Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0423 | 0 | 0.5 |
Onchocerca volvulus | 0.0423 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0423 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.2503 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0423 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2503 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0423 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2503 | 1 | 1 |
Onchocerca volvulus | 0.0423 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.2503 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2503 | 1 | 1 |
Onchocerca volvulus | 0.0423 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.2503 | 1 | 1 |
Onchocerca volvulus | 0.0423 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.2503 | 1 | 1 |
Onchocerca volvulus | 0.0423 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2503 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2503 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2503 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0423 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0423 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2503 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2503 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 50 % | Cytotoxicity against Homo sapiens (human) A549 cells assessed as viable cells at 250 uM by MTT assay in presence of fetal bovine serum | ChEMBL. | No reference |
MIC (functional) | = 16 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 10536 assessed as growth inhibition after 24 hr by broth dilution assay method | ChEMBL. | No reference |
MIC (functional) | = 16 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 21 days by broth dilution assay method | ChEMBL. | No reference |
MIC (functional) | = 31.25 ug ml-1 | Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 assessed as growth inhibition after 24 hr by broth dilution assay method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.