Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0251 | 0.2593 | 0.2593 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0557 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0557 | 1 | 1 |
Giardia lamblia | Kinase, TTK | 0.0144 | 0 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0149 | 0.0129 | 0.0129 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0144 | 0 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0557 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0248 | 0.2529 | 0.2529 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0557 | 1 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0557 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0251 | 0.2593 | 0.2593 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0557 | 1 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0557 | 1 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0557 | 1 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0557 | 1 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0557 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0557 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0149 | 0.0129 | 0.0129 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0144 | 0 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0557 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0557 | 1 | 1 |
Echinococcus multilocularis | 0.0145 | 0.0015 | 0.0015 | |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0467 | 0.783 | 0.783 |
Echinococcus granulosus | insulin receptor | 0.0149 | 0.0129 | 0.0129 |
Schistosoma mansoni | tyrosine kinase | 0.0467 | 0.783 | 0.783 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0144 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0557 | 1 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0467 | 0.783 | 0.783 |
Brugia malayi | Protein kinase domain containing protein | 0.0149 | 0.0129 | 0.0129 |
Schistosoma mansoni | tyrosine kinase | 0.0248 | 0.2529 | 0.2529 |
Schistosoma mansoni | tyrosine kinase | 0.0248 | 0.2529 | 0.2529 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0557 | 1 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0557 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0251 | 0.2593 | 0.2593 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0149 | 0.0129 | 0.0129 |
Schistosoma mansoni | tyrosine kinase | 0.0149 | 0.0129 | 0.0129 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0467 | 0.783 | 0.783 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0149 | 0.0129 | 0.0129 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0557 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0557 | 1 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0149 | 0.0129 | 0.0129 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0467 | 0.783 | 0.783 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0251 | 0.2593 | 0.2593 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0251 | 0.2593 | 0.2593 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0557 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 100 ug ml-1 | Antimicrobial activity against Candida albicans after 72 to 96 hr by two-fold serial dilution method | ChEMBL. | No reference |
MIC (functional) | = 100 ug ml-1 | Antimicrobial activity against Escherichia coli after 24 hr by two-fold serial dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.