Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.1398 | 0.9278 | 0.9211 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1022 | 0.6319 | 0.5363 |
Entamoeba histolytica | protein kinase, putative | 0.1398 | 0.9278 | 0.909 |
Mycobacterium ulcerans | thioesterase TesA | 0.0587 | 0.2908 | 0.443 |
Trichomonas vaginalis | AGC family protein kinase | 0.0571 | 0.2784 | 0.1002 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0705 | 0.383 | 0.5834 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.1335 | 0.8783 | 0.8783 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0919 | 0.5516 | 0.8113 |
Brugia malayi | protein kinase C II. | 0.0479 | 0.2062 | 0.2062 |
Giardia lamblia | Kinase, AGC PKA | 0.093 | 0.5597 | 0.5 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0457 | 0.1888 | 0.0969 |
Echinococcus granulosus | nervana 2 | 0.0919 | 0.5516 | 0.8113 |
Mycobacterium ulcerans | polyketide synthase | 0.0705 | 0.383 | 0.5834 |
Entamoeba histolytica | protein kinase, putative | 0.1491 | 1 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0466 | 0.1957 | 0.2981 |
Trichomonas vaginalis | AGC family protein kinase | 0.1491 | 1 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1022 | 0.6319 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0479 | 0.2062 | 0.0101 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0748 | 0.4174 | 0.6337 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0919 | 0.5516 | 0.8113 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0242 | 0.0201 | 0.0306 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0705 | 0.383 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0506 | 0.2273 | 0.3461 |
Trichomonas vaginalis | AGC family protein kinase | 0.1491 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0479 | 0.2062 | 0.1331 |
Trichomonas vaginalis | AGC family protein kinase | 0.1491 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.0919 | 0.5516 | 0.8113 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0705 | 0.383 | 0.5834 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0748 | 0.4174 | 0.3763 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0285 | 0.0536 | 0.0817 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.093 | 0.5597 | 0.8303 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0748 | 0.4174 | 0.6357 |
Trypanosoma cruzi | Protein kinase B | 0.1022 | 0.6319 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.093 | 0.5597 | 0.4453 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.1398 | 0.9278 | 0.9278 |
Mycobacterium ulcerans | thioesterase | 0.0587 | 0.2908 | 0.443 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0919 | 0.5516 | 0.8113 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0479 | 0.2062 | 0.1331 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0748 | 0.4174 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1053 | 0.6566 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0748 | 0.4174 | 0.6357 |
Brugia malayi | AMP-binding enzyme family protein | 0.0658 | 0.3467 | 0.3467 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0748 | 0.4174 | 0.6337 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0502 | 0.2237 | 0.1395 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1022 | 0.6319 | 0.5363 |
Brugia malayi | Protein kinase domain containing protein | 0.0479 | 0.2062 | 0.2062 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0683 | 0.3661 | 0.5576 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0705 | 0.383 | 0.5834 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1022 | 0.6319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1184 | 0.7591 | 0.7369 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0748 | 0.4174 | 0.6357 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.093 | 0.5597 | 0.8303 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0576 | 0.2823 | 0.4299 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0705 | 0.383 | 0.5834 |
Trichomonas vaginalis | AGC family protein kinase | 0.0479 | 0.2062 | 0.0101 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.1022 | 0.6319 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0919 | 0.5516 | 0.8113 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0705 | 0.383 | 0.5834 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0705 | 0.383 | 0.383 |
Toxoplasma gondii | AGC kinase | 0.1398 | 0.9278 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0567 | 0.275 | 0.4188 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0221 | 0.0037 | 0.0056 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.093 | 0.5597 | 0.8303 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0479 | 0.2062 | 0.1331 |
Brugia malayi | Protein kinase domain containing protein | 0.0479 | 0.2062 | 0.2062 |
Trichomonas vaginalis | AGC family protein kinase | 0.1491 | 1 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0748 | 0.4174 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase | 0.0748 | 0.4174 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0705 | 0.383 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0466 | 0.1957 | 0.2981 |
Brugia malayi | Hr1 repeat family protein | 0.0479 | 0.2062 | 0.2062 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.2062 | 0.1331 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0587 | 0.2908 | 0.443 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0658 | 0.3467 | 0.2866 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.093 | 0.5597 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1053 | 0.6566 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0479 | 0.2062 | 0.1331 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0658 | 0.3467 | 0.528 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0748 | 0.4174 | 0.6357 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.1491 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1491 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1491 | 1 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.1491 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.1491 | 1 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.1022 | 0.6319 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1022 | 0.6319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.1398 | 0.0607 |
Loa Loa (eye worm) | fatty acid synthase | 0.0695 | 0.3757 | 0.3182 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0221 | 0.0037 | 0.0056 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0479 | 0.2062 | 0.1331 |
Trichomonas vaginalis | AGC family protein kinase | 0.0479 | 0.2062 | 0.0101 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0479 | 0.2062 | 0.1331 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0466 | 0.1957 | 0.2941 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0401 | 0.1444 | 0.2199 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0567 | 0.275 | 0.4188 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0683 | 0.3661 | 0.5576 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0705 | 0.383 | 0.5834 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.127 | 0.827 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0705 | 0.383 | 0.581 |
Onchocerca volvulus | 0.1226 | 0.7926 | 0.9285 | |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1053 | 0.6566 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0919 | 0.5516 | 0.8113 |
Echinococcus multilocularis | nervana 2 | 0.0919 | 0.5516 | 0.8113 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1053 | 0.6566 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.093 | 0.5597 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0567 | 0.275 | 0.4155 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0587 | 0.2908 | 0.4398 |
Trichomonas vaginalis | AGC family protein kinase | 0.1491 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.