Detailed information for compound 180974

Basic information

Technical information
  • TDR Targets ID: 180974
  • Name: (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[but yl(propylsulfonyl)amino]ethyl]-2-(4-methoxyph enyl)pyrrolidine-3-carboxylic acid
  • MW: 546.676 | Formula: C28H38N2O7S
  • H donors: 1 H acceptors: 4 LogP: 1.78 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCN(S(=O)(=O)CCC)CCN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2
  • InChi: 1S/C28H38N2O7S/c1-4-6-13-30(38(33,34)16-5-2)15-14-29-18-23(21-9-12-24-25(17-21)37-19-36-24)26(28(31)32)27(29)20-7-10-22(35-3)11-8-20/h7-12,17,23,26-27H,4-6,13-16,18-19H2,1-3H3,(H,31,32)/t23-,26-,27+/m1/s1
  • InChiKey: WZLJNKGZGAUWGV-MVNQZMKCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[butyl(propylsulfonyl)amino]ethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic acid
  • (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(butyl-propylsulfonylamino)ethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
  • (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(butyl-propylsulfonyl-amino)ethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
  • (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(butyl-propylsulfonylamino)ethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Endothelin receptor ET-A Starlite/ChEMBL References
Sus scrofa Endothelin receptor ET-B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Endothelin receptor ET-A   426 aa 412 aa 20.1 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Endothelin receptor ET-A   426 aa 412 aa 21.1 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Endothelin receptor ET-B   443 aa 392 aa 23.5 %
Onchocerca volvulus Endothelin receptor ET-B   443 aa 371 aa 20.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0011 0.0067
Mycobacterium ulcerans two component regulator - sensor kinase 0.0053 0.0169 0.0598
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0079 0.0307 0.1874
Onchocerca volvulus 0.0079 0.0307 0.1874
Echinococcus multilocularis enteropeptidase 0.0099 0.0409 0.0572
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Echinococcus multilocularis allatostatin A receptor 0.0079 0.0307 0.0429
Schistosoma mansoni opsin-like receptor 0.0079 0.0307 0.0891
Onchocerca volvulus 0.006 0.0206 0.1222
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0079 0.0307 0.0429
Brugia malayi Trypsin family protein 0.006 0.0206 0.0206
Brugia malayi hypothetical protein 0.0079 0.0307 0.0307
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0053 0.0169 0.0982
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.3443 1
Plasmodium vivax subtilisin-like protease 1 0.0041 0.0108 0.069
Echinococcus granulosus heat shock protein 90 0.0233 0.1109 0.155
Brugia malayi ORL1-like opioid receptor 0.0079 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.0307 0.0429
Plasmodium vivax heat shock protein 90, putative 0.0158 0.0721 0.4622
Echinococcus granulosus somatostatin receptor 0.0079 0.0307 0.0429
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0053 0.0169 0.0598
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Schistosoma mansoni DNA topoisomerase II 0.0053 0.0169 0.0491
Loa Loa (eye worm) hypothetical protein 0.006 0.0206 0.0206
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0053 0.0169 0.0236
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0053 0.0169 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0125 0.0548 0.0766
Echinococcus granulosus 7tm_1 domain containing protein 0.0079 0.0307 0.0429
Trichomonas vaginalis heat shock protein, putative 0.0124 0.0541 0.3311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0213 0.1006 0.6159
Trypanosoma brucei DNA topoisomerase ii 0.0053 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Toxoplasma gondii subtilisin SUB12 0.0041 0.0108 0.069
Echinococcus granulosus neuroendocrine convertase 2 0.0513 0.2574 0.3598
Mycobacterium leprae Probable two component sensor kinase MprB 0.0053 0.0169 0.0598
Loa Loa (eye worm) hypothetical protein 0.0324 0.1586 0.1586
Brugia malayi G-protein coupled receptor 0.0079 0.0307 0.0307
Leishmania major mitochondrial DNA topoisomerase II 0.0053 0.0169 0.0169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Onchocerca volvulus 0.0079 0.0307 0.1874
Brugia malayi Trypsin family protein 0.006 0.0206 0.0206
Leishmania major heat shock protein, putative 0.0158 0.0721 0.0721
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0066 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0666 0.4079
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0079 0.0307 0.0429
Echinococcus granulosus G protein coupled receptor 139 0.0079 0.0307 0.0429
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0053 0.0169 0.0236
Brugia malayi Dopamine receptor 0.0079 0.0307 0.0307
Loa Loa (eye worm) melatonin receptor type 1A 0.0079 0.0307 0.0307
Echinococcus granulosus g protein coupled receptor 0.0079 0.0307 0.0429
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.0307 0.0891
Echinococcus granulosus intermediate filament protein 0.0024 0.0018 0.0025
Schistosoma mansoni heat shock protein 0.0158 0.0721 0.2094
Trichomonas vaginalis receptor histidine kinase, putative 0.0053 0.0169 0.1035
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Trypanosoma brucei heat shock protein, putative 0.0285 0.1385 0.1385
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Plasmodium vivax heat shock protein 86, putative 0.0285 0.1385 0.8879
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0213 0.1006 0.6159
Schistosoma mansoni histamine h1 receptor 0.0079 0.0307 0.0891
Plasmodium vivax DNA gyrase subunit B, putative 0.0053 0.0169 0.1084
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0108 0.0659
Brugia malayi G protein-coupled receptor F59B2.13 0.0079 0.0307 0.0307
Schistosoma mansoni lipoxygenase 0.008 0.0311 0.0902
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.2354 0.329
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0038 0.0247
Echinococcus multilocularis lamin dm0 0.0024 0.0018 0.0025
Schistosoma mansoni hypothetical protein 0.0043 0.0118 0.0343
Echinococcus granulosus neuropeptide receptor 0.0079 0.0307 0.0429
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0079 0.0307 0.0429
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Plasmodium falciparum cysteine repeat modular protein 1 0.0319 0.156 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0079 0.0307 0.1874
Schistosoma mansoni cercarial elastase (S01 family) 0.006 0.0206 0.0599
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0213 0.1006 0.6159
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0011 0.0011
Giardia lamblia Furin precursor putative serine protease 0.0172 0.0791 0.5712
Echinococcus granulosus tachykinin peptides receptor 99D 0.0079 0.0307 0.0429
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0305 0.1487 0.4319
Plasmodium falciparum DNA topoisomerase 2 0.0053 0.0169 0.1084
Trichomonas vaginalis heat shock protein, putative 0.0177 0.0817 0.5002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0307 0.0891
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0108 0.0456 0.1325
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Echinococcus multilocularis orexin receptor type 2 0.0079 0.0307 0.0429
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Giardia lamblia Pms1-like protein 0.0053 0.0169 0.1221
Brugia malayi hypothetical protein 0.0079 0.0307 0.0307
Brugia malayi hypothetical protein 0.0079 0.0307 0.0307
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Giardia lamblia Heat shock protein HSP 90-alpha 0.0233 0.1109 0.8005
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0053 0.0169 0.0598
Echinococcus granulosus geminin 0.0324 0.1589 0.2221
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0099 0.0409 0.1188
Echinococcus multilocularis endoplasmin 0.0238 0.1135 0.1586
Plasmodium falciparum subtilisin-like protease 1 0.0041 0.0108 0.069
Trypanosoma brucei heat shock protein, putative 0.0285 0.1385 0.1385
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0109 0.0152
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0053 0.0169 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0018 0.0109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0307 0.0891
Echinococcus multilocularis g-protein coupled receptor 0.0079 0.0307 0.0429
Loa Loa (eye worm) subtilase 0.0305 0.1487 0.1487
Schistosoma mansoni hypothetical protein 0.0324 0.1589 0.4616
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0238 0.1135 1
Brugia malayi hypothetical protein 0.0079 0.0307 0.0307
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0053 0.0169 0.0169
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.0307 0.0429
Onchocerca volvulus 0.0079 0.0307 0.1874
Schistosoma mansoni hypothetical protein 0.0319 0.156 0.4531
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0109 0.0697
Schistosoma mansoni amine GPCR 0.0079 0.0307 0.0891
Brugia malayi GnHR receptor homolog 0.0079 0.0307 0.0307
Echinococcus granulosus heat shock protein 90 0.0285 0.1385 0.1936
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0079 0.0307 0.0429
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0362 0.1052
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0307 0.0891
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0053 0.0169 0.0598
Toxoplasma gondii subtilisin SUB11 0.0041 0.0108 0.069
Onchocerca volvulus 0.0079 0.0307 0.1874
Schistosoma mansoni cpg binding protein 0.0028 0.0038 0.0111
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0279 0.1787
Plasmodium vivax heat shock protein, putative 0.0129 0.0567 0.3636
Toxoplasma gondii heat shock protein 75, putative 0.0158 0.0721 0.4622
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0038 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0362 0.0506
Echinococcus multilocularis fmrfamide receptor 0.0079 0.0307 0.0429
Onchocerca volvulus 0.0079 0.0307 0.1874
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0627 0.1822
Echinococcus granulosus g protein coupled receptor 0.0079 0.0307 0.0429
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0079 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0079 0.0307 0.0891
Echinococcus granulosus g protein coupled receptor 0.0079 0.0307 0.0429
Brugia malayi Probable DNA topoisomerase II 0.0053 0.0169 0.0169
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.0307 0.0891
Echinococcus multilocularis G-protein coupled receptor, putative 0.0079 0.0307 0.0429
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Echinococcus granulosus neuropeptide FF receptor 2 0.0079 0.0307 0.0429
Brugia malayi putative neuropeptide receptor NPR1 0.0079 0.0307 0.0307
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0136 0.0604 0.0604
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0053 0.0169 0.0598
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0307 0.0429
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0053 0.0169 0.0598
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0238 0.1135 1
Brugia malayi putative neuropeptide receptor 0.0079 0.0307 0.0307
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0079 0.0307 0.0429
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0148 0.0665 0.1932
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0169 0.1084
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0333 0.1633 1
Schistosoma mansoni neuropeptide receptor 0.0079 0.0307 0.0891
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0108 0.0659
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.0307 0.0307
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Brugia malayi Hsp90 protein 0.0158 0.0721 0.0721
Echinococcus granulosus cpg binding protein 0.0029 0.0047 0.0065
Trypanosoma brucei heat shock protein 84, putative 0.0158 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0053 0.0169 0.0598
Brugia malayi hypothetical protein 0.0048 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.049 0.0685
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0079 0.0307 0.0891
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0362 0.1052
Plasmodium vivax subtilisin-like protease 2, putative 0.0041 0.0108 0.069
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0307 0.0891
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0053 0.0169 0.0169
Trypanosoma brucei Heat shock protein 83, putative 0.0285 0.1385 0.1385
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0079 0.0307 0.0307
Leishmania major importin beta-1 subunit, putative 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0053 0.0169 0.0169
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.008 0.0111
Schistosoma mansoni hypothetical protein 0.0079 0.0307 0.0891
Brugia malayi Dopamine receptor protein 1 0.0079 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0053 0.0169 0.0598
Leishmania major subtilisin-like serine peptidase 0.0041 0.0108 0.0108
Echinococcus multilocularis neuropeptide FF receptor 2 0.0079 0.0307 0.0429
Plasmodium falciparum DNA gyrase subunit B 0.0053 0.0169 0.1084
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0307 0.0429
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.006 0.0206 0.0599
Loa Loa (eye worm) heat shock protein 75 0.0158 0.0721 0.0721
Brugia malayi hypothetical protein 0.0079 0.0307 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0666 0.4079
Mycobacterium leprae Probable two-component sensor kinase 0.0053 0.0169 0.0598
Echinococcus granulosus dnaJ subfamily B 0.0396 0.1965 0.2747
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0135 0.0597 0.0834
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Schistosoma mansoni site-1 peptidase (S08 family) 0.0041 0.0108 0.0313
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0043 0.0118 0.0165
Trypanosoma cruzi heat shock protein 90, putative 0.0233 0.1109 0.1109
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Entamoeba histolytica hypothetical protein 0.0036 0.008 0.0575
Brugia malayi Serotonin receptor 0.0079 0.0307 0.0307
Brugia malayi hypothetical protein 0.0036 0.008 0.008
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0053 0.0169 0.0598
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0079 0.0307 0.0429
Echinococcus multilocularis inhibitor of apoptosis protein 0.0108 0.0456 0.0637
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0053 0.0169 0.0598
Toxoplasma gondii DNA topoisomerase 2, putative 0.0053 0.0169 0.1084
Onchocerca volvulus 0.0319 0.156 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0158 0.0721 0.1008
Loa Loa (eye worm) hypothetical protein 0.0108 0.0456 0.0456
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0053 0.0169 0.0236
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Trichomonas vaginalis heat shock protein, putative 0.0238 0.1135 0.6949
Loa Loa (eye worm) hypothetical protein 0.0136 0.0604 0.0604
Echinococcus multilocularis heat shock protein 90 0.0233 0.1109 0.155
Schistosoma mansoni cercarial elastase (S01 family) 0.006 0.0206 0.0599
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0362 0.0506
Echinococcus multilocularis Furin 1 0.0213 0.1006 0.1406
Toxoplasma gondii subtilisin SUB4 0.0041 0.0108 0.069
Brugia malayi Latrophilin receptor protein 2 0.0043 0.0118 0.0118
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0307 0.0891
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0053 0.0169 0.1035
Brugia malayi Furin-like cysteine rich region family protein 0.0125 0.0548 0.0548
Plasmodium falciparum importin beta, putative 0.0028 0.0038 0.0247
Trypanosoma cruzi Heat shock protein 83, putative 0.0285 0.1385 0.1385
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0065 0.0233 0.0676
Echinococcus granulosus neuropeptide receptor 0.0079 0.0307 0.0429
Trypanosoma cruzi heat shock protein 85, putative 0.0233 0.1109 0.1109
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0053 0.0169 0.0169
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0136 0.0604 0.0604
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0079 0.0307 0.0307
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0053 0.0169 0.0169
Brugia malayi hypothetical protein 0.0079 0.0307 0.0307
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0053 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.006 0.0206 0.0206
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0079 0.0307 0.0891
Brugia malayi hypothetical protein 0.0079 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0213 0.1006 0.2922
Leishmania major hypothetical protein, conserved 0.0074 0.0279 0.0279
Leishmania major hypothetical protein, conserved 0.0319 0.156 0.156
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0091 0.0655
Brugia malayi G-protein coupled receptor 0.0079 0.0307 0.0307
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.006 0.0206 0.0288
Loa Loa (eye worm) latrophilin receptor protein 2 0.0043 0.0118 0.0118
Brugia malayi larval opioid receptor 0.0079 0.0307 0.0307
Toxoplasma gondii subtilisin SUB6 0.0041 0.0108 0.069
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0079 0.0307 0.0429
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0091 0.0655
Onchocerca volvulus 0.0028 0.0038 0.0134
Schistosoma mansoni importin beta-1 0.0028 0.0038 0.0112
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0053 0.0169 0.0598
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.0307 0.0429
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0079 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0362 0.0362
Loa Loa (eye worm) TYRA-2 protein 0.0079 0.0307 0.0307
Mycobacterium ulcerans hypothetical protein 0.006 0.0206 0.0958
Echinococcus granulosus transmembrane protease serine 3 0.006 0.0206 0.0288
Loa Loa (eye worm) hypothetical protein 0.0148 0.0665 0.0665
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0079 0.0307 0.0429
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0041 0.0108 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0362 0.1052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Trichomonas vaginalis DNA topoisomerase II, putative 0.0053 0.0169 0.1035
Schistosoma mansoni hypothetical protein 0.0108 0.0456 0.1325
Trypanosoma cruzi heat shock protein 85, putative 0.0285 0.1385 0.1385
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0066 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0307 0.0891
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0666 0.4079
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0079 0.0307 0.0307
Brugia malayi celfurPC protein 0.0485 0.2428 0.2428
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0307 0.0429
Loa Loa (eye worm) acetyltransferase 0.014 0.0627 0.0627
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0307 0.0891
Toxoplasma gondii heat shock protein HSP90 0.0285 0.1385 0.8879
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0213 0.1006 0.6159
Onchocerca volvulus 0.0088 0.0352 0.2168
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0079 0.0307 0.0891
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.0307 0.0891
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0043 0.0118 0.0165
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0279 0.1787
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Toxoplasma gondii Hsp90 domain-containing protein 0.0129 0.0567 0.3636
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0148 0.0665 0.1932
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.006 0.0206 0.0288
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0043 0.0118 0.0165
Echinococcus multilocularis lamin 0.0024 0.0018 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0279 0.0279
Brugia malayi proprotein convertase 2 0.0513 0.2574 0.2574
Echinococcus granulosus 7TM GPCR rhodopsin 0.0079 0.0307 0.0429
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0307 0.0429
Echinococcus multilocularis fmrfamide receptor 0.0079 0.0307 0.0429
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.0307 0.0429
Loa Loa (eye worm) hypothetical protein 0.0148 0.0665 0.0665
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0627 0.0627
Brugia malayi kinase, mitochondrial precursor 0.0053 0.0169 0.0169
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0041 0.0108 0.0108
Onchocerca volvulus 0.0079 0.0307 0.1874
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0053 0.0169 0.0598
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0041 0.0108 0.0108
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0129 0.0567 0.4095
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0627 0.0877
Entamoeba histolytica heat shock protein 90, putative 0.0285 0.1385 1
Brugia malayi RNA, U transporter 1 0.0079 0.0307 0.0307
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0666 0.4079
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0109 0.0666
Chlamydia trachomatis DNA gyrase subunit B 0.0053 0.0169 0.5
Leishmania major hypothetical protein, conserved 0.0053 0.0169 0.0169
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.006 0.0206 0.0599
Brugia malayi Trypsin family protein 0.006 0.0206 0.0206
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Schistosoma mansoni cercarial elastase (S01 family) 0.006 0.0206 0.0599
Echinococcus granulosus enteropeptidase 0.0099 0.0409 0.0572
Echinococcus granulosus lamin dm0 0.0024 0.0018 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0041 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0988 0.5059 0.5059
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Schistosoma mansoni cercarial elastase (S01 family) 0.006 0.0206 0.0599
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Toxoplasma gondii subtilisin SUB2 0.0041 0.0108 0.069
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Onchocerca volvulus 0.0079 0.0307 0.1874
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0213 0.1006 0.6159
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0053 0.0169 0.0598
Schistosoma mansoni myosin xvIII 0.0079 0.0307 0.0891
Onchocerca volvulus 0.0024 0.0018 0.0002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0607 0.0848
Brugia malayi Subtilase family protein 0.0305 0.1487 0.1487
Plasmodium falciparum subtilisin-like protease 3 0.0041 0.0108 0.069
Schistosoma mansoni hypothetical protein 0.0297 0.1448 0.4205
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0238 0.1135 0.1135
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Chlamydia trachomatis DNA gyrase subunit B 0.0053 0.0169 0.5
Mycobacterium ulcerans putative regultory protein 0.0053 0.0169 0.0598
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0041 0.0108 0.0108
Toxoplasma gondii subtilisin SUB8 0.0041 0.0108 0.069
Plasmodium falciparum heat shock protein 90, putative 0.0153 0.0695 0.4453
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Brugia malayi Endoplasmin precursor 0.0285 0.1385 0.1385
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.0307 0.0429
Schistosoma mansoni cercarial elastase (S01 family) 0.006 0.0206 0.0599
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0233 0.1109 0.155
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0108 0.0659
Echinococcus multilocularis G protein coupled receptor 139 0.0079 0.0307 0.0429
Trichomonas vaginalis receptor histidine kinase, putative 0.0053 0.0169 0.1035
Trypanosoma cruzi heat shock protein 85, putative 0.0285 0.1385 0.1385
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Onchocerca volvulus 0.0108 0.0456 0.2842
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Schistosoma mansoni lamin 0.0024 0.0018 0.0051
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0279 0.0279
Schistosoma mansoni cercarial elastase (S01 family) 0.006 0.0206 0.0599
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0079 0.0307 0.0307
Brugia malayi Tachykinin-like peptides receptor 99D 0.0079 0.0307 0.0307
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0053 0.0169 0.1084
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Schistosoma mansoni growth hormone secretagogue receptor 0.0079 0.0307 0.0891
Schistosoma mansoni hypothetical protein 0.006 0.0206 0.0599
Entamoeba histolytica heat shock protein 90, putative 0.0285 0.1385 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0079 0.0307 0.0429
Echinococcus multilocularis cpg binding protein 0.0029 0.0047 0.0065
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0053 0.0169 0.1035
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0333 0.1633 0.2283
Schistosoma mansoni tyrosine kinase 0.0125 0.0548 0.1592
Loa Loa (eye worm) hypothetical protein 0.1933 1 1
Echinococcus granulosus Mastin 0.0099 0.0409 0.0572
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Echinococcus granulosus fmrfamide receptor 0.0079 0.0307 0.0429
Toxoplasma gondii kringle domain-containing protein 0.0319 0.156 1
Echinococcus granulosus allatostatin A receptor 0.0079 0.0307 0.0429
Echinococcus multilocularis geminin 0.0324 0.1589 0.2221
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.3443 0.4812
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.0307 0.0429
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.0307 0.0307
Echinococcus multilocularis heat shock protein 90 0.0285 0.1385 0.1936
Trypanosoma brucei developmentally regulated phosphoprotein 0.0053 0.0169 0.0169
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0279 0.1787
Echinococcus granulosus importin subunit beta 1 0.0028 0.0038 0.0054
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0172 0.0791 0.4844
Schistosoma mansoni amine GPCR 0.0079 0.0307 0.0891
Entamoeba histolytica hypothetical protein 0.0036 0.008 0.0575
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0011 0.0067
Echinococcus granulosus g-protein coupled receptor 0.0079 0.0307 0.0429
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Echinococcus multilocularis somatostatin receptor 0.0079 0.0307 0.0429
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0079 0.0307 0.0429
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Echinococcus multilocularis epidermal growth factor receptor 0.0125 0.0548 0.0766
Loa Loa (eye worm) heat shock protein 90 0.0285 0.1385 0.1385
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.0307 0.0429
Schistosoma mansoni neuropeptide receptor 0.0079 0.0307 0.0891
Loa Loa (eye worm) hypothetical protein 0.0053 0.0169 0.0169
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1389 0.7155 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0456 0.0456
Leishmania major C-8 sterol isomerase-like protein 0.1933 1 1
Brugia malayi neuropeptide F receptor 0.0079 0.0307 0.0307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0307 0.0891
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Brugia malayi MH2 domain containing protein 0.0233 0.111 0.111
Echinococcus granulosus snurportin 1 0.0297 0.1448 0.2023
Onchocerca volvulus 0.0079 0.0307 0.1874
Mycobacterium ulcerans heat shock protein 90 0.0238 0.1135 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0053 0.0169 0.1035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0307 0.0891
Plasmodium vivax importin-beta 2, putative 0.0028 0.0038 0.0247
Mycobacterium tuberculosis Possible two component sensor kinase 0.0053 0.0169 0.0598
Schistosoma mansoni hypothetical protein 0.0043 0.0118 0.0343
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0333 0.1633 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0079 0.0307 0.0429
Loa Loa (eye worm) hypothetical protein 0.0041 0.0108 0.0108
Brugia malayi Dopamine receptor protein 2 0.0079 0.0307 0.0307
Plasmodium falciparum subtilisin-like protease 2 0.0041 0.0108 0.069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0307 0.0891
Schistosoma mansoni opsin-like receptor 0.0079 0.0307 0.0891
Echinococcus granulosus heat shock protein 0.0285 0.1385 0.1936
Echinococcus multilocularis 0.0485 0.2428 0.3394
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.0307 0.0429
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0109 0.0697
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0053 0.0169 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0666 0.4079
Echinococcus granulosus neuropeptide s receptor 0.0471 0.2354 0.329
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0079 0.0307 0.0891
Echinococcus multilocularis neuropeptide receptor 0.0079 0.0307 0.0429
Schistosoma mansoni adenoreceptor 0.0079 0.0307 0.0891
Echinococcus multilocularis snurportin 1 0.0297 0.1448 0.2023
Onchocerca volvulus 0.0079 0.0307 0.1874
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Onchocerca volvulus 0.006 0.0206 0.1222
Echinococcus multilocularis serotonin receptor 0.0079 0.0307 0.0429
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Mycobacterium ulcerans DNA gyrase subunit B 0.0053 0.0169 0.0598
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0018 0.0018
Onchocerca volvulus 0.0079 0.0307 0.1874
Trichomonas vaginalis sensor histidine kinase, putative 0.0053 0.0169 0.1035
Echinococcus granulosus alpha 1A adrenergic receptor 0.0079 0.0307 0.0429
Brugia malayi hypothetical protein 0.0074 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0018
Onchocerca volvulus 0.006 0.0206 0.1222
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.049 0.0685
Loa Loa (eye worm) hypothetical protein 0.006 0.0206 0.0206
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Loa Loa (eye worm) hypothetical protein 0.0633 0.3202 0.3202
Schistosoma mansoni hypothetical protein 0.0043 0.0118 0.0343
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0172 0.0791 0.4844
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0053 0.0169 0.0598
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0053 0.0169 0.0982
Schistosoma mansoni cercarial elastase (S01 family) 0.006 0.0206 0.0599
Loa Loa (eye worm) hypothetical protein 0.0074 0.0279 0.0279
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0079 0.0307 0.0429
Plasmodium vivax endoplasmin, putative 0.0285 0.1385 0.8879
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.1965 0.2747
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0053 0.0169 0.1035
Echinococcus granulosus dro:myosuppressin receptor 0.0079 0.0307 0.0429
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0079 0.0307 0.0307
Mycobacterium tuberculosis Conserved protein 0.0053 0.0169 0.0598
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Schistosoma mansoni neuropeptide receptor 0.0079 0.0307 0.0891
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0053 0.0169 0.0236
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0079 0.0307 0.0307
Schistosoma mansoni furin-1 (S08 family) 0.0341 0.1676 0.4868
Loa Loa (eye worm) TOPoisomerase family member 0.0053 0.0169 0.0169
Schistosoma mansoni cpg binding protein 0.0029 0.0047 0.0135
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0319 0.156 1
Schistosoma mansoni lamin 0.0024 0.0018 0.0051
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0018 0.0018
Brugia malayi Melatonin receptor type 1A 0.0079 0.0307 0.0307
Echinococcus granulosus sex peptide receptor 0.0079 0.0307 0.0429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0307 0.0891
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Schistosoma mansoni lipoxygenase 0.0114 0.049 0.1424
Schistosoma mansoni alpha-1 adrenergic receptor 0.0079 0.0307 0.0891
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0158 0.0721 0.1008
Plasmodium falciparum heat shock protein 90, putative 0.0129 0.0567 0.3636
Schistosoma mansoni hypothetical protein 0.0079 0.0307 0.0891
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Echinococcus multilocularis glycoprotein Antigen 5 0.0099 0.0409 0.0572
Leishmania major DNA topoisomerase ii 0.0053 0.0169 0.0169
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0109 0.0697
Plasmodium falciparum endoplasmin, putative 0.0177 0.0817 0.5238
Schistosoma mansoni endoplasmin 0.0285 0.1385 0.4023
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.2354 0.329
Trypanosoma brucei heat shock protein, putative 0.0285 0.1385 0.1385
Onchocerca volvulus 0.0079 0.0307 0.1874
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Trypanosoma brucei heat shock protein, putative 0.0285 0.1385 0.1385
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0018 0.0018
Brugia malayi neuroendocrine convertase 1 precursor 0.0664 0.3364 0.3364
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.0307 0.0307
Brugia malayi follicle stimulating hormone receptor 0.0079 0.0307 0.0307
Trypanosoma brucei subtilisin peptidase 0.0041 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0175 0.0807 0.0807
Schistosoma mansoni heat shock protein 0.0285 0.1385 0.4023
Schistosoma mansoni hypothetical protein 0.0148 0.0666 0.1935
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Giardia lamblia Grp94/Hsp90 0.0238 0.1135 0.8195
Brugia malayi hypothetical protein 0.0079 0.0307 0.0307
Schistosoma mansoni intermediate filament proteins 0.0024 0.0018 0.0051
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Trichomonas vaginalis heat shock protein, putative 0.0238 0.1135 0.6949
Schistosoma mansoni biogenic amine receptor 0.0079 0.0307 0.0891
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0135 0.0597 0.0834
Onchocerca volvulus 0.0079 0.0307 0.1874
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.008 0.0111
Loa Loa (eye worm) TK/ROR protein kinase 0.0319 0.156 0.156
Schistosoma mansoni endoplasmin 0.0285 0.1385 0.4023
Schistosoma mansoni hypothetical protein 0.0033 0.0066 0.0191
Schistosoma mansoni hypothetical protein 0.0093 0.0379 0.1101
Brugia malayi latrophilin 2 splice variant baaae 0.0093 0.0379 0.0379
Trypanosoma cruzi DNA topoisomerase II, putative 0.0053 0.0169 0.0169
Entamoeba histolytica hypothetical protein 0.0036 0.008 0.0575
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0186 0.1195
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0666 0.4079
Trypanosoma cruzi heat shock protein, putative 0.0158 0.0721 0.0721
Onchocerca volvulus 0.0079 0.0307 0.1874
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0666 0.4079
Schistosoma mansoni pyruvate dehydrogenase 0.0053 0.0169 0.0491
Plasmodium falciparum heat shock protein 90 0.0285 0.1385 0.8879
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0053 0.0169 0.0598
Brugia malayi neuropeptide F receptor 0.0079 0.0307 0.0307
Schistosoma mansoni cpg binding protein 0.0029 0.0047 0.0135
Brugia malayi Trypsin family protein 0.0148 0.0665 0.0665
Trypanosoma brucei heat shock protein, putative 0.0285 0.1385 0.1385
Schistosoma mansoni site-1 peptidase (S08 family) 0.0041 0.0108 0.0313
Echinococcus granulosus endoplasmin 0.0238 0.1135 0.1586
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.111 0.111
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0053 0.0169 0.0169
Brugia malayi Importin beta-1 subunit 0.0028 0.0038 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Schistosoma mansoni cercarial elastase (S01 family) 0.006 0.0206 0.0599
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0079 0.0307 0.0891
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.006 0.0206 0.0288
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Trypanosoma brucei heat shock protein 90, putative 0.0285 0.1385 0.1385
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0079 0.0307 0.0307
Echinococcus granulosus tm gpcr rhodopsin 0.1389 0.7155 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0079 0.0307 0.0429
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Entamoeba histolytica DNA topoisomerase II, putative 0.0053 0.0169 0.1221
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0307 0.0429
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.008 0.0232
Echinococcus multilocularis serotonin receptor 0.0079 0.0307 0.0429
Loa Loa (eye worm) hypothetical protein 0.0093 0.0379 0.0379
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0043 0.0118 0.0118
Echinococcus multilocularis GPCR, family 2 0.0043 0.0118 0.0165
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0213 0.1006 0.6159
Brugia malayi endoprotease bli-4 precursor 0.0633 0.3202 0.3202
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0279 0.1787
Schistosoma mansoni cercarial elastase (S01 family) 0.006 0.0206 0.0599
Toxoplasma gondii subtilisin SUB10 0.0041 0.0108 0.069
Echinococcus granulosus membrane bound transcription factor site 1 0.0041 0.0108 0.015
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0038 0.0038
Onchocerca volvulus 0.006 0.0206 0.1222
Loa Loa (eye worm) proprotein convertase 2 0.0213 0.1006 0.1006
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.1448 0.1448
Echinococcus multilocularis heat shock protein 0.0285 0.1385 0.1936
Schistosoma mansoni amine GPCR 0.0079 0.0307 0.0891
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0148 0.0666 0.4079
Schistosoma mansoni cercarial elastase (S01 family) 0.006 0.0206 0.0599
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0053 0.0169 0.0236
Schistosoma mansoni cercarial elastase (S01 family) 0.006 0.0206 0.0599
Schistosoma mansoni neuropeptide receptor 0.0079 0.0307 0.0891
Loa Loa (eye worm) hypothetical protein 0.006 0.0206 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0666 0.4079
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Echinococcus multilocularis dro:myosuppressin receptor 0.0079 0.0307 0.0429
Echinococcus multilocularis membrane bound transcription factor site 1 0.0041 0.0108 0.015
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Loa Loa (eye worm) trypsin family protein 0.006 0.0206 0.0206
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0158 0.0721 0.456
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Echinococcus granulosus tissue type plasminogen activator 0.0319 0.156 0.218
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0201 0.0585
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0053 0.0169 0.0982
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0038 0.0038
Brugia malayi G protein-coupled receptor 0.0079 0.0307 0.0307
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0053 0.0169 0.1084
Trypanosoma brucei C-8 sterol isomerase, putative 0.1933 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0015
Trypanosoma brucei heat shock protein, putative 0.0285 0.1385 0.1385
Schistosoma mansoni amine GPCR 0.0079 0.0307 0.0891
Giardia lamblia High cysteine membrane protein Group 2 0.0144 0.0645 0.4658
Echinococcus multilocularis neuropeptide receptor 0.0079 0.0307 0.0429
Toxoplasma gondii subtilisin SUB9 0.0041 0.0108 0.069
Brugia malayi hypothetical protein 0.0079 0.0307 0.0307
Trichomonas vaginalis endoplasmin, putative 0.0177 0.0817 0.5002
Schistosoma mansoni hypothetical protein 0.0079 0.0307 0.0891
Entamoeba histolytica hypothetical protein 0.0036 0.008 0.0575
Echinococcus multilocularis Mastin 0.0099 0.0409 0.0572
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0079 0.0307 0.0307
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Echinococcus granulosus hypothetical protein 0.0079 0.0307 0.0429
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0053 0.0169 0.0598
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.2354 0.329
Echinococcus granulosus serotonin receptor 0.0079 0.0307 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0108 0.0659
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Brugia malayi Calcitonin receptor-like protein seb-1 0.0136 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Trichomonas vaginalis heat shock protein, putative 0.0233 0.1109 0.6788
Onchocerca volvulus 0.0041 0.0108 0.0584
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0053 0.0169 0.1084
Onchocerca volvulus Deterin homolog 0.0108 0.0456 0.2842
Schistosoma mansoni hypothetical protein 0.0396 0.1965 0.5708
Trypanosoma cruzi DNA topoisomerase II, putative 0.0053 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0053 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0233 0.1424
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0718 0.3647 0.5097
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0108 0.0456 0.0637
Echinococcus granulosus lamin 0.0024 0.0018 0.0025
Brugia malayi RE15519p 0.0079 0.0307 0.0307
Plasmodium vivax subtilisin-like serine protease, putative 0.0041 0.0108 0.069
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.006 0.0206 0.0599
Trypanosoma cruzi heat shock protein 90, putative 0.0285 0.1385 0.1385
Onchocerca volvulus 0.0148 0.0665 0.4199
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.006 0.0206 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0666 0.4079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0362 0.0506
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.0307 0.0429
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Onchocerca volvulus 0.0079 0.0307 0.1874
Trypanosoma cruzi heat shock protein 90, putative 0.0161 0.0737 0.0737
Toxoplasma gondii heat shock protein 90, putative 0.0285 0.1385 0.8879
Echinococcus multilocularis musashi 0.0024 0.0018 0.0025
Entamoeba histolytica hypothetical protein 0.0023 0.0011 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0108 0.0456 0.0456
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Brugia malayi Protein kinase domain containing protein 0.0319 0.156 0.156
Trypanosoma brucei heat shock protein, putative 0.0285 0.1385 0.1385
Trypanosoma brucei heat shock protein, putative 0.0285 0.1385 0.1385
Mycobacterium ulcerans two component sensor kinase MprB 0.0053 0.0169 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0666 0.4079
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.0307 0.0429
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Schistosoma mansoni hypothetical protein 0.0043 0.0118 0.0343
Loa Loa (eye worm) endoprotease bli-4 0.0633 0.3202 0.3202
Echinococcus granulosus microtubule associated protein 2 0.0679 0.3443 0.4812
Giardia lamblia Heat shock protein HSP 90-alpha 0.0285 0.1385 1
Trichomonas vaginalis heat shock protein, putative 0.0285 0.1385 0.8479
Schistosoma mansoni hypothetical protein 0.0324 0.1589 0.4616
Echinococcus granulosus Furin 1 0.0213 0.1006 0.1406
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.0307 0.0891
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0238 0.1135 1
Plasmodium vivax DNA topoisomerase II, putative 0.0053 0.0169 0.1084
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0108 0.0456 0.0637
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0362 0.0506
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Brugia malayi Kringle domain containing protein 0.0319 0.156 0.156
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0666 0.4079
Echinococcus granulosus orexin receptor type 2 0.0079 0.0307 0.0429
Schistosoma mansoni opsin-like receptor 0.0079 0.0307 0.0891
Schistosoma mansoni biogenic amine receptor 0.0079 0.0307 0.0891
Echinococcus multilocularis tissue type plasminogen activator 0.0319 0.156 0.218
Echinococcus granulosus GPCR family 2 0.0043 0.0118 0.0165
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1933 1 1
Schistosoma mansoni heat shock protein 0.0285 0.1385 0.4023
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0053 0.0169 0.0598
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.0307 0.0891
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0307 0.0891
Echinococcus granulosus peptide allatostatin:somatostatin 0.0079 0.0307 0.0429
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.0307 0.0429
Onchocerca volvulus 0.0079 0.0307 0.1874
Trichomonas vaginalis hypothetical protein 0.0148 0.0666 0.4079
Echinococcus granulosus inhibitor of apoptosis protein 0.0108 0.0456 0.0637
Echinococcus granulosus furin 0.0633 0.3202 0.4475
Echinococcus granulosus glycoprotein Antigen 5 0.0099 0.0409 0.0572
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0079 0.0307 0.0891
Onchocerca volvulus 0.0079 0.0307 0.1874
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.006 0.0206 0.0599
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0041 0.0108 0.0108
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0307 0.0429
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0043 0.0118 0.0165
Trypanosoma cruzi subtilisin peptidase 0.0041 0.0108 0.0108
Brugia malayi intermediate filament protein 0.0024 0.0018 0.0018
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.0307 0.0429
Trypanosoma cruzi hypothetical protein, conserved 0.0319 0.156 0.156
Brugia malayi sulfakinin receptor protein 0.0079 0.0307 0.0307
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0633 0.3202 0.93
Echinococcus multilocularis transmembrane protease serine 3 0.006 0.0206 0.0288
Brugia malayi CXXC zinc finger family protein 0.0028 0.0038 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0041 0.0108 0.0659
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0307 0.0429
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0079 0.0307 0.0891
Trypanosoma cruzi heat shock protein 85, putative 0.0285 0.1385 0.1385
Echinococcus multilocularis neuroendocrine convertase 2 0.0513 0.2574 0.3598
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Echinococcus multilocularis sex peptide receptor 0.0079 0.0307 0.0429
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0053 0.0169 0.1035
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0108 0.0659
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0053 0.0169 0.1084
Loa Loa (eye worm) endoplasmin 0.0285 0.1385 0.1385
Treponema pallidum heat shock protein 90 0.0238 0.1135 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.006 0.0206 0.0288
Schistosoma mansoni inhibitor of apoptosis protein 0.0108 0.0456 0.1325
Brugia malayi hypothetical protein 0.006 0.0206 0.0206
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.0307 0.0429
Loa Loa (eye worm) TK/EGFR protein kinase 0.0125 0.0548 0.0548
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0053 0.0169 0.0598
Brugia malayi Trypsin-like protease protein 5 0.006 0.0206 0.0206
Toxoplasma gondii subtilisin SUB5 0.0041 0.0108 0.069
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.006 0.0206 0.0599
Schistosoma mansoni hypothetical protein 0.006 0.0206 0.0599
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0091 0.0582
Onchocerca volvulus 0.006 0.0206 0.1222
Schistosoma mansoni hypothetical protein 0.0036 0.008 0.0232
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0053 0.0169 0.0169
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.0307 0.0429
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0307 0.0429
Brugia malayi AKH receptor 0.0079 0.0307 0.0307
Toxoplasma gondii subtilisin SUB7 0.0041 0.0108 0.069
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Toxoplasma gondii subtilisin SUB1 0.0041 0.0108 0.069
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0053 0.0169 0.0598
Loa Loa (eye worm) hypothetical protein 0.0079 0.0307 0.0307
Schistosoma mansoni amine GPCR 0.0079 0.0307 0.0891
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0333 0.1633 0.2283
Brugia malayi Serotonin receptor 0.0079 0.0307 0.0307
Onchocerca volvulus 0.0079 0.0307 0.1874
Leishmania major developmentally regulated phosphoprotein-like protein 0.0053 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0319 0.156 0.156
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0053 0.0169 0.0598
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0108 0.0456 0.0456
Brugia malayi hypothetical protein 0.0079 0.0307 0.0307
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.0307 0.0891
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.111 0.111
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0011 0.0067
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Leishmania major heat shock protein 83-1 0.0285 0.1385 0.1385
Trypanosoma brucei heat shock protein 90, putative 0.0285 0.1385 0.1385
Brugia malayi heat shock protein 90 0.0285 0.1385 0.1385
Schistosoma mansoni biogenic amine receptor 0.0079 0.0307 0.0891
Mycobacterium tuberculosis Probable two component sensor kinase 0.0053 0.0169 0.0598
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0053 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.006 0.0206 0.0206
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0109 0.0666
Schistosoma mansoni neuropeptide f receptor 76f 0.0079 0.0307 0.0891
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0079 0.0307 0.0891
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0053 0.0169 0.0598

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2 nM Ability to displace endothelin ([125I]-ET-1) from endothelin A receptor derived from MMQ cells of rodent. ChEMBL. 9379441
IC50 (binding) = 2 nM Ability to displace endothelin ([125I]-ET-1) from endothelin A receptor derived from MMQ cells of rodent. ChEMBL. 9379441
IC50 (binding) = 60 nM Ability to displace endothelin ([125I]-ET-3) from endothelin B receptor derived from cerebellar tissue of porcine. ChEMBL. 9379441
IC50 (binding) = 60 nM Ability to displace endothelin ([125I]-ET-3) from endothelin B receptor derived from cerebellar tissue of porcine. ChEMBL. 9379441
Ratio (binding) = 30 Ratio of endothelin A receptor and endothelin B receptor. ChEMBL. 9379441
Ratio (binding) = 30 Ratio of endothelin A receptor and endothelin B receptor. ChEMBL. 9379441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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