Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0111 | 0.0111 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0521 | 0.1944 |
Echinococcus multilocularis | Smad4 | 0.0016 | 0.0111 | 0.0416 |
Echinococcus multilocularis | smad | 0.0016 | 0.0111 | 0.0416 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0521 | 0.2114 |
Schistosoma mansoni | smad | 0.0016 | 0.0111 | 0.0416 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0111 | 0.0416 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0521 | 0.1944 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0242 | 0.4574 | 0.4574 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0016 | 0.0111 | 0.0452 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0016 | 0.0111 | 0.0111 |
Brugia malayi | Smad1 | 0.0016 | 0.0111 | 0.0111 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0521 | 0.5 |
Echinococcus granulosus | Smad4 | 0.0016 | 0.0111 | 0.0452 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0521 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0111 | 0.0111 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0111 | 0.0416 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0016 | 0.0111 | 0.0111 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0521 | 0.0521 |
Brugia malayi | MH2 domain containing protein | 0.0242 | 0.4574 | 0.4574 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.2463 | 0.9197 |
Echinococcus granulosus | smad | 0.0016 | 0.0111 | 0.0452 |
Onchocerca volvulus | 0.0516 | 1 | 1 | |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0111 | 0.0416 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.2678 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0111 | 0.0111 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0135 | 0.2463 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0016 | 0.0111 | 0.0416 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0016 | 0.0111 | 0.0416 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0111 | 0.0111 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0016 | 0.0111 | 0.0416 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0242 | 0.4574 | 0.4574 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.2678 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0135 | 0.2463 | 0.9197 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0016 | 0.0111 | 0.0452 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0516 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0521 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0521 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0146 | 0.2678 | 1 |
Schistosoma mansoni | Smad4 | 0.0016 | 0.0111 | 0.0416 |
Loa Loa (eye worm) | Smad1 | 0.0016 | 0.0111 | 0.0111 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0521 | 0.1944 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 40.4 uM | Concentration (10 e-6 M) of the compound required to block [Ca2+]-induced contraction of K+-depolarized hamster aorta | ChEMBL. | 1507210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.