TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 425.603 | Formula: C27H39NO3
H donors: 1 H acceptors: 1 LogP: 5.14 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: O[C@H](CN1CCCCC1)COc1ccccc1[C@H](OC(C)(C)C)CCc1ccccc1
InChi: 1S/C27H39NO3/c1-27(2,3)31-26(17-16-22-12-6-4-7-13-22)24-14-8-9-15-25(24)30-21-23(29)20-28-18-10-5-11-19-28/h4,6-9,12-15,23,26,29H,5,10-11,16-21H2,1-3H3/t23-,26-/m1/s1
InChiKey: FOPMMEATYUWXQX-ZEQKJWHPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glyco protein 6, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	ABC transporter family protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania braziliensis	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-5	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium berghei	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium falciparum	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Onchocerca volvulus		Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Bile salt export pump, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium vivax	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium yoelii	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	smdr2	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	ATP-binding cassette, sub-family B (MDR/TAP), member 4, related	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium parvum	ATP-binding cassette transporter	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium hominis	ATP-binding cassette protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ATP-binding cassette sub-family B member 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	taga, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium knowlesi	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0102	0.3452	0.4436
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0146	0.1744
Echinococcus granulosus	dro:myosuppressin receptor	0.0102	0.3452	0.3452
Echinococcus multilocularis	serotonin receptor	0.0102	0.3452	0.3452
Trypanosoma cruzi	small ubiquitin protein, putative	0.0031	0.0835	0.2855
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0102	0.3452	0.3452
Echinococcus granulosus	ubiquitin	0.0019	0.039	0.039
Giardia lamblia	Sentrin	0.0031	0.0835	1
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0013	0.0146	0.023
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0016	0.028	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Schistosoma mansoni	cell polarity protein	0.0011	0.0097	0.0124
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0118	0.0201
Echinococcus granulosus	Protein kinase C brain isozyme	0.0028	0.0704	0.0704
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0102	0.3452	0.3452
Trypanosoma cruzi	small ubiquitin protein, putative	0.0031	0.0835	0.2855
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0097	0.0153
Echinococcus multilocularis	neuropeptide Y receptor	0.0102	0.3452	0.3452
Onchocerca volvulus		0.0011	0.0096	0.0279
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0012	0.0118	0.0118
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0146	0.1744
Onchocerca volvulus		0.0102	0.3452	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0102	0.3452	1
Brugia malayi	hypothetical protein	0.0102	0.3452	0.5853
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.028	0.036
Onchocerca volvulus		0.0011	0.0097	0.0281
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.3452	0.4436
Trichomonas vaginalis	ubiquitin, putative	0.0019	0.039	0.4674
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0102	0.3452	0.4436
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.028	0.3358
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Schistosoma mansoni	hypothetical protein	0.0102	0.3452	0.4436
Echinococcus granulosus	allatostatin A receptor	0.0102	0.3452	0.3452
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Echinococcus multilocularis	allatostatin A receptor	0.0102	0.3452	0.3452
Schistosoma mansoni	protein kinase C mu	0.0011	0.0096	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0146	0.1744
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.028	0.3358
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.0146	0.0146
Echinococcus granulosus	g protein coupled receptor	0.0102	0.3452	0.3452
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0011	0.0096	0.0096
Trypanosoma brucei	small ubiquitin-related modifier	0.0031	0.0835	0.1073
Echinococcus granulosus	orexin receptor type 2	0.0102	0.3452	0.3452
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.028	0.3358
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.028	0.3358
Onchocerca volvulus		0.0102	0.3452	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Brugia malayi	Ubiquitin-like protein SMT3	0.0031	0.0835	0.1416
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0016	0.028	0.028
Brugia malayi	RE15519p	0.0102	0.3452	0.5853
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0102	0.3452	0.546
Echinococcus granulosus	somatostatin receptor	0.0102	0.3452	0.3452
Schistosoma mansoni	protein kinase C mu	0.0012	0.0118	0.0151
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Loa Loa (eye worm)	zinc finger protein	0.0011	0.0097	0.0153
Brugia malayi	putative neuropeptide receptor	0.0102	0.3452	0.5853
Schistosoma mansoni	P2X receptor subunit	0.0132	0.457	0.5872
Brugia malayi	larval opioid receptor	0.0102	0.3452	0.5853
Brugia malayi	Dopamine receptor	0.0102	0.3452	0.5853
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0102	0.3452	0.3452
Echinococcus granulosus	raf serine:threonine protein kinase	0.0011	0.0096	0.0096
Onchocerca volvulus		0.0012	0.0118	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0019	0.039	0.0617
Schistosoma mansoni	hypothetical protein	0.0011	0.0096	0.0124
Schistosoma mansoni	hypothetical protein	0.0102	0.3452	0.4436
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0102	0.3452	0.3452
Echinococcus granulosus	g protein coupled receptor	0.0102	0.3452	0.3452
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0011	0.0096	0.0152
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0016	0.028	0.0443
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0118	0.0151
Echinococcus granulosus	N chimaerin	0.0011	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0102	0.3452	0.3452
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.028	0.036
Entamoeba histolytica	Ras family GTPase	0.0027	0.0686	0.8215
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0102	0.3452	0.5853
Schistosoma mansoni	amine GPCR	0.0102	0.3452	0.4436
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0102	0.3452	0.4436
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Schistosoma mansoni	amine GPCR	0.0102	0.3452	0.4436
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0146	0.1744
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus granulosus	protein TFG	0.0011	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0096	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus multilocularis	neuropeptide s receptor	0.0102	0.3452	0.3452
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0029	0.0746	0.0958
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0016	0.028	0.028
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0102	0.3452	0.3452
Entamoeba histolytica	diacylglycerol kinase, putative	0.0011	0.0096	0.1153
Brugia malayi	hypothetical protein	0.0102	0.3452	0.5853
Loa Loa (eye worm)	SMO-1 protein	0.0031	0.0835	0.1321
Echinococcus multilocularis	fmrfamide receptor	0.0102	0.3452	0.3452
Echinococcus granulosus	sex peptide receptor	0.0102	0.3452	0.3452
Echinococcus granulosus	g protein coupled receptor	0.0102	0.3452	0.3452
Loa Loa (eye worm)	G-protein coupled receptor	0.0102	0.3452	0.546
Onchocerca volvulus		0.0102	0.3452	1
Echinococcus granulosus	p2X purinoceptor 4	0.0132	0.457	0.457
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0146	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.3452	0.4436
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.028	0.3358
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.3452	0.4436
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0011	0.0096	0.0096
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0016	0.028	0.036
Brugia malayi	diacylglycerol kinase	0.0011	0.0096	0.0163
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0029	0.0746	0.8932
Onchocerca volvulus		0.0102	0.3452	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0146	0.1744
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0102	0.3452	0.546
Onchocerca volvulus		0.0102	0.3452	1
Trichomonas vaginalis	GTP-binding protein rit, putative	0.0027	0.0686	0.8215
Loa Loa (eye worm)	neuropeptide F receptor	0.0102	0.3452	0.546
Trichomonas vaginalis	ras-dva small GTPase, putative	0.0027	0.0686	0.8215
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0146	0.1744
Brugia malayi	Hr1 repeat family protein	0.0016	0.028	0.0475
Brugia malayi	putative neuropeptide receptor NPR1	0.0102	0.3452	0.5853
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0016	0.028	0.028
Brugia malayi	follicle stimulating hormone receptor	0.0102	0.3452	0.5853
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus granulosus	tm gpcr rhodopsin	0.0102	0.3452	0.3452
Brugia malayi	Variant SH3 domain containing protein	0.0011	0.0096	0.0163
Echinococcus granulosus	neuropeptides capa receptor	0.0102	0.3452	0.3452
Echinococcus multilocularis	neuropeptide receptor A26	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Entamoeba histolytica	diacylglycerol kinase, putative	0.0011	0.0096	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Brugia malayi	hypothetical protein	0.0102	0.3452	0.5853
Echinococcus granulosus	ras gtpase	0.0027	0.0686	0.0686
Schistosoma mansoni	histamine h1 receptor	0.0102	0.3452	0.4436
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus multilocularis	neuropeptides capa receptor	0.0102	0.3452	0.3452
Onchocerca volvulus		0.0102	0.3452	1
Brugia malayi	Protein kinase domain containing protein	0.0016	0.028	0.0475
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0016	0.028	0.0443
Entamoeba histolytica	ubiquitin like protein	0.0031	0.0835	1
Brugia malayi	hypothetical protein	0.0102	0.3452	0.5853
Brugia malayi	Ras-related protein R-Ras2	0.0027	0.0686	0.1163
Echinococcus multilocularis	partitioning defective protein 6	0.0011	0.0097	0.0097
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Plasmodium falciparum	small ubiquitin-related modifier	0.0031	0.0835	1
Echinococcus granulosus	protein kinase C gamma type	0.0016	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0102	0.3452	1
Loa Loa (eye worm)	TYRA-2 protein	0.0102	0.3452	0.546
Loa Loa (eye worm)	melatonin receptor type 1A	0.0102	0.3452	0.546
Echinococcus multilocularis	serotonin receptor	0.0102	0.3452	0.3452
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0146	0.1744
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0146	0.0146
Echinococcus multilocularis	multidrug resistance protein 1	0.0009	0.0003	0.0003
Echinococcus multilocularis	protein TFG	0.0011	0.0097	0.0097
Brugia malayi	hypothetical protein	0.0102	0.3452	0.5853
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0146	0.1744
Onchocerca volvulus		0.0102	0.3452	1
Echinococcus granulosus	protein kinase c iota type	0.0183	0.6485	0.6485
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0016	0.028	0.0443
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0029	0.0746	0.8932
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0013	0.0146	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0102	0.3452	0.3452
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0088	0.2925	0.3759
Echinococcus granulosus	protein kinase c epsilon type	0.0028	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Brugia malayi	protein kinase C3,putative	0.0168	0.5899	1
Echinococcus multilocularis	unc 13 (munc13)	0.0011	0.0096	0.0096
Schistosoma mansoni	diacylglycerol kinase theta	0.0011	0.0096	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Echinococcus multilocularis	fmrfamide receptor	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0146	0.1744
Trichomonas vaginalis	rheb, putative	0.0027	0.0686	0.8215
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.028	0.3358
Toxoplasma gondii	AGC kinase	0.0016	0.028	0.2492
Trichomonas vaginalis	taga, putative	0.0013	0.0146	0.1744
Entamoeba histolytica	ras-1, putative	0.0027	0.0686	0.8215
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Entamoeba histolytica	protein kinase, putative	0.0016	0.028	0.3358
Schistosoma mansoni	neuropeptide F-like receptor	0.0102	0.3452	0.4436
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Schistosoma mansoni	unc-13 (munc13)	0.0011	0.0096	0.0124
Schistosoma mansoni	biogenic amine receptor	0.0102	0.3452	0.4436
Echinococcus multilocularis	neuropeptide Y receptor	0.0102	0.3452	0.3452
Schistosoma mansoni	memapsin-2 (A01 family)	0.0211	0.7509	0.9649
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0102	0.3452	0.3452
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0704	0.0905
Echinococcus granulosus	biogenic amine 5HT receptor	0.0102	0.3452	0.3452
Schistosoma mansoni	hypothetical protein	0.0102	0.3452	0.4436
Echinococcus granulosus	unc 13 munc13	0.0011	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0146	0.1744
Brugia malayi	p70 ribosomal S6 kinase beta	0.0016	0.028	0.0475
Echinococcus multilocularis	protein kinase c iota type	0.0183	0.6485	0.6485
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0146	0.0146
Echinococcus granulosus	serotonin receptor	0.0102	0.3452	0.3452
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.0146	0.0146
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0146	0.1744
Onchocerca volvulus	Protein TFG homolog	0.0011	0.0097	0.0281
Echinococcus multilocularis	cathepsin b	0.0088	0.2925	0.2925
Echinococcus granulosus	tm gpcr rhodopsin	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus granulosus	neuropeptide Y receptor	0.0102	0.3452	0.3452
Trichomonas vaginalis	abcb9, putative	0.0013	0.0146	0.1744
Brugia malayi	multidrug resistance protein 3	0.0013	0.0146	0.0247
Brugia malayi	G protein-coupled receptor	0.0102	0.3452	0.5853
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0146	0.1744
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Echinococcus granulosus	biogenic amine 5HT receptor	0.0102	0.3452	0.3452
Echinococcus multilocularis	neuropeptide receptor	0.0102	0.3452	0.3452
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0029	0.0746	0.0958
Brugia malayi	hypothetical protein	0.0102	0.3452	0.5853
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.039	0.4674
Echinococcus multilocularis	p2X purinoceptor 4	0.0132	0.457	0.457
Brugia malayi	hypothetical protein	0.0102	0.3452	0.5853
Brugia malayi	Serotonin receptor	0.0102	0.3452	0.5853
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Schistosoma mansoni	opsin-like receptor	0.0102	0.3452	0.4436
Echinococcus granulosus	tm gpcr rhodopsin	0.0102	0.3452	0.3452
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0011	0.0096	0.0124
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0146	0.0146
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0704	0.0905
Loa Loa (eye worm)	raf kinase	0.0011	0.0096	0.0152
Trichomonas vaginalis	dexras1, putative	0.0027	0.0686	0.8215
Brugia malayi	Melatonin receptor type 1A	0.0102	0.3452	0.5853
Brugia malayi	G-protein coupled receptor	0.0102	0.3452	0.5853
Brugia malayi	G-protein coupled receptor	0.0102	0.3452	0.5853
Loa Loa (eye worm)	Ras protein let-60	0.0027	0.0686	0.1085
Onchocerca volvulus		0.0102	0.3452	1
Echinococcus multilocularis	g protein coupled receptor	0.0102	0.3452	0.3452
Echinococcus granulosus	Small ubiquitin modifier 2	0.0031	0.0835	0.0835
Schistosoma mansoni	opsin-like receptor	0.0102	0.3452	0.4436
Echinococcus multilocularis	g protein coupled receptor	0.0102	0.3452	0.3452
Loa Loa (eye worm)	STE/STE11/MEKK2 protein kinase	0.0012	0.0118	0.0187
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.3452	0.4436
Onchocerca volvulus		0.0011	0.0096	0.0279
Schistosoma mansoni	multidrug resistance protein	0.0013	0.0146	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Onchocerca volvulus		0.0019	0.039	0.1131
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0013	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Entamoeba histolytica	protein kinase, putative	0.0016	0.028	0.3358
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0102	0.3452	0.3452
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0013	0.0146	0.0668
Brugia malayi	RhoGAP domain containing protein	0.0011	0.0096	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Echinococcus multilocularis	serine threonine protein kinase	0.0016	0.028	0.028
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0088	0.2925	0.3759
Brugia malayi	RhoGAP domain containing protein	0.0011	0.0096	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Schistosoma mansoni	biogenic amine receptor	0.0102	0.3452	0.4436
Brugia malayi	G protein-coupled receptor F59B2.13	0.0102	0.3452	0.5853
Leishmania major	p-glycoprotein	0.0013	0.0146	0.1744
Plasmodium vivax	small ubiquitin-related modifier, putative	0.0031	0.0835	1
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0028	0.0704	0.1114
Schistosoma mansoni	unc-13 (munc13)	0.0011	0.0096	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0011	0.0096	0.0096
Schistosoma mansoni	neuropeptide receptor	0.0102	0.3452	0.4436
Echinococcus granulosus	Diacylglycerol kinase theta	0.0011	0.0096	0.0096
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0146	0.1744
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.028	0.036
Echinococcus multilocularis	protein kinase c eta type	0.0011	0.0096	0.0096
Brugia malayi	Ras association domain family 1 isoform A	0.0011	0.0096	0.0163
Onchocerca volvulus		0.0011	0.0096	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus multilocularis	myotubularin protein 13	0.0011	0.0096	0.0096
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0146	0.1744
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0016	0.028	0.028
Echinococcus multilocularis	N chimaerin	0.0011	0.0096	0.0096
Schistosoma mansoni	rac gtpase activating protein	0.0011	0.0096	0.0124
Brugia malayi	Pleckstrin Homology Domain	0.0011	0.0096	0.0163
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0009	0.0003	0.0033
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0102	0.3452	0.3452
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.3452	0.4436
Brugia malayi	ORL1-like opioid receptor	0.0102	0.3452	0.5853
Plasmodium falciparum	multidrug resistance protein 1	0.0013	0.0146	0.1744
Echinococcus multilocularis	orexin receptor type 2	0.0102	0.3452	0.3452
Brugia malayi	Partitioning defective-6 homolog alpha	0.0011	0.0097	0.0164
Echinococcus granulosus	cathepsin b	0.0088	0.2925	0.2925
Echinococcus granulosus	cathepsin b	0.0088	0.2925	0.2925
Echinococcus granulosus	NDR protein kinase	0.0016	0.028	0.028
Trypanosoma cruzi	PB1 domain containing protein, putative	0.0011	0.0097	0.0331
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0011	0.0096	0.0096
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Loa Loa (eye worm)	multidrug resistance protein 3	0.0013	0.0146	0.023
Brugia malayi	RhoGEF domain containing protein	0.0011	0.0096	0.0163
Giardia lamblia	Cathepsin B precursor	0.0029	0.0746	0.8932
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0011	0.0096	0.0152
Echinococcus granulosus	multidrug resistance protein 1	0.0009	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Onchocerca volvulus		0.0102	0.3452	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.3452	0.4436
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0016	0.028	0.028
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0102	0.3452	0.3452
Onchocerca volvulus		0.0102	0.3452	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0102	0.3452	0.5853
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0118	0.02
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus granulosus	p2X purinoceptor 4	0.0132	0.457	0.457
Trichomonas vaginalis	abcb9, putative	0.0013	0.0146	0.1744
Echinococcus granulosus	neuropeptide s receptor	0.0102	0.3452	0.3452
Echinococcus multilocularis	multidrug resistance protein 1	0.0013	0.0146	0.0146
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0012	0.0118	0.0118
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0146	0.1744
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0179	0.6323	1
Brugia malayi	sulfakinin receptor protein	0.0102	0.3452	0.5853
Echinococcus multilocularis	dro:myosuppressin receptor	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0011	0.0096	0.0152
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.028	0.3358
Schistosoma mansoni	neuropeptide F-like receptor	0.0102	0.3452	0.4436
Echinococcus multilocularis	Small ubiquitin modifier 2	0.0031	0.0835	0.0835
Trypanosoma brucei	RNA helicase, putative	0.0218	0.7783	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Onchocerca volvulus		0.0102	0.3452	1
Trypanosoma cruzi	PB1 domain containing protein, putative	0.0011	0.0097	0.0331
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0146	0.1744
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2925	0.4626
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0102	0.3452	0.3452
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0013	0.0146	0.0668
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0146	0.0146
Echinococcus multilocularis	p2X purinoceptor 4	0.0132	0.457	0.457
Echinococcus granulosus	7TM GPCR rhodopsin	0.0102	0.3452	0.3452
Brugia malayi	neuropeptide F receptor	0.0102	0.3452	0.5853
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0102	0.3452	0.4436
Toxoplasma gondii	small ubiquitin family modifier, putative	0.0031	0.0835	1
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.028	0.3358
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0102	0.3452	0.3452
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0146	0.0146
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0088	0.2925	1
Schistosoma mansoni	multidrug resistance protein	0.0013	0.0146	0.0187
Entamoeba histolytica	hypothetical protein	0.0011	0.0096	0.1153
Onchocerca volvulus		0.0102	0.3452	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0102	0.3452	0.4436
Schistosoma mansoni	amine GPCR	0.0102	0.3452	0.4436
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0102	0.3452	0.4436
Onchocerca volvulus		0.0102	0.3452	1
Trypanosoma brucei	PB1 domain containing protein, putative	0.0011	0.0097	0.0124
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0013	0.0146	0.5
Echinococcus granulosus	neuropeptide receptor	0.0102	0.3452	0.3452
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0102	0.3452	0.4436
Echinococcus multilocularis	multidrug resistance protein 1	0.0013	0.0146	0.0146
Schistosoma mansoni	hypothetical protein	0.0218	0.7783	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0102	0.3452	0.3452
Echinococcus granulosus	multidrug resistance protein 1	0.0009	0.0003	0.0003
Echinococcus multilocularis	g protein coupled receptor	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0146	0.023
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Entamoeba histolytica	P-glycoprotein-2	0.0013	0.0146	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.3452	0.4436
Schistosoma mansoni	atypical protein kinase C	0.0195	0.691	0.8878
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Entamoeba histolytica	Ras family GTPase	0.0027	0.0686	0.8215
Entamoeba histolytica	P-glycoprotein-1	0.0013	0.0146	0.1744
Schistosoma mansoni	P2X receptor subunit	0.0132	0.457	0.5872
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.028	0.3358
Brugia malayi	Protein kinase domain containing protein	0.0016	0.028	0.0475
Echinococcus multilocularis	ras gtpase	0.0027	0.0686	0.0686
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0102	0.3452	0.3452
Schistosoma mansoni	diacylglycerol kinase theta	0.0011	0.0096	0.0124
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0146	0.0146
Brugia malayi	Protein kinase domain containing protein	0.0016	0.028	0.0475
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0012	0.0118	0.0186
Echinococcus granulosus	g-protein coupled receptor	0.0102	0.3452	0.3452
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0011	0.0096	0.0124
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0102	0.3452	0.5853
Brugia malayi	hypothetical protein	0.0019	0.039	0.0662
Loa Loa (eye worm)	G-protein coupled receptor	0.0102	0.3452	0.546
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0011	0.0096	0.0096
Schistosoma mansoni	multidrug resistance protein	0.0013	0.0146	0.0187
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0016	0.028	0.028
Trichomonas vaginalis	ral, putative	0.0027	0.0686	0.8215
Entamoeba histolytica	hypothetical protein, conserved	0.0011	0.0097	0.116
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0016	0.028	0.0443
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0016	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus granulosus	protein kinase c eta type	0.0011	0.0096	0.0096
Brugia malayi	Dopamine receptor protein 1	0.0102	0.3452	0.5853
Brugia malayi	diacylglycerol kinase	0.0011	0.0096	0.0163
Brugia malayi	protein kinase C II.	0.0028	0.0704	0.1194
Brugia malayi	AKH receptor	0.0102	0.3452	0.5853
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0016	0.028	0.028
Onchocerca volvulus		0.0102	0.3452	1
Toxoplasma gondii	cathepsin B	0.0029	0.0746	0.8793
Echinococcus granulosus	neuropeptide receptor A26	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Schistosoma mansoni	smdr2	0.0013	0.0146	0.0187
Echinococcus granulosus	neuropeptide receptor	0.0102	0.3452	0.3452
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0102	0.3452	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0013	0.0146	0.5
Schistosoma mansoni	neuropeptide receptor	0.0102	0.3452	0.4436
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Loa Loa (eye worm)	hypothetical protein	0.0016	0.028	0.0443
Echinococcus multilocularis	G protein coupled receptor 139	0.0102	0.3452	0.3452
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0088	0.2925	0.3759
Schistosoma mansoni	neuropeptide f receptor 76f	0.0102	0.3452	0.4436
Loa Loa (eye worm)	neuropeptide F receptor	0.0102	0.3452	0.546
Brugia malayi	hypothetical protein	0.0102	0.3452	0.5853
Echinococcus multilocularis	g-protein coupled receptor	0.0102	0.3452	0.3452
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0146	0.1744
Trichomonas vaginalis	abcb9, putative	0.0013	0.0146	0.1744
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0102	0.3452	0.5853
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0028	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Echinococcus multilocularis	somatostatin receptor	0.0102	0.3452	0.3452
Entamoeba histolytica	P-glyco protein 6, putative	0.0013	0.0146	0.1744
Echinococcus granulosus	serine:threonine protein kinase N2	0.0016	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Schistosoma mansoni	growth hormone secretagogue receptor	0.0102	0.3452	0.4436
Echinococcus granulosus	hypothetical protein	0.0102	0.3452	0.3452
Onchocerca volvulus		0.0013	0.0146	0.0422
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0011	0.0096	0.0096
Brugia malayi	Protein kinase c protein 2	0.0012	0.0118	0.02
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0102	0.3452	0.3452
Schistosoma mansoni	amine GPCR	0.0102	0.3452	0.4436
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0704	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Entamoeba histolytica	P-glycoprotein-5	0.0013	0.0146	0.1744
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Leishmania major	small ubiquitin protein, putative	0.0031	0.0835	1
Onchocerca volvulus		0.0102	0.3452	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0102	0.3452	0.4436
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0102	0.3452	0.4436
Echinococcus granulosus	myotubularin protein 13	0.0011	0.0096	0.0096
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0016	0.028	0.0443
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0102	0.3452	0.5853
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0016	0.0259	0.3101
Echinococcus granulosus	p2X purinoceptor 4	0.0132	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Leishmania major	hypothetical protein, conserved	0.0011	0.0097	0.116
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0686	0.1085
Schistosoma mansoni	adenoreceptor	0.0102	0.3452	0.4436
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.028	0.036
Brugia malayi	C1-like domain containing protein	0.0012	0.0118	0.02
Echinococcus multilocularis	ATP binding cassette sub family B	0.0013	0.014	0.014
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0102	0.3452	0.3452
Giardia lamblia	Cathepsin B precursor	0.0029	0.0746	0.8932
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0102	0.3452	0.4436
Brugia malayi	cathepsin B-like cysteine proteinase	0.0088	0.2925	0.4959
Giardia lamblia	Cathepsin B precursor	0.0029	0.0746	0.8932
Trichomonas vaginalis	rap1 and, putative	0.0027	0.0686	0.8215
Schistosoma mansoni	neuropeptide receptor	0.0102	0.3452	0.4436
Loa Loa (eye worm)	cathepsin B	0.0029	0.0746	0.118
Echinococcus granulosus	7tm_1 domain containing protein	0.0102	0.3452	0.3452
Onchocerca volvulus		0.0102	0.3452	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0146	0.1744
Brugia malayi	hypothetical protein	0.0102	0.3452	0.5853
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0102	0.3452	0.546
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0102	0.3452	0.3452
Echinococcus multilocularis	ubiquitin	0.0019	0.039	0.039
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0102	0.3452	0.4436
Echinococcus multilocularis	p2X purinoceptor 4	0.0132	0.457	0.457
Schistosoma mansoni	neuropeptide receptor	0.0102	0.3452	0.4436
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0835	1
Entamoeba histolytica	P-glycoprotein 5, putative	0.0013	0.0146	0.1744
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0102	0.3452	0.546
Loa Loa (eye worm)	PAR-6 protein	0.0011	0.0097	0.0153
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0102	0.3452	0.5853
Schistosoma mansoni	biogenic amine receptor	0.0102	0.3452	0.4436
Brugia malayi	hypothetical protein	0.0102	0.3452	0.5853
Brugia malayi	neuropeptide F receptor	0.0102	0.3452	0.5853
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0016	0.028	0.0443
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0029	0.0746	0.255
Schistosoma mansoni	ubiquitin-like protein sumo/smt3-related	0.0031	0.0835	0.1073
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0102	0.3452	0.3452
Brugia malayi	Serotonin receptor	0.0102	0.3452	0.5853
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0011	0.0096	0.0152
Brugia malayi	GnHR receptor homolog	0.0102	0.3452	0.5853
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0102	0.3452	0.3452
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.3452	0.4436
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0102	0.3452	0.3452
Echinococcus multilocularis	protein kinase c epsilon type	0.0028	0.0704	0.0704
Echinococcus granulosus	fmrfamide receptor	0.0102	0.3452	0.3452
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0102	0.3452	0.3452
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0013	0.0146	0.1744
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0012	0.0118	0.02
Echinococcus granulosus	neuropeptide FF receptor 2	0.0102	0.3452	0.3452
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0102	0.3452	0.4436
Entamoeba histolytica	P-glycoprotein-2	0.0013	0.0146	0.1744
Echinococcus multilocularis	neuropeptide receptor	0.0102	0.3452	0.3452
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.0146	0.0146
Schistosoma mansoni	hypothetical protein	0.0102	0.3452	0.4436
Schistosoma mansoni	vav2	0.0011	0.0096	0.0124
Echinococcus granulosus	neuropeptide Y receptor	0.0102	0.3452	0.3452
Schistosoma mansoni	serine/threonine kinase	0.0016	0.028	0.036
Echinococcus granulosus	Rac GTPase activating protein 1	0.0011	0.0096	0.0096
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0102	0.3452	0.4436
Schistosoma mansoni	protein kinase C	0.0011	0.0096	0.0124
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0146	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0146	0.023
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0088	0.2925	0.3759
Schistosoma mansoni	P2X receptor subunit	0.0132	0.457	0.5872
Echinococcus multilocularis	neuropeptides capa receptor	0.0102	0.3452	0.3452
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0146	0.1744
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.3452	0.3452
Schistosoma mansoni	P2X receptor subunit	0.0132	0.457	0.5872
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0146	0.1744
Echinococcus granulosus	neuropeptides capa receptor	0.0102	0.3452	0.3452
Entamoeba histolytica	hypothetical protein	0.0019	0.039	0.4674
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0011	0.0096	0.0096
Entamoeba histolytica	P-glycoprotein-2, putative	0.0013	0.0146	0.1744
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.028	0.3358
Brugia malayi	ABC transporter family protein	0.0013	0.0146	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0102	0.3452	0.4436
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0102	0.3452	0.4436
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0016	0.028	0.028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.3452	0.4436
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0118	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0013	0.014	0.0222
Schistosoma mansoni	myosin xvIII	0.0102	0.3452	0.4436
Echinococcus multilocularis	cathepsin b	0.0088	0.2925	0.2925
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0102	0.3452	0.4436
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0096	0.0152
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0278	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0146	0.1744
Echinococcus multilocularis	sex peptide receptor	0.0102	0.3452	0.3452
Brugia malayi	Dopamine receptor protein 2	0.0102	0.3452	0.5853
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3452	0.546
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0013	0.0146	0.1744
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0146	0.1744
Schistosoma mansoni	opsin-like receptor	0.0102	0.3452	0.4436
Entamoeba histolytica	protein kinase, putative	0.0016	0.028	0.3358
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.028	0.3358
Entamoeba histolytica	protein kinase, putative	0.0016	0.028	0.3358
Echinococcus granulosus	G protein coupled receptor 139	0.0102	0.3452	0.3452
Brugia malayi	Ras protein let-60	0.0027	0.0686	0.1163
Schistosoma mansoni	amine GPCR	0.0102	0.3452	0.4436
Onchocerca volvulus		0.0102	0.3452	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0102	0.3452	0.546

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 6.4	SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2449387

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1810124