Detailed information for compound 1807510

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 464.62 | Formula: C27H32N2O3S
  • H donors: 0 H acceptors: 0 LogP: 5.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C=N[C@H](C1C[C@]23C=C[C@]1(OC)[C@H]1[C@]43CCN([C@@H]2Cc2c4c(O1)c(OC)cc2)CC1CC1)C
  • InChi: 1S/C27H32N2O3S/c1-16(28-15-33)19-13-25-8-9-27(19,31-3)24-26(25)10-11-29(14-17-4-5-17)21(25)12-18-6-7-20(30-2)23(32-24)22(18)26/h6-9,16-17,19,21,24H,4-5,10-14H2,1-3H3/t16-,19?,21+,24+,25+,26-,27+/m0/s1
  • InChiKey: CBPASLHMRDUOQC-OQICXIPYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Mu opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Mu opioid receptor   401 aa 341 aa 26.7 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   401 aa 385 aa 23.4 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   401 aa 323 aa 24.1 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   401 aa 334 aa 23.4 %
Echinococcus multilocularis allatostatin A receptor Mu opioid receptor   401 aa 341 aa 29.0 %
Echinococcus granulosus allatostatin A receptor Mu opioid receptor   401 aa 346 aa 29.2 %
Onchocerca volvulus Mu opioid receptor   401 aa 321 aa 20.9 %
Echinococcus granulosus thyrotropin releasing hormone receptor Mu opioid receptor   401 aa 373 aa 27.6 %
Onchocerca volvulus Mu opioid receptor   401 aa 354 aa 24.6 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   401 aa 335 aa 20.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Mu opioid receptor   401 aa 373 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide Y receptor 0.0122 0.032 0.032
Echinococcus multilocularis serotonin receptor 0.026 0.0785 0.0819
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.032 0.032
Brugia malayi Protein kinase domain containing protein 0.0192 0.0556 0.0708
Onchocerca volvulus 0.0141 0.0387 0.1224
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.007 0.0145 0.0152
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.032 0.0334
Schistosoma mansoni phd/f-box containing protein 0.0065 0.0128 0.0154
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0122 0.032 0.0403
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0392 0.1231 0.2571
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.001 0.001
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0047 0.0067 0.0067
Toxoplasma gondii non-specific serine/threonine protein kinase 0.003 0.001 0.0024
Onchocerca volvulus 0.003 0.0012 0.0006
Plasmodium falciparum glutathione reductase 0.0046 0.0065 0.1405
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0111 0.0283 0.0573
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0114 0.0295 0.0295
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0141 0.0387 0.0387
Brugia malayi Bromodomain containing protein 0.0145 0.0399 0.0504
Plasmodium vivax glutathione reductase, putative 0.0046 0.0065 0.1405
Onchocerca volvulus 0.0392 0.1231 0.3969
Echinococcus multilocularis sex peptide receptor 0.0122 0.032 0.0334
Echinococcus multilocularis g protein coupled receptor 0.0122 0.032 0.0334
Schistosoma mansoni growth hormone secretagogue receptor 0.0122 0.032 0.0403
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.003 0.001 0.0001
Brugia malayi Serotonin receptor 0.204 0.6773 0.8767
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Loa Loa (eye worm) hypothetical protein 0.0145 0.0399 0.0504
Onchocerca volvulus Glutaminyl cyclase homolog 0.0738 0.2393 0.7745
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0211 0.0621 0.1293
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0122 0.032 0.0334
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0018 0.0018
Echinococcus multilocularis G-protein coupled receptor, putative 0.0122 0.032 0.0334
Onchocerca volvulus 0.0151 0.0419 0.1329
Schistosoma mansoni tyrosine kinase 0.0319 0.0985 0.1265
Echinococcus multilocularis g protein coupled receptor 0.0122 0.032 0.0334
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0065 0.0149
Echinococcus multilocularis 0.003 0.001 0.001
Schistosoma mansoni histamine h1 receptor 0.0122 0.032 0.0403
Schistosoma mansoni nAChR subunit 0.0141 0.0387 0.0489
Schistosoma mansoni hypothetical protein 0.0145 0.0399 0.0505
Loa Loa (eye worm) hypothetical protein 0.0571 0.1832 0.2362
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0317 0.0398
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0141 0.0387 0.0403
Schistosoma mansoni plexin 0.003 0.0012 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0419 0.0869
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Echinococcus granulosus g protein coupled receptor 0.0122 0.032 0.032
Schistosoma mansoni nAChR subunit 0.0141 0.0387 0.0489
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0065 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.032 0.0334
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0141 0.0387 0.0489
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0017 0.0028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0513 0.1635 0.2106
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0141 0.0387 0.0488
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0162 0.0456 0.0476
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0122 0.032 0.0334
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0146 0.0176
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0192 0.0556 0.0556
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.013 0.0348 0.072
Loa Loa (eye worm) hypothetical protein 0.0629 0.2027 0.2614
Echinococcus multilocularis dnaJ subfamily B 0.0807 0.2626 0.2738
Loa Loa (eye worm) beta-lactamase 0.007 0.0146 0.0176
Loa Loa (eye worm) leucyl aminopeptidase 0.0151 0.0419 0.053
Plasmodium falciparum amino acid transporter, putative 0.0047 0.0067 0.1475
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0163 0.0335
Echinococcus multilocularis geminin 0.0543 0.1738 0.1812
Loa Loa (eye worm) hypothetical protein 0.0151 0.0419 0.053
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0065 0.0128 0.2458
Loa Loa (eye worm) hypothetical protein 0.0274 0.0834 0.1068
Schistosoma mansoni hypothetical protein 0.0122 0.032 0.0403
Loa Loa (eye worm) hypothetical protein 0.0274 0.0834 0.1068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.032 0.0403
Onchocerca volvulus 0.0031 0.0014 0.0012
Schistosoma mansoni biogenic amine (5HT) receptor 0.026 0.0785 0.1006
Echinococcus multilocularis PHD finger protein rhinoceros 0.0145 0.0399 0.0416
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0074
Schistosoma mansoni neurotransmitter gated ion channel 0.0065 0.013 0.0157
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0687 0.2221 0.4646
Loa Loa (eye worm) hypothetical protein 0.0392 0.1231 0.1583
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0262 0.1106
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0122 0.032 0.0402
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.013 0.0348 0.0438
Loa Loa (eye worm) phosphatidylinositol 3 0.0182 0.0521 0.0663
Schistosoma mansoni neuropeptide receptor 0.0296 0.0906 0.1162
Brugia malayi RE15519p 0.0122 0.032 0.0402
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0067 0.0074
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0447 0.1415 0.6167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0709 0.2296 0.2394
Loa Loa (eye worm) hypothetical protein 0.0245 0.0736 0.0941
Echinococcus granulosus carboxylesterase 5A 0.2322 0.7724 0.7724
Schistosoma mansoni tyrosine kinase 0.059 0.1897 0.2447
Trichomonas vaginalis chromobox protein, putative 0.007 0.0145 0.0296
Echinococcus granulosus lysine specific demethylase 5A 0.0248 0.0744 0.0744
Loa Loa (eye worm) hypothetical protein 0.0076 0.0167 0.0204
Echinococcus multilocularis acetylcholinesterase 0.2322 0.7724 0.8054
Loa Loa (eye worm) hypothetical protein 0.2322 0.7724 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0067 0.1205
Brugia malayi hypothetical protein 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.007 0.0146 0.0176
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0065 0.0128 0.0323
Loa Loa (eye worm) TK/EGFR protein kinase 0.059 0.1897 0.2446
Loa Loa (eye worm) hypothetical protein 0.0076 0.0167 0.0204
Loa Loa (eye worm) jmjC domain-containing protein 0.03 0.0919 0.1178
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0122 0.032 0.0403
Schistosoma mansoni tyrosine kinase 0.0311 0.0958 0.123
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0067 0.0074
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0031
Brugia malayi FXNA 0.0151 0.0419 0.053
Schistosoma mansoni nAChR subunit 0.0141 0.0387 0.0489
Entamoeba histolytica hypothetical protein 0.0072 0.0153 0.0301
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.013 0.0348 0.6972
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0211 0.0621 0.0792
Echinococcus multilocularis conserved hypothetical protein 0.2877 0.959 1
Leishmania major hypothetical protein, conserved 0.0151 0.0419 0.1117
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0076 0.0167 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.039 0.0494
Loa Loa (eye worm) hypothetical protein 0.0351 0.1093 0.1403
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0167 0.0204
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0141 0.0387 0.0488
Echinococcus granulosus glycine receptor subunit alpha 1 0.0141 0.0387 0.0387
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.013 0.0156
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0074
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0122 0.032 0.0334
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.039 0.039
Schistosoma mansoni gliotactin 0.0392 0.1231 0.1583
Echinococcus multilocularis neuropeptides capa receptor 0.0122 0.032 0.0334
Loa Loa (eye worm) carboxylesterase 0.0392 0.1231 0.1583
Brugia malayi Furin-like cysteine rich region family protein 0.059 0.1897 0.2446
Onchocerca volvulus 0.0141 0.0387 0.1224
Onchocerca volvulus 0.0392 0.1231 0.3969
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0122 0.032 0.1009
Echinococcus multilocularis neuroglian 0.0046 0.0065 0.0068
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0052 0.0101
Brugia malayi hypothetical protein 0.0122 0.032 0.0402
Schistosoma mansoni amine GPCR 0.0122 0.032 0.0403
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1037 0.3399 0.3399
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0031
Echinococcus granulosus alpha 1A adrenergic receptor 0.0122 0.032 0.032
Onchocerca volvulus 0.0122 0.032 0.1009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1447 0.4778 1
Schistosoma mansoni biogenic amine receptor 0.0122 0.032 0.0403
Schistosoma mansoni neuropeptide receptor 0.0122 0.032 0.0403
Echinococcus granulosus biogenic amine 5HT receptor 0.026 0.0785 0.0785
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.013 0.0348 0.072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.039 0.0407
Trypanosoma brucei trypanothione reductase 0.0046 0.0065 0.0149
Loa Loa (eye worm) hypothetical protein 0.0592 0.1901 0.2451
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0145 0.0175
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0211 0.0621 0.1669
Toxoplasma gondii thioredoxin reductase 0.0046 0.0065 0.1148
Echinococcus granulosus peptide allatostatin:somatostatin 0.0122 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0392 0.1231 0.1583
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0301 0.1278
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0141 0.0387 0.0488
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.013 0.0348 0.0438
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Schistosoma mansoni hypothetical protein 0.0162 0.0456 0.0579
Echinococcus granulosus tm gpcr rhodopsin 0.0122 0.032 0.032
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0052 0.0055
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Entamoeba histolytica hypothetical protein 0.0076 0.0167 0.0329
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0153 0.0153
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0562 0.1803 0.3768
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0067 0.0075
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0122 0.032 0.0402
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0065 0.013 0.0156
Brugia malayi Carboxylesterase family protein 0.2322 0.7724 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0076 0.0167 0.0204
Brugia malayi hypothetical protein 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Echinococcus granulosus orexin receptor type 2 0.0122 0.032 0.032
Loa Loa (eye worm) serotonin transporter b 0.0274 0.0834 0.1068
Brugia malayi larval opioid receptor 0.0122 0.032 0.0402
Echinococcus granulosus neuropeptide s receptor 0.0122 0.032 0.032
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0562 0.1803 0.3768
Echinococcus multilocularis peregrin 0.0145 0.0399 0.0416
Loa Loa (eye worm) hypothetical protein 0.0392 0.1231 0.1583
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0163 0.042
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0542 0.1735 0.1809
Brugia malayi hypothetical protein 0.0122 0.032 0.0402
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0399 1
Echinococcus granulosus roundabout 2 0.0058 0.0105 0.0105
Echinococcus multilocularis phd:f box containing protein 0.0065 0.0128 0.0134
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0182 0.0521 0.1397
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0067 0.0074
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Brugia malayi Carboxylesterase family protein 0.0392 0.1231 0.1583
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Schistosoma mansoni tyrosine kinase 0.0192 0.0556 0.0709
Echinococcus multilocularis neuropeptide Y receptor 0.0122 0.032 0.0334
Echinococcus granulosus peregrin 0.0145 0.0399 0.0399
Loa Loa (eye worm) jmjC domain-containing protein 0.0248 0.0744 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.039 0.0494
Brugia malayi Pre-SET motif family protein 0.0121 0.0317 0.0397
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0211 0.0621 0.1281
Echinococcus multilocularis neuropeptide receptor 0.0122 0.032 0.0334
Loa Loa (eye worm) acetylcholinesterase 1 0.2322 0.7724 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Leishmania major hypothetical protein, conserved 0.007 0.0146 0.0372
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.013 0.0348 0.0348
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0146 0.0598
Echinococcus granulosus chromobox protein 1 0.007 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0053 0.0087 0.01
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0065 0.0128 0.0323
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.0031 0.0014 0.0005
Schistosoma mansoni tyrosine kinase 0.0311 0.0958 0.123
Brugia malayi ORL1-like opioid receptor 0.0122 0.032 0.0402
Onchocerca volvulus 0.0065 0.013 0.0391
Brugia malayi hypothetical protein 0.0392 0.1231 0.1583
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.001 0.0024
Onchocerca volvulus 0.0122 0.032 0.1009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0122 0.032 0.0403
Onchocerca volvulus 0.007 0.0146 0.0442
Echinococcus granulosus serotonin transporter 0.0274 0.0834 0.0834
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0052 0.0102
Loa Loa (eye worm) hypothetical protein 0.0076 0.0167 0.0204
Echinococcus multilocularis orexin receptor type 2 0.0122 0.032 0.0334
Schistosoma mansoni hypothetical protein 0.0807 0.2626 0.3392
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.013 0.0348 0.0923
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0337 0.1044 0.4193
Brugia malayi Dopamine receptor 0.0122 0.032 0.0402
Loa Loa (eye worm) GABA receptor subunit 0.0076 0.0167 0.0204
Schistosoma mansoni hypothetical protein 0.0047 0.007 0.0079
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0052 0.0056
Brugia malayi sulfakinin receptor protein 0.0122 0.032 0.0402
Echinococcus granulosus jumonji domain containing 1A 0.0065 0.0128 0.0128
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0211 0.0621 0.1293
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1447 0.4778 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.003 0.001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.0151 0.0419 0.053
Schistosoma mansoni cpg binding protein 0.0094 0.0228 0.0284
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0065 0.0128 0.2458
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.032 0.0334
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0151 0.0419 0.0531
Onchocerca volvulus 0.0122 0.032 0.1009
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.013 0.0348 0.6972
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0163 0.5
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0141 0.0387 0.0488
Loa Loa (eye worm) ACC-1 protein 0.0141 0.0387 0.0488
Mycobacterium tuberculosis Conserved protein 0.007 0.0146 0.0598
Echinococcus multilocularis GPCR, family 2 0.0162 0.0456 0.0476
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0065 0.013 0.013
Schistosoma mansoni adenoreceptor 0.0122 0.032 0.0403
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.001 0.0024
Mycobacterium tuberculosis Conserved protein 0.007 0.0146 0.0598
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0141 0.0387 0.0387
Onchocerca volvulus 0.0047 0.0067 0.0187
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Trichomonas vaginalis spcc417.12 protein, putative 0.0392 0.1231 0.2571
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Brugia malayi beta-lactamase family protein 0.007 0.0146 0.0176
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0122 0.032 0.0403
Echinococcus granulosus serine:threonine protein kinase SMG1 0.003 0.001 0.001
Brugia malayi Pre-SET motif family protein 0.083 0.2702 0.3489
Schistosoma mansoni hypothetical protein 0.0162 0.0456 0.0579
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0047 0.0067 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.032 0.032
Onchocerca volvulus Neuropeptide F receptor homolog 0.0122 0.032 0.1009
Brugia malayi hypothetical protein 0.0065 0.013 0.0156
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Echinococcus multilocularis jumonji domain containing protein 0.0202 0.059 0.0615
Schistosoma mansoni inositol monophosphatase 0.0075 0.0163 0.02
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0067 0.0075
Brugia malayi excitatory GABA receptor EXP-1A 0.0141 0.0387 0.0488
Echinococcus granulosus tachykinin peptides receptor 99D 0.0122 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0592 0.1901 0.2451
Toxoplasma gondii target of rapamycin (TOR), putative 0.003 0.001 0.0024
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0141 0.0387 0.0387
Loa Loa (eye worm) carboxylesterase 0.2322 0.7724 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0262 0.1106
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.013 0.0348 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0687 0.2221 0.4639
Toxoplasma gondii hypothetical protein 0.0151 0.0419 0.8434
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0163 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0092 0.0221 0.0273
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0128 0.0153
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Loa Loa (eye worm) neuropeptide F receptor 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.0076 0.0167 0.0204
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0707 0.2288 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0118 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0122 0.032 0.032
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0122 0.032 0.032
Schistosoma mansoni sodium/chloride dependent transporter 0.0274 0.0834 0.1069
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Echinococcus multilocularis neuropeptides capa receptor 0.0122 0.032 0.0334
Onchocerca volvulus 0.0122 0.032 0.1009
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0118 0.0306 0.0385
Loa Loa (eye worm) hypothetical protein 0.007 0.0146 0.0176
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0336 0.104 0.1335
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Loa Loa (eye worm) hypothetical protein 0.0042 0.0052 0.0055
Echinococcus granulosus glycine receptor subunit beta 0.0141 0.0387 0.0387
Onchocerca volvulus Putative nachr subunit 0.0141 0.0387 0.1224
Echinococcus granulosus neuropeptide receptor 0.0122 0.032 0.032
Schistosoma mansoni neuropeptide receptor 0.0122 0.032 0.0403
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1447 0.4778 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.032 0.0403
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.032 0.0403
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0122 0.032 0.0403
Schistosoma mansoni nicalin (M28 family) 0.0151 0.0419 0.0531
Entamoeba histolytica hypothetical protein 0.0072 0.0153 0.0301
Brugia malayi Carboxylesterase family protein 0.0392 0.1231 0.1583
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0141 0.0387 0.0489
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1037 0.3399 0.3544
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Loa Loa (eye worm) hypothetical protein 0.0274 0.0834 0.1068
Schistosoma mansoni alpha-1 adrenergic receptor 0.0122 0.032 0.0403
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0076 0.0167 0.0204
Brugia malayi hypothetical protein 0.0065 0.013 0.0156
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0151 0.0419 0.0869
Schistosoma mansoni biogenic amine receptor 0.0122 0.032 0.0403
Echinococcus multilocularis neuropeptide receptor 0.0296 0.0906 0.0944
Onchocerca volvulus 0.0065 0.013 0.0391
Loa Loa (eye worm) hypothetical protein 0.0076 0.0167 0.0204
Onchocerca volvulus 0.0122 0.032 0.1009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0122 0.032 0.0334
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0031
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0067 0.0075
Loa Loa (eye worm) cytochrome P450 family protein 0.0105 0.0265 0.0331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.032 0.0403
Giardia lamblia PHD finger protein 15 0.0145 0.0399 0.0816
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0076 0.0167 0.0204
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1117 0.367 1
Onchocerca volvulus 0.0141 0.0387 0.1224
Echinococcus multilocularis g protein coupled receptor 0.0122 0.032 0.0334
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Echinococcus granulosus g protein coupled receptor 0.0122 0.032 0.032
Echinococcus multilocularis BC026374 protein (S09 family) 0.0392 0.1231 0.1283
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Brugia malayi Immunoglobulin I-set domain containing protein 0.0599 0.1924 0.2481
Onchocerca volvulus 0.0274 0.0834 0.2678
Brugia malayi Dopamine receptor protein 2 0.0122 0.032 0.0402
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.032 0.0403
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.003 0.001 0.001
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0047 0.007 0.0165
Onchocerca volvulus 0.0122 0.032 0.1009
Loa Loa (eye worm) G-protein coupled receptor 0.0122 0.032 0.0402
Echinococcus multilocularis para nitrobenzyl esterase 0.0392 0.1231 0.1283
Leishmania major C-8 sterol isomerase-like protein 0.1117 0.367 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0047 0.007 0.1264
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.016 0.0195
Echinococcus granulosus glycine receptor subunit beta 0.0141 0.0387 0.0387
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0052 0.0052
Toxoplasma gondii PHD-finger domain-containing protein 0.0145 0.0399 0.8027
Brugia malayi PHD-finger family protein 0.0145 0.0399 0.0504
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0151 0.0419 0.1794
Schistosoma mansoni BC026374 protein (S09 family) 0.0392 0.1231 0.1583
Loa Loa (eye worm) hypothetical protein 0.0392 0.1231 0.1583
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1037 0.3399 0.4394
Echinococcus multilocularis Immunoglobulin 0.0037 0.0034 0.0035
Schistosoma mansoni inositol monophosphatase 0.0075 0.0163 0.02
Loa Loa (eye worm) hypothetical protein 0.0151 0.0419 0.053
Brugia malayi follicle stimulating hormone receptor 0.0122 0.032 0.0402
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.001 0.0024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0122 0.032 0.0334
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0067 0.0075
Schistosoma mansoni amine GPCR 0.0122 0.032 0.0403
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.003 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0074
Loa Loa (eye worm) inositol-1 0.0075 0.0163 0.0199
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0162 0.0456 0.0578
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0132 0.0355 0.0448
Echinococcus multilocularis plexin a4 0.0036 0.003 0.0032
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0141 0.0387 0.0488
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Echinococcus multilocularis lysine specific demethylase 5A 0.0243 0.0727 0.0758
Loa Loa (eye worm) hypothetical protein 0.0076 0.0167 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.013 0.0348 0.0923
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0146 0.0598
Brugia malayi G-protein coupled receptor 0.0122 0.032 0.0402
Schistosoma mansoni hypothetical protein 0.0162 0.0456 0.0579
Plasmodium falciparum transporter, putative 0.0047 0.0067 0.1475
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.003 0.001 0.001
Giardia lamblia Fructose-bisphosphate aldolase 0.1447 0.4778 1
Schistosoma mansoni chromobox protein 0.007 0.0145 0.0176
Brugia malayi hypothetical protein 0.0122 0.032 0.0402
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0065 0.0128 0.0154
Schistosoma mansoni amine GPCR 0.0122 0.032 0.0403
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.007 0.0145 0.0145
Echinococcus granulosus PHD finger protein rhinoceros 0.0145 0.0399 0.0399
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1447 0.4778 1
Echinococcus multilocularis neuropeptide s receptor 0.0122 0.032 0.0334
Brugia malayi Thioredoxin reductase 0.0046 0.0065 0.0071
Echinococcus granulosus histone lysine methyltransferase setb 0.0121 0.0317 0.0317
Onchocerca volvulus 0.0141 0.0387 0.1224
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0392 0.1231 0.1283
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0092 0.0221 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Echinococcus multilocularis nAChR subunit 0.0076 0.0167 0.0174
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0657 0.2122 0.443
Mycobacterium tuberculosis Probable reductase 0.0104 0.0262 0.1106
Echinococcus granulosus JmjC domain containing protein 4 0.0065 0.0128 0.0128
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0141 0.0387 0.0488
Echinococcus granulosus fmrfamide receptor 0.0122 0.032 0.032
Brugia malayi jmjC domain containing protein 0.0065 0.0128 0.0153
Brugia malayi Tachykinin-like peptides receptor 99D 0.0122 0.032 0.0402
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0163 0.042
Brugia malayi Serotonin receptor 0.0122 0.032 0.0402
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0122 0.032 0.0403
Brugia malayi Cation transporter family protein 0.0141 0.0387 0.0488
Loa Loa (eye worm) hypothetical protein 0.0065 0.0128 0.0153
Schistosoma mansoni nAChR subunit 0.0141 0.0387 0.0489
Onchocerca volvulus 0.0122 0.032 0.1009
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Onchocerca volvulus 0.0944 0.3086 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Onchocerca volvulus 0.0122 0.032 0.1009
Echinococcus multilocularis carboxylesterase 5A 0.2322 0.7724 0.8054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.039 0.0494
Brugia malayi AKH receptor 0.0122 0.032 0.0402
Schistosoma mansoni tyrosine kinase 0.0192 0.0556 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0419 0.0869
Echinococcus granulosus epidermal growth factor receptor 0.0319 0.0985 0.0985
Onchocerca volvulus Fxna peptidase homolog 0.0151 0.0419 0.1329
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0122 0.032 0.0403
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1447 0.4778 1
Echinococcus multilocularis glycine receptor subunit beta 0.0141 0.0387 0.0403
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0031
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.003 0.001 0.0013
Schistosoma mansoni hypothetical protein 0.0072 0.0153 0.0187
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0065 0.013 0.013
Schistosoma mansoni hypothetical protein 0.035 0.1089 0.14
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0301 0.1278
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Brugia malayi Plexin repeat family protein 0.003 0.0012 0.0002
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0052 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0122 0.032 0.0402
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0687 0.2221 0.6042
Onchocerca volvulus 0.0047 0.0067 0.0187
Schistosoma mansoni neuropeptide F-like receptor 0.0122 0.032 0.0403
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0146 0.0152
Echinococcus granulosus neuropeptide FF receptor 2 0.0122 0.032 0.032
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0118 0.0306 0.032
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0048 0.0074 0.0074
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Schistosoma mansoni Fxna peptidase (M28 family) 0.0151 0.0419 0.0531
Schistosoma mansoni nAChR subunit 0.0141 0.0387 0.0489
Loa Loa (eye worm) hypothetical protein 0.007 0.0146 0.0176
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.032 0.0334
Mycobacterium leprae Probable lipase LipE 0.007 0.0146 0.0598
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0141 0.0387 0.0403
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.035 0.1089 0.1399
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0146 0.0298
Entamoeba histolytica hypothetical protein 0.0072 0.0153 0.0301
Mycobacterium leprae conserved hypothetical protein 0.007 0.0146 0.0598
Echinococcus granulosus 7TM GPCR rhodopsin 0.0122 0.032 0.032
Schistosoma mansoni nAChR subunit 0.0141 0.0387 0.0489
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0319 0.0985 0.0985
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0141 0.0387 0.0387
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0495 0.1577 0.2032
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0067 0.0067
Onchocerca volvulus 0.0122 0.032 0.1009
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.003 0.001 0.001
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0151 0.0419 0.0437
Schistosoma mansoni phosphatidylinositol 4-kinase 0.003 0.001 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0162 0.0456 0.0456
Brugia malayi nicalin 0.0151 0.0419 0.053
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0052 0.0102
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0052 0.0089
Schistosoma mansoni jumonji domain containing protein 0.0445 0.1406 0.1811
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0163 0.0322
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.039 0.0407
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0076 0.0167 0.0204
Schistosoma mansoni cpg binding protein 0.0094 0.0228 0.0284
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0122 0.032 0.0402
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0145 0.0399 0.0505
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Mycobacterium ulcerans carboxylesterase, LipT 0.0392 0.1231 0.5064
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.003 0.001 0.001
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0065 0.013 0.0156
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0687 0.2221 0.2867
Plasmodium falciparum thioredoxin reductase 0.0046 0.0065 0.1405
Echinococcus granulosus sex peptide receptor 0.0122 0.032 0.032
Schistosoma mansoni amine GPCR 0.031 0.0953 0.1223
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.0707 0.0904
Loa Loa (eye worm) hypothetical protein 0.1117 0.367 0.4744
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0065 0.013 0.0156
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0122 0.032 0.0334
Brugia malayi hypothetical protein 0.0245 0.0736 0.0941
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0067 0.1205
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.0736 0.0736
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0122 0.032 0.0334
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0151 0.0419 0.0437
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0274 0.0834 0.1069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.032 0.0403
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0707 0.2288 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0122 0.032 0.0402
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0141 0.0387 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Brugia malayi Carboxylesterase family protein 0.0392 0.1231 0.1583
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.003 0.001 0.001
Brugia malayi chromobox protein homolog 3 0.0039 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Brugia malayi hypothetical protein 0.0065 0.013 0.0156
Loa Loa (eye worm) hypothetical protein 0.0392 0.1231 0.1583
Echinococcus multilocularis chromobox protein 1 0.007 0.0145 0.0151
Schistosoma mansoni cell adhesion molecule 0.0048 0.0074 0.0083
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0392 0.1231 0.1583
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0738 0.2393 0.2495
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0122 0.032 0.032
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.013 0.0156
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Echinococcus multilocularis cpg binding protein 0.0094 0.0228 0.0238
Brugia malayi F/Y-rich N-terminus family protein 0.0079 0.0177 0.0216
Echinococcus multilocularis Immunoglobulin 0.0037 0.0034 0.0035
Schistosoma mansoni tyrosine kinase 0.0311 0.0958 0.123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.032 0.0334
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0141 0.0387 0.0489
Echinococcus multilocularis dro:myosuppressin receptor 0.0122 0.032 0.0334
Onchocerca volvulus 0.0392 0.1231 0.3969
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Onchocerca volvulus 0.0122 0.032 0.1009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0141 0.0387 0.0403
Loa Loa (eye worm) hypothetical protein 0.0162 0.0456 0.0578
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0387 0.0488
Schistosoma mansoni acetylcholine receptor-related 0.0065 0.013 0.0157
Echinococcus granulosus twitchin 0.0046 0.0065 0.0065
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0141 0.0387 0.0387
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0017 0.0028
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0211 0.0261
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0392 0.1231 0.5359
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0141 0.0387 0.0488
Echinococcus granulosus epidermal growth factor receptor 0.059 0.1897 0.1897
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0313 0.0964 0.419
Leishmania major trypanothione reductase 0.0046 0.0065 0.0149
Echinococcus granulosus glycine receptor subunit alpha 1 0.0141 0.0387 0.0387
Echinococcus granulosus geminin 0.0543 0.1738 0.1738
Echinococcus granulosus jumonji domain containing protein 0.0202 0.059 0.059
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0738 0.2393 0.2393
Trichomonas vaginalis chromobox protein, putative 0.007 0.0145 0.0296
Loa Loa (eye worm) hypothetical protein 0.0151 0.0419 0.053
Plasmodium vivax amine transporter, putative 0.0047 0.0067 0.1475
Echinococcus multilocularis insulin receptor 0.0192 0.0556 0.058
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Onchocerca volvulus 0.0122 0.032 0.1009
Brugia malayi PHD-finger family protein 0.0053 0.0087 0.01
Loa Loa (eye worm) hypothetical protein 0.007 0.0146 0.0176
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1447 0.4778 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0067 0.007
Brugia malayi neuropeptide F receptor 0.0122 0.032 0.0402
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0513 0.1635 0.2106
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.013 0.0348 0.0348
Toxoplasma gondii hypothetical protein 0.0047 0.0067 0.1205
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0194 0.0563 0.0717
Brugia malayi jmjC domain containing protein 0.0065 0.0128 0.0153
Onchocerca volvulus 0.0047 0.0067 0.0187
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0392 0.1231 0.5359
Schistosoma mansoni biogenic amine receptor 0.0122 0.032 0.0403
Echinococcus granulosus neuropeptide receptor 0.0296 0.0906 0.0906
Loa Loa (eye worm) hypothetical protein 0.0336 0.104 0.1335
Onchocerca volvulus 0.0122 0.032 0.1009
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0037 0.0034 0.0031
Echinococcus granulosus acetylcholinesterase 0.2322 0.7724 0.7724
Brugia malayi G protein-coupled receptor F59B2.13 0.0122 0.032 0.0402
Echinococcus granulosus chromobox protein 1 0.007 0.0145 0.0145
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0211 0.0621 0.1669
Brugia malayi jmjC domain containing protein 0.0542 0.1735 0.2236
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.013 0.0348 0.0708
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0163 0.0335
Toxoplasma gondii histone lysine methyltransferase SET1 0.0174 0.0495 1
Echinococcus granulosus neuropeptides capa receptor 0.0122 0.032 0.032
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0481 0.153 0.3187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.039 0.0493
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0122 0.032 0.0403
Schistosoma mansoni hypothetical protein 0.003 0.001 0.0001
Echinococcus multilocularis JmjC domain containing protein 4 0.0065 0.0128 0.0134
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0687 0.2221 0.4646
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0067 0.0067
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0052 0.0089
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0065 0.013 0.0136
Echinococcus granulosus G protein coupled receptor 139 0.0122 0.032 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.007 0.0146 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Brugia malayi hypothetical protein 0.0122 0.032 0.0402
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.013 0.0348 0.8682
Loa Loa (eye worm) carboxylesterase 0.0392 0.1231 0.1583
Echinococcus multilocularis fmrfamide receptor 0.0122 0.032 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0067 0.0075
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0122 0.032 0.0402
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0141 0.0387 0.0403
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0128 0.0153
Loa Loa (eye worm) hypothetical protein 0.047 0.1491 0.192
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0301 0.1278
Brugia malayi Carboxylesterase family protein 0.2322 0.7724 1
Schistosoma mansoni nAChR subunit 0.0141 0.0387 0.0489
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0074
Brugia malayi Heterochromatin protein 1 0.007 0.0145 0.0175
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0122 0.032 0.0403
Loa Loa (eye worm) hypothetical protein 0.0495 0.1577 0.2032
Leishmania major phosphatidylinositol 3-kinase, putative 0.013 0.0348 0.0923
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0122 0.032 0.0334
Plasmodium falciparum phosphatidylinositol 3-kinase 0.013 0.0348 0.8682
Loa Loa (eye worm) glutathione reductase 0.0046 0.0065 0.0071
Echinococcus granulosus allatostatin A receptor 0.0122 0.032 0.032
Brugia malayi plexin A 0.0036 0.003 0.0027
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0065 0.0128 0.0323
Schistosoma mansoni hypothetical protein 0.0543 0.1738 0.224
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0067 0.1475
Onchocerca volvulus Fxna peptidase homolog 0.0151 0.0419 0.1329
Schistosoma mansoni hypothetical protein 0.0543 0.1738 0.224
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0067 0.0075
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0128 0.0154
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0122 0.032 0.0402
Loa Loa (eye worm) histone methyltransferase 0.0032 0.0018 0.0011
Onchocerca volvulus 0.0076 0.0167 0.0511
Echinococcus multilocularis neuropeptide FF receptor 2 0.0122 0.032 0.0334
Brugia malayi Dopamine receptor protein 1 0.0122 0.032 0.0402
Schistosoma mansoni cpg binding protein 0.0089 0.0211 0.0262
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0146 0.0372
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0122 0.032 0.0334
Echinococcus granulosus Immunoglobulin 0.0037 0.0034 0.0034
Mycobacterium tuberculosis Conserved protein 0.007 0.0146 0.0598
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0146 0.0598
Toxoplasma gondii ABC1 family protein 0.007 0.0146 0.2825
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0118 0.0306 0.032
Schistosoma mansoni amine GPCR 0.0122 0.032 0.0403
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1447 0.4778 1
Echinococcus granulosus para nitrobenzyl esterase 0.0392 0.1231 0.1231
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0141 0.0387 0.0489
Brugia malayi leucyl aminopeptidase 0.0151 0.0419 0.053
Onchocerca volvulus Alhambra homolog 0.0145 0.0399 0.1264
Brugia malayi jmjC domain containing protein 0.0248 0.0744 0.0951
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0163 0.0335
Trypanosoma brucei glutaminyl cyclase, putative 0.0151 0.0419 0.1117
Echinococcus multilocularis g-protein coupled receptor 0.0122 0.032 0.0334
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0146 0.0176
Schistosoma mansoni myosin xvIII 0.0122 0.032 0.0403
Loa Loa (eye worm) hypothetical protein 0.007 0.0146 0.0176
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0122 0.032 0.0402
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1117 0.367 0.4744
Brugia malayi beta-lactamase 0.007 0.0146 0.0176
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Schistosoma mansoni acetylcholinesterase 0.0392 0.1231 0.1583
Loa Loa (eye worm) solute carrier family 6 member 4 0.0274 0.0834 0.1068
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0163 0.0163
Echinococcus granulosus neuroligin 0.0392 0.1231 0.1231
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0419 0.0869
Onchocerca volvulus 0.0141 0.0387 0.1224
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0151 0.0419 0.1273
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0053 0.0089 0.2021
Brugia malayi Latrophilin receptor protein 2 0.0162 0.0456 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0146 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0118 0.0306 0.0306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1447 0.4778 1
Echinococcus multilocularis chromobox protein 1 0.007 0.0145 0.0151
Leishmania major hypothetical protein, conserved 0.0065 0.0128 0.0323
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.0121 0.0317 0.0397
Echinococcus granulosus biogenic amine 5HT receptor 0.0122 0.032 0.032
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0092 0.0221 0.0273
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0146 0.0598
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0146 0.0298
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.013 0.0348 0.0438
Onchocerca volvulus 0.0132 0.0355 0.1121
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0163 0.3183
Loa Loa (eye worm) hypothetical protein 0.0065 0.0128 0.0153
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Schistosoma mansoni phosphatidylserine receptor 0.0065 0.0128 0.0154
Onchocerca volvulus 0.0122 0.032 0.1009
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0141 0.0387 0.0488
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1447 0.4778 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0065 0.013 0.0156
Onchocerca volvulus 0.0122 0.032 0.1009
Plasmodium falciparum JmjC domain-containing protein, putative 0.0065 0.0128 0.3042
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0606 0.1948 0.4066
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0141 0.0387 0.0403
Loa Loa (eye worm) hypothetical protein 0.0738 0.2393 0.3089
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0122 0.032 0.0403
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0047 0.0067 0.0074
Brugia malayi Calcitonin receptor-like protein seb-1 0.0513 0.1635 0.2106
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0211 0.0621 0.1293
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0017 0.0028
Brugia malayi neuropeptide F receptor 0.0122 0.032 0.0402
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.001 0.0001
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.013 0.0348 0.0923
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.032 0.032
Schistosoma mansoni opsin-like receptor 0.0122 0.032 0.0403
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0707 0.2288 1
Onchocerca volvulus 0.0122 0.032 0.1009
Schistosoma mansoni fkbp-rapamycin associated protein 0.003 0.001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0017 0.0028
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0065 0.0065
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0067 0.007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0146 0.0177
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0122 0.032 0.032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0306 0.6125
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0392 0.1231 0.1231
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0262 0.1106
Loa Loa (eye worm) hypothetical protein 0.0392 0.1231 0.1583
Loa Loa (eye worm) hypothetical protein 0.0076 0.0167 0.0204
Schistosoma mansoni nAChR subunit 0.0065 0.013 0.0157
Schistosoma mansoni hypothetical protein 0.005 0.0079 0.009
Brugia malayi hypothetical protein 0.0122 0.032 0.0402
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0167 0.0204
Brugia malayi Melatonin receptor type 1A 0.0122 0.032 0.0402
Schistosoma mansoni nephrin 0.0046 0.0065 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0141 0.0387 0.0403
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0141 0.0387 0.0488
Entamoeba histolytica hypothetical protein 0.0606 0.1948 0.4066
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0047 0.0067 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0599 0.1924 0.2481
Toxoplasma gondii hypothetical protein 0.0047 0.0067 0.1205
Loa Loa (eye worm) hypothetical protein 0.0048 0.0074 0.0083
Trypanosoma cruzi glutaminyl cyclase, putative 0.0151 0.0419 0.1117
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0122 0.032 0.0334
Loa Loa (eye worm) neuropeptide F receptor 0.0122 0.032 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0052 0.0102
Treponema pallidum fructose-bisphosphate aldolase 0.1447 0.4778 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Schistosoma mansoni survival motor neuron protein 0.005 0.0079 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.032 0.0334
Brugia malayi glutathione reductase 0.0046 0.0065 0.0071
Loa Loa (eye worm) LGC-31 protein 0.0141 0.0387 0.0488
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0052 0.0052
Echinococcus multilocularis acetylcholinesterase 0.2322 0.7724 0.8054
Echinococcus granulosus neuropeptide receptor A26 0.0122 0.032 0.032
Echinococcus granulosus tm gpcr rhodopsin 0.0122 0.032 0.032
Loa Loa (eye worm) ACC-1 protein 0.0141 0.0387 0.0488
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0067 0.0074
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0151 0.0419 0.0419
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0542 0.1735 0.1735
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0163 0.042
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0262 0.1106
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0031
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0121 0.0317 0.033
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0141 0.0387 0.0489
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0037 0.0034 0.0031
Trichomonas vaginalis set domain proteins, putative 0.0944 0.3086 0.6457
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0387 0.0488
Echinococcus multilocularis glycine receptor subunit beta 0.0141 0.0387 0.0403
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0092 0.0221 0.023
Schistosoma mansoni biogenic amine (5HT) receptor 0.0122 0.032 0.0403
Echinococcus multilocularis somatostatin receptor 0.0122 0.032 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0141 0.0387 0.0488
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0146 0.0177
Loa Loa (eye worm) hypothetical protein 0.026 0.0785 0.1005
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Echinococcus multilocularis jumonji domain containing 1A 0.0065 0.0128 0.0134
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0687 0.2221 0.4646
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0079 0.0089
Schistosoma mansoni neuropeptide F-like receptor 0.0122 0.032 0.0403
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0146 0.0372
Trypanosoma cruzi glutaminyl cyclase, putative 0.0151 0.0419 0.1117
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0141 0.0387 0.0403
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0336 0.104 0.104
Echinococcus granulosus BC026374 protein S09 family 0.0392 0.1231 0.1231
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Brugia malayi MH2 domain containing protein 0.0237 0.0707 0.0904
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.032 0.032
Brugia malayi hypothetical protein 0.0037 0.0034 0.0031
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0262 0.1106
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0141 0.0387 0.0488
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0122 0.032 0.0403
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0052 0.0116
Echinococcus granulosus 7tm_1 domain containing protein 0.0122 0.032 0.032
Onchocerca volvulus 0.0542 0.1734 0.5604
Echinococcus multilocularis lysine specific demethylase 6a 0.0065 0.0128 0.0134
Schistosoma mansoni opsin-like receptor 0.0122 0.032 0.0403
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.013 0.0348 0.0923
Echinococcus granulosus cpg binding protein 0.0094 0.0228 0.0228
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0141 0.0387 0.0387
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0042 0.0104
Loa Loa (eye worm) G-protein coupled receptor 0.0122 0.032 0.0402
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0074
Onchocerca volvulus Fxna peptidase homolog 0.0151 0.0419 0.1329
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0274 0.0834 0.1068
Echinococcus granulosus serotonin receptor 0.0122 0.032 0.032
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.003 0.001 0.001
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0122 0.032 0.032
Onchocerca volvulus 0.0141 0.0387 0.1224
Onchocerca volvulus 0.005 0.0079 0.0224
Schistosoma mansoni sodium-dependent amino acid transporter 0.0047 0.0067 0.0075
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0017 0.0028
Echinococcus multilocularis allatostatin A receptor 0.0122 0.032 0.0334
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0163 0.0081
Loa Loa (eye worm) hypothetical protein 0.026 0.0785 0.1005
Onchocerca volvulus 0.007 0.0146 0.0442
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0141 0.0387 0.0403
Leishmania major glutaminyl cyclase, putative 0.0151 0.0419 0.1117
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0065 0.013 0.0136
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0074
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0122 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0694 0.2246 0.2899
Schistosoma mansoni neurotransmitter gated ion channel 0.0065 0.013 0.0157
Brugia malayi putative neuropeptide receptor 0.0122 0.032 0.0402
Plasmodium vivax SET domain protein, putative 0.0121 0.0317 0.7884
Schistosoma mansoni opsin-like receptor 0.0122 0.032 0.0403
Brugia malayi hypothetical protein 0.0047 0.0067 0.0074
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.003 0.001 0.001
Echinococcus multilocularis Zinc finger, PHD finger 0.013 0.0348 0.0362
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.035 0.1088 0.1398
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.083 0.2702 0.3489
Toxoplasma gondii peptidase, M28 family protein 0.0151 0.0419 0.8434
Brugia malayi putative neuropeptide receptor NPR1 0.0122 0.032 0.0402
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0317 0.0398
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0121 0.0317 0.6333
Echinococcus multilocularis nAChR subunit 0.0141 0.0387 0.0403
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.032 0.0403
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0337 0.1044 0.4193
Echinococcus multilocularis serotonin transporter 0.0274 0.0834 0.0869
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.032 0.032
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0065 0.013 0.0136
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0031
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0065 0.1405
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0317 0.0398
Echinococcus granulosus tm gpcr rhodopsin 0.0709 0.2296 0.2296
Brugia malayi Inositol-1 0.0075 0.0163 0.0199
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0141 0.0387 0.0403
Echinococcus granulosus dro:myosuppressin receptor 0.0122 0.032 0.032
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2322 0.7724 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Brugia malayi CXXC zinc finger family protein 0.0089 0.0211 0.0261
Echinococcus granulosus neuroglian 0.0046 0.0065 0.0065
Echinococcus granulosus defective proboscis extension response 0.0037 0.0034 0.0034
Echinococcus granulosus serine protein kinase ATM 0.003 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Echinococcus granulosus nAChR subunit 0.0076 0.0167 0.0167
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0047 0.0067 0.007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0262 0.1106
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.0267 0.0808 0.1034
Echinococcus multilocularis G protein coupled receptor 139 0.0296 0.0906 0.0944
Schistosoma mansoni jumonji/arid domain-containing protein 0.0248 0.0744 0.0952
Loa Loa (eye worm) hypothetical protein 0.0392 0.1231 0.1583
Brugia malayi Cation transporter family protein 0.0141 0.0387 0.0488
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Onchocerca volvulus Tyrosine kinase homolog 0.0559 0.1793 0.5795
Echinococcus granulosus glycine receptor subunit alpha 1 0.0141 0.0387 0.0387
Loa Loa (eye worm) phosphatidylinositol 3 0.0956 0.3126 0.4039
Loa Loa (eye worm) hypothetical protein 0.0058 0.0105 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0089 0.2021
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0146 0.0146
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0017 0.0028
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0336 0.104 0.1084
Loa Loa (eye worm) PHD-finger family protein 0.0145 0.0399 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0141 0.0387 0.0489
Entamoeba histolytica hypothetical protein 0.0072 0.0153 0.0301
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0392 0.1231 0.1583
Loa Loa (eye worm) hypothetical protein 0.0513 0.1635 0.2106
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0211 0.0621 0.0792
Brugia malayi latrophilin 2 splice variant baaae 0.035 0.1089 0.1399
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0137 0.0558
Loa Loa (eye worm) acetylcholine receptor protein 0.0065 0.013 0.0156
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0387 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.032 0.0334
Trypanosoma brucei C-8 sterol isomerase, putative 0.1117 0.367 1
Brugia malayi AF-10 protein 0.0047 0.007 0.0078
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0122 0.032 0.0334
Brugia malayi Cytochrome P450 family protein 0.0105 0.0265 0.0331
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0052 0.0116
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0146 0.0598
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0151 0.0419 0.0531
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.013 0.0156
Echinococcus multilocularis neuroligin 0.0392 0.1231 0.1283
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.032 0.0403
Schistosoma mansoni neuroligin 3 (S09 family) 0.0392 0.1231 0.1583
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.003 0.001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0076 0.0167 0.0204
Echinococcus granulosus insulin receptor 0.0192 0.0556 0.0556
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0128 0.0153
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.0736 0.0767
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0122 0.032 0.0402
Schistosoma mansoni neuropeptide f receptor 76f 0.0122 0.032 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Brugia malayi G protein-coupled receptor 0.0122 0.032 0.0402
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.013 0.0348 0.0708
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0122 0.032 0.0403
Schistosoma mansoni vesicular amine transporter 0.0037 0.0034 0.0031
Echinococcus granulosus neuropeptide Y receptor 0.0122 0.032 0.032
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0121 0.0317 0.033
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0052 0.0116
Brugia malayi hypothetical protein 0.0072 0.0153 0.0186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.039 0.039
Echinococcus granulosus somatostatin receptor 0.0122 0.032 0.032
Echinococcus granulosus g-protein coupled receptor 0.0122 0.032 0.032
Loa Loa (eye worm) norepinephrine transporter 0.0274 0.0834 0.1068
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0146 0.0298
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.003 0.001 0.0013
Brugia malayi GnHR receptor homolog 0.0122 0.032 0.0402
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0065 0.024
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0151 0.0419 0.0419
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0153 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0042 0.008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0254 0.0766 0.1587
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0052 0.0137
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0387 0.0488
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0163 0.017
Loa Loa (eye worm) TYRA-2 protein 0.0122 0.032 0.0402
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0118 0.0306 0.0622
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0122 0.032 0.0403
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0052 0.0052
Onchocerca volvulus 0.0392 0.1231 0.3969
Brugia malayi hypothetical protein 0.0122 0.032 0.0402
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0017 0.0028
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0052 0.0055
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0392 0.1231 0.1583
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0122 0.032 0.0334
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Schistosoma mansoni hypothetical protein 0.0122 0.032 0.0403
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.003 0.001 0.001
Schistosoma mansoni protein phosphatase 2C 0.0065 0.0128 0.0154
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0146 0.0298
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0141 0.0387 0.0387
Loa Loa (eye worm) latrophilin receptor protein 2 0.0162 0.0456 0.0578
Echinococcus granulosus nAChR subunit 0.0141 0.0387 0.0387
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0387 0.0488
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0153 0.0187
Plasmodium vivax JmjC domain containing protein 0.0065 0.0128 0.3042
Mycobacterium tuberculosis Conserved protein 0.0151 0.0419 0.1794
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0052 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.003 0.001 0.0013
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0047 0.0067 0.5
Brugia malayi jmjC domain containing protein 0.0065 0.0128 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.032 0.0403
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0211 0.0621 0.1281
Schistosoma mansoni jumonji/arid domain-containing protein 0.0248 0.0744 0.0952
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0067 0.0067
Schistosoma mansoni phosphatidylinositol 4-kinase 0.013 0.0348 0.0438
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0146 0.0598
Onchocerca volvulus 0.0065 0.013 0.0391
Brugia malayi hypothetical protein 0.0065 0.013 0.0156
Echinococcus multilocularis 0.0181 0.052 0.0543
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0687 0.2221 0.6042
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0047 0.007 0.0165
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0141 0.0387 0.0488
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0122 0.032 0.0403
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0067 0.1205
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0047 0.0067 0.007
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.032 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0031
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0052 0.0055
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0065 0.013 0.0156
Loa Loa (eye worm) plexin A 0.0036 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0042 0.008
Brugia malayi hypothetical protein 0.0122 0.032 0.0402
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0067 0.0074
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.001 0.0001
Brugia malayi Carboxylesterase family protein 0.0392 0.1231 0.1583
Onchocerca volvulus 0.0392 0.1231 0.3969
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0074
Brugia malayi G-protein coupled receptor 0.0122 0.032 0.0402
Echinococcus multilocularis serotonin receptor 0.026 0.0785 0.0819
Brugia malayi Cation transporter family protein 0.0141 0.0387 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Schistosoma mansoni hypothetical protein 0.0122 0.032 0.0403
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0141 0.0387 0.0488
Echinococcus multilocularis epidermal growth factor receptor 0.0319 0.0985 0.1027
Loa Loa (eye worm) hypothetical protein 0.2322 0.7724 1
Echinococcus granulosus neuropeptides capa receptor 0.0122 0.032 0.032
Onchocerca volvulus 0.0122 0.032 0.1009
Brugia malayi hypothetical protein 0.0065 0.013 0.0156
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0052 0.0055
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0738 0.2393 0.3089
Plasmodium falciparum phd finger protein, putative 0.0145 0.0399 1
Schistosoma mansoni nAChR subunit 0.0065 0.013 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0052 0.0101
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Loa Loa (eye worm) hypothetical protein 0.0058 0.0105 0.0123
Schistosoma mansoni hypothetical protein 0.0162 0.0456 0.0579
Onchocerca volvulus 0.007 0.0146 0.0442
Brugia malayi Peptidase family M28 containing protein 0.0738 0.2393 0.3089
Echinococcus multilocularis epidermal growth factor receptor 0.059 0.1897 0.1978
Echinococcus multilocularis neuropeptide receptor A26 0.0122 0.032 0.0334
Loa Loa (eye worm) hypothetical protein 0.0694 0.2246 0.2899
Loa Loa (eye worm) hypothetical protein 0.0141 0.0387 0.0488
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.003 0.001 0.001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0122 0.032 0.0334
Toxoplasma gondii PHD-finger domain-containing protein 0.0145 0.0399 0.8027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0031
Echinococcus granulosus g protein coupled receptor 0.0122 0.032 0.032
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0301 0.1278
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Trichomonas vaginalis esterase, putative 0.007 0.0146 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Schistosoma mansoni neuropeptide receptor 0.0122 0.032 0.0403
Onchocerca volvulus 0.0089 0.0211 0.0654
Mycobacterium ulcerans hypothetical protein 0.0151 0.0419 0.1273
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0192 0.0556 0.058
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0141 0.0387 0.0403
Schistosoma mansoni acetylcholine receptor subunit beta 0.0065 0.013 0.0157
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0387 0.0488
Toxoplasma gondii FATC domain-containing protein 0.003 0.001 0.0024
Echinococcus granulosus dnaJ subfamily B 0.0807 0.2626 0.2626
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.032 0.0334
Echinococcus granulosus acetylcholinesterase 0.2322 0.7724 0.7724
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0146 0.0598
Schistosoma mansoni chromobox protein 0.007 0.0145 0.0176
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0137 0.0558
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0037 0.0034 0.0035
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0141 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0118 0.0306 0.0384
Loa Loa (eye worm) TK/INSR protein kinase 0.0192 0.0556 0.0708
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.032 0.032
Echinococcus multilocularis roundabout 2 0.0058 0.0105 0.011
Onchocerca volvulus 0.0122 0.032 0.1009
Schistosoma mansoni tyrosine kinase 0.0319 0.0985 0.1265
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0141 0.0387 0.0488
Brugia malayi hypothetical protein 0.0122 0.032 0.0402
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1447 0.4778 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.0707 0.0904
Echinococcus granulosus phd:f box containing protein 0.0065 0.0128 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0146 0.0372
Brugia malayi beta-lactamase family protein 0.007 0.0146 0.0176
Echinococcus granulosus GPCR family 2 0.0162 0.0456 0.0456
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.013 0.0348 0.072
Echinococcus multilocularis fmrfamide receptor 0.0122 0.032 0.0334
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0162 0.0456 0.0456
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0151 0.0419 0.0437
Onchocerca volvulus 0.0076 0.0167 0.0511
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0042
Toxoplasma gondii PHD-finger domain-containing protein 0.0047 0.007 0.1264
Echinococcus granulosus plexin a4 0.0036 0.003 0.003
Echinococcus multilocularis serine protein kinase ATM 0.003 0.001 0.001
Mycobacterium tuberculosis Carboxylesterase LipT 0.0392 0.1231 0.5359
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0122 0.032 0.0402
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0065 0.0067
Plasmodium vivax hypothetical protein, conserved 0.007 0.0146 0.35
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0402
Brugia malayi jmjC domain containing protein 0.0065 0.0128 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0065 0.013 0.0156
Echinococcus multilocularis neuropeptide Y receptor 0.0122 0.032 0.0334
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.039 0.0493
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0162 0.0456 0.0476
Echinococcus granulosus lysine specific demethylase 6a 0.0065 0.0128 0.0128

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 171 nM Inhibition of 0.5 nM [3H]- Bremazocine binding to Opioid receptor mu 1 of bovine striatum membrane ChEMBL. 2165166

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.