Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Bradykinin B2 receptor | Starlite/ChEMBL | References |
Homo sapiens | bradykinin receptor B2 | Starlite/ChEMBL | References |
Homo sapiens | bradykinin receptor B1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Bradykinin B2 receptor | 396 aa | 347 aa | 22.5 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | bradykinin receptor B2 | 391 aa | 354 aa | 19.2 % |
Echinococcus multilocularis | allatostatin A receptor | Bradykinin B2 receptor | 396 aa | 319 aa | 25.7 % |
Onchocerca volvulus | Bradykinin B2 receptor | 396 aa | 329 aa | 21.6 % | |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Bradykinin B2 receptor | 396 aa | 317 aa | 23.7 % |
Onchocerca volvulus | Bradykinin B2 receptor | 396 aa | 317 aa | 19.6 % | |
Echinococcus multilocularis | rhodopsin orphan GPCR | Bradykinin B2 receptor | 396 aa | 320 aa | 22.2 % |
Schistosoma japonicum | Rhodopsin, putative | Bradykinin B2 receptor | 396 aa | 332 aa | 22.9 % |
Echinococcus granulosus | rhodopsin orphan GPCR | Bradykinin B2 receptor | 396 aa | 323 aa | 22.3 % |
Echinococcus granulosus | allatostatin A receptor | Bradykinin B2 receptor | 396 aa | 319 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.28 | 0.5865 | 0.5 |
Brugia malayi | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.28 | 0.5865 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.28 | 0.5865 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.28 | 0.5865 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.3198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.28 | 0.5865 | 0.5 |
Onchocerca volvulus | 0.28 | 0.5865 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.28 | 0.5865 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.28 | 0.5865 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.28 | 0.5865 | 0.5865 |
Schistosoma mansoni | peroxidasin | 0.28 | 0.5865 | 0.5865 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.3198 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.28 | 0.5865 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.28 | 0.5865 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.28 | 0.5865 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.28 | 0.5865 | 0.5 |
Onchocerca volvulus | 0.28 | 0.5865 | 0.5 | |
Brugia malayi | Peroxidasin | 0.28 | 0.5865 | 0.5 |
Onchocerca volvulus | 0.28 | 0.5865 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.28 | 0.5865 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.34 | In vitro Bradykinin receptor B1 antagonist activity in functional tissue within rabbit aorta | ChEMBL. | 8691478 |
Kd (functional) | = 5.85 | In vitro Bradykinin receptor B2 antagonist activity of the compound was determined by using rat uterus functional assay | ChEMBL. | 8691478 |
Ki (binding) | = -7.64 | Binding affinity towards Bradykinin receptor B2 in human S34 clone cells | ChEMBL. | 8691478 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.