Detailed information for compound 1809915

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 543.653 | Formula: C32H37N3O5
  • H donors: 1 H acceptors: 1 LogP: 7.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1cc(N/N=C/c2ccc(cc2)O[C@H]2O[C@@H]3O[C@@]4(C)CC[C@@H]5[C@]3([C@H]([C@H]2C)CC[C@H]5C)OO4)c2c(n1)cccc2
  • InChi: 1S/C32H37N3O5/c1-19-9-14-26-21(3)29(37-30-32(26)25(19)15-16-31(4,38-30)39-40-32)36-23-12-10-22(11-13-23)18-33-35-28-17-20(2)34-27-8-6-5-7-24(27)28/h5-8,10-13,17-19,21,25-26,29-30H,9,14-16H2,1-4H3,(H,34,35)/b33-18+/t19-,21-,25+,26+,29+,30-,31-,32-/m1/s1
  • InChiKey: WZVHVYABNBLYPV-HFNBMXKMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum cysteine proteinase falcipain 2a Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax vivapain-3 cysteine proteinase falcipain 2a 484 aa 497 aa 45.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Onchocerca volvulus 0.0027 0.0261 0.0179
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0261 0.0179
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0515 1 1
Onchocerca volvulus 0.0515 1 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0515 1 1
Echinococcus granulosus tyrosine kinase 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0515 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0515 1 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Loa Loa (eye worm) TK/ACK protein kinase 0.0515 1 1
Plasmodium vivax vivapain-2 0.0027 0.0261 0.0261
Onchocerca volvulus 0.0027 0.0261 0.0179
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0515 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0261 0.0261
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0515 1 1
Echinococcus granulosus insulin receptor 0.0515 1 1
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0515 1 1
Echinococcus granulosus protein kinase 0.0515 1 1
Entamoeba histolytica hypothetical protein 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Echinococcus multilocularis insulin receptor 0.0515 1 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0515 1 1
Echinococcus granulosus activated cdc42 kinase 1 0.0515 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0261 0.0261
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0261 0.0261
Trichomonas vaginalis AGC family protein kinase 0.0515 1 1
Trypanosoma cruzi protein kinase, putative 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Schistosoma mansoni protein tyrosine kinase 0.0515 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0261 0.0261
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0515 1 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0515 1 1
Brugia malayi ephrin receptor 1 precursor 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0515 1 1
Brugia malayi hypothetical protein 0.0515 1 1
Onchocerca volvulus 0.0027 0.0261 0.0179
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0261 0.0261
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0515 1 1
Schistosoma mansoni protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0515 1 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0515 1 1
Schistosoma mansoni protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0261 0.0261
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0261 0.0261
Echinococcus multilocularis tyrosine protein kinase Blk 0.0515 1 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0515 1 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0515 1 1
Plasmodium falciparum protein kinase, putative 0.0515 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0515 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0515 1 1
Onchocerca volvulus 0.0515 1 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0515 1 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0261 0.0261
Plasmodium vivax tyrosine kinase-like protein, putative 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0261 0.0179
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Echinococcus granulosus protein tyrosine kinase 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Trypanosoma brucei protein kinase, putative 0.0515 1 1
Schistosoma mansoni tyrosine protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0261 0.0261
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Schistosoma mansoni protein kinase 0.0515 1 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0515 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0515 1 1
Schistosoma mansoni ephrin receptor 0.0515 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0261 0.0261
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0261 0.0261
Loa Loa (eye worm) protein kinase domain-containing protein 0.0515 1 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0515 1 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Schistosoma mansoni ephrin receptor 0.0515 1 1
Echinococcus multilocularis tyrosine kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.0261 0.0261
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.0261 0.0261
Loa Loa (eye worm) TK/EGFR protein kinase 0.0515 1 1
Echinococcus multilocularis integrin linked protein kinase 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Entamoeba histolytica hypothetical protein 0.0515 1 1
Echinococcus multilocularis heat shock protein 70 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trichomonas vaginalis protein kinase atn1, putative 0.0515 1 1
Brugia malayi Furin-like cysteine rich region family protein 0.0515 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0261 0.0261
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Toxoplasma gondii STE kinase 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Onchocerca volvulus 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Trichomonas vaginalis STE family protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0515 1 1
Echinococcus granulosus activin receptor type 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0515 1 1
Loa Loa (eye worm) fibroinase 0.0027 0.0261 0.0179
Giardia lamblia Kinase, NEK 0.0515 1 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Schistosoma mansoni protein kinase 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase shark 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0261 0.0261
Trypanosoma brucei Flagellum attachment zone protein 20 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Brugia malayi C-terminal src kinase protein 1 0.0515 1 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0515 1 1
Schistosoma mansoni serine/threonine RGC 0.0515 1 1
Entamoeba histolytica cysteine surface protein, putative 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.0261 0.0179
Loa Loa (eye worm) TK protein kinase 0.0515 1 1
Echinococcus multilocularis activated cdc42 kinase 1 0.0515 1 1
Echinococcus multilocularis tyrosine kinase 0.0515 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0515 1 1
Echinococcus multilocularis activin receptor type 0.0515 1 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0018 0.0083 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0083 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0515 1 1
Entamoeba histolytica tyrosin kinase, putative 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Entamoeba histolytica hypothetical protein 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0083 0.0083
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Entamoeba histolytica hypothetical protein 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Brugia malayi Raf kinase 0.0515 1 1
Entamoeba histolytica ankyrin repeat protein 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Loa Loa (eye worm) TK/INSR protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Entamoeba histolytica receptor protein kinase, putative 0.0515 1 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0515 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.0261 0.0261
Onchocerca volvulus 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0515 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0515 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0261 0.0261
Echinococcus multilocularis kinase suppressor of Ras 1 0.0515 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0261 0.0261
Schistosoma mansoni protein kinase 0.0515 1 1
Brugia malayi cathepsin L-like precursor 0.0018 0.0083 0.0083
Entamoeba histolytica tyrosin kinase, putative 0.0515 1 1
Echinococcus multilocularis transfer RNA-Thr 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0515 1 1
Onchocerca volvulus 0.0027 0.0261 0.0179
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Loa Loa (eye worm) TK protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Leishmania major protein kinase, putative 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0515 1 1
Echinococcus multilocularis protein tyrosine kinase 0.0515 1 1
Loa Loa (eye worm) TK/Met protein kinase 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Trypanosoma cruzi protein kinase, putative 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0515 1 1
Entamoeba histolytica hypothetical protein 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Giardia lamblia Protein 21.1 0.0515 1 0.5
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0083 0.0083
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Echinococcus granulosus c src tyrosine kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Echinococcus granulosus cathepsin l1 0.0018 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Loa Loa (eye worm) TK protein kinase 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Brugia malayi SRC-1 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Loa Loa (eye worm) TK protein kinase 0.0515 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0261 0.0261
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Schistosoma mansoni protein kinase 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0515 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Onchocerca volvulus 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Onchocerca volvulus 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0515 1 1
Entamoeba histolytica hypothetical protein 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Entamoeba histolytica tyrosin kinase, putative 0.0515 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0515 1 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0515 1 1
Echinococcus granulosus activated cdc42 kinase 1 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Onchocerca volvulus Cathepsin F homolog 0.0027 0.0261 0.0179
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Onchocerca volvulus 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Brugia malayi bone morphogenetic protein type 1 receptor 0.0515 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0261 0.0261
Brugia malayi Guanylyl cyclase protein 23 0.0515 1 1
Echinococcus granulosus tyrosine kinase 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0515 1 1
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0515 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Onchocerca volvulus 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0515 1 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0515 1 1
Schistosoma mansoni protein kinase 0.0515 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0515 1 1
Echinococcus multilocularis protein kinase 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Echinococcus granulosus tyrosine protein kinase 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Schistosoma mansoni protein kinase 0.0515 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0515 1 1
Plasmodium falciparum tyrosine kinase-like protein 0.0515 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0261 0.0261
Brugia malayi SH2 domain containing protein 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0515 1 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Brugia malayi protein-tyrosine kinase 0.0515 1 1
Entamoeba histolytica hypothetical protein 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0515 1 1
Echinococcus multilocularis FL cytokine receptor 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica hypothetical protein 0.0515 1 1
Onchocerca volvulus Tyrosine kinase homolog 0.0515 1 1
Onchocerca volvulus 0.0027 0.0261 0.0179
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0515 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Loa Loa (eye worm) TK protein kinase 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0515 1 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0515 1 1
Trypanosoma brucei Pseudokinase, putative 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0261 0.0261
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Brugia malayi Tyrosine-protein kinase PR2 0.0515 1 1
Trichomonas vaginalis TK family protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0261 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0261 0.0261
Echinococcus granulosus tyrosine protein kinase Fyn 0.0515 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0515 1 1
Schistosoma mansoni hypothetical protein 0.0515 1 1
Schistosoma mansoni protein kinase 0.0515 1 1
Loa Loa (eye worm) TK protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Toxoplasma gondii protein kinase 0.0515 1 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0261 0.0261
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0515 1 1
Entamoeba histolytica tyrosin kinase, putative 0.0515 1 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0515 1 1
Plasmodium falciparum protein kinase, putative 0.0515 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0261 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0261 0.0261
Loa Loa (eye worm) SRC-1 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0261 0.0261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0261 0.0261
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0515 1 1
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0515 1 1
Plasmodium vivax vivapain-2 0.0027 0.0261 0.0261
Loa Loa (eye worm) TK protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Echinococcus multilocularis cysteine protease 0.0027 0.0261 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0261 0.0261
Loa Loa (eye worm) RGC/RGC protein kinase 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0515 1 1
Onchocerca volvulus 0.0027 0.0261 0.0179
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Onchocerca volvulus 0.0515 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0515 1 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0261 0.0261
Onchocerca volvulus 0.0515 1 1
Onchocerca volvulus 0.0515 1 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0083 0.0083
Echinococcus multilocularis c src tyrosine kinase 0.0515 1 1
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Entamoeba histolytica receptor protein kinase, putative 0.0515 1 1
Schistosoma mansoni protein kinase 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0261 0.0261
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0515 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0515 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Leishmania major hypothetical protein, conserved 0.0515 1 1
Onchocerca volvulus 0.0027 0.0261 0.0179
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0261 0.0179
Echinococcus multilocularis tyrosine protein kinase 0.0515 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0515 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0515 1 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0261 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0261 0.0261
Plasmodium falciparum tyrosine kinase-like protein 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0515 1 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0515 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0261 0.0261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0261 0.0261
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0515 1 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0515 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0083 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0515 1 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0515 1 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0515 1 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0515 1 1
Echinococcus multilocularis protein kinase 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0515 1 1
Echinococcus granulosus tyrosine kinase 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0515 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0515 1 1
Entamoeba histolytica hypothetical protein 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Leishmania major protein kinase, putative 0.0515 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica ankyrin repeat protein 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0261 0.0261
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0515 1 1
Echinococcus multilocularis cysteine protease 0.0027 0.0261 0.0261
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0515 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0515 1 1
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0261 0.0179
Brugia malayi Cathepsin L-like precursor 0.0027 0.0261 0.0261
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0515 1 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0261 0.0261
Loa Loa (eye worm) TK protein kinase 0.0515 1 1
Brugia malayi hypothetical protein 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0515 1 1
Echinococcus granulosus cathepsin l1 0.0027 0.0261 0.0261
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Plasmodium falciparum protein kinase, putative 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0515 1 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0515 1 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0515 1 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0515 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Brugia malayi Receptor family ligand binding region containing protein 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica hypothetical protein 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 1 1
Onchocerca volvulus 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0515 1 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0515 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0515 1 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0515 1 1
Loa Loa (eye worm) TK protein kinase 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0515 1 1
Onchocerca volvulus 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0261 0.0261
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0261 0.0261
Brugia malayi hypothetical protein 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Echinococcus granulosus integrin linked protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0261 0.0261
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.0261 0.0261
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0261 0.0261
Loa Loa (eye worm) RGC/RGC protein kinase 0.0515 1 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0515 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0515 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Toxoplasma gondii protein kinase domain-containing protein 0.0515 1 1
Brugia malayi integrin-linked kinase 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0261 0.0261
Plasmodium vivax protein kinase, putative 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0261 0.0261
Loa Loa (eye worm) cysteine protease 0.0027 0.0261 0.0179
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Onchocerca volvulus 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Brugia malayi SH2 domain containing protein 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0515 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0515 1 1
Loa Loa (eye worm) ctsf protein 0.0027 0.0261 0.0179
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Giardia lamblia Kinase 0.0515 1 0.5
Entamoeba histolytica hypothetical protein 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0261 0.0261
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Schistosoma mansoni protein kinase 0.0515 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0515 1 1
Loa Loa (eye worm) TK protein kinase 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0515 1 1
Schistosoma mansoni tyrosine kinase 0.0515 1 1
Entamoeba histolytica protein kinase, putative 0.0515 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0515 1 1
Giardia lamblia Kinase, NEK 0.0515 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Trichomonas vaginalis TKL family protein kinase 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Brugia malayi Protein kinase domain containing protein 0.0515 1 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0515 1 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0515 1 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0515 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0515 1 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0515 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0515 1 1
Onchocerca volvulus 0.0515 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.89 uM Inhibition of Plasmodium falciparum recombinant falcipain 2 expressed in Escherichia coli using Z-Leu-Arg-AMC as substrate incubated for 30 min prior to substrate addition measured for 30 min by fluorometric analysis ChEMBL. No reference
Inhibition (binding) = 94.06 % Inhibition of Plasmodium falciparum recombinant falcipain 2 expressed in Escherichia coli using Z-Leu-Arg-AMC as substrate at 10 uM incubated for 30 min prior to substrate addition measured for 30 min by fluorometric analysis ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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