtsZ 0.0299 0.2093 1
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0031 0.0093 0.0092
Schistosoma mansoni amine GPCR 0.002 0.0005 0.0004
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0048 0.0215 0.0213
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0005 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 0.4154 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0125 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0079
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0005 0.0004
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0005 0.0004
Onchocerca volvulus 0.002 0.0005 0.0011
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0051 0.0118
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0165 0.0163
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0034 0.0156
Echinococcus granulosus hypothetical protein 0.07 0.5095 0.5094
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0005 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0005 0.0004
Onchocerca volvulus 0.0027 0.0058 0.0341
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0125 0.0123
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0402 0.0964
Echinococcus granulosus allatostatin A receptor 0.002 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.06 0.4344 1
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0288
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.1556 0.7433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0005 0.0004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0165 0.0163
Schistosoma mansoni tsg101-related 0.0057 0.0286 0.0285
Onchocerca volvulus 0.0101 0.0617 0.3828
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0079
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0005 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0004 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0005 0.0004
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0165 0.0163
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0165 0.0163
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0005 0.0012
Schistosoma mansoni opsin-like receptor 0.002 0.0005 0.0004
Mycobacterium ulcerans cell division protein FtsZ 0.0299 0.2093 1
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0005 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0005 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Echinococcus granulosus serotonin receptor 0.002 0.0005 0.0004
Onchocerca volvulus 0.002 0.0005 0.0011
Brugia malayi Carboxylesterase family protein 0.0101 0.0617 0.1417
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0165 0.0376
Brugia malayi Inositol-1 0.0073 0.0402 0.0922
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0121 0.0763 0.1756
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0051 0.0193
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0126
Loa Loa (eye worm) hypothetical protein 0.0101 0.0617 0.1421
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0125 0.0589
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0005 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 0.0156
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0288
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.008 0.0078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 0.4154 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.008 0.0078
Schistosoma mansoni intermediate filament proteins 0.0027 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0029 0.008 0.0183
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0023 0.0084
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0281 0.1957 0.9354
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0165 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0125 0.0589
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0165 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Plasmodium falciparum serine/threonine protein kinase, putative 0.0137 0.0884 0.2273
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0472 0.3386 0.7794
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0165 0.0376
Echinococcus multilocularis musashi 0.0027 0.0058 0.0057
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0165 0.0163
Loa Loa (eye worm) hypothetical protein 0.0041 0.0165 0.038
Loa Loa (eye worm) carboxylesterase 0.0101 0.0617 0.1421
Echinococcus granulosus survival motor neuron protein 1 0.0465 0.3334 0.3333
Brugia malayi sulfakinin receptor protein 0.002 0.0005 0.0008
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0083 0.0482 0.2985
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Echinococcus multilocularis allatostatin A receptor 0.002 0.0005 0.0004
Echinococcus granulosus lamin 0.0027 0.0058 0.0057
Plasmodium falciparum DNA gyrase subunit A 0.0029 0.0079 0.0076
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0165 0.038
Echinococcus granulosus fmrfamide receptor 0.002 0.0005 0.0004
Onchocerca volvulus Huntingtin homolog 0.0121 0.0763 0.4738
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0005 0.0004
Loa Loa (eye worm) TOPoisomerase family member 0.0137 0.0883 0.2032
Onchocerca volvulus 0.0095 0.0568 0.3523
Brugia malayi Flap endonuclease-1 0.0026 0.0051 0.0115
Mycobacterium ulcerans hypothetical protein 0.0023 0.0034 0.0156
Brugia malayi Pre-SET motif family protein 0.0205 0.1394 0.3207
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0005 0.0004
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0564 0.0563
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0031 0.0093 0.0356
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0165 0.0376
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0402 0.1556
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0126
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0961 0.0959
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0034 0.0156
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0183 0.1228 0.4764
Onchocerca volvulus 0.0041 0.0165 0.1007
Loa Loa (eye worm) ThiF family protein 0.0031 0.0093 0.0215
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0165 0.0163
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0195
Schistosoma mansoni amine GPCR 0.002 0.0005 0.0004
Brugia malayi Carboxylesterase family protein 0.0101 0.0617 0.1417
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.06 0.4344 0.4343
Echinococcus multilocularis serotonin receptor 0.002 0.0005 0.0004
Brugia malayi hypothetical protein 0.0465 0.3334 0.7675
Brugia malayi beta-lactamase family protein 0.0036 0.0125 0.0284
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0005 0.0004
Schistosoma mansoni DNA topoisomerase type I 0.0183 0.1228 0.1226
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0402 0.1556
Echinococcus multilocularis fmrfamide receptor 0.002 0.0005 0.0004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0101 0.0617 0.0615
Onchocerca volvulus 0.002 0.0005 0.0011
Mycobacterium ulcerans beta-lactamase 0.0036 0.0125 0.0589
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0137 0.0884 0.2125
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0005 0.0004
Echinococcus multilocularis lamin dm0 0.0027 0.0058 0.0057
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0005 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0118 0.0272
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0004 0.0008
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0165 0.0163
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0564 0.1355
Echinococcus granulosus carboxylesterase 5A 0.06 0.4344 0.4343
Brugia malayi Carboxylesterase family protein 0.06 0.4344 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0126
Onchocerca volvulus Huntingtin homolog 0.0121 0.0763 0.4738
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0005 0.0004
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0123 0.0279
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0005 0.0004
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0023 0.0084
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0066 0.0349 0.0347
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0069 0.0372 0.0857
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0034 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0165 0.0376
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0005 0.0012
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0165 0.038
Schistosoma mansoni inositol monophosphatase 0.0073 0.0402 0.0401
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0004 0.0002
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0125 0.0589
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0005 0.0004
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0402 0.1603
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0154 0.1008 0.391
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0005 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0197 0.0195
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0005 0.0004
Brugia malayi Serotonin receptor 0.002 0.0005 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0165 0.0376
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0005 0.0008
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0123 0.058
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0051 0.012
Schistosoma mansoni hypothetical protein 0.0167 0.1109 0.1108
Schistosoma mansoni kinase 0.0048 0.0222 0.022
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0051 0.005
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0137 0.0883 0.0881
Mycobacterium ulcerans carboxylesterase, LipT 0.0101 0.0617 0.2943
Treponema pallidum cell division protein FtsZ 0.0299 0.2093 0.494
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0005 0.0004
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0093 0.0551 0.3415
Onchocerca volvulus 0.002 0.0005 0.0011
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0137 0.0883 0.2029
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0564 0.1355
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0005 0.0004
Toxoplasma gondii DNA topoisomerase 2, putative 0.0137 0.0883 0.7065
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0005 0.0004
Echinococcus granulosus muscleblind protein 0.0147 0.0961 0.0959
Toxoplasma gondii ABC1 family protein 0.0036 0.0125 0.0625
Loa Loa (eye worm) hypothetical protein 0.0049 0.0227 0.0523
Echinococcus granulosus g protein coupled receptor 0.002 0.0005 0.0004
Loa Loa (eye worm) AUR protein kinase 0.0137 0.0884 0.2035
Schistosoma mansoni myosin xvIII 0.002 0.0005 0.0004
Leishmania major cytochrome p450-like protein 0.0035 0.0118 0.0452
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0564 0.1355
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0005 0.0004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0101 0.0617 0.0615
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0215 0.0214
Echinococcus granulosus sex peptide receptor 0.002 0.0005 0.0004
Brugia malayi nuclear receptor NHR-88 0.0019 0.0004 0.0004
Brugia malayi PAS domain containing protein 0.0048 0.0215 0.0492
Entamoeba histolytica hypothetical protein 0.0035 0.0125 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0005 0.0004
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0125 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0165 0.0376
Plasmodium falciparum topoisomerase I 0.0183 0.1228 0.3212
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Onchocerca volvulus 0.002 0.0005 0.0011
Echinococcus multilocularis carboxylesterase 5A 0.06 0.4344 0.4343
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Mycobacterium ulcerans hypothetical protein 0.0036 0.0125 0.0589
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0564 0.3499
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0034 0.0156
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0005 0.0004
Entamoeba histolytica DNA topoisomerase II, putative 0.0137 0.0883 0.2121
Giardia lamblia Fructose-bisphosphate aldolase 0.0575 0.4154 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0005 0.0004
Brugia malayi beta-lactamase family protein 0.0036 0.0125 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0195
Schistosoma mansoni DNA topoisomerase type I 0.0183 0.1228 0.1226
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0034 0.0156
Leishmania major hypothetical protein, conserved 0.0036 0.0125 0.0479
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Echinococcus granulosus somatostatin receptor 0.002 0.0005 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0005 0.0004
Brugia malayi steroid hormone receptor 0.0041 0.0165 0.0376
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0004 0.0002
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0005 0.0012
Brugia malayi hypothetical protein 0.0022 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0004 0.0002
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0043 0.0182 0.0181
Onchocerca volvulus 0.002 0.0005 0.0011
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0125 0.0589
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0005 0.0004
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0005 0.0004
Schistosoma mansoni flap endonuclease-1 0.0023 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.008 0.0456 0.0924
Schistosoma mansoni neuropeptide receptor 0.002 0.0005 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0125 0.0123
Brugia malayi G-protein coupled receptor 0.002 0.0005 0.0008
Brugia malayi RE15519p 0.002 0.0005 0.0008
Schistosoma mansoni zinc finger protein 0.0019 0.0004 0.0002
Brugia malayi nuclear receptor RXR 0.0019 0.0004 0.0004
Plasmodium vivax topoisomerase I, putative 0.0183 0.1228 0.3212
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0165 0.0376
Leishmania major C-8 sterol isomerase-like protein 0.0363 0.2575 1
Echinococcus multilocularis geminin 0.0167 0.1109 0.1108
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0165 0.0163
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0005 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0165 0.0163
Loa Loa (eye worm) acetylcholinesterase 1 0.06 0.4344 1
Brugia malayi conserved hypotetical protein 0.0019 0.0004 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0125 0.0479
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0005 0.0004
Mycobacterium tuberculosis Conserved protein 0.0036 0.0125 0.0589
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0075
Onchocerca volvulus 0.002 0.0005 0.0011
Loa Loa (eye worm) beta-lactamase 0.0036 0.0125 0.0288
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 0.0156
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0165 0.0163
Brugia malayi ThiF family protein 0.0031 0.0093 0.0211
Chlamydia trachomatis DNA gyrase subunit A 0.0029 0.0079 0.1646
Loa Loa (eye worm) hypothetical protein 0.0147 0.0961 0.2212
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0564 0.1355
Schistosoma mansoni microtubule-associated protein tau 0.1357 1 1
Loa Loa (eye worm) inositol-1 0.0073 0.0402 0.0926
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0005 0.0004
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0047 0.0208 0.0497
Leishmania major DNA topoisomerase ii 0.013 0.0827 0.3208
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0005 0.0004
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0048 0.0215 0.0213
Loa Loa (eye worm) hypothetical protein 0.0101 0.0617 0.1421
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0041 0.0165 0.038
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0402 0.0964
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0165 0.038
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0005 0.0004
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0125 0.0589
Echinococcus multilocularis microtubule associated protein 2 0.1357 1 1
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0884 0.2125
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0564 0.1355
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0402 0.0401
Loa Loa (eye worm) hypothetical protein 0.0041 0.0165 0.038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0048
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0005 0.0004
Schistosoma mansoni tsg101-related 0.0047 0.0208 0.0207
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Entamoeba histolytica hypothetical protein 0.0035 0.0125 0.0296
Onchocerca volvulus 0.0029 0.008 0.0474
Plasmodium vivax telomerase reverse transcriptase, putative 0.0516 0.3714 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0884 0.2125
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0005 0.0004
Loa Loa (eye worm) AUR protein kinase 0.0137 0.0884 0.2035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0165 0.038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Schistosoma mansoni inositol monophosphatase 0.0073 0.0402 0.0401
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0005 0.0004
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0005 0.0008
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0123 0.0121
Onchocerca volvulus 0.002 0.0005 0.0011
Giardia lamblia Aurora kinase 0.0137 0.0884 0.2125
Echinococcus granulosus DNA topoisomerase 1 0.0183 0.1228 0.1226
Mycobacterium ulcerans lipase LipD 0.0036 0.0125 0.0589
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0165 0.0376
Schistosoma mansoni DNA topoisomerase II 0.0137 0.0883 0.0881
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0005 0.0004
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0066 0.0349 0.0837
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 0.4154 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0125 0.0479
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0029 0.0079 0.0372
Plasmodium vivax DNA gyrase subunit A, putative 0.0029 0.0079 0.0076
Echinococcus granulosus BC026374 protein S09 family 0.0101 0.0617 0.0615
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0066 0.0349 0.0837
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0083 0.0482 0.1866
Brugia malayi hypothetical protein 0.0101 0.0617 0.1417
Leishmania major ubiquitin-activating enzyme-like protein 0.0031 0.0093 0.0356
Echinococcus granulosus neuropeptide s receptor 0.0473 0.3398 0.3397
Echinococcus granulosus orexin receptor type 2 0.002 0.0005 0.0004
Brugia malayi Probable DNA topoisomerase II 0.0137 0.0883 0.2029
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0021 0.0048
Mycobacterium tuberculosis Conserved protein 0.0036 0.0125 0.0589
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0034 0.0156
Echinococcus granulosus para nitrobenzyl esterase 0.0101 0.0617 0.0615
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0048 0.0215 0.0446
Schistosoma mansoni acetylcholinesterase 0.0101 0.0617 0.0615
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.584 0.5839
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0165 0.0163
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0058 0.0134
Brugia malayi Pre-SET motif family protein 0.0029 0.008 0.0179
Mycobacterium tuberculosis Carboxylesterase LipT 0.0101 0.0617 0.2943
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0029 0.0079 0.0238
Brugia malayi Dopamine receptor protein 2 0.002 0.0005 0.0008
Brugia malayi Muscleblind-like protein 0.0147 0.0961 0.2209
Mycobacterium tuberculosis Conserved protein 0.0036 0.0125 0.0589
Echinococcus multilocularis neuropeptide receptor 0.002 0.0005 0.0004
Onchocerca volvulus 0.002 0.0005 0.0011
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0004 0.0002
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0125 0.0441
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0093 0.0551 0.3415
Brugia malayi nuclear receptor RXR 0.0022 0.0021 0.0044
Brugia malayi hypothetical protein 0.0019 0.0004 0.0004
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.016 0.1054 0.2427
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1394 0.321
Chlamydia trachomatis DNA gyrase subunit B 0.0063 0.0331 0.7221
Brugia malayi hypothetical protein 0.016 0.1054 0.2424
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0137 0.0884 0.0883
Schistosoma mansoni neuropeptide receptor 0.002 0.0005 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0004 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0005 0.0004
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0125 0.0123
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Leishmania major protein kinase, putative 0.0137 0.0884 0.3429
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0005 0.0004
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0005 0.0004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0125 0.0123
Onchocerca volvulus 0.0101 0.0617 0.3828
Echinococcus granulosus acetylcholinesterase 0.06 0.4344 0.4343
Schistosoma mansoni biogenic amine receptor 0.002 0.0005 0.0004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0125 0.0123
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Loa Loa (eye worm) DNA topoisomerase I 0.0183 0.1228 0.2826
Loa Loa (eye worm) hypothetical protein 0.0101 0.0617 0.1421
Echinococcus granulosus g-protein coupled receptor 0.002 0.0005 0.0004
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.008 0.0078
Onchocerca volvulus 0.0027 0.0058 0.0341
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 0.4154 1
Onchocerca volvulus 0.0101 0.0617 0.3828
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0299 0.2093 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0568 0.1305
Brugia malayi GnHR receptor homolog 0.002 0.0005 0.0008
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0183 0.1228 0.4764
Brugia malayi Melatonin receptor type 1A 0.002 0.0005 0.0008
Echinococcus granulosus acetylcholinesterase 0.06 0.4344 0.4343
Echinococcus multilocularis BC026374 protein (S09 family) 0.0101 0.0617 0.0615
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0005 0.0004
Brugia malayi Carboxylesterase family protein 0.06 0.4344 1
Leishmania major telomerase reverse transcriptase, putative 0.0083 0.0482 0.1866
Schistosoma mansoni opsin-like receptor 0.002 0.0005 0.0004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0125 0.0284
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0058 0.013
Loa Loa (eye worm) hypothetical protein 0.0147 0.0961 0.2212
Brugia malayi intermediate filament protein 0.0027 0.0058 0.013
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0213 0.0508
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0005 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0564 0.1355
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0154 0.1008 0.391
Schistosoma mansoni gliotactin 0.0101 0.0617 0.0615
Schistosoma mansoni hypothetical protein 0.0167 0.1109 0.1108
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0005 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0021 0.0044
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0125 0.0288
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0027 0.0061 0.0229
Loa Loa (eye worm) hypothetical protein 0.0186 0.1247 0.2872
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0165 0.0163
Toxoplasma gondii hypothetical protein 0.0048 0.0215 0.139
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0165 0.0163
Onchocerca volvulus 0.0036 0.0125 0.0757
Echinococcus multilocularis serotonin receptor 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Toxoplasma gondii aurora kinase 0.0137 0.0884 0.7079
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0165 0.0163
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0165 0.0376
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0005 0.0012
Trypanosoma cruzi hypothetical protein 0.0066 0.0349 0.135
Onchocerca volvulus 0.002 0.0005 0.0011
Entamoeba histolytica hypothetical protein 0.0035 0.0125 0.0296
Echinococcus granulosus flap endonuclease 1 0.0026 0.0051 0.005
Leishmania major DNA topoisomerase IB, large subunit 0.0183 0.1228 0.4764
Brugia malayi Dopamine receptor 0.002 0.0005 0.0008
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0363 0.2575 0.5926
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0165 0.0163
Trichomonas vaginalis Sentrin-specific protease, putative 0.0066 0.0349 0.0837
Brugia malayi Cell division protein ftsZ 0.0143 0.0931 0.214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0005 0.0004
Leishmania major mitochondrial DNA topoisomerase II 0.0154 0.1008 0.391
Schistosoma mansoni neuropeptide receptor 0.002 0.0005 0.0004
Schistosoma mansoni nuclear receptor 0.0019 0.0004 0.0002
Echinococcus multilocularis sentrin specific protease 8 0.0066 0.0349 0.0347
Loa Loa (eye worm) hypothetical protein 0.0041 0.0165 0.038
Brugia malayi hypoxia-induced factor 1 0.0147 0.0962 0.221
Chlamydia trachomatis DNA gyrase subunit B 0.008 0.0456 1
Brugia malayi putative neuropeptide receptor 0.002 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0564 0.2187
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0125 0.0589
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0125 0.0589
Onchocerca volvulus 0.0101 0.0617 0.3828
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0021 0.0019
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0165 0.0163
Echinococcus multilocularis somatostatin receptor 0.002 0.0005 0.0004
Trypanosoma brucei DNA topoisomerase ii 0.0154 0.1008 0.391
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0004 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0075
Echinococcus multilocularis DNA topoisomerase 1 0.0183 0.1228 0.1226
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0101 0.0617 0.0615
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0048
Giardia lamblia Kinase, PLK 0.0094 0.0564 0.1355
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0036 0.0125 0.0442
Onchocerca volvulus 0.002 0.0005 0.0011
Schistosoma mansoni amine GPCR 0.002 0.0005 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0575 0.4154 1
Schistosoma mansoni opsin-like receptor 0.002 0.0005 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0165 0.038
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0031 0.0093 0.0114
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0564 0.2187
Loa Loa (eye worm) hypothetical protein 0.0363 0.2575 0.5928
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Plasmodium vivax DNA topoisomerase II, putative 0.0137 0.0883 0.2269
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0066 0.0349 0.08
Loa Loa (eye worm) hypothetical protein 0.0093 0.0552 0.127
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0137 0.0884 0.0883
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Echinococcus multilocularis g protein coupled receptor 0.002 0.0005 0.0004
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0031 0.0093 0.0356
Echinococcus multilocularis acetylcholinesterase 0.06 0.4344 0.4343
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0884 0.2125
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0165 0.0163
Plasmodium vivax SET domain protein, putative 0.0029 0.008 0.0077
Loa Loa (eye worm) hypothetical protein 0.0056 0.0276 0.0634
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0118 0.0452
Brugia malayi beta-lactamase 0.0036 0.0125 0.0284
Echinococcus multilocularis muscleblind protein 0.0147 0.0961 0.0959
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0564 0.1299
Brugia malayi ecdysone receptor 0.0019 0.0004 0.0004
Loa Loa (eye worm) carboxylesterase 0.06 0.4344 1
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0118 0.0452
Echinococcus multilocularis fmrfamide receptor 0.002 0.0005 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0012
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.0345 0.1643
Brugia malayi ThiF family protein 0.0048 0.0215 0.0491
Onchocerca volvulus 0.0101 0.0617 0.3828
Loa Loa (eye worm) hypothetical protein 0.0121 0.0763 0.1756
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0343 0.2423 0.5831
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0005 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0564 0.0563

Activities

Activity type Activity value Assay description Source Reference
Ratio (binding) = 0.76 Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 2 hr by competitive inhibition assay relative to ryanodine ChEMBL. 8387597
Ratio (binding) = 0.88 Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 1 hr by competitive inhibition assay in presence of ATP relative to ryanodine ChEMBL. 8387597

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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