Detailed information for compound 181086

Basic information

Technical information
  • TDR Targets ID: 181086
  • Name: prop-2-ynyl N-[2-[4-[[(1S,2R)-2-hydroxycycloh exyl]methyl]phenoxy]ethyl]carbamate
  • MW: 331.406 | Formula: C19H25NO4
  • H donors: 2 H acceptors: 2 LogP: 3.01 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CCOC(=O)NCCOc1ccc(cc1)C[C@@H]1CCCC[C@H]1O
  • InChi: 1S/C19H25NO4/c1-2-12-24-19(22)20-11-13-23-17-9-7-15(8-10-17)14-16-5-3-4-6-18(16)21/h1,7-10,16,18,21H,3-6,11-14H2,(H,20,22)/t16-,18+/m0/s1
  • InChiKey: KSXLDJPOFWYJDZ-FUHWJXTLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[4-[[(1S,2R)-2-hydroxycyclohexyl]methyl]phenoxy]ethyl]carbamic acid prop-2-ynyl ester
  • N-[2-[4-[[(1S,2R)-2-hydroxycyclohexyl]methyl]phenoxy]ethyl]carbamic acid propargyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus geminin 0.0352 0.2718 1
Brugia malayi 6-phosphofructokinase 0.0109 0.0798 0.4463
Echinococcus granulosus intermediate filament protein 0.0027 0.0145 0.0532
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.008 0.02
Trypanosoma cruzi thymidine kinase, putative 0.0502 0.3903 1
Schistosoma mansoni hypothetical protein 0.0222 0.1688 0.1688
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.008 0.0182
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0011 0.001
Brugia malayi ABC transporter family protein 0.0014 0.0043 0.0237
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0061 0.0151
Echinococcus granulosus ATP binding cassette sub family G 0.0009 0.0002 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0058
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0043 0.0087
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0072 0.0503 0.547
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0398
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0145 0.0809
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0058
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0796 0.2034
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0014 0.0043 0.0105
Echinococcus multilocularis multidrug resistance protein 1 0.0014 0.0043 0.0156
Giardia lamblia Ribonuclease H 0.0022 0.0106 0.0272
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0231 0.1761 0.1761
Onchocerca volvulus Putative thymidylate kinase 0.0072 0.0503 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.001 0.0012 0.0042
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0307 0.6079
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0014 0.0041 0.0148
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0061 0.1199
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0146 0.0369
Schistosoma mansoni thymidylate kinase 0.0072 0.0503 0.0503
Echinococcus multilocularis ATP binding cassette sub family G 0.0009 0.0002 0.0005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.008 0.02
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0796 0.4452
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0043 0.0156
Plasmodium vivax glutathione reductase, putative 0.0048 0.0307 0.6079
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0061 0.0151
Echinococcus granulosus FTZ F1 alpha 0.001 0.0011 0.0038
Echinococcus granulosus lamin dm0 0.0027 0.0145 0.0532
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0011 0.001
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0043 0.0156
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0061 0.0214
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0467 0.0466
Schistosoma mansoni hypothetical protein 0.0072 0.0503 0.0503
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0061 0.0151
Schistosoma mansoni coup transcription factor 0.001 0.0011 0.001
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0045 0.0251
Trypanosoma brucei ribonuclease H1 0.0022 0.0106 0.0267
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0043 0.0087
Trichomonas vaginalis abcb9, putative 0.0014 0.0043 0.0087
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.001 0.0012 0.0042
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.008 0.0446
Echinococcus granulosus bloom syndrome protein 0.0021 0.01 0.0367
Brugia malayi 6-phosphofructokinase 0.0109 0.0796 0.4452
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0043 0.0087
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0061 0.0156
Toxoplasma gondii ribonuclease HI protein 0.0022 0.0106 0.2101
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0796 0.8941
Trypanosoma brucei ingi protein (ORF1) 0.0027 0.0146 0.0369
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0044 0.0863
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0043 0.0087
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0061 0.0151
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0789 0.7488
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0032 0.0188 0.1048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0058
Brugia malayi glutathione reductase 0.0048 0.0307 0.1715
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0164 0.3254
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0043 0.0156
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0011 0.0038
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0061 0.0741
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0796 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0021 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0467 0.0466
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0043 0.0087
Giardia lamblia CDC8 0.0072 0.0503 0.1289
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0061 0.0741
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0062 0.0421 0.1546
Entamoeba histolytica P-glycoprotein-2, putative 0.0014 0.0043 0.0105
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0043 0.0156
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0009 0.0032
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0021 0.0049
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0043 0.0087
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0061 0.0741
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0038
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.008 0.0984
Schistosoma mansoni lamin 0.0027 0.0145 0.0145
Trypanosoma brucei trypanothione reductase 0.0048 0.0307 0.0781
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0061 0.0151
Schistosoma mansoni hypothetical protein 0.001 0.0012 0.0011
Echinococcus granulosus ATP binding cassette sub family G 0.0009 0.0002 0.0005
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0164 0.0398
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0164 0.2635
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.008 0.0443
Echinococcus granulosus thymidylate kinase 0.0072 0.0503 0.185
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0009 0.0032
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0021 0.0049
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0061 0.1199
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0011 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0058
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0796 0.2925
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0034 0.0123
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0061 0.0151
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0014 0.0043 0.0087
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0809
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0043 0.0156
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0058
Schistosoma mansoni ap endonuclease 0.0019 0.008 0.008
Entamoeba histolytica P-glycoprotein-2 0.0014 0.0043 0.0105
Brugia malayi multidrug resistance protein 3 0.0014 0.0043 0.0237
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0164 0.3254
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0885 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0307 0.3135
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0011 0.0058
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0164 0.3254
Schistosoma mansoni hypothetical protein 0.0352 0.2718 0.2718
Toxoplasma gondii exonuclease III APE 0.0019 0.008 0.1583
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0796 0.2034
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0043 0.0087
Brugia malayi thymidylate kinase 0.0072 0.0503 0.2815
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0045 0.0863
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.001 0.0012 0.0063
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0043 0.0156
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.001 0.0012 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0058
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0001 0.0001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0011 0.0038
Trichomonas vaginalis thymidine kinase, putative 0.0502 0.3903 1
Trypanosoma cruzi thymidylate kinase, putative 0.0072 0.0503 0.1285
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0061 0.0151
Loa Loa (eye worm) RNA binding protein 0.0068 0.0467 0.2612
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.008 0.0182
Chlamydia trachomatis thymidylate kinase 0.0072 0.0503 1
Echinococcus multilocularis GPCR, family 2 0.001 0.0012 0.0042
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0011 0.0058
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0789 0.8862
Trypanosoma brucei ingi protein (ORF1) 0.0027 0.0146 0.0369
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.008 0.1558
Loa Loa (eye worm) RecQ helicase 0.0021 0.01 0.0558
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0061 0.006
Trypanosoma brucei RNA helicase, putative 0.0222 0.1688 0.4322
Schistosoma mansoni hypothetical protein 0.001 0.0012 0.0011
Entamoeba histolytica P-glycoprotein 5, putative 0.0014 0.0043 0.0105
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0467 0.1716
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.0058
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0164 0.3254
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0038
Toxoplasma gondii thioredoxin reductase 0.0048 0.0307 0.6091
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.008 0.0293
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0398
Brugia malayi Thioredoxin reductase 0.0048 0.0307 0.1715
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0061 0.0151
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0043 0.0087
Leishmania major trypanothione reductase 0.0048 0.0307 0.0781
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0058
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0061 0.0222
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0043 0.0156
Echinococcus multilocularis ATP binding cassette sub family G 0.0009 0.0002 0.0005
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0467 0.0466
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0164 0.3234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0058
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0014 0.0043 0.0237
Leishmania major thymidylate kinase-like protein 0.0072 0.0503 0.1285
Mycobacterium tuberculosis Probable reductase 0.0108 0.0789 0.8862
Brugia malayi latrophilin 2 splice variant baaae 0.0022 0.0106 0.0592
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0058
Plasmodium falciparum thymidylate kinase 0.0072 0.0503 1
Trypanosoma brucei thymidylate kinase, putative 0.0072 0.0503 0.1285
Brugia malayi hypothetical protein 0.0062 0.0421 0.2353
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0011 0.001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0038
Trypanosoma brucei thymidylate kinase, putative 0.0072 0.0503 0.1285
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0061 0.0151
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0796 0.2019
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0061 0.1199
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0011 0.001
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0061 0.0151
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0058
Echinococcus multilocularis multidrug resistance protein 1 0.0014 0.0043 0.0156
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0796 0.2019
Echinococcus multilocularis geminin 0.0352 0.2718 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0011 0.001
Trypanosoma brucei thymidine kinase 0.0502 0.3903 1
Entamoeba histolytica hypothetical protein 0.0062 0.0421 0.1074
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0165
Onchocerca volvulus 0.0027 0.0145 0.2725
Onchocerca volvulus 0.0027 0.0145 0.2725
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.008 0.02
Schistosoma mansoni smdr2 0.0014 0.0043 0.0042
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0001 0.00000000063505
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0011 0.0038
Echinococcus granulosus ribonuclease H1 0.0022 0.0106 0.0389
Entamoeba histolytica P-glycoprotein-2 0.0014 0.0043 0.0105
Entamoeba histolytica P-glycoprotein-1 0.0014 0.0043 0.0105
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0043 0.0087
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.01 0.0558
Loa Loa (eye worm) hypothetical protein 0.0027 0.0141 0.0787
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0796 0.0795
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0164 0.2635
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0796 0.7663
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0061 0.0151
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0058
Loa Loa (eye worm) glutathione reductase 0.0048 0.0307 0.1715
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0061 0.0222
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0026 0.0144
Brugia malayi TAR-binding protein 0.0068 0.0467 0.2612
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0038
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0041 0.0148
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0398
Leishmania major p-glycoprotein 0.0014 0.0043 0.0105
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0467 0.2612
Brugia malayi RNA binding protein 0.0068 0.0467 0.2612
Echinococcus multilocularis thymidylate kinase 0.0072 0.0503 0.185
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0043 0.0156
Entamoeba histolytica P-glycoprotein-5 0.0014 0.0043 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0796 0.2019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0058
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0398
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0164 0.0416
Echinococcus multilocularis bloom syndrome protein 0.0021 0.01 0.0367
Schistosoma mansoni phosphoglucomutase 0.0022 0.0106 0.0106
Schistosoma mansoni phosphoglucomutase 0.0022 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0237
Treponema pallidum ribonuclease H (rnhA) 0.0022 0.0106 0.0617
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0058
Brugia malayi ecdysteroid receptor 0.001 0.0011 0.0058
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0062 0.0421 0.1546
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.0106 0.0249
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0011 0.001
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0022 0.0106 0.1025
Trypanosoma cruzi thymidylate kinase, putative 0.0072 0.0503 0.1285
Leishmania major ribonuclease H1, putative 0.0022 0.0106 0.0267
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0164 0.1406
Trichomonas vaginalis thymidine kinase, putative 0.0502 0.3903 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0043 0.0087
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.001 0.0012 0.0042
Brugia malayi phosphofructokinase 0.0109 0.0796 0.4452
Plasmodium falciparum glutathione reductase 0.0016 0.0061 0.1199
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0027 0.0146 0.0369
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.008 0.02
Treponema pallidum thymidylate kinase (tmk) 0.0072 0.0503 0.6022
Schistosoma mansoni intermediate filament proteins 0.0027 0.0145 0.0145
Schistosoma mansoni hypothetical protein 0.0352 0.2718 0.2718
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0796 1
Brugia malayi follicle stimulating hormone receptor 0.0234 0.1787 1
Schistosoma mansoni multidrug resistance protein 0.0014 0.0043 0.0042
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0043 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0058
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.01 0.0234
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0028 0.0155 0.0393
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.008 0.0262
Entamoeba histolytica Thymidylate kinase, putative 0.0072 0.0503 0.1285
Entamoeba histolytica thymidine kinase, putative 0.0502 0.3903 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0061 0.0151
Schistosoma mansoni ap endonuclease 0.0019 0.008 0.008
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0789 0.8862
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0307 0.1715
Entamoeba histolytica hypothetical protein 0.0062 0.0421 0.1074
Entamoeba histolytica hypothetical protein 0.0062 0.0421 0.1074
Plasmodium vivax multidrug resistance protein 1, putative 0.0014 0.0043 0.0814
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0009 0.0002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0237
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0009 0.0002 0.0001
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0043 0.0087
Echinococcus multilocularis lamin 0.0027 0.0145 0.0532
Brugia malayi intermediate filament protein 0.0027 0.0145 0.0809
Plasmodium falciparum thioredoxin reductase 0.0048 0.0307 0.6091
Brugia malayi Calcitonin receptor-like protein seb-1 0.0032 0.0188 0.1048
Echinococcus multilocularis ATP binding cassette sub family G 0.0009 0.0002 0.0005
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0796 0.2034
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0398
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0043 0.0156
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0011 0.001
Brugia malayi steroid hormone receptor 0.001 0.0011 0.0058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.008 0.02
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0885 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0065 0.0064
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0061 0.0133
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0021 0.0031
Trichomonas vaginalis abcb9, putative 0.0014 0.0043 0.0087
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.01 0.0234
Plasmodium falciparum glutathione reductase 0.0048 0.0307 0.6091
Schistosoma mansoni multidrug resistance protein 0.0014 0.0043 0.0042
Plasmodium falciparum multidrug resistance protein 1 0.0014 0.0043 0.0841
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0164 0.0421
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0028 0.0155 0.0393
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0061 0.0151
Entamoeba histolytica P-glyco protein 6, putative 0.0014 0.0043 0.0105
Trypanosoma cruzi thymidine kinase, putative 0.0502 0.3903 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0032 0.0188 0.1048
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.008 0.0205
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0061 0.0133
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0061 0.1174
Trichomonas vaginalis abcb9, putative 0.0014 0.0043 0.0087
Schistosoma mansoni hypothetical protein 0.001 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0058
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0885 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0061 0.1199
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0043 0.0087
Schistosoma mansoni multidrug resistance protein 0.0014 0.0043 0.0042
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0043 0.0087
Plasmodium falciparum thioredoxin reductase 0.0016 0.0061 0.1199
Loa Loa (eye worm) hypothetical protein 0.0022 0.0106 0.0592
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0058
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0043 0.0087
Onchocerca volvulus Ribonuclease H1 homolog 0.0022 0.0106 0.1936
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0796 0.2034
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0307 0.0781
Brugia malayi RNase H family protein 0.0022 0.0106 0.0592
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0796 0.2034
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0307 0.1127
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0045 0.0251
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0043 0.0156
Brugia malayi RNase H family protein 0.0022 0.0106 0.0592
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0398
Trichomonas vaginalis thymidylate kinase, putative 0.0072 0.0503 0.1269
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0011 0.0038
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0014 0.0043 0.0841
Loa Loa (eye worm) thymidylate kinase 0.0072 0.0503 0.2815
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0038
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0021 0.0049
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0106 0.0267
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0011 0.0038
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0043 0.0156
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0796 0.4452
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0789 0.8862
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0061 0.0391
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.001 0.0012 0.0042
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0796 0.0795
Loa Loa (eye worm) hypothetical protein 0.0032 0.0188 0.1048
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0043 0.0087
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.0058
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.008 0.0436
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0467 0.0466
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0061 0.0151
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0026 0.0144
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0011 0.0058
Trypanosoma brucei unspecified product 0.0027 0.0146 0.0369
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0011 0.0058
Trichomonas vaginalis thymidylate kinase, putative 0.0072 0.0503 0.1269
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.008 0.1573
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0058
Schistosoma mansoni phosphoglucomutase 0.0022 0.0106 0.0106
Giardia lamblia Thymidine kinase 0.0502 0.3903 1
Mycobacterium ulcerans thymidylate kinase 0.0072 0.0503 0.6317
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0043 0.0087
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0072 0.0503 1
Echinococcus granulosus ATP binding cassette sub family G 0.0009 0.0002 0.0005
Leishmania major thymidine kinase, putative 0.0502 0.3903 1
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0885 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0187
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.008 0.0293
Echinococcus multilocularis musashi 0.0027 0.0145 0.0532
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0789 0.8862
Onchocerca volvulus 0.0014 0.0043 0.0649
Schistosoma mansoni lamin 0.0027 0.0145 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0058
Echinococcus multilocularis lamin dm0 0.0027 0.0145 0.0532
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0061 0.1174
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0011 0.0038
Schistosoma mansoni hypothetical protein 0.0062 0.0421 0.042
Echinococcus multilocularis ribonuclease H1 0.0022 0.0106 0.0389
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.1787 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0164 0.3254
Schistosoma mansoni hypothetical protein 0.0022 0.0106 0.0106
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.008 0.1583
Echinococcus granulosus GPCR family 2 0.001 0.0012 0.0042
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0043 0.0156
Loa Loa (eye worm) latrophilin receptor protein 2 0.001 0.0012 0.0063
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0467 0.2612
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0106 0.0267
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0145 0.0809
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0011 0.001
Schistosoma mansoni thymidylate kinase 0.0072 0.0503 0.0503
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0043 0.0087
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0011 0.0038
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0145 0.0809
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0043 0.0087
Toxoplasma gondii thymidylate kinase 0.0072 0.0503 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0043 0.0087
Brugia malayi RNase H family protein 0.0022 0.0106 0.0592
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0061 0.0151
Leishmania major hypothetical protein, conserved 0.0028 0.0155 0.0393
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0796 0.2034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0011 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0062 0.0421 0.042
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0043 0.0841
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0061 0.0338
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0058
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0796 0.2925
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0063
Echinococcus granulosus lamin 0.0027 0.0145 0.0532
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0467 0.2612
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0307 0.1127
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0034 0.0123
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0061 0.0151
Plasmodium falciparum ABC transporter G family member 2 0.0009 0.0002 0.0029
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.008 0.0446
Echinococcus granulosus tar DNA binding protein 0.0068 0.0467 0.1716
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0014 0.0043 0.0087
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0043 0.0087
Entamoeba histolytica hypothetical protein 0.0062 0.0421 0.1074
Plasmodium vivax thymidylate kinase, putative 0.0072 0.0503 1
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0796 0.2019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0011 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0038
Trichomonas vaginalis thymidine kinase, putative 0.0502 0.3903 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0366
Brugia malayi Latrophilin receptor protein 2 0.001 0.0012 0.0063
Trichomonas vaginalis taga, putative 0.0014 0.0043 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0467 0.0466
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0061 0.0151
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0043 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0058
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0796 0.4452
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0164 0.3234
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0009 0.0032
Loa Loa (eye worm) multidrug resistance protein 3 0.0014 0.0043 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0058
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0043 0.0087
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0789 0.8862
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0043 0.0087

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 ug ml-1 Growth inhibitory activity of the compound was tested against Trypanosoma cruzi (Epimastigote) ChEMBL. 9873713
IC50 (functional) > 100 ug ml-1 Growth inhibitory activity of the compound was tested against Trypanosoma cruzi (Epimastigote) ChEMBL. 9873713

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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