Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0254 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | coup transcription factor | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0254 | 1 | 1 |
Brugia malayi | galactokinase family protein | 0.0083 | 0.1427 | 0.1427 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Wolbachia endosymbiont of Brugia malayi | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 0.0055 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | nuclear receptor | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0254 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Loa Loa (eye worm) | DR-78 | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0134 | 0.3991 | 0.3991 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.012 | 0.327 | 0.327 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0254 | 1 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.012 | 0.327 | 0.327 |
Brugia malayi | hypothetical protein | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | nuclear hormone receptor | 0.0254 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.012 | 0.327 | 0.327 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | thyroid hormone receptor | 0.0254 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.012 | 0.327 | 0.327 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | zinc finger protein | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0254 | 1 | 1 |
Giardia lamblia | Mevalonate kinase | 0.0055 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Schistosoma mansoni | nuclear hormone receptor | 0.012 | 0.327 | 0.327 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0254 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0254 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0254 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0134 | 0.3991 | 0.3991 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0254 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.012 | 0.327 | 0.327 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0254 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0134 | 0.3991 | 0.3991 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Echinococcus granulosus | FTZ F1 alpha | 0.0254 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0134 | 0.3991 | 0.3991 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0254 | 1 | 1 |
Trichomonas vaginalis | galactokinase, putative | 0.0083 | 0.1427 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0254 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.012 | 0.327 | 0.327 |
Leishmania major | galactokinase-like protein | 0.0178 | 0.6209 | 1 |
Trichomonas vaginalis | galactokinase, putative | 0.0083 | 0.1427 | 0.5 |
Trypanosoma cruzi | galactokinase, putative | 0.0155 | 0.5048 | 0.813 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Trypanosoma cruzi | galactokinase, putative | 0.0178 | 0.6209 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0254 | 1 | 1 |
Trypanosoma cruzi | galactokinase, putative | 0.0178 | 0.6209 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0254 | 1 | 1 |
Mycobacterium leprae | Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) | 0.0055 | 0 | 0.5 |
Toxoplasma gondii | GHMP kinase, N-terminal domain-containing protein | 0.0083 | 0.1427 | 1 |
Brugia malayi | hypothetical protein | 0.012 | 0.327 | 0.327 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0254 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0254 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0254 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0254 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0254 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.012 | 0.327 | 0.327 |
Trichomonas vaginalis | galactokinase, putative | 0.0083 | 0.1427 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0254 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0254 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0134 | 0.3991 | 0.3991 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0254 | 1 | 1 |
Treponema pallidum | galactokinase | 0.0155 | 0.5048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0254 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0134 | 0.3991 | 0.3991 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0254 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.012 | 0.327 | 0.327 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0254 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.012 | 0.327 | 0.327 |
Mycobacterium ulcerans | galactokinase | 0.0178 | 0.6209 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Echinococcus granulosus | N acetylgalactosamine kinase | 0.0083 | 0.1427 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0254 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.012 | 0.327 | 0.327 |
Brugia malayi | nuclear hormone receptor | 0.012 | 0.327 | 0.327 |
Brugia malayi | ecdysone receptor | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0134 | 0.3991 | 0.3991 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0254 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0134 | 0.3991 | 0.3991 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.012 | 0.327 | 0.327 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.012 | 0.327 | 0.327 |
Trypanosoma cruzi | galactokinase-like protein, putative | 0.0155 | 0.5048 | 0.813 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | galactokinase | 0.0083 | 0.1427 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Brugia malayi | tailless protein | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | thyroid hormone receptor | 0.0254 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0254 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.012 | 0.327 | 0.327 |
Mycobacterium tuberculosis | Probable galactokinase GalK (galactose kinase) | 0.0178 | 0.6209 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0254 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0254 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.012 | 0.327 | 0.327 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0254 | 1 | 1 |
Echinococcus granulosus | galactokinase | 0.0178 | 0.6209 | 0.6209 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0254 | 1 | 1 |
Echinococcus multilocularis | N acetylgalactosamine kinase | 0.0083 | 0.1427 | 0.1427 |
Schistosoma mansoni | galactokinase | 0.0083 | 0.1427 | 0.1427 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0254 | 1 | 1 |
Echinococcus multilocularis | galactokinase | 0.0178 | 0.6209 | 0.6209 |
Entamoeba histolytica | galactokinase, putative | 0.0178 | 0.6209 | 0.5 |
Trichomonas vaginalis | galactokinase, putative | 0.0083 | 0.1427 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.012 | 0.327 | 0.327 |
Brugia malayi | steroid hormone receptor | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0254 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.012 | 0.327 | 0.327 |
Onchocerca volvulus | 0.0254 | 1 | 1 | |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0254 | 1 | 1 |
Trypanosoma brucei | galactokinase-like protein, putative | 0.0118 | 0.3204 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.