Detailed information for compound 1810892

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.533 | Formula: C25H32N2O3
  • H donors: 1 H acceptors: 2 LogP: 5.25 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)cc(c1)C(=O)N(C(C)(C)C)NC(=O)c1ccc2c(c1C)CC(O2)(C)C
  • InChi: 1S/C25H32N2O3/c1-15-11-16(2)13-18(12-15)23(29)27(24(4,5)6)26-22(28)19-9-10-21-20(17(19)3)14-25(7,8)30-21/h9-13H,14H2,1-8H3,(H,26,28)
  • InChiKey: QHPPPCDCWLXZAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans polyketide synthase 0.0026 0.0118 0.0381
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0025 0.0109 0.0858
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0274 0.3073
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0961 0.283
Plasmodium falciparum plasmepsin II 0.0082 0.0644 1
Toxoplasma gondii subtilisin SUB12 0.0025 0.0109 0.0825
Plasmodium falciparum plasmepsin V 0.0045 0.0296 0.3494
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0118 0.1206
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0274 0.3073
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0277 0.2504 0.3006
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0118 0.1206
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0088 0.0893
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0043 0.0274 0.2353
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0274 0.3073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0361 0.3301 1
Loa Loa (eye worm) hypothetical protein 0.021 0.1864 0.1864
Echinococcus multilocularis membrane bound transcription factor site 1 0.0025 0.0109 0.0116
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0045 0.0296 0.0296
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0016 0.0017 0.0005
Onchocerca volvulus 0.0277 0.2504 1
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0025 0.0109 0.0345
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0061 0.0609
Schistosoma mansoni tyrosine kinase 0.0057 0.0409 0.0512
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0654 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0961 0.283
Echinococcus multilocularis p2X purinoceptor 4 0.0354 0.3233 0.3885
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0277 0.2504 0.3146
Echinococcus granulosus p2X purinoceptor 4 0.0354 0.3233 0.3885
Brugia malayi Myb-like DNA-binding domain containing protein 0.0174 0.1521 0.1506
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0043 0.0274 0.1007
Schistosoma mansoni cathepsin D (A01 family) 0.0175 0.1531 0.1923
Brugia malayi Protein kinase domain containing protein 0.0057 0.0409 0.0392
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0096 0.0979
Echinococcus granulosus Mastin 0.0277 0.2504 0.3006
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0016 0.0017 0.0017
Brugia malayi hypothetical protein 0.0045 0.0296 0.028
Trichomonas vaginalis hypothetical protein 0.0115 0.0961 0.283
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0109 0.0222
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.006 0.006
Echinococcus multilocularis glycoprotein Antigen 5 0.0277 0.2504 0.3006
Brugia malayi Furin-like cysteine rich region family protein 0.017 0.1488 0.1473
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0158 0.0198
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0025 0.0109 0.1114
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0064 0.122
Echinococcus multilocularis prolyl endopeptidase 0.0129 0.1095 0.1306
Brugia malayi endoprotease bli-4 precursor 0.0594 0.5517 0.551
Brugia malayi Glutamate receptor 2 precursor 0.0031 0.0158 0.0142
Echinococcus granulosus prolyl endopeptidase 0.0129 0.1095 0.1306
Onchocerca volvulus 0.0025 0.0109 0.0372
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0109
Schistosoma mansoni memapsin-2 (A01 family) 0.0851 0.7957 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.0356 1
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.006 0.0043
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0096 0.0979
Echinococcus multilocularis nmda type glutamate receptor 0.0016 0.0017 0.0005
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0274 0.2381
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.0356 0.3671
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0685 0.6378 0.768
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0025 0.0109 0.0345
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.0356 0.3145
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0961 0.283
Plasmodium falciparum plasmepsin IX 0.0045 0.0296 0.3494
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0388 0.0388
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0078 0.0612 1
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0025 0.0109 0.1114
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0158 0.0198
Schistosoma mansoni cercarial elastase (S01 family) 0.0277 0.2504 0.3146
Toxoplasma gondii aspartyl protease ASP3 0.0045 0.0296 0.2562
Schistosoma mansoni hypothetical protein 0.0055 0.0388 0.0486
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0025 0.0109 0.0093
Schistosoma mansoni tyrosine kinase 0.0093 0.0754 0.0946
Echinococcus multilocularis receptor type guanylyl cyclase 0.002 0.006 0.0056
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0115 0.0961 0.283
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Entamoeba histolytica hypothetical protein 0.0018 0.0037 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0262 0.2354 0.2341
Brugia malayi aspartic protease BmAsp-1, identical 0.0045 0.0296 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0961 0.283
Loa Loa (eye worm) hypothetical protein 0.0277 0.2504 0.2504
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0025 0.0109 0.2578
Loa Loa (eye worm) hypothetical protein 0.0277 0.2504 0.2504
Onchocerca volvulus 0.0045 0.0296 0.1123
Loa Loa (eye worm) hypothetical protein 0.0042 0.0264 0.0264
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.006 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0277 0.2504 0.3146
Echinococcus multilocularis p2X purinoceptor 4 0.0354 0.3233 0.3885
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0961 0.283
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0037
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0088 0.0088
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0058 0.1016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Schistosoma mansoni P2X receptor subunit 0.0354 0.3233 0.4062
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0043 0.0274 0.1007
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0274 0.1007
Onchocerca volvulus 0.0277 0.2504 1
Brugia malayi Pepsin A precursor 0.0045 0.0296 0.028
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0046 0.0307 0.0355
Echinococcus granulosus p2X purinoceptor 4 0.0354 0.3233 0.3885
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0961 0.283
Giardia lamblia Furin precursor putative serine protease 0.0115 0.0961 0.4786
Echinococcus granulosus tyrosine kinase 0.002 0.006 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Onchocerca volvulus 0.002 0.006 0.0172
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0277 0.2504 0.3146
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0277 0.2504 0.3006
Echinococcus granulosus nmda type glutamate receptor 0.0109 0.0903 0.1074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Brugia malayi neuroendocrine convertase 1 precursor 0.0374 0.3418 0.3407
Echinococcus granulosus metabotropic glutamate receptor 5 0.0016 0.0017 0.0005
Plasmodium falciparum plasmepsin X 0.0045 0.0296 0.3494
Loa Loa (eye worm) TK/INSR protein kinase 0.0057 0.0409 0.0409
Echinococcus granulosus glutamate receptor subunit protein glur 0.0031 0.0158 0.0176
Plasmodium falciparum plasmepsin VIII, putative 0.0045 0.0296 0.3494
Loa Loa (eye worm) TK/EGFR protein kinase 0.017 0.1488 0.1488
Onchocerca volvulus Prolyl endopeptidase homolog 0.0129 0.1095 0.4336
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0274 0.3073
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0058 0.0136
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0118 0.0381
Brugia malayi aspartic protease BmAsp-2, identical 0.0045 0.0296 0.028
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0654 0.0639
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0109 0.0222
Schistosoma mansoni cercarial elastase (S01 family) 0.0277 0.2504 0.3146
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0025 0.0109 0.0116
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0018 0.0037 0.0029
Onchocerca volvulus CoRest homolog 0.0179 0.1569 0.6241
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0104 0.0322
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0078 0.0612 0.6329
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0158 0.0198
Plasmodium falciparum plasmepsin III 0.0045 0.0296 0.3494
Echinococcus granulosus epidermal growth factor receptor 0.0093 0.0754 0.0894
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0307 0.0355
Plasmodium vivax aspartyl proteinase, putative 0.0082 0.0644 1
Echinococcus multilocularis tyrosine kinase 0.002 0.006 0.0056
Loa Loa (eye worm) hypothetical protein 0.0082 0.0644 0.0644
Echinococcus multilocularis nmda type glutamate receptor 0.0109 0.0903 0.1074
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0274 0.2353
Plasmodium falciparum plasmepsin I 0.0082 0.0644 1
Leishmania major UDP-galactopyranose mutase 0.0043 0.0274 0.2381
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0104 0.1054
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.0356 0.134
Leishmania major oligopeptidase b 0.0051 0.0356 0.3145
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0274 0.3073
Schistosoma mansoni metabotropic glutamate receptor 0.0016 0.0017 0.002
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0277 0.2504 0.3006
Loa Loa (eye worm) hypothetical protein 0.0277 0.2504 0.2504
Onchocerca volvulus 0.0277 0.2504 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0274 0.0315
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0274 0.0315
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0307 0.0355
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.014 0.1202 0.357
Chlamydia trachomatis glutamine binding protein 0.0078 0.0612 1
Toxoplasma gondii subtilisin SUB2 0.0025 0.0109 0.0825
Leishmania major subtilisin-like serine peptidase 0.0025 0.0109 0.0858
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0031 0.0158 0.0176
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Echinococcus multilocularis Furin 1 0.014 0.1202 0.1435
Echinococcus multilocularis roundabout 2 0.0018 0.0039 0.0032
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0296 0.0371
Echinococcus multilocularis glutamate receptor 2 0.0031 0.0158 0.0176
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0274 0.2817
Brugia malayi Trypsin-like protease protein 5 0.0277 0.2504 0.2491
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0296 0.0371
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0961 0.283
Schistosoma mansoni cercarial elastase (S01 family) 0.0277 0.2504 0.3146
Onchocerca volvulus 0.0023 0.0088 0.0286
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0654 0.0639
Echinococcus granulosus roundabout 2 0.0018 0.0039 0.0032
Toxoplasma gondii aspartyl protease 0.0045 0.0296 0.2562
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0277 0.2504 0.3146
Echinococcus granulosus glycoprotein Antigen 5 0.0277 0.2504 0.3006
Echinococcus multilocularis 0.0479 0.4424 0.5323
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0118 0.0906
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.014 0.1202 0.357
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0109 0.0222
Brugia malayi Eukaryotic aspartyl protease family protein 0.0045 0.0296 0.028
Toxoplasma gondii subtilisin SUB10 0.0025 0.0109 0.0825
Brugia malayi Trypsin family protein 0.0277 0.2504 0.2491
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0277 0.2504 0.3146
Mycobacterium ulcerans hypothetical protein 0.0277 0.2504 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.021 0.1864 0.2234
Loa Loa (eye worm) hypothetical protein 0.0277 0.2504 0.2504
Brugia malayi hypothetical protein 0.0043 0.0274 0.0257
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.014 0.1202 0.357
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.0356 0.2502
Echinococcus multilocularis enteropeptidase 0.0277 0.2504 0.3006
Schistosoma mansoni P2X receptor subunit 0.0354 0.3233 0.4062
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.1095 0.1376
Loa Loa (eye worm) proprotein convertase 2 0.014 0.1202 0.1202
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Echinococcus multilocularis NMDA receptor 0.0031 0.0158 0.0176
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0109 0.0903 0.1074
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.022 0.0792
Giardia lamblia High cysteine membrane protein Group 2 0.0221 0.1967 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0078 0.0612 0.2373
Toxoplasma gondii subtilisin SUB4 0.0025 0.0109 0.0825
Schistosoma mansoni P2X receptor subunit 0.0354 0.3233 0.4062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0064 0.0163
Loa Loa (eye worm) hypothetical protein 0.0043 0.0274 0.0274
Schistosoma mansoni hypothetical protein 0.0115 0.0961 0.1206
Toxoplasma gondii subtilisin SUB9 0.0025 0.0109 0.0825
Schistosoma mansoni hypothetical protein 0.0083 0.0654 0.0822
Echinococcus multilocularis GPCR, family 2 0.0083 0.0654 0.0774
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.022 0.2262
Toxoplasma gondii subtilisin SUB5 0.0025 0.0109 0.0825
Toxoplasma gondii subtilisin SUB1 0.0025 0.0109 0.0825
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0025 0.0109 0.1114
Schistosoma mansoni tyrosine kinase 0.002 0.006 0.0074
Toxoplasma gondii subtilisin SUB8 0.0025 0.0109 0.0825
Schistosoma mansoni tyrosine kinase 0.0089 0.0711 0.0893
Loa Loa (eye worm) hypothetical protein 0.021 0.1864 0.1864
Schistosoma mansoni cercarial elastase (S01 family) 0.0277 0.2504 0.3146
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0961 0.283
Schistosoma mansoni cercarial elastase (S01 family) 0.0277 0.2504 0.3146
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Schistosoma mansoni glutamate receptor NMDA 0.0046 0.0307 0.0385
Schistosoma mansoni ATP-binding cassette transporter 0.0031 0.0158 0.0198
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Echinococcus multilocularis insulin receptor 0.0057 0.0409 0.0477
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0961 0.283
Schistosoma mansoni amine oxidase 0.0043 0.0274 0.0343
Brugia malayi celfurPC protein 0.0479 0.4424 0.4415
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0036 0.0138
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.0356 0.3145
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0093 0.0754 0.0894
Echinococcus multilocularis epidermal growth factor receptor 0.0093 0.0754 0.0894
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0104 0.2402
Echinococcus granulosus p2X purinoceptor 4 0.0354 0.3233 0.3885
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Mycobacterium ulcerans thioesterase 0.0021 0.0064 0.0163
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0031 0.0158 0.0176
Onchocerca volvulus 0.0277 0.2504 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0071
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0685 0.6378 0.768
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0296 0.0371
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Echinococcus granulosus Furin 1 0.014 0.1202 0.1435
Onchocerca volvulus 0.0045 0.0296 0.1123
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0118 0.2842
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0654 0.0774
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0082 0.0644 0.0761
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.002 0.006 0.0074
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0296 0.0371
Plasmodium vivax aspartyl proteinase, putative 0.0045 0.0296 0.3494
Schistosoma mansoni cercarial elastase (S01 family) 0.0277 0.2504 0.3146
Loa Loa (eye worm) endoprotease bli-4 0.0594 0.5517 0.5517
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0031 0.0158 0.0176
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0388 0.0486
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0262 0.2354 0.2354
Loa Loa (eye worm) glutamate receptor 0.0016 0.0017 0.0017
Echinococcus multilocularis p2X purinoceptor 4 0.0354 0.3233 0.3885
Trypanosoma cruzi prolyl endopeptidase 0.0129 0.1095 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0274 0.2381
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.022 0.5908
Schistosoma mansoni hypothetical protein 0.0055 0.0388 0.0486
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0118 0.2842
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.002 0.006 0.0172
Loa Loa (eye worm) hypothetical protein 0.0129 0.1095 0.1095
Echinococcus granulosus metabotropic glutamate receptor 2 0.0016 0.0017 0.0005
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0078 0.0612 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0179 0.1567 0.1567
Plasmodium vivax aspartyl protease, putative 0.0045 0.0296 0.3494
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0307 0.0355
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0078 0.0612 0.5
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.022 0.2262
Schistosoma mansoni hypothetical protein 0.0179 0.1567 0.1969
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Onchocerca volvulus Fatty acid synthase homolog 0.0045 0.0293 0.1109
Schistosoma mansoni P2X receptor subunit 0.0354 0.3233 0.4062
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0129 0.1095 1
Plasmodium vivax aspartyl protease, putative 0.0045 0.0296 0.3494
Echinococcus granulosus epidermal growth factor receptor 0.017 0.1488 0.1779
Loa Loa (eye worm) aspartyl protease 6 0.0045 0.0296 0.0296
Schistosoma mansoni tyrosine kinase 0.0057 0.0409 0.0512
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0274 0.3073
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0307 0.0355
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0104 0.0087
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0115 0.0961 0.283
Brugia malayi prolyl oligopeptidase family protein 0.0129 0.1095 0.108
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0016 0.0017 0.0005
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0025 0.0109 0.2578
Trypanosoma cruzi oligopeptidase b 0.0051 0.0356 0.3145
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0296 0.0371
Loa Loa (eye worm) trypsin family protein 0.0277 0.2504 0.2504
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0016 0.0019 0.0019
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0082 0.0644 0.0808
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0082 0.0644 0.5798
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.014 0.1202 0.357
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Echinococcus granulosus membrane bound transcription factor site 1 0.0025 0.0109 0.0116
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.1095 0.1376
Loa Loa (eye worm) hypothetical protein 0.0277 0.2504 0.2504
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0388 0.0486
Schistosoma mansoni tyrosine kinase 0.0093 0.0754 0.0946
Loa Loa (eye worm) hypothetical protein 0.1066 1 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0388 0.0372
Echinococcus granulosus enteropeptidase 0.0277 0.2504 0.3006
Toxoplasma gondii subtilisin SUB7 0.0025 0.0109 0.0825
Loa Loa (eye worm) subtilase 0.0025 0.0109 0.0109
Echinococcus granulosus glutamate receptor 2 0.0046 0.0307 0.0355
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0274 0.1007
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0277 0.2504 0.3006
Schistosoma mansoni hypothetical protein 0.0055 0.0388 0.0486
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0274 0.2817
Echinococcus multilocularis glutamate receptor 2 0.0016 0.0017 0.0005
Plasmodium falciparum plasmepsin IV 0.0082 0.0644 1
Schistosoma mansoni hypothetical protein 0.0031 0.0158 0.0198
Plasmodium vivax plasmepsin IV, putative 0.0082 0.0644 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.014 0.1202 0.357
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0082 0.0644 0.0644
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0031 0.0158 0.0176
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0361 0.3301 0.3968
Brugia malayi latrophilin 2 splice variant baaae 0.0179 0.1567 0.1553
Brugia malayi Trypsin family protein 0.0277 0.2504 0.2491
Echinococcus granulosus receptor type guanylyl cyclase 0.002 0.006 0.0056
Toxoplasma gondii prolyl endopeptidase 0.0129 0.1095 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0025 0.0109 0.0858
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0025 0.0109 0.0858
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0025 0.0109 0.0116
Loa Loa (eye worm) hypothetical protein 0.0233 0.2084 0.2084
Echinococcus granulosus neuroendocrine convertase 2 0.0374 0.3418 0.4108
Loa Loa (eye worm) hypothetical protein 0.0594 0.5517 0.5517
Brugia malayi Trypsin family protein 0.0277 0.2504 0.2491
Brugia malayi amine oxidase, flavin-containing family protein 0.006 0.0443 0.0426
Echinococcus granulosus nmda type glutamate receptor 0.0016 0.0017 0.0005
Brugia malayi Guanylyl cyclase protein 23 0.002 0.006 0.0043
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0058 0.0136
Echinococcus granulosus lysine specific histone demethylase 1A 0.021 0.1864 0.2234
Schistosoma mansoni hypothetical protein 0.0083 0.0654 0.0822
Schistosoma mansoni site-1 peptidase (S08 family) 0.0025 0.0109 0.0136
Echinococcus granulosus GPCR family 2 0.0083 0.0654 0.0774
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Echinococcus granulosus transmembrane protease serine 3 0.0277 0.2504 0.3006
Echinococcus multilocularis glutamate receptor 2 0.0046 0.0307 0.0355
Schistosoma mansoni hypothetical protein 0.0277 0.2504 0.3146
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0277 0.2504 0.3146
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0961 0.283
Brugia malayi SWIRM domain containing protein 0.0018 0.0037 0.002
Brugia malayi Trypsin family protein 0.0277 0.2504 0.2491
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0025 0.0109 0.0345
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0361 0.3301 1
Schistosoma mansoni hypothetical protein 0.0083 0.0654 0.0822
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0277 0.2504 0.3146
Toxoplasma gondii SWIRM domain-containing protein 0.0018 0.0037 0.0149
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0296 0.0371
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0082 0.0644 0.1859
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0064 0.0647
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0388 0.0452
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0388 0.0452
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0307 0.0355
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0307 0.0355
Brugia malayi Glutamate receptor 1 precursor 0.0031 0.0158 0.0142
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0274 0.0343
Loa Loa (eye worm) hypothetical protein 0.0228 0.2033 0.2033
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0115 0.0961 0.283
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0025 0.0109 0.1114
Entamoeba histolytica SWIRM domain protein 0.0018 0.0037 1
Schistosoma mansoni hypothetical protein 0.0083 0.0654 0.0822
Schistosoma mansoni tyrosine kinase 0.0089 0.0711 0.0893
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0046 0.0307 0.0355
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0025 0.0109 0.0136
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.0017 0.0017
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0315 0.0298
Schistosoma mansoni SWI/SNF complex-related 0.0018 0.0037 0.0045
Schistosoma mansoni tyrosine kinase 0.017 0.1488 0.1869
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0654 0.0654
Trypanosoma brucei prolyl endopeptidase 0.0129 0.1095 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.014 0.1202 0.357
Loa Loa (eye worm) fatty acid synthase 0.0024 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0179 0.1569 0.1569
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0158 0.0198
Schistosoma mansoni tyrosine kinase 0.0089 0.0711 0.0893
Mycobacterium ulcerans oxidoreductase 0.0043 0.0274 0.1007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0277 0.2504 0.3146
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0016 0.0017 0.0005
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0118 0.0381
Toxoplasma gondii subtilisin SUB11 0.0025 0.0109 0.0825
Echinococcus multilocularis epidermal growth factor receptor 0.017 0.1488 0.1779
Schistosoma mansoni cathepsin D (A01 family) 0.0175 0.1531 0.1923
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0361 0.3301 0.3968
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0296 0.0371
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0104 0.0322
Toxoplasma gondii aspartyl protease ASP1 0.0082 0.0644 0.5798
Schistosoma mansoni cercarial elastase (S01 family) 0.0277 0.2504 0.3146
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Echinococcus multilocularis transmembrane protease serine 3 0.0277 0.2504 0.3006
Echinococcus granulosus atrial natriuretic peptide receptor 0.0016 0.0017 0.0005
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.006 0.006
Echinococcus multilocularis neuroendocrine convertase 2 0.0374 0.3418 0.4108
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0274 0.3073
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0116 0.0967 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.021 0.1864 0.2342
Plasmodium falciparum plasmepsin VII 0.0045 0.0296 0.3494
Brugia malayi hypothetical protein 0.0277 0.2504 0.2491
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0118 0.2842
Echinococcus granulosus furin 0.0594 0.5517 0.6641
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0158 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0109 0.0222
Echinococcus granulosus glutamate NMDA receptor subunit 0.0258 0.2317 0.2781
Trypanosoma cruzi oligopeptidase b 0.0051 0.0356 0.3145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0025 0.0109 0.0136
Schistosoma mansoni amine oxidase 0.0043 0.0274 0.0343
Loa Loa (eye worm) hypothetical protein 0.0083 0.0654 0.0654
Echinococcus multilocularis 0.0043 0.0274 0.0315
Trypanosoma brucei oligopeptidase b 0.0051 0.0356 0.2502
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0104 0.1054
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0082 0.0644 0.0761
Brugia malayi proprotein convertase 2 0.0374 0.3418 0.3407
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.0356 0.3145
Schistosoma mansoni metabotropic glutamate receptor 0.0016 0.0017 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0296 0.0371
Mycobacterium ulcerans dehydrogenase 0.0043 0.0274 0.1007
Onchocerca volvulus 0.0277 0.2504 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0296 0.0296
Schistosoma mansoni cercarial elastase (S01 family) 0.0277 0.2504 0.3146
Loa Loa (eye worm) hypothetical protein 0.006 0.0443 0.0443
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Plasmodium falciparum plasmepsin VI 0.0082 0.0644 1
Toxoplasma gondii subtilisin SUB6 0.0025 0.0109 0.0825
Schistosoma mansoni cercarial elastase (S01 family) 0.0277 0.2504 0.3146
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0887 0.8301 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0039
Mycobacterium leprae Possible secreted protease 0.0025 0.0109 0.2578
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0104 0.0322
Echinococcus granulosus insulin receptor 0.0057 0.0409 0.0477
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0104 0.2402
Brugia malayi SWIRM domain containing protein 0.0228 0.2033 0.202
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0037 0.0366
Onchocerca volvulus 0.0277 0.2504 1
Brugia malayi Subtilase family protein 0.0025 0.0109 0.0093
Loa Loa (eye worm) glutamate receptor 1 0.0031 0.0158 0.0158
Schistosoma mansoni protein kinase 0.002 0.006 0.0074
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0018 0.0037 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Schistosoma mansoni furin-1 (S08 family) 0.0259 0.2325 0.2922
Echinococcus granulosus glutamate receptor 2 0.0016 0.0017 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0961 0.283
Loa Loa (eye worm) hypothetical protein 0.0174 0.1521 0.1521
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0258 0.2317 0.2781
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.014 0.1202 0.151
Loa Loa (eye worm) hypothetical protein 0.0055 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0277 0.2504 0.2504
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0019 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Echinococcus multilocularis Mastin 0.0277 0.2504 0.3006
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0594 0.5517 0.6934
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Loa Loa (eye worm) glutamate receptor 2 0.0031 0.0158 0.0158
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0031 0.0158 0.0176
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0109 0.0222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0277 0.2504 0.3146
Loa Loa (eye worm) hypothetical protein 0.0045 0.0296 0.0296
Schistosoma mansoni hypothetical protein 0.0277 0.2504 0.3146
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0277 0.2504 0.3146
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0045 0.0296 0.2562
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0025 0.0109 0.0093
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.0356 0.2502
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0104 0.1054
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0043 0.0274 0.7519
Plasmodium vivax aspartyl protease, putative 0.0045 0.0296 0.3494
Mycobacterium ulcerans polyketide synthase 0.0025 0.0104 0.0322
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0277 0.2504 0.2491
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0118 0.1206
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0887 0.8301 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0057 0.0409 0.0477
Plasmodium vivax plasmepsin V, putative 0.0045 0.0296 0.3494
Brugia malayi hypothetical protein 0.0045 0.0296 0.028
Loa Loa (eye worm) hypothetical protein 0.0277 0.2504 0.2504
Trypanosoma cruzi subtilisin peptidase 0.0025 0.0109 0.0858
Onchocerca volvulus 0.0228 0.2033 0.8106
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0109 0.0222
Entamoeba histolytica SWIRM domain protein 0.0018 0.0037 1
Schistosoma mansoni nephrin 0.0015 0.0013 0.0015
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.0017 0.0017
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0104 0.0322
Echinococcus multilocularis 0.0052 0.0359 0.0417
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0057 0.0409 0.0477
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0031 0.0158 0.0176
Schistosoma mansoni site-1 peptidase (S08 family) 0.0025 0.0109 0.0136
Mycobacterium tuberculosis Probable peptidase 0.0051 0.0356 0.3671
Onchocerca volvulus 0.0043 0.0278 0.105
Schistosoma mansoni glutamate receptor NMDA 0.0258 0.2317 0.2912

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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