Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0587 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.4039 | 0.2638 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.4039 | 0.5193 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.4039 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.4039 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1903 | 0.198 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.7234 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0078 | 0.4039 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.2279 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.678 | 0.9318 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.7234 | 0.6583 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.2279 | 0.0464 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.4039 | 1 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.678 | 0.9373 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.7234 | 0.6583 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.2279 | 0.4744 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.2279 | 0.0464 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.7234 | 1 |
Brugia malayi | RNA binding protein | 0.0127 | 0.7234 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0078 | 0.4039 | 0.5583 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.4039 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.2279 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0587 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1903 | 0.2631 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0027 | 0.069 | 0.0298 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.7234 | 0.6583 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0587 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.7234 | 0.6583 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.7234 | 0.6583 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0078 | 0.4039 | 0.2638 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.7234 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.7234 | 0.6583 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.4039 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.4039 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.7234 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0027 | 0.069 | 0.0298 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.4039 | 0.2638 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.4039 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.4039 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0027 | 0.069 | 0.0298 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.4039 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.678 | 0.9318 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.7234 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0587 | 0.0812 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.7234 | 0.6583 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0587 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0078 | 0.4039 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.