Detailed information for compound 1808119

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 951.127 | Formula: C53H46N10O4S2
  • H donors: 2 H acceptors: 4 LogP: 9.5 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: [O-]c1on[n+](c1CN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2)c1ccc(cc1)Cc1ccc(cc1)[n+]1noc(c1CN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2)[O-]
  • InChi: 1S/C53H46N10O4S2/c64-52-44(34-58-25-29-60(30-26-58)50-40-9-1-5-13-46(40)68-48-15-7-3-11-42(48)54-50)62(56-66-52)38-21-17-36(18-22-38)33-37-19-23-39(24-20-37)63-45(53(65)67-57-63)35-59-27-31-61(32-28-59)51-41-10-2-6-14-47(41)69-49-16-8-4-12-43(49)55-51/h1-24H,25-35H2
  • InChiKey: PVQJXFXBZVQTGR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0027 0.0026
Onchocerca volvulus Tyrosine kinase homolog 0.0979 0.1471 1
Echinococcus multilocularis tyrosine protein kinase otk 0.0046 0.0006 0.0006
Plasmodium vivax histone deacetylase, putative 0.0724 0.107 0.8622
Loa Loa (eye worm) TK/ABL protein kinase 0.0293 0.0394 0.0388
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0054 0.0018 0.0013
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.0035 0.003
Onchocerca volvulus 0.0065 0.0035 0.0204
Brugia malayi SH2 domain containing protein 0.0065 0.0035 0.003
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0052 0.0015 0.001
Schistosoma mansoni tyrosine kinase 0.3498 0.5424 0.5422
Echinococcus granulosus histone deacetylase 6 0.0724 0.107 0.107
Echinococcus multilocularis activin receptor type 0.0055 0.0021 0.0021
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.0058 0.0053
Onchocerca volvulus 0.0052 0.0015 0.0066
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Onchocerca volvulus 0.0065 0.0035 0.0204
Brugia malayi Histone deacetylase family protein 0.0724 0.107 0.1065
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0104 0.0098 0.0098
Echinococcus granulosus histone deacetylase 3 0.0831 0.1238 0.1238
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.0015 0.001
Onchocerca volvulus 0.0052 0.0015 0.0066
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.0035 0.003
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.0015 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0015 0.001
Trypanosoma cruzi histone deacetylase 1, putative 0.0831 0.1238 0.2764
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0048 0.0043
Schistosoma mansoni tyrosine kinase 0.0104 0.0098 0.0092
Onchocerca volvulus 0.0065 0.0035 0.0204
Echinococcus granulosus lachesin 0.0046 0.0006 0.0006
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0823 0.1225 0.1221
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.1068 0.161 0.3603
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.2066 0.3177 0.3177
Trypanosoma brucei protein kinase, putative 0.0055 0.0021 0.0012
Trypanosoma brucei histone deacetylase 1 0.0831 0.1238 0.2764
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0055 0.0021 0.0012
Echinococcus granulosus roundabout 2 0.0125 0.013 0.013
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0052 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0075 0.0051 0.0051
Onchocerca volvulus 0.0065 0.0035 0.0204
Brugia malayi Tyrosine-protein kinase abl-1 0.0159 0.0184 0.0178
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0052 0.0015 0.0015
Echinococcus granulosus tyrosine protein kinase Fyn 0.0104 0.0098 0.0098
Echinococcus multilocularis histone deacetylase 6 0.0724 0.107 0.107
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0052 0.0015 0.0015
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0065 0.0035 0.0035
Trypanosoma cruzi histone deacetylase, putative 0.0724 0.107 0.2383
Schistosoma mansoni nephrin 0.0102 0.0094 0.0088
Schistosoma mansoni histone deacetylase 4 5 0.0724 0.107 0.1065
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.0035 0.003
Echinococcus granulosus insulin receptor 0.2058 0.3164 0.3164
Onchocerca volvulus 0.0065 0.0035 0.0204
Plasmodium falciparum histone deacetylase, putative 0.0724 0.107 0.8622
Loa Loa (eye worm) histone deacetylase 1 0.0831 0.1238 0.1234
Echinococcus multilocularis protein kinase 0.0052 0.0015 0.0015
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0075 0.0051 0.0051
Echinococcus multilocularis natriuretic peptide receptor 1 0.0052 0.0015 0.0015
Schistosoma mansoni tyrosine protein kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0054 0.0018 0.0013
Schistosoma mansoni protein kinase 0.0052 0.0015 0.001
Brugia malayi Receptor family ligand binding region containing protein 0.0052 0.0015 0.001
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Echinococcus granulosus Immunoglobulin 0.0071 0.0046 0.0046
Loa Loa (eye worm) TK protein kinase 0.0084 0.0066 0.006
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0048 0.0043
Echinococcus granulosus tyrosine protein kinase shark 0.0065 0.0035 0.0035
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1051 0.1584 0.1579
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0027 0.0027
Toxoplasma gondii histone deacetylase HDAC2 0.0831 0.1238 0.2764
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0293 0.0394 0.0394
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0027 0.0021
Echinococcus multilocularis tyrosine kinase 0.0065 0.0035 0.0035
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0052 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0072 0.0047 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0027 0.0094
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0065 0.0035 0.0164
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0052 0.0015 0.001
Echinococcus granulosus c src tyrosine kinase 0.0072 0.0047 0.0047
Echinococcus granulosus tyrosine protein kinase csk 0.0052 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0104 0.0098 0.0098
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.0015 0.001
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0052 0.0015 0.001
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0055 0.0021 0.0021
Trypanosoma brucei histone deacetylase, putative 0.0724 0.107 0.2383
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0052 0.0015 0.001
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.0015 0.001
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) hypothetical protein 0.0071 0.0046 0.004
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0831 0.1238 1
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0052 0.0015 0.0015
Schistosoma mansoni tyrosine kinase 0.2058 0.3164 0.316
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0831 0.1238 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0055 0.0021 0.0021
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Toxoplasma gondii histone deacetylase HDAC3 0.0831 0.1238 0.2764
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0048 0.0043
Echinococcus granulosus roundabout 2 0.0054 0.0018 0.0018
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0071 0.0046 0.004
Schistosoma mansoni protein kinase 0.0052 0.0015 0.001
Echinococcus multilocularis heat shock protein 70 0.0052 0.0015 0.0015
Trypanosoma cruzi histone deacetylase 1, putative 0.0831 0.1238 0.2764
Schistosoma mansoni protein kinase 0.0052 0.0015 0.001
Echinococcus multilocularis microtubule associated protein 2 0.0764 0.1133 0.1133
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) hypothetical protein 0.0095 0.0082 0.0076
Schistosoma mansoni microtubule-associated protein tau 0.0764 0.1133 0.1128
Trypanosoma brucei fructose-1,6-bisphosphatase 0.2871 0.4441 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Schistosoma mansoni protein kinase 0.0055 0.0021 0.0015
Echinococcus multilocularis transfer RNA-Thr 0.0052 0.0015 0.0015
Echinococcus granulosus receptor type guanylyl cyclase 0.0052 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase pr2 0.0052 0.0015 0.0015
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.0015 0.001
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0027 0.0026
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.1068 0.161 0.3603
Brugia malayi histone deacetylase 3 (HD3) 0.0831 0.1238 0.1234
Loa Loa (eye worm) TK/EPH protein kinase 0.0331 0.0454 0.0448
Echinococcus multilocularis protein kinase 0.0052 0.0015 0.0015
Echinococcus multilocularis histone deacetylase 6 0.074 0.1096 0.1096
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0104 0.0098 0.0098
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0048 0.027
Echinococcus multilocularis mitogen activated protein kinase 11 0.042 0.0593 0.0593
Echinococcus multilocularis protein tyrosine kinase 0.0052 0.0015 0.0015
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0054 0.0018 0.0018
Echinococcus granulosus tyrosine kinase 0.0052 0.0015 0.0015
Loa Loa (eye worm) TK protein kinase 0.0052 0.0015 0.001
Brugia malayi histone deacetylase 1 (HD1) 0.0831 0.1238 0.1234
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0052 0.0015 0.001
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Echinococcus granulosus tyrosine kinase 0.0065 0.0035 0.0035
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0072 0.0047 0.0041
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0027 0.0026
Echinococcus granulosus histone deacetylase 0.0724 0.107 0.107
Echinococcus granulosus protein kinase 0.0052 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.008 0.0058 0.0053
Brugia malayi hypothetical protein 0.008 0.0058 0.0053
Echinococcus multilocularis Immunoglobulin 0.0071 0.0046 0.0046
Trichomonas vaginalis histone deacetylase, putative 0.0831 0.1238 1
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0021 0.0044
Echinococcus multilocularis mitogen activated protein kinase 14 0.042 0.0593 0.0593
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0052 0.0015 0.001
Echinococcus granulosus mitogen activated protein kinase 11 0.042 0.0593 0.0593
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0052 0.0015 0.0015
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0052 0.0015 0.001
Echinococcus multilocularis insulin receptor 0.2058 0.3164 0.3164
Giardia lamblia Histone deacetylase 0.0831 0.1238 1
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.0015 0.001
Schistosoma mansoni histone deacetylase 1 2 3 0.0352 0.0485 0.048
Onchocerca volvulus 0.0905 0.1354 0.9201
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0104 0.0098 0.0098
Echinococcus granulosus mitogen activated protein kinase 14 0.042 0.0593 0.0593
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0104 0.0098 0.0098
Echinococcus multilocularis tyrosine protein kinase 0.0052 0.0015 0.0015
Brugia malayi Protein kinase domain containing protein 0.0065 0.0035 0.003
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.0015 0.0015
Echinococcus granulosus protein tyrosine kinase 0.0052 0.0015 0.0015
Loa Loa (eye worm) TK/FAK protein kinase 0.0052 0.0015 0.001
Echinococcus granulosus tyrosine protein kinase ABL1 0.0293 0.0394 0.0394
Schistosoma mansoni histone deacetylase hda2 0.074 0.1096 0.1091
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2871 0.4441 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Echinococcus multilocularis neuroglian 0.0094 0.0081 0.0081
Brugia malayi Protein kinase domain containing protein 0.0065 0.0035 0.003
Echinococcus multilocularis histone deacetylase 1 0.0831 0.1238 0.1238
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0104 0.0098 0.0098
Trichomonas vaginalis histone deacetylase, putative 0.0831 0.1238 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0052 0.0015 0.0015
Echinococcus granulosus peroxidasin 0.0046 0.0006 0.0006
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0054 0.0018 0.0013
Echinococcus granulosus activated cdc42 kinase 1 0.0052 0.0015 0.0015
Brugia malayi Tyrosine-protein kinase abl-1 0.0141 0.0155 0.0149
Echinococcus granulosus tyrosine kinase 0.0097 0.0086 0.0086
Schistosoma mansoni tyrosine kinase 0.3446 0.5343 0.534
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0027 0.0027
Brugia malayi Tyrosine-protein kinase PR2 0.0052 0.0015 0.001
Brugia malayi MAP kinase sur-1 0.0059 0.0027 0.0021
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0048 0.0075
Echinococcus multilocularis tyrosine protein kinase Blk 0.0097 0.0086 0.0086
Schistosoma mansoni tyrosine kinase 0.6413 1 1
Brugia malayi Protein kinase domain containing protein 0.0823 0.1225 0.1221
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0118 0.0118 0.0843
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.0035 0.003
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0052 0.0015 0.0066
Echinococcus granulosus ephrin type A receptor 4 A 0.0286 0.0382 0.0382
Echinococcus granulosus neuroglian 0.0094 0.0081 0.0081
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0052 0.0015 0.0015
Echinococcus granulosus activin receptor type 0.0055 0.0021 0.0021
Plasmodium vivax histone deacetylase, putative 0.0352 0.0485 0.3844
Trypanosoma cruzi histone deacetylase, putative 0.0724 0.107 0.2383
Trichomonas vaginalis histone deacetylase, putative 0.0831 0.1238 1
Brugia malayi Histone deacetylase 1 0.0831 0.1238 0.1234
Echinococcus multilocularis histone deacetylase 7 0.0724 0.107 0.107
Echinococcus multilocularis lachesin 0.0046 0.0006 0.0006
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.042 0.0593 0.1306
Brugia malayi Immunoglobulin I-set domain containing protein 0.0054 0.0018 0.0013
Plasmodium vivax histone deacetylase 1, putative 0.0831 0.1238 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0052 0.0015 0.0015
Schistosoma mansoni nephrin 0.0054 0.0018 0.0013
Echinococcus granulosus histone deacetylase 1 0.0831 0.1238 0.1238
Brugia malayi histone deacetylase 11 0.0352 0.0485 0.048
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.3498 0.5424 0.5424
Brugia malayi fructose-1,6-bisphosphatase 0.2871 0.4441 0.4438
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Trypanosoma brucei histone deacetylase 4 0.0724 0.107 0.2383
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0052 0.0015 0.0015
Brugia malayi hypothetical protein 0.0052 0.0015 0.001
Loa Loa (eye worm) histone deacetylase 0.0724 0.107 0.1065
Echinococcus granulosus histone deacetylase 6 0.0724 0.107 0.107
Schistosoma mansoni tyrosine kinase 0.028 0.0374 0.0368
Trypanosoma brucei histone deacetylase 2 0.0352 0.0485 0.1062
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0065 0.0035 0.0035
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0052 0.0015 0.001
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0052 0.0015 0.001
Leishmania major histone deacetylase, putative 0.0724 0.107 0.2383
Loa Loa (eye worm) histone deacetylase 7A 0.0724 0.107 0.1065
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0004 0.0004
Echinococcus granulosus tyrosine protein kinase HCK 0.0084 0.0066 0.0066
Echinococcus multilocularis protein KINase family member (kin 25) 0.0052 0.0015 0.0015
Schistosoma mansoni tyrosine kinase 0.3446 0.5343 0.534
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Loa Loa (eye worm) thymidylate synthase 0.0084 0.0065 0.0059
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0052 0.0015 0.0015
Brugia malayi ephrin receptor 1 precursor 0.0155 0.0177 0.0172
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0052 0.0015 0.0015
Toxoplasma gondii fructose-bisphospatase II 0.2871 0.4441 1
Schistosoma mansoni tyrosine kinase 0.3446 0.5343 0.534
Loa Loa (eye worm) hypothetical protein 0.008 0.0058 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.0051 0.0045
Brugia malayi P38 map kinase family protein 2 0.042 0.0593 0.0588
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.042 0.0593 0.0588
Loa Loa (eye worm) TK protein kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) protein kinase domain-containing protein 0.0052 0.0015 0.001
Onchocerca volvulus 0.0052 0.0015 0.0066
Mycobacterium ulcerans thymidylate synthase 0.0084 0.0065 0.5
Echinococcus multilocularis peroxidasin 0.0046 0.0006 0.0006
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Echinococcus multilocularis 0.2047 0.3147 0.3147
Echinococcus multilocularis histone deacetylase 0.0724 0.107 0.107
Echinococcus granulosus defective proboscis extension response 0.0071 0.0046 0.0046
Schistosoma mansoni cell adhesion molecule 0.0054 0.0018 0.0013
Echinococcus multilocularis hemicentin 1 0.0046 0.0006 0.0006
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0118 0.0118 0.0233
Trichomonas vaginalis histone deacetylase, putative 0.0831 0.1238 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0004 0.0004
Brugia malayi C-terminal src kinase protein 1 0.0052 0.0015 0.001
Echinococcus granulosus histone deacetylase 7 0.0724 0.107 0.107
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0027 0.0026
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0048 0.0048
Brugia malayi SRC-1 0.0104 0.0098 0.0092
Onchocerca volvulus 0.0084 0.0065 0.0405
Schistosoma mansoni tyrosine kinase 0.3498 0.5424 0.5422
Loa Loa (eye worm) TK protein kinase 0.0052 0.0015 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0104 0.0098 0.0098
Echinococcus granulosus thymidylate synthase 0.0084 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0372 0.0518 0.0513
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0052 0.0015 0.0066
Trichomonas vaginalis histone deacetylase, putative 0.0831 0.1238 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0118 0.0118 0.0233
Schistosoma mansoni protein tyrosine kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) hypothetical protein 0.0071 0.0046 0.004
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.0035 0.003
Schistosoma mansoni vesicular amine transporter 0.0071 0.0046 0.004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0054 0.0018 0.0013
Echinococcus multilocularis ephrin type A receptor 4 A 0.0286 0.0382 0.0382
Echinococcus multilocularis tyrosine protein kinase HCK 0.0084 0.0066 0.0066
Brugia malayi integrin-linked kinase 0.0052 0.0015 0.001
Echinococcus multilocularis epidermal growth factor receptor 0.3498 0.5424 0.5424
Loa Loa (eye worm) histone deacetylase 3 0.0831 0.1238 0.1234
Trypanosoma brucei histone deacetylase 3 0.0724 0.107 0.2383
Echinococcus granulosus retinal guanylyl cyclase 2 0.0052 0.0015 0.0015
Schistosoma mansoni protein kinase 0.0052 0.0015 0.001
Echinococcus multilocularis c src tyrosine kinase 0.0072 0.0047 0.0047
Schistosoma mansoni protein kinase 0.0052 0.0015 0.001
Schistosoma mansoni tyrosine kinase 0.2058 0.3164 0.316
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2871 0.4441 1
Toxoplasma gondii fructose-bisphospatase I 0.1068 0.161 0.3603
Schistosoma mansoni protein kinase 0.0055 0.0021 0.0015
Echinococcus multilocularis tyrosine kinase 0.0052 0.0015 0.0015
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0052 0.0015 0.0015
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0104 0.0098 0.0098
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.0035 0.003
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0071 0.0046 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0027 0.0094
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0072 0.0047 0.0047
Echinococcus granulosus tyrosine protein kinase 0.0052 0.0015 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0027 0.0094
Trichomonas vaginalis histone deacetylase, putative 0.0831 0.1238 1
Echinococcus multilocularis Immunoglobulin 0.0071 0.0046 0.0046
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0052 0.0015 0.0015
Echinococcus multilocularis histone deacetylase 6 0.0724 0.107 0.107
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.0015 0.001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0104 0.0098 0.0098
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0054 0.0018 0.0018
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Echinococcus multilocularis roundabout 2 0.0054 0.0018 0.0018
Schistosoma mansoni tyrosine kinase 0.0098 0.0087 0.0082
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0097 0.0086 0.0086
Echinococcus granulosus epidermal growth factor receptor 0.3498 0.5424 0.5424
Onchocerca volvulus 0.0052 0.0015 0.0066
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Echinococcus granulosus microtubule associated protein 2 0.0764 0.1133 0.1133
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0046 0.0006 0.0006
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.0015 0.0015
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.2871 0.4441 0.4441
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Trypanosoma brucei protein kinase, putative 0.0059 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0065 0.0035 0.003
Echinococcus granulosus integrin linked protein kinase 0.0052 0.0015 0.0015
Onchocerca volvulus 0.0052 0.0015 0.0066
Echinococcus granulosus tyrosine protein kinase pr2 0.0052 0.0015 0.0015
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.042 0.0593 0.1306
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0831 0.1238 1
Schistosoma mansoni histone deacetylase 0.0831 0.1238 0.1234
Schistosoma mansoni protein kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.0035 0.003
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0118 0.0118 0.0233
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Trypanosoma cruzi histone deacetylase, putative 0.0352 0.0485 0.1062
Leishmania major 0.2871 0.4441 1
Echinococcus granulosus roundabout 2 0.0054 0.0018 0.0018
Echinococcus granulosus retinal guanylyl cyclase 2 0.0052 0.0015 0.0015
Schistosoma mansoni ephrin receptor 0.0271 0.0359 0.0354
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0027 0.0027
Loa Loa (eye worm) histone deacetylase 11 0.0352 0.0485 0.048
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0095 0.0082 0.0082
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0058 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.0112 0.0109 0.0103
Toxoplasma gondii histone deacetylase HDAC1 0.0724 0.107 0.2383
Schistosoma mansoni protein kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) TK protein kinase 0.0052 0.0015 0.001
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0097 0.0086 0.0086
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.0035 0.003
Schistosoma mansoni protein kinase 0.0052 0.0015 0.001
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0054 0.0018 0.0018
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0054 0.0018 0.0018
Brugia malayi Guanylyl cyclase protein 23 0.0052 0.0015 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0015 0.001
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0048 0.0048
Echinococcus granulosus epidermal growth factor receptor 0.6413 1 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.042 0.0593 0.0593
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0052 0.0015 0.001
Echinococcus granulosus tyrosine protein kinase Lyn 0.0108 0.0103 0.0103
Echinococcus granulosus fructose 16 bisphosphatase 1 0.2871 0.4441 0.4441
Echinococcus granulosus tyrosine protein kinase csk 0.0052 0.0015 0.0015
Onchocerca volvulus 0.0219 0.0278 0.1857
Plasmodium falciparum histone deacetylase 2 0.0724 0.107 0.8622
Echinococcus granulosus tyrosine protein kinase Srms 0.0065 0.0035 0.0035
Echinococcus multilocularis tyrosine protein kinase Srms 0.0097 0.0086 0.0086
Schistosoma mansoni ephrin receptor 0.006 0.0028 0.0023
Echinococcus granulosus contactin 0.0054 0.0018 0.0018
Echinococcus multilocularis thymidylate synthase 0.0084 0.0065 0.0065
Trypanosoma cruzi histone deacetylase, putative 0.0724 0.107 0.2383
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0139 0.0152 0.0147
Echinococcus granulosus twitchin 0.0097 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.008 0.0058 0.0053
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0104 0.0098 0.0098
Loa Loa (eye worm) TK/RYK protein kinase 0.0052 0.0015 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0027 0.0021
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0055 0.0021 0.0012
Schistosoma mansoni tyrosine kinase 0.0065 0.0035 0.003
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0052 0.0015 0.001
Echinococcus multilocularis histone deacetylase 3 0.0831 0.1238 0.1238
Leishmania major histone deacetylase, putative 0.0831 0.1238 0.2764
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.1068 0.161 0.3603
Echinococcus multilocularis kinase suppressor of Ras 1 0.0052 0.0015 0.0015
Echinococcus granulosus retinal guanylyl cyclase 2 0.0052 0.0015 0.0015
Plasmodium vivax histone deacetylase 2, putative 0.0724 0.107 0.8622
Echinococcus granulosus histone deacetylase 6 0.074 0.1096 0.1096
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.0035 0.003
Echinococcus multilocularis hemicentin 1 0.0046 0.0006 0.0006
Brugia malayi Cytochrome P450 family protein 0.0062 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Echinococcus granulosus tyrosine protein kinase Src64B 0.0104 0.0098 0.0098
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0052 0.0015 0.0015
Echinococcus granulosus neuroglian 0.0054 0.0018 0.0018
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0052 0.0015 0.0015
Toxoplasma gondii histone deacetylase HDAC4 0.0352 0.0485 0.1062
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0048 0.0075
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0052 0.0015 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0104 0.0098 0.0098
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0027 0.0021
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0389 0.0544 0.0539
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.0015 0.001
Schistosoma mansoni fructose-16-bisphosphatase-related 0.2871 0.4441 0.4438
Schistosoma mansoni tyrosine kinase 0.0072 0.0047 0.0041
Schistosoma mansoni neuroglian 0.0054 0.0018 0.0013
Echinococcus granulosus hemicentin 1 0.0046 0.0006 0.0006
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Loa Loa (eye worm) TK protein kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) TK/Met protein kinase 0.0052 0.0015 0.001
Schistosoma mansoni cell adhesion molecule 0.0103 0.0095 0.0089
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Schistosoma mansoni tyrosine kinase 0.0104 0.0098 0.0092
Schistosoma mansoni histone deacetylase hda2 0.0352 0.0485 0.048
Echinococcus multilocularis activated cdc42 kinase 1 0.0052 0.0015 0.0015
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Echinococcus granulosus activated cdc42 kinase 1 0.0052 0.0015 0.0015
Leishmania major histone deacetylase, putative 0.0724 0.107 0.2383
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Loa Loa (eye worm) TK protein kinase 0.0075 0.0051 0.0045
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.0015 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0054 0.0018 0.0013
Loa Loa (eye worm) TK/ROR protein kinase 0.0075 0.0051 0.0045
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.0015 0.0015
Plasmodium vivax protein kinase, putative 0.0069 0.0042 0.0221
Brugia malayi Protein kinase domain containing protein 0.0065 0.0035 0.003
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0052 0.0015 0.001
Echinococcus granulosus histone deacetylase 8 0.0352 0.0485 0.0485
Leishmania major histone deacetylase, putative 0.0831 0.1238 0.2764
Brugia malayi Protein kinase domain containing protein 0.2058 0.3164 0.316
Loa Loa (eye worm) hypothetical protein 0.0219 0.0278 0.0272
Loa Loa (eye worm) TK protein kinase 0.0097 0.0086 0.0081
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Brugia malayi Histone deacetylase family protein 0.0724 0.107 0.1065
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase Abl 0.0159 0.0184 0.0184
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0054 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0027 0.0026
Plasmodium falciparum histone deacetylase 1 0.0831 0.1238 1
Onchocerca volvulus Histone deacetylase 10 homolog 0.0352 0.0485 0.3275
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.1068 0.161 0.3603
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) TK/ALK protein kinase 0.0052 0.0015 0.001
Echinococcus multilocularis histone deacetylase 8 0.0352 0.0485 0.0485
Brugia malayi Immunoglobulin I-set domain containing protein 0.1051 0.1584 0.1579
Onchocerca volvulus 0.0052 0.0015 0.0066
Echinococcus granulosus tyrosine protein kinase Fyn 0.0104 0.0098 0.0098
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0118 0.0118 0.0843
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.0015 0.0015
Echinococcus granulosus tyrosine protein kinase csk 0.0052 0.0015 0.0015
Echinococcus multilocularis neuroglian 0.0054 0.0018 0.0018
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Loa Loa (eye worm) hypothetical protein 0.0071 0.0046 0.004
Brugia malayi SH2 domain containing protein 0.0065 0.0035 0.003
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0052 0.0015 0.0015
Brugia malayi hypothetical protein 0.0065 0.0035 0.003
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Loa Loa (eye worm) serine/threonine protein kinase 0.0052 0.0015 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0027 0.0094
Loa Loa (eye worm) hypothetical protein 0.0831 0.1238 0.1234
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Echinococcus granulosus natriuretic peptide receptor 1 0.0052 0.0015 0.0015
Loa Loa (eye worm) TK/CSK protein kinase 0.0052 0.0015 0.001
Echinococcus granulosus insulin growth factor 1 receptor beta 0.2066 0.3177 0.3177
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0052 0.0015 0.001
Toxoplasma gondii histone deacetylase HDAC5 0.0352 0.0485 0.1062
Leishmania major protein kinase, putative 0.0055 0.0021 0.0012
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0052 0.0015 0.001
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0027 0.0094
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0052 0.0015 0.001
Onchocerca volvulus 0.0052 0.0015 0.0066
Echinococcus multilocularis roundabout 2 0.0054 0.0018 0.0018
Brugia malayi Protein kinase domain containing protein 0.0065 0.0035 0.003
Schistosoma mansoni histone deacetylase 4 5 0.0724 0.107 0.1065
Brugia malayi thymidylate synthase 0.0084 0.0065 0.0059
Echinococcus multilocularis epidermal growth factor receptor 0.6413 1 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.042 0.0593 0.0593
Echinococcus multilocularis raf serine:threonine protein kinase 0.0052 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0352 0.0485 0.048
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0104 0.0098 0.0098
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0048 0.0075
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0084 0.0065 0.5
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0052 0.0015 0.0015
Entamoeba histolytica protein kinase, putative 0.0084 0.0066 0.0414
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.2871 0.4441 0.4438
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.0015 0.001
Echinococcus granulosus tyrosine protein kinase Src42A 0.0104 0.0098 0.0098
Brugia malayi hypothetical protein 0.0052 0.0015 0.001
Echinococcus multilocularis integrin linked protein kinase 0.0052 0.0015 0.0015
Loa Loa (eye worm) TK protein kinase 0.0052 0.0015 0.001
Loa Loa (eye worm) TK/EGFR protein kinase 0.6413 1 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Brugia malayi bone morphogenetic protein type 1 receptor 0.0052 0.0015 0.001
Loa Loa (eye worm) TK/INSR protein kinase 0.2058 0.3164 0.316
Schistosoma mansoni hypothetical protein 0.0052 0.0015 0.001
Brugia malayi Fibronectin type III domain containing protein 0.008 0.0058 0.0053
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0084 0.0065 0.0059
Loa Loa (eye worm) TK/ACK protein kinase 0.0052 0.0015 0.001
Echinococcus granulosus tyrosine protein kinase otk 0.0046 0.0006 0.0006
Schistosoma mansoni histone deacetylase 0.0831 0.1238 0.1234
Echinococcus granulosus tyrosine protein kinase Blk 0.0097 0.0086 0.0086
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0084 0.0065 0.5
Schistosoma mansoni cell adhesion molecule 0.0054 0.0018 0.0013
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0055 0.0021 0.0012
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase shark 0.0065 0.0035 0.0035
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Brugia malayi Raf kinase 0.0052 0.0015 0.001
Brugia malayi protein-tyrosine kinase 0.0097 0.0086 0.0081
Trypanosoma cruzi histone deacetylase, putative 0.0352 0.0485 0.1062
Loa Loa (eye worm) hypothetical protein 0.0117 0.0117 0.0112
Loa Loa (eye worm) TK/DDR protein kinase 0.0052 0.0015 0.001
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001
Onchocerca volvulus 0.0052 0.0015 0.0066
Loa Loa (eye worm) TK protein kinase 0.0052 0.0015 0.001
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.042 0.0593 0.1306
Echinococcus granulosus raf serine:threonine protein kinase 0.0052 0.0015 0.0015
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0055 0.0021 0.0012
Schistosoma mansoni serine/threonine RGC 0.0052 0.0015 0.001
Schistosoma mansoni tyrosine kinase 0.0072 0.0047 0.0041
Echinococcus multilocularis receptor type guanylyl cyclase 0.0052 0.0015 0.0015
Entamoeba histolytica histone deacetylase, putative 0.0831 0.1238 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0117 0.0112
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0027 0.0026
Echinococcus multilocularis roundabout 2 0.0125 0.013 0.013
Onchocerca volvulus 0.0065 0.0035 0.0204
Brugia malayi Protein kinase domain containing protein 0.0065 0.0035 0.003
Onchocerca volvulus 0.0052 0.0015 0.0066
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0071 0.0046 0.004
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0052 0.0015 0.0015
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0118 0.0118 0.0233
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0052 0.0015 0.0015
Echinococcus multilocularis FL cytokine receptor 0.0052 0.0015 0.0015
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0027 0.0026
Loa Loa (eye worm) SRC-1 0.0104 0.0098 0.0092
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.0035 0.003
Schistosoma mansoni tyrosine kinase 0.0052 0.0015 0.001
Schistosoma mansoni tyrosine kinase 0.0065 0.0035 0.003
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0052 0.0015 0.001
Schistosoma mansoni protein kinase 0.0055 0.0021 0.0015
Plasmodium falciparum protein kinase, putative 0.0055 0.0021 0.0044
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0048 0.0075
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.042 0.0593 0.1306
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Brugia malayi Protein kinase domain containing protein 0.0052 0.0015 0.001

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 11.6 ug ml-1 Cytotoxicity against human MT4 cells by MTT assay ChEMBL. No reference
IZ (functional) = 19 mm Antibacterial activity against Escherichia coli MTCC 443 at 250 ug/ml after 24 hrs by Kirby-Bauer method ChEMBL. No reference
IZ (functional) = 25 mm Antifungal activity against Candida albicans MTCC 227 at 250 ug/ml after 74 hrs by Kirby-Bauer method ChEMBL. No reference
MIC (functional) = 250 ug ml-1 Antibacterial activity against Escherichia coli MTCC 443 after 24 hrs by broth dilution method ChEMBL. No reference
MIC (functional) = 500 ug ml-1 Antifungal activity against Candida albicans MTCC 227 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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