Detailed information for compound 1810375

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.105 | Formula: C6H18AlO9P3
  • H donors: 3 H acceptors: 6 LogP: 0.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]P(=O)OCC.[O-]P(=O)OCC.[O-]P(=O)OCC.[Al+3]
  • InChi: 1S/3C2H7O3P.Al/c3*1-2-5-6(3)4;/h3*6H,2H2,1H3,(H,3,4);/q;;;+3/p-3
  • InChiKey: ZKZMJOFIHHZSRW-UHFFFAOYSA-K  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi TAR-binding protein 0.0062 0.3 0.3
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1814 0.1814
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0 0.5
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.3133 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.3133 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0064 0.3133 0.3133
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3 0.3
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.3 0.3
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.3 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.2019 0.6729
Leishmania major dihydroorotate dehydrogenase 0.0164 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3 0.3
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0064 0.3133 1
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0164 1 1
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0164 1 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0164 1 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.3 0.9575
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.3133 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0 0.5
Plasmodium falciparum dihydroorotate dehydrogenase 0.0164 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3 0.3
Brugia malayi RNA binding protein 0.0062 0.3 0.3
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0064 0.3133 1
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0164 1 1
Brugia malayi Cytochrome P450 family protein 0.0048 0.2019 0.2019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1814 0.5791
Echinococcus granulosus tar DNA binding protein 0.0062 0.3 0.9575
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0064 0.3133 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1814 0.6048
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3 0.3
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1814 0.1814
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0164 1 0.5
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0164 1 1
Schistosoma mansoni dihydroorotate dehydrogenase 0.0164 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1814 0.5791
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0164 1 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0164 1 1
Brugia malayi Zinc finger, C2H2 type family protein 0.0064 0.3133 0.3133
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0164 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3 0.3
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1814 0.5791
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0164 1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.3133 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1814 0.5791
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0064 0.3133 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.3133 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.3 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0064 0.3133 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1814 0.1814
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0064 0.3133 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.3 1
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0164 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1814 0.1814

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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