TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 247.333 | Formula: C15H21NO2
H donors: 2 H acceptors: 1 LogP: 2.77 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCNC[C@H](c1oc2c(c1CC)cccc2)O
InChi: 1S/C15H21NO2/c1-3-9-16-10-13(17)15-11(4-2)12-7-5-6-8-14(12)18-15/h5-8,13,16-17H,3-4,9-10H2,1-2H3/t13-/m1/s1
InChiKey: GEZXOQACQRMLMK-CYBMUJFWSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	smdr2	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-5	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	taga, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium knowlesi	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium hominis	ATP-binding cassette protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium yoelii	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-1	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium parvum	ATP-binding cassette transporter	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ATP-binding cassette sub-family B member 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium falciparum	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Onchocerca volvulus		Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania braziliensis	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Bile salt export pump, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium vivax	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	ATP-binding cassette, sub-family B (MDR/TAP), member 4, related	Get druggable targets OG5_126596	All targets in OG5_126596
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium berghei	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	ABC transporter family protein	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glyco protein 6, putative	Get druggable targets OG5_126596	All targets in OG5_126596

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptide s receptor	0.0024	0.0849	0.0849
Schistosoma mansoni	histamine h1 receptor	0.0024	0.0849	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0212	0.0212
Brugia malayi	Serotonin receptor	0.0024	0.0849	1
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0849	0.0849
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Brugia malayi	hypothetical protein	0.0024	0.0849	1
Brugia malayi	AKH receptor	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0212	0.0119
Onchocerca volvulus		0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Onchocerca volvulus		0.0024	0.0849	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0024	0.0849	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0212	0.0212
Brugia malayi	Serotonin receptor	0.0024	0.0849	1
Schistosoma mansoni	amine GPCR	0.0024	0.0849	0.0651
Brugia malayi	neuropeptide F receptor	0.0024	0.0849	1
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.019	1	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0024	0.0849	0.0849
Brugia malayi	G-protein coupled receptor	0.0024	0.0849	1
Echinococcus multilocularis	serotonin receptor	0.0024	0.0849	0.0849
Onchocerca volvulus		0.0024	0.0849	1
Onchocerca volvulus		0.0024	0.0849	1
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0212	0.0212
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0024	0.0849	0.0651
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Echinococcus multilocularis	serotonin receptor	0.0024	0.0849	0.0849
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0024	0.0849	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0212	0.0212
Onchocerca volvulus		0.0024	0.0849	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0212	0.0212
Schistosoma mansoni	neuropeptide F-like receptor	0.0024	0.0849	0.0651
Brugia malayi	putative neuropeptide receptor NPR1	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0212	0.0212
Loa Loa (eye worm)	neuropeptide F receptor	0.0024	0.0849	1
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0849	0.0651
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0849	0.0849
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0013	0.0212	0.0212
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.019	1	0.5
Brugia malayi	larval opioid receptor	0.0024	0.0849	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.0212	0.0212
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.019	1	0.5
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0849	0.0651
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0849	0.0651
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0024	0.0849	0.0651
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0013	0.0212	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus granulosus	somatostatin receptor	0.0024	0.0849	0.0849
Echinococcus granulosus	neuropeptide FF receptor 2	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0024	0.0849	0.0849
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0849	0.0651
Brugia malayi	follicle stimulating hormone receptor	0.0024	0.0849	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0849	0.0651
Echinococcus granulosus	serotonin receptor	0.0024	0.0849	0.0849
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0212	0.0212
Brugia malayi	Dopamine receptor protein 1	0.0024	0.0849	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0849	0.0849
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0212	0.0212
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0024	0.0849	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0024	0.0849	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0024	0.0849	1
Brugia malayi	hypothetical protein	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0849	0.0849
Brugia malayi	hypothetical protein	0.0024	0.0849	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0024	0.0849	0.0849
Brugia malayi	ORL1-like opioid receptor	0.0024	0.0849	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0849	0.0849
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.019	1	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0024	0.0849	0.0849
Trichomonas vaginalis	abcb9, putative	0.0013	0.0212	0.0212
Brugia malayi	sulfakinin receptor protein	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0849	0.0651
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0849	0.0849
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0024	0.0849	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Onchocerca volvulus		0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0212	0.0119
Schistosoma mansoni	amine GPCR	0.0024	0.0849	0.0651
Echinococcus multilocularis	neuropeptide receptor A26	0.0024	0.0849	0.0849
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0849	0.0651
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0849	0.0651
Giardia lamblia	Rrm3p helicase	0.019	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0024	0.0849	0.0849
Echinococcus multilocularis	ATP binding cassette sub family B	0.0013	0.0204	0.0204
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0849	0.0651
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0024	0.0849	1
Brugia malayi	hypothetical protein	0.0024	0.0849	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0024	0.0849	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0024	0.0849	0.0849
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0212	0.0212
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0212	0.0212
Echinococcus multilocularis	multidrug resistance protein 1	0.0013	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0849	0.0651
Brugia malayi	hypothetical protein	0.0024	0.0849	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0024	0.0849	1
Entamoeba histolytica	hypothetical protein, conserved	0.019	1	1
Brugia malayi	G protein-coupled receptor	0.0024	0.0849	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0849	0.0849
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0212	0.0212
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0024	0.0849	1
Echinococcus granulosus	orexin receptor type 2	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Onchocerca volvulus		0.0024	0.0849	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.019	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0212	0.0212
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0849	0.0849
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0024	0.0849	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0024	0.0849	0.0849
Echinococcus multilocularis	sex peptide receptor	0.0024	0.0849	0.0849
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.019	1	1
Schistosoma mansoni	myosin xvIII	0.0024	0.0849	0.0651
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0849	0.0651
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0212	0.0212
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0849	0.0849
Echinococcus granulosus	neuropeptide s receptor	0.0024	0.0849	0.0849
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0212	0.0212
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0849	0.0849
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0024	0.0849	0.0651
Onchocerca volvulus		0.0024	0.0849	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0849	0.0849
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Brugia malayi	hypothetical protein	0.0024	0.0849	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0849	0.0849
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0013	0.0212	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0849	0.0849
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.019	1	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0024	0.0849	1
Loa Loa (eye worm)	multidrug resistance protein 3	0.0013	0.0212	0.0119
Echinococcus granulosus	G protein coupled receptor 139	0.0024	0.0849	0.0849
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0212	0.0212
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0849	0.0849
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0212	0.0212
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0849	0.0849
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0013	0.0212	0.0119
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Loa Loa (eye worm)	G-protein coupled receptor	0.0024	0.0849	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0024	0.0849	0.0849
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0849	0.0849
Brugia malayi	hypothetical protein	0.0024	0.0849	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0024	0.0849	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0024	0.0849	0.0651
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0849	0.0849
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0212	0.0212
Onchocerca volvulus		0.0024	0.0849	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0212	0.0212
Echinococcus multilocularis	dro:myosuppressin receptor	0.0024	0.0849	0.0849
Echinococcus multilocularis	g-protein coupled receptor	0.0024	0.0849	0.0849
Onchocerca volvulus		0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0849	0.0849
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Onchocerca volvulus		0.0024	0.0849	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0849	0.0849
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0212	0.0212
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0849	0.0849
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0212	0.0212
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0212	0.0212
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0849	0.0849
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Onchocerca volvulus		0.0024	0.0849	1
Brugia malayi	RE15519p	0.0024	0.0849	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Brugia malayi	hypothetical protein	0.0024	0.0849	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0212	0.0212
Echinococcus granulosus	neuropeptide receptor A26	0.0024	0.0849	0.0849
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0024	0.0849	0.0849
Schistosoma mansoni	amine GPCR	0.0024	0.0849	0.0651
Echinococcus multilocularis	orexin receptor type 2	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus granulosus	hypothetical protein	0.0024	0.0849	0.0849
Brugia malayi	putative neuropeptide receptor	0.0024	0.0849	1
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0849	0.0849
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0849	0.0849
Loa Loa (eye worm)	TYRA-2 protein	0.0024	0.0849	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0212	0.0212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0849	0.0651
Schistosoma mansoni	hypothetical protein	0.0024	0.0849	0.0651
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0024	0.0849	0.0651
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0024	0.0849	0.0849
Plasmodium vivax	multidrug resistance protein 1, putative	0.0013	0.0212	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0849	0.0651
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0212	0.0212
Schistosoma mansoni	opsin-like receptor	0.0024	0.0849	0.0651
Onchocerca volvulus		0.0024	0.0849	1
Brugia malayi	hypothetical protein	0.0024	0.0849	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0849	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Brugia malayi	neuropeptide F receptor	0.0024	0.0849	1
Echinococcus granulosus	fmrfamide receptor	0.0024	0.0849	0.0849
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0849	0.0651
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0849	0.0849
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0849	0.0849
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus multilocularis	allatostatin A receptor	0.0024	0.0849	0.0849
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0013	0.0212	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0024	0.0849	0.0849
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0212	0.0212
Schistosoma mansoni	adenoreceptor	0.0024	0.0849	0.0651
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0849	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0212	0.0212
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0849	0.0849
Brugia malayi	Melatonin receptor type 1A	0.0024	0.0849	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0849	0.0651
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus granulosus	g-protein coupled receptor	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0013	0.0212	0.0212
Schistosoma mansoni	hypothetical protein	0.019	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0024	0.0849	0.0849
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0212	0.0212
Onchocerca volvulus		0.0024	0.0849	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0849	0.0651
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0849	0.0849
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0849	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.0212	0.0212
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0849	0.0849
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0212	0.0212
Echinococcus granulosus	7TM GPCR rhodopsin	0.0024	0.0849	0.0849
Echinococcus multilocularis	somatostatin receptor	0.0024	0.0849	0.0849
Trichomonas vaginalis	abcb9, putative	0.0013	0.0212	0.0212
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0013	0.0212	0.0212
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.019	1	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0849	0.0651
Schistosoma mansoni	neuropeptide F-like receptor	0.0024	0.0849	0.0651
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0849	0.0849
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0024	0.0849	0.0849
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0024	0.0849	0.0849
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0849	0.0651
Trichomonas vaginalis	abcb9, putative	0.0013	0.0212	0.0212
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0024	0.0849	0.0849
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0013	0.0212	0.5
Brugia malayi	Dopamine receptor protein 2	0.0024	0.0849	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0024	0.0849	0.0651
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0024	0.0849	0.0849
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0013	0.0204	0.0204
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0024	0.0849	0.0651
Echinococcus granulosus	sex peptide receptor	0.0024	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus granulosus	allatostatin A receptor	0.0024	0.0849	0.0849
Onchocerca volvulus		0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Schistosoma mansoni	amine GPCR	0.0024	0.0849	0.0651
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0024	0.0849	0.0651
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0024	0.0849	0.0849
Plasmodium falciparum	multidrug resistance protein 1	0.0013	0.0212	0.5
Trichomonas vaginalis	taga, putative	0.0013	0.0212	0.0212
Brugia malayi	G-protein coupled receptor	0.0024	0.0849	1
Schistosoma mansoni	amine GPCR	0.0024	0.0849	0.0651
Schistosoma mansoni	hypothetical protein	0.0024	0.0849	0.0651
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0024	0.0849	0.0651
Brugia malayi	Dopamine receptor	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Onchocerca volvulus		0.0024	0.0849	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0024	0.0849	0.0651
Brugia malayi	G protein-coupled receptor F59B2.13	0.0024	0.0849	1
Schistosoma mansoni	opsin-like receptor	0.0024	0.0849	0.0651
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0212	0.0212
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0024	0.0849	0.0651
Brugia malayi	GnHR receptor homolog	0.0024	0.0849	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0849	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0024	0.0849	0.0651
Onchocerca volvulus		0.0024	0.0849	1
Brugia malayi	hypothetical protein	0.0024	0.0849	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0849	0.0849
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0024	0.0849	0.0651
Trichomonas vaginalis	conserved hypothetical protein	0.019	1	1
Entamoeba histolytica	DNA repair and recombination protein, putative	0.019	1	1
Schistosoma mansoni	opsin-like receptor	0.0024	0.0849	0.0651

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 4.94	SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2449357

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1809668