Detailed information for compound 1808196

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 406.886 | Formula: C18H19ClN4O3S
  • H donors: 0 H acceptors: 1 LogP: 4.06 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)nc2n1s/c(=N\C(=O)C(c1ccc(cc1)Cl)C(C)C)/n2
  • InChi: 1S/C18H19ClN4O3S/c1-10(2)15(11-5-7-12(19)8-6-11)16(24)21-18-22-17-20-13(25-3)9-14(26-4)23(17)27-18/h5-10,15H,1-4H3/b21-18-
  • InChiKey: UQPJYSKFSBMLMM-UZYVYHOESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Leishmania major ABC-thiol transporter 0.0018 0.0616 0.0551
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.567 0.567
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0162 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.0366 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Giardia lamblia MRP-like ABC transporter 0.0018 0.0616 1
Brugia malayi hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0018 0.0592 0.0592
Brugia malayi putative neuropeptide receptor 0.0096 0.567 0.567
Entamoeba histolytica hypothetical protein 0.0018 0.0616 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0096 0.567 0.5625
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.567 0.5625
Onchocerca volvulus 0.0162 1 1
Echinococcus granulosus neuropeptide receptor 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Brugia malayi nuclear receptor RXR 0.0086 0.5007 0.5007
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.567 0.567
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.0366 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.567 0.5625
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0015 0.0366 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.567 0.5625
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0162 1 1
Echinococcus granulosus neuropeptide s receptor 0.0096 0.567 0.5625
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0162 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0153 0.9425 1
Schistosoma mansoni adenoreceptor 0.0096 0.567 0.567
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0076 0.4409 0.4351
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0086 0.5007 0.5007
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0015 0.0366 0.0284
Echinococcus multilocularis neuropeptide FF receptor 2 0.0096 0.567 0.5625
Loa Loa (eye worm) melatonin receptor type 1A 0.0096 0.567 0.567
Schistosoma mansoni hypothetical protein 0.0096 0.567 0.567
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.567 0.5625
Brugia malayi nuclear hormone receptor family member nhr-6 0.0076 0.4409 0.4409
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Brugia malayi Dopamine receptor protein 2 0.0096 0.567 0.567
Schistosoma mansoni nuclear receptor 0.0076 0.4409 0.4409
Echinococcus multilocularis G protein coupled receptor 139 0.0096 0.567 0.5625
Echinococcus granulosus alpha 1A adrenergic receptor 0.0096 0.567 0.5625
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0162 1 1
Brugia malayi Nuclear hormone receptor E75 0.0076 0.4409 0.4409
Brugia malayi nuclear receptor RXR 0.0076 0.4409 0.4409
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Brugia malayi hypothetical protein 0.0076 0.4409 0.4409
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.567 0.567
Schistosoma mansoni thyroid hormone receptor 0.0162 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0096 0.567 0.5625
Brugia malayi Nuclear hormone receptor E75 0.0076 0.4409 0.4409
Brugia malayi G protein-coupled receptor F59B2.13 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Trichomonas vaginalis abcb9, putative 0.0015 0.0366 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.567 0.5625
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Brugia malayi fructose-1,6-bisphosphatase 0.0153 0.9425 0.9425
Schistosoma mansoni amine GPCR 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Onchocerca volvulus 0.0096 0.567 0.5505
Loa Loa (eye worm) nuclear receptor NHR-67 0.0076 0.4409 0.4409
Trichomonas vaginalis ABC transporter, putative 0.0015 0.0366 0.5
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0015 0.0366 0.0267
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.567 0.5625
Brugia malayi larval opioid receptor 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.567 0.5625
Schistosoma mansoni neuropeptide receptor 0.0096 0.567 0.567
Echinococcus granulosus somatostatin receptor 0.0096 0.567 0.5625
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.0366 0.0267
Brugia malayi hypothetical protein 0.0086 0.5007 0.5007
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0018 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0343 0.0243
Schistosoma mansoni hypothetical protein 0.0096 0.567 0.567
Onchocerca volvulus 0.0096 0.567 0.5505
Trypanosoma brucei multidrug resistance protein E 0.0018 0.0616 0.0551
Entamoeba histolytica multidrug resistance protein, putative 0.0018 0.0616 1
Brugia malayi nuclear hormone receptor 0.0162 1 1
Entamoeba histolytica P-glyco protein 6, putative 0.0015 0.0366 0.5145
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0096 0.567 0.567
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0057 0.3138 0.3257
Echinococcus multilocularis neuropeptide s receptor 0.0096 0.567 0.5625
Brugia malayi G-protein coupled receptor 0.0096 0.567 0.567
Brugia malayi Serotonin receptor 0.0096 0.567 0.567
Schistosoma mansoni steroid hormone receptor ad4bp 0.0162 1 1
Echinococcus multilocularis g protein coupled receptor 0.0096 0.567 0.5625
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.567 0.567
Echinococcus granulosus nuclear receptor nhr 48 0.0076 0.4409 0.4351
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0162 1 1
Schistosoma mansoni multidrug resistance protein 0.0018 0.0616 0.0616
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0018 0.0616 0.0551
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0015 0.0366 0.0267
Brugia malayi nuclear receptor NHR-88 0.0076 0.4409 0.4409
Brugia malayi nuclear hormone receptor 0.0076 0.4409 0.4409
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.5007 0.5007
Brugia malayi putative neuropeptide receptor NPR1 0.0096 0.567 0.567
Entamoeba histolytica P-glycoprotein-1 0.0015 0.0366 0.5145
Onchocerca volvulus 0.0096 0.567 0.5505
Brugia malayi multidrug resistance related protein 1 0.0018 0.0616 0.0616
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0162 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.0366 0.5
Onchocerca volvulus 0.0096 0.567 0.5505
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0096 0.567 0.567
Onchocerca volvulus 0.0096 0.567 0.5505
Brugia malayi hypothetical protein 0.0096 0.567 0.567
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0018 0.0616 0.0551
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0096 0.567 0.567
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0076 0.4409 0.4196
Trypanosoma brucei p-glycoprotein 0.0018 0.0616 0.0551
Echinococcus multilocularis neuropeptide receptor A26 0.0096 0.567 0.5625
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0015 0.0366 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0086 0.5007 0.5007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0162 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.0366 0.0284
Plasmodium falciparum multidrug resistance protein 1 0.0015 0.0366 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus granulosus multidrug resistance associated protein 4 0.0011 0.0159 0.0058
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0366 0.0267
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0015 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Giardia lamblia Multidrug resistance-associated protein 1 0.0018 0.0616 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Schistosoma mansoni histamine h1 receptor 0.0096 0.567 0.567
Brugia malayi orphan nuclear receptor NR2E1 0.0076 0.4409 0.4409
Echinococcus multilocularis neuropeptide receptor 0.0096 0.567 0.5625
Brugia malayi ecdysone receptor 0.0076 0.4409 0.4409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0096 0.567 0.567
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0096 0.567 0.567
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0018 0.0616 0.0551
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.567 0.5625
Schistosoma mansoni coup transcription factor 0.0162 1 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0018 0.0616 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0366 0.0267
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.0366 0.5
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0015 0.0366 0.5
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0153 0.9425 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0162 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.567 0.567
Echinococcus granulosus tachykinin peptides receptor 99D 0.0096 0.567 0.5625
Schistosoma mansoni RAR-like nuclear receptor 0.0162 1 1
Brugia malayi Melatonin receptor type 1A 0.0096 0.567 0.567
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0096 0.567 0.5625
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.567 0.567
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.567 0.5625
Brugia malayi photoreceptor-specific nuclear receptor 0.0162 1 1
Echinococcus multilocularis somatostatin receptor 0.0096 0.567 0.5625
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0015 0.0366 0.0284
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.567 0.567
Loa Loa (eye worm) DR-78 0.0076 0.4409 0.4409
Trichomonas vaginalis abcb9, putative 0.0015 0.0366 0.5
Schistosoma mansoni amine GPCR 0.0096 0.567 0.567
Echinococcus multilocularis allatostatin A receptor 0.0096 0.567 0.5625
Schistosoma mansoni hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Entamoeba histolytica P-glycoprotein-2 0.0015 0.0366 0.5145
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0366 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.567 0.5625
Echinococcus granulosus g protein coupled receptor 0.0096 0.567 0.5625
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0015 0.0366 0.5
Schistosoma mansoni amine GPCR 0.0096 0.567 0.567
Echinococcus granulosus ecdysone induced protein 78C 0.0162 1 1
Onchocerca volvulus 0.0096 0.567 0.5505
Echinococcus granulosus FTZ F1 alpha 0.0162 1 1
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0153 0.9425 0.9419
Brugia malayi steroid hormone receptor 0.0162 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0076 0.4409 0.4409
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0162 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0162 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0096 0.567 0.567
Onchocerca volvulus 0.0096 0.567 0.5505
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.567 0.5625
Trichomonas vaginalis taga, putative 0.0015 0.0366 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0162 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0015 0.0366 0.0267
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0096 0.567 0.5505
Loa Loa (eye worm) hypothetical protein 0.0015 0.0366 0.0366
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0096 0.567 0.5625
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0162 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0076 0.4409 0.4409
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0086 0.5007 0.5007
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.0366 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0162 1 1
Brugia malayi hypothetical protein 0.0096 0.567 0.567
Onchocerca volvulus Protein ultraspiracle homolog 0.0162 1 1
Schistosoma mansoni multidrug resistance protein 0.0015 0.0366 0.0366
Schistosoma mansoni biogenic amine receptor 0.0096 0.567 0.567
Brugia malayi Nuclear hormone receptor-like 1 0.0162 1 1
Toxoplasma gondii fructose-bisphospatase II 0.0153 0.9425 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0096 0.567 0.5625
Brugia malayi neuropeptide F receptor 0.0096 0.567 0.567
Echinococcus granulosus dro:myosuppressin receptor 0.0096 0.567 0.5625
Schistosoma mansoni nuclear hormone receptor 0.0076 0.4409 0.4409
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0076 0.4409 0.4351
Schistosoma mansoni multidrug resistance protein 0.0015 0.0366 0.0366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0086 0.5007 0.4956
Entamoeba histolytica P-glycoprotein-5 0.0015 0.0366 0.5145
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0015 0.0366 0.0267
Echinococcus multilocularis G-protein coupled receptor, putative 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus multilocularis ecdysone induced protein 78C 0.0162 1 1
Schistosoma mansoni multidrug resistance protein 0.0018 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Onchocerca volvulus 0.0096 0.567 0.5505
Brugia malayi nuclear receptor NHR-88 0.0162 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0076 0.4409 0.4409
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.567 0.567
Entamoeba histolytica P-glycoprotein 5, putative 0.0015 0.0366 0.5145
Echinococcus multilocularis g-protein coupled receptor 0.0096 0.567 0.5625
Entamoeba histolytica ATP-binding cassette protein, putative 0.0018 0.0616 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.567 0.5625
Trichomonas vaginalis abcb9, putative 0.0015 0.0366 0.5
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.001 0.0102 0.0102
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0076 0.4409 0.4351
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0162 1 1
Schistosoma mansoni multidrug resistance protein 0.0018 0.0616 0.0616
Entamoeba histolytica P-glycoprotein-2, putative 0.0015 0.0366 0.5145
Brugia malayi G protein-coupled receptor 0.0096 0.567 0.567
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.0366 0.5
Leishmania major 0.0153 0.9425 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0076 0.4409 0.4351
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0086 0.5007 0.5007
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.5007 0.5007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.567 0.567
Onchocerca volvulus 0.0096 0.567 0.5505
Echinococcus granulosus g protein coupled receptor 0.0096 0.567 0.5625
Trichomonas vaginalis ABC transporter, putative 0.0015 0.0366 0.5
Schistosoma mansoni nuclear hormone receptor 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.5007 0.5007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.567 0.5625
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0015 0.0366 0.0267
Schistosoma mansoni retinoic acid receptor RXR 0.0162 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0096 0.567 0.567
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0162 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0162 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.567 0.5625
Trichomonas vaginalis ABC transporter, putative 0.0015 0.0366 0.5
Echinococcus granulosus serotonin receptor 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0086 0.5007 0.5007
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0015 0.0366 0.0267
Leishmania major p-glycoprotein 0.0015 0.0366 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0162 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.0366 0.0267
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.567 0.5625
Brugia malayi ABC transporter family protein 0.0015 0.0366 0.0366
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.0366 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0057 0.3138 0.3257
Echinococcus multilocularis g protein coupled receptor 0.0096 0.567 0.5625
Brugia malayi hypothetical protein 0.0096 0.567 0.567
Brugia malayi hypothetical protein 0.0096 0.567 0.567
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.567 0.5625
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0015 0.0366 0.0267
Echinococcus multilocularis multidrug resistance associated protein 7 0.0018 0.0616 0.0519
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.567 0.567
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0096 0.567 0.567
Brugia malayi Serotonin receptor 0.0096 0.567 0.567
Schistosoma mansoni opsin-like receptor 0.0096 0.567 0.567
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.567 0.567
Brugia malayi neuropeptide F receptor 0.0096 0.567 0.567
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.0366 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Onchocerca volvulus 0.0096 0.567 0.5505
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.567 0.5625
Echinococcus granulosus peptide allatostatin:somatostatin 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.567 0.5625
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.567 0.567
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0366 0.5
Plasmodium vivax multidrug resistance protein 1, putative 0.0015 0.0366 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.567 0.567
Echinococcus granulosus multidrug resistance associated protein 7 0.0018 0.0616 0.0519
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.567 0.567
Trichomonas vaginalis ABC transporter, putative 0.0015 0.0366 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Schistosoma mansoni biogenic amine receptor 0.0096 0.567 0.567
Toxoplasma gondii fructose-bisphospatase I 0.0057 0.3138 0.3257
Brugia malayi Steroid receptor seven-up type 2 0.0162 1 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0014 0.0343 0.0243
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.0366 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0366 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0076 0.4409 0.4351
Brugia malayi ABC transporter transmembrane region family protein 0.0018 0.0616 0.0616
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0096 0.567 0.567
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0162 1 1
Trypanosoma cruzi multidrug resistance protein E, putative 0.0018 0.0616 0.0551
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.0366 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0162 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0057 0.3138 0.3257
Echinococcus granulosus neuropeptide FF receptor 2 0.0096 0.567 0.5625
Schistosoma mansoni myosin xvIII 0.0096 0.567 0.567
Brugia malayi hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Leishmania major p-glycoprotein e 0.0018 0.0616 0.0551
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0018 0.0616 0.0551
Schistosoma mansoni biogenic amine receptor 0.0096 0.567 0.567
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0162 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.0366 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0096 0.567 0.567
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0102 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.567 0.5625
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.567 0.5625
Giardia lamblia Multidrug resistance-associated protein 1 0.0018 0.0592 0.9563
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0076 0.4409 0.4409
Schistosoma mansoni opsin-like receptor 0.0096 0.567 0.567
Brugia malayi G-protein coupled receptor 0.0096 0.567 0.567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0162 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0096 0.567 0.567
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0366 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus multilocularis g protein coupled receptor 0.0096 0.567 0.5625
Echinococcus granulosus hypothetical protein 0.0096 0.567 0.5625
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0076 0.4409 0.4351
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0153 0.9425 0.9425
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0018 0.0616 0.0551
Trypanosoma cruzi hypothetical protein 0.0011 0.0159 0.0061
Brugia malayi tailless protein 0.0076 0.4409 0.4409
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0102 0.5
Brugia malayi follicle stimulating hormone receptor 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0018 0.0616 0.0616
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0096 0.567 0.567
Echinococcus granulosus multidrug resistance associated protein 1 0.0018 0.0616 0.0519
Brugia malayi GnHR receptor homolog 0.0096 0.567 0.567
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0162 1 1
Echinococcus granulosus sex peptide receptor 0.0096 0.567 0.5625
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Leishmania major pentamidine resistance protein 1 0.0018 0.0616 0.0551
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.567 0.5625
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0096 0.567 0.5625
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0096 0.567 0.5625
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0162 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.567 0.5625
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0162 1 1
Onchocerca volvulus 0.0096 0.567 0.5505
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Loa Loa (eye worm) multidrug resistance protein 3 0.0015 0.0366 0.0366
Echinococcus granulosus neuropeptide receptor 0.0096 0.567 0.5625
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0162 1 1
Schistosoma mansoni nuclear hormone receptor 0.0076 0.4409 0.4409
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0162 1 1
Onchocerca volvulus 0.0076 0.4409 0.4196
Brugia malayi nuclear receptor NHR-67 0.0076 0.4409 0.4409
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Echinococcus multilocularis serotonin receptor 0.0096 0.567 0.5625
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0096 0.567 0.5625
Onchocerca volvulus 0.0096 0.567 0.5505
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0096 0.567 0.567
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.567 0.567
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0018 0.0616 0.0551
Onchocerca volvulus 0.0096 0.567 0.5505
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0366 0.5
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0366 0.0267
Schistosoma mansoni neuropeptide receptor 0.0096 0.567 0.567
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.567 0.567
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Brugia malayi hypothetical protein 0.0096 0.567 0.567
Echinococcus multilocularis fmrfamide receptor 0.0096 0.567 0.5625
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Schistosoma mansoni neuropeptide receptor 0.0096 0.567 0.567
Onchocerca volvulus 0.0096 0.567 0.5505
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus granulosus G protein coupled receptor 139 0.0096 0.567 0.5625
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0076 0.4409 0.4351
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.0366 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0018 0.0616 0.0551
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0096 0.567 0.567
Schistosoma mansoni nuclear receptor nhr-48 0.0076 0.4409 0.4409
Echinococcus multilocularis sex peptide receptor 0.0096 0.567 0.5625
Brugia malayi RE15519p 0.0096 0.567 0.567
Echinococcus granulosus neuropeptide receptor A26 0.0096 0.567 0.5625
Echinococcus granulosus Nuclear hormone receptor HR96 0.0076 0.4409 0.4351
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.567 0.5625
Schistosoma mansoni zinc finger protein 0.0076 0.4409 0.4409
Brugia malayi ORL1-like opioid receptor 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Schistosoma mansoni thyroid hormone receptor 0.0162 1 1
Brugia malayi hypothetical protein 0.0096 0.567 0.567
Echinococcus multilocularis dro:myosuppressin receptor 0.0096 0.567 0.5625
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.0366 0.5
Entamoeba histolytica ATP-binding cassette protein, putative 0.0018 0.0616 1
Brugia malayi conserved hypotetical protein 0.0076 0.4409 0.4409
Entamoeba histolytica ATP-binding cassette protein, putative 0.0018 0.0616 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.5007 0.5007
Schistosoma mansoni nuclear receptor 0.0076 0.4409 0.4409
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0076 0.4409 0.4351
Brugia malayi hypothetical protein 0.0086 0.5007 0.5007
Schistosoma mansoni amine GPCR 0.0096 0.567 0.567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0162 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0102 0.5
Brugia malayi hypothetical protein 0.0076 0.4409 0.4409
Onchocerca volvulus 0.0096 0.567 0.5505
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0096 0.567 0.5625
Onchocerca volvulus 0.0096 0.567 0.5505
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0076 0.4409 0.4409
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0162 1 1
Brugia malayi hypothetical protein 0.0096 0.567 0.567
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0076 0.4409 0.4196
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.567 0.5625
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0015 0.0366 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0162 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.0366 0.5
Schistosoma mansoni hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0076 0.4409 0.4409
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.567 0.5625
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.567 0.567
Echinococcus multilocularis neuropeptide receptor 0.0096 0.567 0.5625
Schistosoma mansoni growth hormone secretagogue receptor 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0086 0.5007 0.5007
Echinococcus granulosus allatostatin A receptor 0.0096 0.567 0.5625
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0018 0.0616 0.0551
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0162 1 1
Echinococcus granulosus g-protein coupled receptor 0.0096 0.567 0.5625
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0018 0.0616 0.0616
Echinococcus granulosus Nuclear hormone receptor HR96 0.0076 0.4409 0.4351
Brugia malayi multidrug resistance protein 3 0.0015 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Loa Loa (eye worm) multidrug resistance-associated protein 0.0012 0.0182 0.0182
Onchocerca volvulus Neuropeptide F receptor homolog 0.0096 0.567 0.5505
Echinococcus multilocularis serotonin receptor 0.0096 0.567 0.5625
Schistosoma mansoni amine GPCR 0.0096 0.567 0.567
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.0366 0.5
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0015 0.0366 0.0267
Loa Loa (eye worm) TYRA-2 protein 0.0096 0.567 0.567
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.567 0.567
Echinococcus granulosus g protein coupled receptor 0.0096 0.567 0.5625
Entamoeba histolytica ABC transporter, putative 0.0018 0.0616 1
Schistosoma mansoni multidrug resistance protein 0.0015 0.0366 0.0366
Schistosoma mansoni multidrug resistance protein 0.0018 0.0616 0.0616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0162 1 1
Brugia malayi sulfakinin receptor protein 0.0096 0.567 0.567
Brugia malayi AKH receptor 0.0096 0.567 0.567
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.567 0.567
Echinococcus multilocularis FTZ F1 alpha 0.0162 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0162 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0096 0.567 0.567
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0153 0.9425 0.9419
Loa Loa (eye worm) hypothetical protein 0.0076 0.4409 0.4409
Onchocerca volvulus Bile acid receptor homolog 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Schistosoma mansoni opsin-like receptor 0.0096 0.567 0.567
Schistosoma mansoni smdr2 0.0015 0.0366 0.0366
Brugia malayi Dopamine receptor protein 1 0.0096 0.567 0.567
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0096 0.567 0.5625
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0096 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0162 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0018 0.0616 1
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0153 0.9425 1
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.567 0.5625
Echinococcus granulosus orexin receptor type 2 0.0096 0.567 0.5625
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0162 1 1
Giardia lamblia ABC transporter, putative 0.0018 0.0616 1
Echinococcus multilocularis orexin receptor type 2 0.0096 0.567 0.5625
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0096 0.567 0.5625
Schistosoma mansoni neuropeptide receptor 0.0096 0.567 0.567
Echinococcus multilocularis nuclear receptor nhr 48 0.0076 0.4409 0.4351
Echinococcus multilocularis multidrug resistance associated protein 4 0.0011 0.0159 0.0058
Loa Loa (eye worm) hypothetical protein 0.0096 0.567 0.567
Brugia malayi Dopamine receptor 0.0096 0.567 0.567
Echinococcus multilocularis fmrfamide receptor 0.0096 0.567 0.5625
Onchocerca volvulus 0.0076 0.4409 0.4196
Entamoeba histolytica P-glycoprotein-2 0.0015 0.0366 0.5145
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0162 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0162 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0096 0.567 0.5625
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0153 0.9425 0.9425
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.567 0.567
Onchocerca volvulus 0.0096 0.567 0.5505
Echinococcus multilocularis multidrug resistance associated protein 1 0.0018 0.0616 0.0519
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0015 0.0366 0.0267
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.567 0.567
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0086 0.5007 0.4956
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0057 0.3138 0.3257
Loa Loa (eye worm) hypothetical protein 0.0014 0.0343 0.0343
Brugia malayi hypothetical protein 0.0096 0.567 0.567
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0018 0.0616 0.0551
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.567 0.5625
Echinococcus granulosus fmrfamide receptor 0.0096 0.567 0.5625

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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