Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0487 | 0.6666 | 0.6633 |
Echinococcus multilocularis | insulin receptor | 0.0155 | 0.0097 | 0.0097 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0487 | 0.6666 | 0.6666 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0487 | 0.6666 | 0.6633 |
Schistosoma mansoni | tyrosine kinase | 0.0261 | 0.2199 | 0.2123 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0155 | 0.0097 | 0.0097 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0487 | 0.6666 | 0.6633 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0655 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0487 | 0.6666 | 0.6633 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0261 | 0.2199 | 0.2199 |
Schistosoma mansoni | tyrosine kinase | 0.0259 | 0.2144 | 0.2067 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0261 | 0.2199 | 0.2123 |
Schistosoma mansoni | tyrosine kinase | 0.0259 | 0.2144 | 0.2067 |
Schistosoma mansoni | tyrosine kinase | 0.0261 | 0.2199 | 0.2123 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0655 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0259 | 0.2144 | 0.2067 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0655 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0655 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0655 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0655 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0655 | 1 | 1 |
Leishmania major | 0.0655 | 1 | 0.5 | |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0261 | 0.2199 | 0.2123 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0655 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hr by broth microdilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.