Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bombyx mori | Ecdysone receptor | Starlite/ChEMBL | References |
Spodoptera littoralis | Ecdysone receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | Ecdysone receptor | 585 aa | 476 aa | 25.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0395 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 5.97 | Agonist activity at ecdysone receptor in Spodoptera littoralis Sl2 cells after 24 hr by luciferase reporter gene assay | ChEMBL. | 20069627 |
EC50 (binding) | = 6.35 | Agonist activity at ecdysone receptor in Bombyx mori Bm5 cells after 24 hr by luciferase reporter gene assay | ChEMBL. | 20069627 |
Efficacy (binding) | = 93 % | Agonist activity at ecdysone receptor in Bombyx mori Bm5 cells after 24 hr by luciferase reporter gene assay relative to tebufenozide | ChEMBL. | 20069627 |
Efficacy (binding) | = 101 % | Agonist activity at ecdysone receptor in Spodoptera littoralis Sl2 cells after 24 hr by luciferase reporter gene assay relative to tebufenozide | ChEMBL. | 20069627 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.