Detailed information for compound 1808805

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 293.213 | Formula: C11H14Cl2N2OS
  • H donors: 1 H acceptors: 0 LogP: 4.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCO/N=C/Nc1cc(Cl)c(c(c1)Cl)SCC
  • InChi: 1S/C11H14Cl2N2OS/c1-3-16-15-7-14-8-5-9(12)11(17-4-2)10(13)6-8/h5-7H,3-4H2,1-2H3,(H,14,15)
  • InChiKey: FLCSRWBWCAUOMP-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0046 0.3082 0.3082
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Trichomonas vaginalis histone deacetylase, putative 0.0074 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Trichomonas vaginalis histone deacetylase, putative 0.0074 1 1
Brugia malayi histone deacetylase 1 (HD1) 0.0074 1 1
Plasmodium falciparum histone deacetylase 2 0.0057 0.5816 0.3952
Trypanosoma brucei histone deacetylase 4 0.0057 0.5816 0.3952
Mycobacterium tuberculosis Probable oxidoreductase 0.0046 0.3082 0.5
Onchocerca volvulus 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Onchocerca volvulus 0.0046 0.3082 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.3082 0.3082
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Echinococcus granulosus histone deacetylase 0.0057 0.5816 0.3952
Echinococcus multilocularis histone deacetylase 7 0.0057 0.5816 0.3952
Mycobacterium tuberculosis Probable oxidoreductase 0.0046 0.3082 0.5
Loa Loa (eye worm) oxidoreductase 0.0046 0.3082 0.3082
Schistosoma mansoni histone deacetylase hda2 0.0063 0.7306 0.6105
Echinococcus granulosus histone deacetylase 6 0.0057 0.5816 0.3952
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Plasmodium falciparum histone deacetylase, putative 0.0057 0.5816 0.3952
Loa Loa (eye worm) hypothetical protein 0.0046 0.3082 0.3082
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Schistosoma mansoni histone deacetylase 0.0074 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Schistosoma mansoni histone deacetylase 0.0074 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.3082 0.3082
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0046 0.3082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Loa Loa (eye worm) histone deacetylase 1 0.0074 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Trichomonas vaginalis histone deacetylase, putative 0.0074 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0046 0.3082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0046 0.3082 0.5
Loa Loa (eye worm) oxidoreductase 0.0046 0.3082 0.3082
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Loa Loa (eye worm) dehydrogenase 0.0046 0.3082 0.3082
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0046 0.3082 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0046 0.3082 0.5
Schistosoma mansoni histone deacetylase 4 5 0.0057 0.5816 0.3952
Echinococcus multilocularis histone deacetylase 6 0.0057 0.5816 0.3952
Trichomonas vaginalis histone deacetylase, putative 0.0074 1 1
Echinococcus granulosus histone deacetylase 1 0.0074 1 1
Toxoplasma gondii histone deacetylase HDAC1 0.0057 0.5816 0.3952
Leishmania major histone deacetylase, putative 0.0074 1 1
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Onchocerca volvulus 0.0046 0.3082 0.5
Echinococcus multilocularis histone deacetylase 6 0.0063 0.7306 0.6105
Onchocerca volvulus 0.0046 0.3082 0.5
Giardia lamblia Histone deacetylase 0.0074 1 1
Onchocerca volvulus 0.0046 0.3082 0.5
Echinococcus multilocularis histone deacetylase 6 0.0057 0.5816 0.3952
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Mycobacterium ulcerans short-chain type oxidoreductase 0.0046 0.3082 0.5
Onchocerca volvulus 0.0046 0.3082 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0046 0.3082 0.5
Loa Loa (eye worm) oxidoreductase 0.0046 0.3082 0.3082
Plasmodium vivax histone deacetylase, putative 0.0057 0.5816 0.3952
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.3082 0.3082
Trypanosoma brucei histone deacetylase 1 0.0074 1 1
Onchocerca volvulus 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.3082 0.3082
Onchocerca volvulus 0.0046 0.3082 0.5
Plasmodium vivax histone deacetylase 2, putative 0.0057 0.5816 0.3952
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0046 0.3082 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0046 0.3082 0.3082
Onchocerca volvulus 0.0046 0.3082 0.5
Trypanosoma brucei histone deacetylase 3 0.0057 0.5816 0.3952
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Loa Loa (eye worm) oxidoreductase 0.0046 0.3082 0.3082
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0046 0.3082 0.5
Loa Loa (eye worm) oxidoreductase 0.0046 0.3082 0.3082
Onchocerca volvulus 0.0046 0.3082 0.5
Plasmodium falciparum histone deacetylase 1 0.0074 1 1
Loa Loa (eye worm) oxidoreductase 0.0046 0.3082 0.3082
Toxoplasma gondii histone deacetylase HDAC2 0.0074 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0046 0.3082 0.5
Trypanosoma cruzi histone deacetylase, putative 0.0057 0.5816 0.3952
Loa Loa (eye worm) hypothetical protein 0.0046 0.3082 0.3082
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0046 0.3082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Onchocerca volvulus 0.0046 0.3082 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Trypanosoma brucei histone deacetylase, putative 0.0057 0.5816 0.3952
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.3082 0.3082
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Loa Loa (eye worm) oxidoreductase 0.0046 0.3082 0.3082
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Onchocerca volvulus Sepiapterin reductase homolog 0.0046 0.3082 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0046 0.3082 0.5
Mycobacterium leprae Probable oxidoreductase 0.0046 0.3082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0074 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0046 0.3082 0.5
Echinococcus multilocularis histone deacetylase 0.0057 0.5816 0.3952
Entamoeba histolytica histone deacetylase, putative 0.0074 1 1
Brugia malayi Histone deacetylase family protein 0.0057 0.5816 0.3952
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Toxoplasma gondii histone deacetylase HDAC3 0.0074 1 1
Brugia malayi Histone deacetylase family protein 0.0057 0.5816 0.3952
Plasmodium vivax histone deacetylase 1, putative 0.0074 1 1
Mycobacterium ulcerans dehydrogenase/reductase 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0074 1 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Echinococcus granulosus histone deacetylase 3 0.0074 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.3082 0.3082
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Trypanosoma cruzi histone deacetylase, putative 0.0057 0.5816 0.3952
Loa Loa (eye worm) histone deacetylase 7A 0.0057 0.5816 0.5816
Echinococcus multilocularis histone deacetylase 3 0.0074 1 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0046 0.3082 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0046 0.3082 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.3082 0.3082
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0046 0.3082 0.5
Loa Loa (eye worm) dehydrogenase 0.0046 0.3082 0.3082
Trypanosoma cruzi histone deacetylase 1, putative 0.0074 1 1
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0046 0.3082 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.3082 0.3082
Mycobacterium tuberculosis Probable oxidoreductase 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0074 1 1
Leishmania major histone deacetylase, putative 0.0074 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0046 0.3082 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Trichomonas vaginalis histone deacetylase, putative 0.0074 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0046 0.3082 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0046 0.3082 0.5
Mycobacterium ulcerans dehydrogenase 0.0046 0.3082 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0046 0.3082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0046 0.3082 0.5
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0046 0.3082 0.5
Loa Loa (eye worm) histone deacetylase 0.0057 0.5816 0.5816
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0046 0.3082 0.5
Trypanosoma cruzi histone deacetylase, putative 0.0057 0.5816 0.3952
Mycobacterium ulcerans ketoacyl reductase 0.0046 0.3082 0.5
Brugia malayi Histone deacetylase 1 0.0074 1 1
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0046 0.3082 0.5
Trichomonas vaginalis histone deacetylase, putative 0.0074 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0046 0.3082 0.5
Onchocerca volvulus 0.0046 0.3082 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0046 0.3082 0.5
Echinococcus granulosus histone deacetylase 6 0.0063 0.7306 0.6105
Echinococcus granulosus histone deacetylase 7 0.0057 0.5816 0.3952
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0046 0.3082 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0046 0.3082 0.5
Loa Loa (eye worm) oxidoreductase 0.0046 0.3082 0.3082
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Trypanosoma cruzi histone deacetylase 1, putative 0.0074 1 1
Schistosoma mansoni histone deacetylase 4 5 0.0057 0.5816 0.3952
Echinococcus multilocularis histone deacetylase 1 0.0074 1 1
Mycobacterium ulcerans oxidoreductase 0.0046 0.3082 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Leishmania major histone deacetylase, putative 0.0057 0.5816 0.3952
Mycobacterium ulcerans short-chain dehydrogenase 0.0046 0.3082 0.5
Loa Loa (eye worm) histone deacetylase 3 0.0074 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0046 0.3082 0.5
Mycobacterium ulcerans oxidoreductase 0.0046 0.3082 0.5
Leishmania major histone deacetylase, putative 0.0057 0.5816 0.3952
Mycobacterium ulcerans short-chain dehydrogenase 0.0046 0.3082 0.5
Echinococcus granulosus histone deacetylase 6 0.0057 0.5816 0.3952
Mycobacterium ulcerans short chain dehydrogenase 0.0046 0.3082 0.5
Onchocerca volvulus 0.0046 0.3082 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0046 0.3082 0.5
Loa Loa (eye worm) oxidoreductase 0.0046 0.3082 0.3082

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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