Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0041 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0277 | 0.0287 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase precursor, putative | 0.0162 | 0.0277 | 0.0449 |
Plasmodium vivax | carbamoyl phosphate synthetase, putative | 0.0398 | 0.0791 | 0.1097 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.0364 | 0.0377 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.1763 | 0.3762 | 0.3762 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0041 | 0.0013 | 0.0013 |
Schistosoma mansoni | tyrosine kinase | 0.0177 | 0.0309 | 0.0309 |
Brugia malayi | SH2 domain containing protein | 0.0041 | 0.0013 | 0.0013 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0177 | 0.0309 | 0.0309 |
Echinococcus granulosus | c src tyrosine kinase | 0.007 | 0.0077 | 0.0077 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0041 | 0.0013 | 0.0013 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.006 | 0.0054 | 0.0054 |
Echinococcus multilocularis | c src tyrosine kinase | 0.007 | 0.0077 | 0.0077 |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0162 | 0.0277 | 0.0277 |
Schistosoma mansoni | tyrosine kinase | 0.007 | 0.0077 | 0.0077 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.0071 | 0.0071 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0109 | 0.0161 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0296 | 0.0307 |
Echinococcus granulosus | tyrosine kinase | 0.0215 | 0.0393 | 0.0393 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.007 | 0.0077 | 0.0077 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0245 | 0.0458 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0041 | 0.0013 | 0.0013 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.006 | 0.0054 | 0.1268 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.4627 | 1 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.4627 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0162 | 0.0277 | 0.0277 |
Toxoplasma gondii | dihydrolipoamide acyltransferase, putative | 0.0162 | 0.0277 | 0.0277 |
Onchocerca volvulus | 0.0041 | 0.0013 | 0.0299 | |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.0071 | 0.0074 |
Trypanosoma brucei | glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative | 0.0398 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0041 | 0.0013 | 0.0013 |
Echinococcus multilocularis | tumor protein p63 | 0.0328 | 0.0638 | 0.0638 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0006 | 0.0152 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.006 | 0.0055 | 0.0057 |
Echinococcus granulosus | tumor protein p63 | 0.0328 | 0.0638 | 0.0638 |
Echinococcus granulosus | Biotin lipoyl attachment | 0.0162 | 0.0277 | 0.0277 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.0627 | 0.1289 | 0.3427 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.1763 | 0.3762 | 1 |
Trypanosoma brucei | pyruvate dehydrogenase complex E3 binding protein, putative | 0.0162 | 0.0277 | 0.0277 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0245 | 0.0458 | 0.0458 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1763 | 0.3762 | 0.3762 |
Loa Loa (eye worm) | cathepsin B | 0.006 | 0.0054 | 0.0056 |
Treponema pallidum | pyruvate carboxylase subunit B | 0.0162 | 0.0277 | 0.5 |
Mycobacterium tuberculosis | DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase | 0.0162 | 0.0277 | 0.0736 |
Echinococcus granulosus | dihydrolipoyllysine residue succinyltransferase | 0.0162 | 0.0277 | 0.0277 |
Toxoplasma gondii | cathepsin B | 0.006 | 0.0054 | 0.0054 |
Echinococcus multilocularis | cathepsin b | 0.0171 | 0.0296 | 0.0296 |
Trypanosoma cruzi | dihydrolipoamide branched chain transacylase, putative | 0.0162 | 0.0277 | 0.0449 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0245 | 0.0458 | 0.0458 |
Trypanosoma cruzi | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0162 | 0.0277 | 0.0449 |
Echinococcus granulosus | insulin receptor | 0.0109 | 0.0161 | 0.0161 |
Mycobacterium leprae | ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 | 0.0627 | 0.1289 | 0.3427 |
Brugia malayi | Protein kinase domain containing protein | 0.0041 | 0.0013 | 0.0013 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.006 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0041 | 0.0013 | 0.0013 |
Toxoplasma gondii | 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein | 0.0162 | 0.0277 | 0.0277 |
Mycobacterium tuberculosis | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) | 0.0627 | 0.1289 | 0.3427 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.0627 | 0.1289 | 0.3427 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0013 | 0.0299 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0041 | 0.0013 | 0.0013 |
Mycobacterium leprae | Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) | 0.0627 | 0.1289 | 0.3427 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0041 | 0.0013 | 0.0013 |
Echinococcus granulosus | cathepsin b | 0.0171 | 0.0296 | 0.0296 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0185 | 0.0327 | 0.0327 |
Echinococcus granulosus | NCK adaptor protein | 0.006 | 0.0055 | 0.0055 |
Trypanosoma cruzi | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0162 | 0.0277 | 0.0449 |
Onchocerca volvulus | 0.0041 | 0.0013 | 0.0299 | |
Trypanosoma brucei | unspecified product | 0.1159 | 0.2447 | 0.2447 |
Schistosoma mansoni | aspartate carbamoyltransferase | 0.0398 | 0.0791 | 0.0791 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase, putative | 0.0162 | 0.0277 | 0.0449 |
Mycobacterium ulcerans | carbamoyl phosphate synthase large subunit | 0.0398 | 0.0791 | 0.2104 |
Mycobacterium leprae | Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB | 0.0162 | 0.0277 | 0.0736 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0398 | 0.0791 | 0.0791 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0171 | 0.0296 | 0.0296 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0627 | 0.1289 | 0.1289 |
Onchocerca volvulus | 0.0048 | 0.0028 | 0.067 | |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.0627 | 0.1289 | 0.3427 |
Mycobacterium ulcerans | dihydrolipoamide acetyltransferase | 0.0162 | 0.0277 | 0.0736 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0171 | 0.0296 | 0.0307 |
Echinococcus multilocularis | insulin receptor | 0.0109 | 0.0161 | 0.0161 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0322 | 0.0625 | 0.0648 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.4627 | 1 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.0215 | 0.0393 | 0.0407 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.006 | 0.0054 | 0.0054 |
Leishmania major | dihydrolipoamide acetyltransferase precursor, putative | 0.0162 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0028 | 0.0029 |
Entamoeba histolytica | protein kinase, putative | 0.0185 | 0.0327 | 0.1927 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0245 | 0.0458 | 0.0458 |
Schistosoma mansoni | adapter molecule crk | 0.006 | 0.0055 | 0.0055 |
Leishmania major | dihydrolipoamide branched chain transacylase, putative | 0.0162 | 0.0277 | 0.0277 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.007 | 0.0077 | 0.008 |
Trypanosoma brucei | 2-oxoglutarate dehydrogenase E2 component, putative | 0.0162 | 0.0277 | 0.0277 |
Brugia malayi | Protein kinase domain containing protein | 0.0109 | 0.0161 | 0.0166 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.0006 | 0.0152 |
Schistosoma mansoni | tyrosine kinase | 0.0109 | 0.0161 | 0.0161 |
Schistosoma mansoni | nck2/grb4 | 0.006 | 0.0055 | 0.0055 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0185 | 0.0327 | 0.0327 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E2 component BkdC | 0.0162 | 0.0277 | 0.0736 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.0071 | 0.0074 |
Chlamydia trachomatis | biotin carboxylase | 0.1601 | 0.3409 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0245 | 0.0458 | 0.0458 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.0364 | 0.0377 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.0627 | 0.1289 | 0.2092 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.007 | 0.0077 | 0.0077 |
Onchocerca volvulus | 0.0041 | 0.0013 | 0.0299 | |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0245 | 0.0458 | 0.0458 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.006 | 0.0054 | 0.0087 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0245 | 0.0458 | 0.0458 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.007 | 0.0077 | 0.0077 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.1763 | 0.3762 | 1 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0627 | 0.1289 | 0.2092 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0627 | 0.1289 | 0.1289 |
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.0287 | 0.0287 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0177 | 0.0309 | 0.0309 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0171 | 0.0296 | 0.0296 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0245 | 0.0458 | 0.0458 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 0.0126 | 0.0126 |
Plasmodium falciparum | carbamoyl phosphate synthetase | 0.0398 | 0.0791 | 0.0742 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0109 | 0.0161 | 0.0161 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.1763 | 0.3762 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0028 | 0.0028 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.0071 | 0.0071 |
Schistosoma mansoni | serine/threonine protein kinase | 0.004 | 0.0011 | 0.0011 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.006 | 0.0055 | 0.0055 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0789 | 0.1642 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0055 | 0.0057 |
Brugia malayi | Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor | 0.0162 | 0.0277 | 0.0287 |
Trypanosoma brucei | dihydrolipoamide branched chain transacylase, putative | 0.0162 | 0.0277 | 0.0277 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.0627 | 0.1289 | 0.1289 |
Schistosoma mansoni | tyrosine kinase | 0.0041 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | hypothetical protein | 0.0162 | 0.0277 | 0.0736 |
Toxoplasma gondii | pyruvate carboxylase | 0.1763 | 0.3762 | 0.3762 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.006 | 0.0055 | 0.0057 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.0071 | 0.0071 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0041 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0109 | 0.0161 | 0.0166 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0245 | 0.0458 | 0.0458 |
Toxoplasma gondii | carbamoylphosphate synthetase | 0.0398 | 0.0791 | 0.0791 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0215 | 0.0393 | 0.0393 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.006 | 0.0054 | 0.0054 |
Echinococcus granulosus | dihydrolipoyllysine residue acetyltransferase | 0.0162 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0041 | 0.0013 | 0.0013 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.004 | 0.0011 | 0.0011 |
Schistosoma mansoni | pyruvate carboxylase | 0.1763 | 0.3762 | 0.3762 |
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.0287 | 0.0287 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.006 | 0.0055 | 0.0055 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0215 | 0.0393 | 0.0393 |
Mycobacterium leprae | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) | 0.0627 | 0.1289 | 0.3427 |
Brugia malayi | Variant SH3 domain containing protein | 0.006 | 0.0055 | 0.0057 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0041 | 0.0013 | 0.0013 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.0627 | 0.1289 | 0.1289 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.1763 | 0.3762 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0041 | 0.0013 | 0.0013 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1763 | 0.3762 | 0.3762 |
Mycobacterium tuberculosis | Biotinylated protein TB7.3 | 0.0162 | 0.0277 | 0.0736 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1763 | 0.3762 | 0.3762 |
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.0287 | 0.0287 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.006 | 0.0055 | 0.0055 |
Trypanosoma cruzi | glutamine-dependent carbamoyl-phosphate synthetase, putative | 0.0398 | 0.0791 | 0.1284 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0215 | 0.0393 | 0.0393 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0041 | 0.0013 | 0.0013 |
Trypanosoma cruzi | dihydrolipoamide branched chain transacylase, putative | 0.0162 | 0.0277 | 0.0449 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.007 | 0.0077 | 0.0077 |
Schistosoma mansoni | tyrosine kinase | 0.0245 | 0.0458 | 0.0458 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0171 | 0.0296 | 0.0296 |
Mycobacterium leprae | Probable biotinylated protein homolog TB7.3 | 0.0162 | 0.0277 | 0.0736 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.1763 | 0.3762 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0205 | 0.037 | 0.037 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.006 | 0.0055 | 0.0055 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0322 | 0.0625 | 0.0625 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 0.0126 | 0.0126 |
Schistosoma mansoni | tyrosine kinase | 0.007 | 0.0077 | 0.0077 |
Onchocerca volvulus | 0.0041 | 0.0013 | 0.0299 | |
Brugia malayi | Carboxyl transferase domain containing protein | 0.4465 | 0.9647 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.3349 | 0.7216 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0245 | 0.0458 | 0.0458 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0245 | 0.0458 | 0.0458 |
Brugia malayi | Protein kinase domain containing protein | 0.0041 | 0.0013 | 0.0013 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.2865 | 0.6162 | 1 |
Leishmania major | dihydrolipoamide acetyltransferase precursorlike protein | 0.0162 | 0.0277 | 0.0277 |
Brugia malayi | Protein kinase domain containing protein | 0.0041 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0277 | 0.0287 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.041 | 0.1091 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0322 | 0.0625 | 0.0648 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0013 | 0.0299 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.0051 | 0.0053 |
Mycobacterium tuberculosis | Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 | 0.0627 | 0.1289 | 0.3427 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0245 | 0.0458 | 0.0458 |
Trypanosoma cruzi | glutamine dependent carbamoyl-phosphate synthase, putative | 0.0398 | 0.0791 | 0.1284 |
Leishmania major | carboxylase, putative | 0.1763 | 0.3762 | 0.3762 |
Loa Loa (eye worm) | TK protein kinase | 0.0185 | 0.0327 | 0.0339 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.006 | 0.0055 | 0.0057 |
Toxoplasma gondii | acyl-CoA carboxyltransferase beta chain, putative | 0.0627 | 0.1289 | 0.1289 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.001 | 0.001 |
Leishmania major | carbamoyl-phosphate synthase, putative | 0.0398 | 0.0791 | 0.0791 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.0084 | 0.0084 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0041 | 0.0013 | 0.0013 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.0071 | 0.0071 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.0071 | 0.0071 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1763 | 0.3762 | 0.3762 |
Schistosoma mansoni | tyrosine kinase | 0.0322 | 0.0625 | 0.0625 |
Chlamydia trachomatis | acetyl-coenzyme A carboxylase carboxyl transferase subunit beta | 0.0627 | 0.1289 | 0.3233 |
Schistosoma mansoni | dihydrolipoamide S-acetyltransferase | 0.0162 | 0.0277 | 0.0277 |
Toxoplasma gondii | dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase | 0.0162 | 0.0277 | 0.0277 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0071 | 0.1676 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.0006 | 0.0007 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0177 | 0.0309 | 0.0309 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0627 | 0.1289 | 0.2092 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.0627 | 0.1289 | 0.1289 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.4627 | 1 | 1 |
Echinococcus multilocularis | NCK adaptor protein | 0.006 | 0.0055 | 0.0055 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.1763 | 0.3762 | 0.3762 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.1763 | 0.3762 | 0.3762 |
Onchocerca volvulus | 0.004 | 0.0011 | 0.0261 | |
Wolbachia endosymbiont of Brugia malayi | carbamoyl phosphate synthase large subunit | 0.0398 | 0.0791 | 0.1476 |
Echinococcus multilocularis | cathepsin b | 0.0171 | 0.0296 | 0.0296 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1763 | 0.3762 | 0.6105 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0245 | 0.0458 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.003 | 0.0031 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.3349 | 0.7216 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.4627 | 1 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.1763 | 0.3762 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0245 | 0.0458 | 0.0458 |
Trypanosoma brucei | dihydrolipoamide acetyltransferase E2 subunit, putative | 0.0162 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0041 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.1763 | 0.3762 | 1 |
Onchocerca volvulus | 0.0041 | 0.0013 | 0.0299 | |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1763 | 0.3762 | 0.6105 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0041 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0041 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | SRC-1 | 0.0245 | 0.0458 | 0.0474 |
Mycobacterium ulcerans | branched-chain alpha-keto acid dehydrogenase subunit E2 | 0.0162 | 0.0277 | 0.0736 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0006 | 0.0152 |
Echinococcus multilocularis | tyrosine kinase | 0.0041 | 0.0013 | 0.0013 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0245 | 0.0458 | 0.0458 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0245 | 0.0458 | 0.0458 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0205 | 0.037 | 0.037 |
Onchocerca volvulus | 0.023 | 0.0425 | 1 | |
Loa Loa (eye worm) | TK protein kinase | 0.0215 | 0.0393 | 0.0407 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.0627 | 0.1289 | 0.3427 |
Brugia malayi | jmjC domain containing protein | 0.0093 | 0.0126 | 0.013 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase precursor, putative | 0.0162 | 0.0277 | 0.0449 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.001 | 0.001 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0071 | 0.1676 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0041 | 0.0013 | 0.0013 |
Plasmodium vivax | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative | 0.0162 | 0.0277 | 0.0384 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.0627 | 0.1289 | 0.3427 |
Brugia malayi | Protein kinase domain containing protein | 0.0041 | 0.0013 | 0.0013 |
Echinococcus granulosus | cathepsin b | 0.0171 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.4465 | 0.9647 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0013 | 0.0299 |
Echinococcus multilocularis | dihydrolipoyllysine residue acetyltransferase | 0.0162 | 0.0277 | 0.0277 |
Echinococcus granulosus | tyrosine kinase | 0.0041 | 0.0013 | 0.0013 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0215 | 0.0393 | 0.0393 |
Plasmodium vivax | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative | 0.0162 | 0.0277 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0277 | 0.0287 |
Brugia malayi | SH2 domain containing protein | 0.0041 | 0.0013 | 0.0013 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.0627 | 0.1289 | 0.1289 |
Brugia malayi | Variant SH3 domain containing protein | 0.006 | 0.0055 | 0.0057 |
Schistosoma mansoni | tyrosine kinase | 0.0041 | 0.0013 | 0.0013 |
Echinococcus multilocularis | dihydrolipoyllysine residue succinyltransferase | 0.0162 | 0.0277 | 0.0277 |
Brugia malayi | SRC-1 | 0.0245 | 0.0458 | 0.0474 |
Schistosoma mansoni | tyrosine kinase | 0.0177 | 0.0309 | 0.0309 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0789 | 0.1642 | 1 |
Brugia malayi | dihydrolipoamide S-acetyltransferase precursor, putative | 0.0162 | 0.0277 | 0.0287 |
Leishmania major | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0162 | 0.0277 | 0.0277 |
Onchocerca volvulus | 0.0041 | 0.0013 | 0.0299 | |
Brugia malayi | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta | 0.0162 | 0.0277 | 0.0287 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.1763 | 0.3762 | 1 |
Echinococcus multilocularis | 0.0097 | 0.0135 | 0.0135 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0006 | 0.0007 |
Toxoplasma gondii | biotin-requiring enzyme domain-containing protein | 0.0162 | 0.0277 | 0.0277 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0171 | 0.0296 | 0.0296 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0215 | 0.0393 | 0.0393 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0398 | 0.0791 | 0.0791 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0245 | 0.0458 | 0.0458 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0041 | 0.0013 | 0.0013 |
Schistosoma mansoni | tyrosine kinase | 0.0109 | 0.0161 | 0.0161 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.4627 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl-CoA carboxylase, carboxyltransferase component | 0.0627 | 0.1289 | 0.2905 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.0071 | 0.0071 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0171 | 0.0296 | 0.048 |
Schistosoma mansoni | dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase | 0.0162 | 0.0277 | 0.0277 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E2 | 0.0162 | 0.0277 | 0.0277 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0322 | 0.0625 | 0.0625 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0245 | 0.0458 | 0.0458 |
Echinococcus multilocularis | Biotin lipoyl attachment | 0.0162 | 0.0277 | 0.0277 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.0627 | 0.1289 | 0.3427 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0013 | 0.0013 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.0425 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 58.16 % | Analgesic activity in Mus musculus Swiss albino (mouse) assessed as protection against acetic acid-induced writhing at 100 mg/kg, po administered 1 hr prior challenge measured after 5 min of challenge for 20 min | ChEMBL. | No reference |
IZ (functional) | = 22 mm | Antimicrobial activity against Candida albicans at 40 ug/ml after 72 hr by agar well diffusion method | ChEMBL. | No reference |
MIC (functional) | = 30 ug/uL | Antimicrobial activity against Candida albicans after 24 hr by micro dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.