Detailed information for compound 1809864

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.42 | Formula: C22H20N4O2
  • H donors: 3 H acceptors: 2 LogP: 2.08 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC[C@@H]1Cn2c(C1)c(c1c2cccc1)C1=C(Nc2ccccc2)C(=O)NC1=O
  • InChi: 1S/C22H20N4O2/c23-11-13-10-17-18(15-8-4-5-9-16(15)26(17)12-13)19-20(22(28)25-21(19)27)24-14-6-2-1-3-7-14/h1-9,13H,10-12,23H2,(H2,24,25,27,28)/t13-/m1/s1
  • InChiKey: VCGDMSXJUNSZGP-CYBMUJFWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase C, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.5845 0.5829
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0043 0.5845 0.5829
Brugia malayi putative neuropeptide receptor 0.0043 0.5845 0.71
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Onchocerca volvulus 0.0043 0.5845 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0043 0.5845 0.5829
Brugia malayi hypothetical protein 0.0043 0.5845 0.71
Onchocerca volvulus 0.0043 0.5845 0.5
Echinococcus multilocularis protein kinase c iota type 0.0018 0.1328 0.1293
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus multilocularis protein kinase c epsilon type 0.0019 0.1595 0.1562
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Loa Loa (eye worm) hypothetical protein 0.0055 0.791 1
Brugia malayi neuropeptide F receptor 0.0043 0.5845 0.71
Schistosoma mansoni biogenic amine (5HT) receptor 0.0043 0.5845 0.5829
Trichomonas vaginalis AGC family protein kinase 0.001 0.0039 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.5845 0.5829
Schistosoma mansoni histamine h1 receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis sex peptide receptor 0.0043 0.5845 0.5829
Schistosoma mansoni amine GPCR 0.0043 0.5845 0.5829
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0043 0.5845 0.71
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Onchocerca volvulus 0.0043 0.5845 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.6622 0.8363
Brugia malayi hypothetical protein 0.0043 0.5845 0.71
Schistosoma mansoni neuropeptide receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.1595 0.1562
Echinococcus granulosus G protein coupled receptor 139 0.0043 0.5845 0.5829
Echinococcus granulosus peptide allatostatin:somatostatin 0.0043 0.5845 0.5829
Brugia malayi larval opioid receptor 0.0043 0.5845 0.71
Echinococcus granulosus neuropeptide s receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis allatostatin A receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus multilocularis serotonin receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.5845 0.7377
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Toxoplasma gondii AGC kinase 0.001 0.0039 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.5845 0.5829
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Onchocerca volvulus 0.0043 0.5845 0.5
Echinococcus granulosus neuropeptide receptor 0.0043 0.5845 0.5829
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0043 0.5845 0.5829
Onchocerca volvulus 0.0043 0.5845 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis serine threonine protein kinase 0.0059 0.8712 0.8707
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.5845 0.7377
Schistosoma mansoni amine GPCR 0.0043 0.5845 0.5829
Schistosoma mansoni hypothetical protein 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.5845 0.5829
Onchocerca volvulus 0.0043 0.5845 0.5
Onchocerca volvulus 0.0043 0.5845 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.5845 0.5829
Brugia malayi hypothetical protein 0.0043 0.5845 0.71
Schistosoma mansoni adenoreceptor 0.0043 0.5845 0.5829
Brugia malayi Serotonin receptor 0.0043 0.5845 0.71
Echinococcus multilocularis neuropeptide FF receptor 2 0.0043 0.5845 0.5829
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0043 0.5845 0.5829
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.5845 0.5829
Schistosoma mansoni biogenic amine receptor 0.0043 0.5845 0.5829
Entamoeba histolytica protein kinase, putative 0.001 0.0039 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Onchocerca volvulus 0.0043 0.5845 0.5
Onchocerca volvulus 0.0043 0.5845 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.5845 0.5829
Trichomonas vaginalis AGC family protein kinase 0.001 0.0039 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0043 0.5845 0.5829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.5845 0.5829
Echinococcus granulosus 7TM GPCR rhodopsin 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Schistosoma mansoni neuropeptide f receptor 76f 0.0043 0.5845 0.5829
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0043 0.5845 0.7377
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.6622 0.6609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.5845 0.5829
Echinococcus multilocularis neuropeptide receptor 0.0043 0.5845 0.5829
Brugia malayi sulfakinin receptor protein 0.0043 0.5845 0.71
Brugia malayi G-protein coupled receptor 0.0043 0.5845 0.71
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Brugia malayi Dopamine receptor protein 1 0.0043 0.5845 0.71
Brugia malayi Protein kinase c protein 2 0.0057 0.8217 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0043 0.5845 0.5
Echinococcus granulosus fmrfamide receptor 0.0043 0.5845 0.5829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.5845 0.5829
Brugia malayi hypothetical protein 0.0043 0.5845 0.71
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0043 0.5845 0.71
Brugia malayi G protein-coupled receptor F59B2.13 0.0043 0.5845 0.71
Schistosoma mansoni neuropeptide receptor 0.0043 0.5845 0.5829
Brugia malayi follicle stimulating hormone receptor 0.0043 0.5845 0.71
Trichomonas vaginalis AGC family protein kinase 0.001 0.0039 1
Onchocerca volvulus 0.0043 0.5845 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0067 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0043 0.5845 0.5829
Schistosoma mansoni biogenic amine receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Brugia malayi putative neuropeptide receptor NPR1 0.0043 0.5845 0.71
Schistosoma mansoni biogenic amine receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis somatostatin receptor 0.0043 0.5845 0.5829
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Echinococcus granulosus neuropeptide receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) TYRA-2 protein 0.0043 0.5845 0.7377
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Schistosoma mansoni atypical protein kinase C 0.0018 0.1328 0.1293
Echinococcus multilocularis orexin receptor type 2 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0019 0.1595 0.1977
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0043 0.5845 0.5829
Entamoeba histolytica protein kinase, putative 0.001 0.0039 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0043 0.5845 0.5829
Echinococcus multilocularis neuropeptide receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Schistosoma mansoni biogenic amine (5HT) receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0043 0.5845 0.5829
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis g protein coupled receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0043 0.5845 0.5829
Echinococcus granulosus 7tm_1 domain containing protein 0.0043 0.5845 0.5829
Schistosoma mansoni neuropeptide receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Brugia malayi hypothetical protein 0.0043 0.5845 0.71
Brugia malayi hypothetical protein 0.0043 0.5845 0.71
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Schistosoma mansoni myosin xvIII 0.0043 0.5845 0.5829
Echinococcus multilocularis G protein coupled receptor 139 0.0043 0.5845 0.5829
Trichomonas vaginalis AGC family protein kinase 0.001 0.0039 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0043 0.5845 0.5829
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0043 0.5845 0.71
Trichomonas vaginalis AGC family protein kinase 0.001 0.0039 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.5845 0.5829
Echinococcus granulosus neuropeptide receptor A26 0.0043 0.5845 0.5829
Echinococcus granulosus allatostatin A receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0043 0.5845 0.5829
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0043 0.5845 0.5829
Brugia malayi GnHR receptor homolog 0.0043 0.5845 0.71
Schistosoma mansoni serine/threonine protein kinase 0.0067 1 1
Schistosoma mansoni hypothetical protein 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0043 0.5845 0.71
Echinococcus granulosus somatostatin receptor 0.0043 0.5845 0.5829
Echinococcus granulosus hypothetical protein 0.0043 0.5845 0.5829
Trichomonas vaginalis AGC family protein kinase 0.001 0.0039 1
Brugia malayi hypothetical protein 0.0043 0.5845 0.71
Schistosoma mansoni amine GPCR 0.0043 0.5845 0.5829
Brugia malayi Tachykinin-like peptides receptor 99D 0.0043 0.5845 0.71
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.5845 0.7377
Echinococcus granulosus neuropeptide FF receptor 2 0.0043 0.5845 0.5829
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus granulosus serotonin receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0067 1 1
Brugia malayi Dopamine receptor protein 2 0.0043 0.5845 0.71
Onchocerca volvulus 0.0043 0.5845 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0043 0.5845 0.7377
Echinococcus multilocularis fmrfamide receptor 0.0043 0.5845 0.5829
Trichomonas vaginalis AGC family protein kinase 0.001 0.0039 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Brugia malayi G protein-coupled receptor 0.0043 0.5845 0.71
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0043 0.5845 0.5829
Echinococcus granulosus protein kinase c epsilon type 0.0019 0.1595 0.1562
Schistosoma mansoni opsin-like receptor 0.0043 0.5845 0.5829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.5845 0.5829
Echinococcus granulosus dro:myosuppressin receptor 0.0043 0.5845 0.5829
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0043 0.5845 0.5829
Schistosoma mansoni opsin-like receptor 0.0043 0.5845 0.5829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.5845 0.5829
Onchocerca volvulus 0.0043 0.5845 0.5
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0049 0.6929 0.8753
Brugia malayi Dopamine receptor 0.0043 0.5845 0.71
Trichomonas vaginalis AGC family protein kinase 0.001 0.0039 1
Brugia malayi neuropeptide F receptor 0.0043 0.5845 0.71
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0043 0.5845 0.5829
Brugia malayi ORL1-like opioid receptor 0.0043 0.5845 0.71
Trichomonas vaginalis AGC family protein kinase 0.001 0.0039 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0043 0.5845 0.7377
Echinococcus granulosus g protein coupled receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Onchocerca volvulus 0.0043 0.5845 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0043 0.5845 0.5829
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.5845 0.5829
Schistosoma mansoni hypothetical protein 0.0043 0.5845 0.5829
Echinococcus granulosus protein kinase c iota type 0.0018 0.1328 0.1293
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.5845 0.5829
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.6622 0.6609
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Trichomonas vaginalis AGC family protein kinase 0.001 0.0039 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Echinococcus multilocularis g protein coupled receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0043 0.5845 0.7377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.5845 0.5829
Echinococcus granulosus alpha 1A adrenergic receptor 0.0043 0.5845 0.5829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.5845 0.5829
Onchocerca volvulus 0.0043 0.5845 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.5845 0.5829
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0043 0.5845 0.5829
Onchocerca volvulus 0.0043 0.5845 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.5845 0.7377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.5845 0.5829
Echinococcus multilocularis fmrfamide receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0043 0.5845 0.5829
Entamoeba histolytica protein kinase, putative 0.001 0.0039 0.5
Schistosoma mansoni amine GPCR 0.0043 0.5845 0.5829
Echinococcus granulosus sex peptide receptor 0.0043 0.5845 0.5829
Echinococcus granulosus g protein coupled receptor 0.0043 0.5845 0.5829
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0043 0.5845 0.5829
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0043 0.5845 0.71
Brugia malayi G-protein coupled receptor 0.0043 0.5845 0.71
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Brugia malayi Melatonin receptor type 1A 0.0043 0.5845 0.71
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.5845 0.5829
Echinococcus granulosus tachykinin peptides receptor 99D 0.0043 0.5845 0.5829
Schistosoma mansoni growth hormone secretagogue receptor 0.0043 0.5845 0.5829
Echinococcus granulosus orexin receptor type 2 0.0043 0.5845 0.5829
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Echinococcus multilocularis g-protein coupled receptor 0.0043 0.5845 0.5829
Schistosoma mansoni opsin-like receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Schistosoma mansoni hypothetical protein 0.0043 0.5845 0.5829
Entamoeba histolytica protein kinase, putative 0.001 0.0039 0.5
Trypanosoma brucei rac serine-threonine kinase, putative 0.001 0.0039 0.5
Onchocerca volvulus 0.0043 0.5845 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0043 0.5845 0.7377
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Brugia malayi Serotonin receptor 0.0043 0.5845 0.71
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Brugia malayi hypothetical protein 0.0043 0.5845 0.71
Echinococcus granulosus protein kinase C gamma type 0.0059 0.8712 0.8707
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Schistosoma mansoni amine GPCR 0.0043 0.5845 0.5829
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.6622 0.6609
Brugia malayi AKH receptor 0.0043 0.5845 0.71
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus granulosus g-protein coupled receptor 0.0043 0.5845 0.5829
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0043 0.5845 0.5829
Echinococcus multilocularis G-protein coupled receptor, putative 0.0043 0.5845 0.5829
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.5845 0.5829
Echinococcus multilocularis serotonin receptor 0.0043 0.5845 0.5829
Schistosoma mansoni neuropeptide receptor 0.0043 0.5845 0.5829
Brugia malayi hypothetical protein 0.0043 0.5845 0.71
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0043 0.5845 0.5829
Echinococcus granulosus biogenic amine 5HT receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Brugia malayi hypothetical protein 0.0043 0.5845 0.71
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.5845 0.5829
Onchocerca volvulus 0.0043 0.5845 0.5
Trichomonas vaginalis AGC family protein kinase 0.001 0.0039 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0043 0.5845 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.5845 0.5829
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.5845 0.5829
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0043 0.5845 0.7377
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.5845 0.5829
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.5845 0.5829
Echinococcus multilocularis g protein coupled receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Echinococcus granulosus g protein coupled receptor 0.0043 0.5845 0.5829
Schistosoma mansoni alpha-1 adrenergic receptor 0.0043 0.5845 0.5829
Loa Loa (eye worm) hypothetical protein 0.0043 0.5845 0.7377
Brugia malayi RE15519p 0.0043 0.5845 0.71
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.5845 0.5829
Brugia malayi protein kinase C II. 0.0019 0.1595 0.1903

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8.85 Inhibition of PKCbeta2 (unknown origin) ChEMBL. No reference
IC50 (binding) = 1.4 nM Inhibition of PKCbeta2 (unknown origin) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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