Detailed information for compound 1809487

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 872.863 | Formula: C46H48O17
  • H donors: 5 H acceptors: 7 LogP: 4.48 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1O[C@@H]1O[C@H](COC(=O)/C=C/c2ccc(c(c2)OC)O)[C@H]([C@@H]([C@H]1O)OC(=O)/C=C/c1ccc(c(c1)OC)O)O)[C@@H]1OC[C@@H]2[C@H]1CO[C@H]2c1ccc(c(c1)OC)O
  • InChi: 1S/C46H48O17/c1-54-34-17-24(5-11-30(34)47)7-15-39(50)58-23-38-41(52)45(63-40(51)16-8-25-6-12-31(48)35(18-25)55-2)42(53)46(62-38)61-33-14-10-27(20-37(33)57-4)44-29-22-59-43(28(29)21-60-44)26-9-13-32(49)36(19-26)56-3/h5-20,28-29,38,41-49,52-53H,21-23H2,1-4H3/b15-7+,16-8+/t28-,29-,38-,41-,42-,43+,44+,45+,46-/m1/s1
  • InChiKey: LVCYOGTWEKMMSO-PMGFHEBOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica peptidase, C54 family 0.0058 0.0092 0.7448
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.011 0.011
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0035 0.0092
Brugia malayi hypothetical protein 0.0071 0.0118 0.0118
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0215 0.0215
Trypanosoma cruzi ISWI complex protein 0.0015 0.0007 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0032 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0035 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0009
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0025 0.0025
Entamoeba histolytica peptidase, C54 family 0.0022 0.0022 0.0635
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.193 0.3809 1
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0215 0.0215
Brugia malayi Peptidase family C54 containing protein 0.0058 0.0092 0.0092
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.5047 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0008 0.0022
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0047 0.0039
Mycobacterium tuberculosis Conserved protein 0.0035 0.0047 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0011
Schistosoma mansoni cpg binding protein 0.0032 0.0041 0.0041
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0015 0.0015
Trichomonas vaginalis esterase, putative 0.0035 0.0047 0.5131
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0015 0.1663
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.004
Onchocerca volvulus 0.0035 0.0047 0.0194
Schistosoma mansoni zinc finger protein 0.0021 0.0019 0.0019
Echinococcus granulosus expressed protein 0.0033 0.0042 0.0042
Echinococcus multilocularis dna polymerase eta 0.0045 0.0066 0.0066
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0039 0.0103
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0057 0.009 0.009
Onchocerca volvulus 0.0035 0.0047 0.0194
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0012 0.0012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0039 0.0039
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.0092 0.0092
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0027 0.0032 0.0032
Plasmodium falciparum cysteine protease ATG4, putative 0.0022 0.0022 0.0057
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0092 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0006 0.0006
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0067 0.011 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.004
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0095 0.0165 0.0165
Echinococcus granulosus epidermal growth factor receptor 0.0095 0.0165 0.0165
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0047 0.0047
Echinococcus granulosus neuroglian 0.0014 0.0004 0.0004
Schistosoma mansoni cell adhesion molecule 0.0014 0.0006 0.0006
Leishmania major DNA polymerase eta, putative 0.0031 0.0039 0.0103
Schistosoma mansoni tyrosine kinase 0.0093 0.0161 0.0161
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.5047 1 1
Echinococcus granulosus GPCR family 2 0.0031 0.0039 0.0039
Echinococcus multilocularis cysteine protease atg4b 0.0058 0.0092 0.0092
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0172 0.0172
Entamoeba histolytica hypothetical protein 0.0071 0.0118 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0003 0.0003
Echinococcus multilocularis expressed protein 0.0033 0.0042 0.0042
Onchocerca volvulus 0.0035 0.0047 0.0194
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.004 0.0106
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0034 0.0034
Onchocerca volvulus Phospholipase A2 homolog 0.0427 0.0825 1
Echinococcus multilocularis neuroglian 0.0014 0.0004 0.0004
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0015 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0008
Schistosoma mansoni bromodomain containing protein 0.0065 0.0105 0.0105
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0008 0.0022
Trypanosoma brucei unspecified product 0.0013 0.0003 0.0009
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0008 0.0022
Plasmodium falciparum phd finger protein, putative 0.0029 0.0035 0.0092
Echinococcus multilocularis tumor protein p63 0.0339 0.0651 0.0651
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0047 0.0039
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0022 0.0022 0.0057
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0026 0.0068
Echinococcus multilocularis roundabout 2 0.0017 0.0011 0.0011
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0031 0.0039 0.0039
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0015 0.0015
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0397 0.0766 0.0766
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0066 0.0066
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0015 0.0015
Brugia malayi Protein kinase domain containing protein 0.0057 0.009 0.009
Leishmania major dihydrofolate reductase-thymidylate synthase 0.193 0.3809 1
Schistosoma mansoni cpg binding protein 0.0032 0.0041 0.0041
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0048 0.0048
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0215 0.0215
Schistosoma mansoni hypothetical protein 0.0071 0.0118 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0012 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0008
Trypanosoma brucei unspecified product 0.0019 0.0015 0.004
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0118 0.0118
Echinococcus granulosus Peptidase C54 0.0058 0.0092 0.0092
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0092 1
Brugia malayi PHD-finger family protein 0.0029 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.004
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0008 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0008
Leishmania major DNA polymerase kappa, putative 0.0019 0.0015 0.004
Trypanosoma cruzi ISWI complex protein 0.0015 0.0007 0.0019
Brugia malayi PHD-finger family protein 0.0013 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0029 0.0035 0.0035
Trichomonas vaginalis rotamase, putative 0.0032 0.004 0.4412
Loa Loa (eye worm) hypothetical protein 0.005 0.0076 0.0076
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0047 0.0039
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0048 0.0048
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0003 0.0003
Brugia malayi intermediate filament protein 0.0027 0.0032 0.0032
Brugia malayi Bromodomain containing protein 0.0038 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0031 0.0039 0.0039
Brugia malayi Phospholipase A2 family protein 0.009 0.0156 0.0156
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0047
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0047 0.5131
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0215 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.004
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0025 0.0025
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0172 0.0172
Giardia lamblia PHD finger protein 15 0.0029 0.0035 1
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0066 0.0172
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.005 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0045 0.0066 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.004
Onchocerca volvulus Alhambra homolog 0.0029 0.0035 0.0046
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0008
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0006 0.0006
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0215 0.0215
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.004 0.0106
Echinococcus granulosus tumor protein p63 0.0339 0.0651 0.0651
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0057 0.009 0.009
Schistosoma mansoni cpg binding protein 0.0028 0.0034 0.0034
Echinococcus granulosus roundabout 2 0.0017 0.0011 0.0011
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0008 0.0008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0047 0.0039
Brugia malayi hypothetical protein 0.0016 0.0009 0.0009
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0015 0.1663
Schistosoma mansoni autophagin-1 (C54 family) 0.0058 0.0092 0.0092
Echinococcus granulosus twitchin 0.0015 0.0007 0.0007
Echinococcus multilocularis musashi 0.0027 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0031 0.0039 0.0039
Echinococcus multilocularis epidermal growth factor receptor 0.0095 0.0165 0.0165
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0008 0.0008
Schistosoma mansoni lamin 0.0027 0.0032 0.0032
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0047 0.0032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0026
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0025 0.0025
Echinococcus granulosus cpg binding protein 0.0032 0.0041 0.0041
Trypanosoma brucei ISWI complex protein 0.0015 0.0007 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0042 0.4579
Schistosoma mansoni tyrosine kinase 0.0175 0.0325 0.0325
Loa Loa (eye worm) dihydrofolate reductase 0.5047 1 1
Loa Loa (eye worm) hypothetical protein 0.0427 0.0825 0.0825
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.193 0.3809 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0215 0.02
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0047 0.0123
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.004 0.0106
Echinococcus granulosus peregrin 0.0032 0.004 0.004
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.004
Brugia malayi isocitrate dehydrogenase 0.0016 0.0008 0.0008
Echinococcus multilocularis GPCR, family 2 0.0031 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.0093 0.0161 0.0161
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0026 0.0068
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0054 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0047 0.0123
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0215 0.02
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0018 0.0018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.1579 0.1579
Mycobacterium ulcerans lipase LipD 0.0035 0.0047 0.0032
Entamoeba histolytica peptidase, C54 family 0.0022 0.0022 0.0635
Echinococcus multilocularis insulin receptor 0.0057 0.009 0.009
Schistosoma mansoni zinc finger protein 0.0015 0.0007 0.0007
Schistosoma mansoni tyrosine kinase 0.0095 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0047
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0032 0.0032
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0071 0.0118 1
Leishmania major hypothetical protein, conserved 0.0025 0.0026 0.0068
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.0092 0.0092
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0092 0.024
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0215 0.0564
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0128 0.0128
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0039 0.0039
Brugia malayi Dihydrofolate reductase 0.5047 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0035 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0092 1
Leishmania major hypothetical protein, conserved 0.0015 0.0007 0.0019
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0065
Loa Loa (eye worm) TK/EGFR protein kinase 0.0175 0.0325 0.0325
Echinococcus granulosus zinc finger protein 0.0021 0.0019 0.0019
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0012 0.0012
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0167 0.0167
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0026 0.0068
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0047 0.5131
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0009
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0047 0.0032
Loa Loa (eye worm) hypothetical protein 0.0067 0.011 0.011
Trypanosoma brucei unspecified product 0.0013 0.0003 0.0009
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0047 0.0123
Brugia malayi PHD-finger family protein 0.0026 0.003 0.003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0012 0.0012
Onchocerca volvulus Phospholipase A2 homolog 0.009 0.0156 0.1563
Toxoplasma gondii ABC1 family protein 0.0035 0.0047 0.0123
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0215 0.0564
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0032 0.0032
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0047 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0009
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0015 0.0007
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0092 1
Onchocerca volvulus 0.0161 0.0298 0.3352
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0039 0.0039
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0047 0.0039
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0011 0.0011
Schistosoma mansoni tyrosine kinase 0.0057 0.009 0.009
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0092 1
Brugia malayi Bromodomain containing protein 0.0032 0.004 0.004
Echinococcus granulosus intermediate filament protein 0.0027 0.0032 0.0032
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0022 0.0022 0.0057
Schistosoma mansoni tyrosine kinase 0.0095 0.0165 0.0165
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.0782 0.0782
Chlamydia trachomatis dihydrofolate reductase 0.5047 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0011
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0039 0.0039
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0172 0.0172
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0047 0.0047
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0047 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.004
Mycobacterium tuberculosis Conserved protein 0.0035 0.0047 0.0039
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0003 0.0003
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0003 0.0003
Schistosoma mansoni intermediate filament proteins 0.0027 0.0032 0.0032
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0092 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0047 0.5131
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.193 0.3809 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0047 0.0039
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0047
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0058 0.0092 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0022 0.0022 0.0057
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0008 0.0022
Mycobacterium ulcerans beta-lactamase 0.0035 0.0047 0.0032
Entamoeba histolytica peptidase, C54 family 0.0022 0.0022 0.0635
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0423 0.0415
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0008 0.0022
Brugia malayi jmjC domain containing protein 0.0096 0.0167 0.0167
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0008 0.0022
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0098 0.0172 0.0172
Leishmania major DNA polymerase eta, putative 0.0045 0.0066 0.0172
Schistosoma mansoni hypothetical protein 0.0031 0.0039 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0097 0.0097
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0008 0.0008
Echinococcus multilocularis lamin dm0 0.0027 0.0032 0.0032
Brugia malayi beta-lactamase family protein 0.0035 0.0047 0.0047
Schistosoma mansoni tyrosine kinase 0.0093 0.0161 0.0161
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0039 0.0039
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0047 0.0123
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0118 0.0118
Echinococcus multilocularis dihydrofolate reductase 0.5047 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.004
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0035 0.0092
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0026 0.0068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0047 0.0047
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0042 0.0042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0178 0.033 0.033
Brugia malayi hypothetical protein 0.0025 0.0026 0.0026
Onchocerca volvulus 0.005 0.0076 0.0556
Onchocerca volvulus Tyrosine kinase homolog 0.0166 0.0307 0.3471
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0047 0.0047
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0089 0.0233
Echinococcus granulosus lamin 0.0027 0.0032 0.0032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0047 0.0047
Echinococcus granulosus dna polymerase kappa 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0053 0.0053
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0015 0.004
Schistosoma mansoni nephrin 0.0014 0.0004 0.0004
Brugia malayi Bromodomain containing protein 0.0076 0.0128 0.0128
Entamoeba histolytica hypothetical protein 0.0071 0.0118 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0066 0.0172
Loa Loa (eye worm) TK/INSR protein kinase 0.0057 0.009 0.009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0054 0.0054
Echinococcus multilocularis epidermal growth factor receptor 0.0175 0.0325 0.0325
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0015 0.0015
Echinococcus multilocularis cpg binding protein 0.0032 0.0041 0.0041
Echinococcus granulosus dnaJ subfamily B 0.0405 0.0782 0.0782
Onchocerca volvulus 0.0028 0.0034 0.0025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0039 0.0039
Echinococcus multilocularis zinc finger protein 0.0021 0.0019 0.0019
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0008 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.004
Echinococcus granulosus insulin receptor 0.0057 0.009 0.009
Trichomonas vaginalis rotamase, putative 0.0033 0.0042 0.4579
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0015 0.0015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0054 0.0054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0047 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.004
Echinococcus multilocularis lamin 0.0027 0.0032 0.0032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.001 0.001
Echinococcus granulosus lamin dm0 0.0027 0.0032 0.0032
Schistosoma mansoni DNA polymerase eta 0.0045 0.0066 0.0066
Schistosoma mansoni lamin 0.0027 0.0032 0.0032
Echinococcus granulosus dihydrofolate reductase 0.5047 1 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.004 0.0106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0405 0.0782 0.0782
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0031
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0047
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0397 0.0766 0.0766
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.007 0.0117 0.0117
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.004 0.2456
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0178 0.033 0.033
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.193 0.3809 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.193 0.3809 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0015 0.4322
Schistosoma mansoni rotamase 0.0033 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.004
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.5047 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0035
Entamoeba histolytica hypothetical protein 0.0071 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0047
Echinococcus multilocularis peregrin 0.0032 0.004 0.004
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0167 0.0167
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.004 0.0106
Echinococcus granulosus cysteine protease atg4b 0.0058 0.0092 0.0092
Echinococcus multilocularis 0.0054 0.0084 0.0084
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0092 0.024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0012 0.0012
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0017 0.0017
Mycobacterium tuberculosis Conserved protein 0.0035 0.0047 0.0039
Brugia malayi beta-lactamase family protein 0.0035 0.0047 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0026 0.0068
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0215 0.02
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0058
Echinococcus granulosus epidermal growth factor receptor 0.0175 0.0325 0.0325
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0039 0.0103
Schistosoma mansoni tyrosine kinase 0.0057 0.009 0.009
Brugia malayi CXXC zinc finger family protein 0.0028 0.0034 0.0034
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0098 0.0098
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0008 0.0022
Entamoeba histolytica peptidase, C54 family 0.0022 0.0022 0.0635
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0008 0.0008
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0022 0.0022 0.0057
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0058 0.0058
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0022 0.0022 0.0057
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.009 0.0156 0.0156
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0097 0.0097
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0008 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.004
Brugia malayi Furin-like cysteine rich region family protein 0.0175 0.0325 0.0325
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0054 0.0054
Echinococcus granulosus dna polymerase eta 0.0045 0.0066 0.0066
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0042 0.0042
Mycobacterium ulcerans hypothetical protein 0.0035 0.0047 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0047 0.5131
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0015 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0047 0.5131
Echinococcus multilocularis Peptidase C54 0.0058 0.0092 0.0092
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0118 0.0118
Leishmania major hypothetical protein, conserved 0.0035 0.0047 0.0123
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0014 0.0006 0.0006
Brugia malayi beta-lactamase 0.0035 0.0047 0.0047
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0011 0.0011
Schistosoma mansoni dihydrofolate reductase 0.5047 1 1
Brugia malayi jmjC domain containing protein 0.0039 0.0054 0.0054
Loa Loa (eye worm) beta-lactamase 0.0035 0.0047 0.0047

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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