Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0062 | 0.3288 | 0.3447 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0852 | 0.3404 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0021 | 0.0632 | 0.0997 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.2504 | 0.2172 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.873 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.873 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.873 | 0.8674 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.873 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.873 | 0.8674 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.2504 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3288 | 0.3766 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.2504 | 0.2869 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.2504 | 0.2172 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0018 | 0.0425 | 0.1697 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3288 | 0.299 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.2504 | 1 |
Toxoplasma gondii | FATC domain-containing protein | 0.0024 | 0.0852 | 0.3404 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3288 | 0.3766 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0018 | 0.0425 | 0.1697 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3288 | 0.3447 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3288 | 0.3766 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.2504 | 0.2172 |
Echinococcus granulosus | serine protein kinase ATM | 0.0024 | 0.0852 | 0.0446 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3288 | 0.299 |
Echinococcus multilocularis | geminin | 0.0165 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3288 | 0.299 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3288 | 0.299 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.0427 | 0.0011 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3288 | 0.299 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0024 | 0.0852 | 0.0446 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0632 | 0.0724 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.2504 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.0425 | 0.0487 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0024 | 0.0852 | 0.0515 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.2504 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.0425 | 0.0487 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.873 | 0.8674 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.2504 | 0.2172 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0852 | 0.3404 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.2504 | 0.2172 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.2504 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3288 | 0.3447 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.2504 | 0.2504 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0852 | 0.2055 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2504 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.0427 | 0.0011 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3288 | 0.299 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0024 | 0.0852 | 0.0446 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0852 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3288 | 0.299 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.2504 | 1 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibacterial activity against Escherichia coli NCIM 2068 after 18 to 20 hr by plate method | ChEMBL. | No reference | |
MIC (functional) | = 500 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 after 24 hr by paper disk method | ChEMBL. | No reference |
MIC (functional) | = 600 ug ml-1 | Antibacterial activity against Escherichia coli NCIM 2068 after 18 to 20 hr by plate method | ChEMBL. | No reference |
MIC (functional) | = 800 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae MTCC 36 after 24 hr by paper disk method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.