Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Mu opioid receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Delta opioid receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Delta opioid receptor | 372 aa | 316 aa | 26.9 % | |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 353 aa | 21.0 % | |
Onchocerca volvulus | Programmed cell death protein 5 homolog | Mu opioid receptor | 398 aa | 323 aa | 24.1 % |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | Delta opioid receptor | 372 aa | 366 aa | 22.7 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 344 aa | 22.1 % | |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Delta opioid receptor | 372 aa | 320 aa | 25.6 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Delta opioid receptor | 372 aa | 330 aa | 24.5 % |
Schistosoma mansoni | neuropeptide F-like receptor | Mu opioid receptor | 398 aa | 335 aa | 20.6 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Delta opioid receptor | 372 aa | 330 aa | 24.2 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Delta opioid receptor | 372 aa | 315 aa | 28.6 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Delta opioid receptor | 372 aa | 353 aa | 29.2 % |
Loa Loa (eye worm) | neuropeptide F receptor | Delta opioid receptor | 372 aa | 317 aa | 23.3 % |
Brugia malayi | GnHR receptor homolog | Delta opioid receptor | 372 aa | 313 aa | 18.5 % |
Echinococcus multilocularis | allatostatin A receptor | Delta opioid receptor | 372 aa | 302 aa | 28.5 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 349 aa | 22.1 % | |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 386 aa | 22.8 % | |
Schistosoma japonicum | Rhodopsin, putative | Mu opioid receptor | 398 aa | 328 aa | 23.2 % |
Brugia malayi | ORL1-like opioid receptor | Delta opioid receptor | 372 aa | 300 aa | 24.7 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Mu opioid receptor | 398 aa | 334 aa | 23.1 % |
Echinococcus granulosus | allatostatin A receptor | Delta opioid receptor | 372 aa | 302 aa | 27.8 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Mu opioid receptor | 398 aa | 397 aa | 22.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | 0.0631 | 0.5433 | 0.5433 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0046 | 0.0034 | 0.0034 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0046 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.0904 | 0.0872 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0117 | 0.069 | 0.069 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0631 | 0.5433 | 0.5433 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0349 | 0.0349 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.069 | 0.0658 |
Onchocerca volvulus | 0.0341 | 0.2755 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0349 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0117 | 0.069 | 0.069 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0046 | 0.0034 | 0.0034 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0366 | 0.299 | 0.299 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1125 | 1 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1125 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1125 | 1 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0046 | 0.0034 | 0.0034 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0046 | 0.0034 | 0.0034 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.0904 | 0.0904 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.0904 | 0.0872 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1125 | 1 | 0.5 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1125 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.28 | 0.2775 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.008 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1125 | 1 | 0.5 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1125 | 1 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0117 | 0.069 | 0.0658 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0046 | 0.0034 | 0.0034 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0564 nM | The compound was tested In vitro for the ability to inhibit electrically induced contractions of the mouse vas deferens | ChEMBL. | 2536436 |
Ki (binding) | = 0.63 nM | The compound was tested for the ability to displace opioid receptor delta specific radioligand [3H]-DPDPE | ChEMBL. | 2536436 |
Ki (binding) | = 2.3 nM | The compound was tested for the ability to displace opioid receptor delta specific radioligand [3H]-DSLET | ChEMBL. | 2536436 |
Ki (binding) | = 20.9 nM | The compound was tested for the ability to displace mu-receptor specific radioligand [3H]-DAGO | ChEMBL. | 2536436 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2536436 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.