Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0513 | 0.3081 | 0.5 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0513 | 0.3081 | 0.2979 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0513 | 0.3081 | 0.3081 |
Schistosoma mansoni | tyrosine kinase | 0.0522 | 0.3217 | 0.3117 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0513 | 0.3081 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0528 | 0.3299 | 0.32 |
Leishmania major | 0.0513 | 0.3081 | 0.5 | |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0513 | 0.3081 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0528 | 0.3299 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0522 | 0.3217 | 0.3117 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0983 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0513 | 0.3081 | 0.2979 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0314 | 0.0145 | 0.0145 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0983 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0522 | 0.3217 | 0.3117 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0513 | 0.3081 | 0.2979 |
Echinococcus multilocularis | insulin receptor | 0.0314 | 0.0145 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0528 | 0.3299 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0983 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0513 | 0.3081 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0983 | 1 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0513 | 0.3081 | 0.2979 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0528 | 0.3299 | 0.3299 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0528 | 0.3299 | 0.32 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 24 mm | Antimicrobial activity against Candida albicans MTCC 183 assessed as diameter of growth zone inhibition by agar streak dilution method | ChEMBL. | No reference |
IZ (functional) | = 24 mm | Antimicrobial activity against Escherichia coli MTCC 739 assessed as diameter of growth zone inhibition by agar streak dilution method | ChEMBL. | No reference |
MIC (functional) | = 12.5 ug ml-1 | Antimicrobial activity against Escherichia coli MTCC 739 assessed as growth inhibition by agar streak dilution method | ChEMBL. | No reference |
MIC (functional) | = 62.5 ug ml-1 | Antimicrobial activity against Candida albicans MTCC 183 assessed as growth inhibition by agar streak dilution method | ChEMBL. | No reference |
MIC (functional) | = 125 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by BACTEC MGIT method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.