TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 423.548 | Formula: C25H33N3O3
H donors: 2 H acceptors: 3 LogP: 4.35 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: ONC(=O)CCCCCCCC(=O)c1ccc(cc1)N1CCN(CC1)c1ccccc1
InChi: 1S/C25H33N3O3/c29-24(11-7-2-1-3-8-12-25(30)26-31)21-13-15-23(16-14-21)28-19-17-27(18-20-28)22-9-5-4-6-10-22/h4-6,9-10,13-16,31H,1-3,7-8,11-12,17-20H2,(H,26,30)
InChiKey: ASBKFWFYFSTTDJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	histone deacetylase 8	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	histone deacetylase 1	histone deacetylase 8	286 aa	241 aa	44.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.339	0.2893
Loa Loa (eye worm)	histone deacetylase	0.0044	0.3904	0.3896
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.339	0.3381
Echinococcus granulosus	histone deacetylase 3	0.0099	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.339	0.3381
Echinococcus granulosus	lamin	0.0027	0.1996	0.1986
Schistosoma mansoni	opsin-like receptor	0.0039	0.339	0.2893
Plasmodium vivax	histone deacetylase 2, putative	0.0044	0.3904	0.3446
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.339	0.3381
Brugia malayi	hypothetical protein	0.0039	0.339	0.339
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.1996	0.1986
Onchocerca volvulus		0.0027	0.1996	0.4048
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus multilocularis	serotonin receptor	0.0039	0.339	0.3381
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0057	0.5318	0.5312
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0057	0.5318	0.4966
Loa Loa (eye worm)	hypothetical protein	0.0044	0.3904	0.3896
Schistosoma mansoni	neuropeptide receptor	0.0039	0.339	0.2893
Echinococcus granulosus	intermediate filament protein	0.0027	0.1996	0.1986
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0015	0.0699	0.0687
Echinococcus multilocularis	orexin receptor type 2	0.0039	0.339	0.3381
Onchocerca volvulus		0.0039	0.339	0.8395
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0039	0.339	0.3381
Echinococcus multilocularis	dro:myosuppressin receptor	0.0039	0.339	0.3381
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Schistosoma mansoni	hypothetical protein	0.0039	0.339	0.2893
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.339	0.3381
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0039	0.339	0.3381
Onchocerca volvulus		0.0027	0.1996	0.4048
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.339	0.3381
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.339	0.2893
Echinococcus granulosus	neuropeptide s receptor	0.0039	0.339	0.3381
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0039	0.339	0.3381
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0039	0.339	0.339
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0057	0.5318	0.4966
Brugia malayi	hypothetical protein	0.0039	0.339	0.339
Brugia malayi	neuropeptide F receptor	0.0039	0.339	0.339
Schistosoma mansoni	hypothetical protein	0.0057	0.5318	0.4966
Onchocerca volvulus		0.0039	0.339	0.8395
Echinococcus granulosus	hypothetical protein	0.0039	0.339	0.3381
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.339	0.2893
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0039	0.339	0.2893
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0039	0.339	0.3381
Echinococcus granulosus	somatostatin receptor	0.0039	0.339	0.3381
Schistosoma mansoni	neuropeptide receptor	0.0039	0.339	0.2893
Echinococcus multilocularis	histone deacetylase 1	0.0099	1	1
Brugia malayi	GnHR receptor homolog	0.0039	0.339	0.339
Brugia malayi	Dopamine receptor protein 1	0.0039	0.339	0.339
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Onchocerca volvulus		0.0039	0.339	0.8395
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.339	0.3381
Echinococcus granulosus	biogenic amine 5HT receptor	0.0039	0.339	0.3381
Echinococcus granulosus	g-protein coupled receptor	0.0039	0.339	0.3381
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0466	0.0454
Brugia malayi	histone deacetylase 11	0.0044	0.3904	0.3904
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0623	0.0623
Brugia malayi	G-protein coupled receptor	0.0039	0.339	0.339
Echinococcus granulosus	serotonin receptor	0.0039	0.339	0.3381
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0039	0.339	0.339
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0057	0.5318	0.4966
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.339	0.3381
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Brugia malayi	putative neuropeptide receptor NPR1	0.0039	0.339	0.339
Brugia malayi	Histone deacetylase family protein	0.0044	0.3904	0.3904
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.339	0.3381
Toxoplasma gondii	histone deacetylase HDAC3	0.0099	1	1
Echinococcus granulosus	histone deacetylase 8	0.0044	0.3904	0.3896
Schistosoma mansoni	hypothetical protein	0.0039	0.339	0.2893
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Schistosoma mansoni	opsin-like receptor	0.0039	0.339	0.2893
Brugia malayi	larval opioid receptor	0.0039	0.339	0.339
Schistosoma mansoni	histone deacetylase 4 5	0.0044	0.3904	0.3446
Schistosoma mansoni	neuropeptide f receptor 76f	0.0039	0.339	0.2893
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus granulosus	g protein coupled receptor	0.0039	0.339	0.3381
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.339	0.3381
Onchocerca volvulus		0.0039	0.339	0.8395
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0039	0.339	0.3381
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0057	0.5318	0.4966
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.1996	0.1996
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.1996	0.1986
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1942	0.1932
Schistosoma mansoni	biogenic amine receptor	0.0039	0.339	0.2893
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Echinococcus granulosus	histone deacetylase 6	0.0044	0.3904	0.3896
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0039	0.339	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Plasmodium vivax	histone deacetylase, putative	0.0044	0.3904	0.3446
Treponema pallidum	ATP-dependent RNA helicase	0.0015	0.0699	0.5
Brugia malayi	CXXC zinc finger family protein	0.0028	0.2189	0.2189
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus multilocularis	lamin dm0	0.0027	0.1996	0.1986
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0039	0.339	0.8395
Echinococcus granulosus	histone deacetylase 6	0.0044	0.3904	0.3896
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Schistosoma mansoni	histone deacetylase	0.0099	1	1
Brugia malayi	hypothetical protein	0.0039	0.339	0.339
Trichomonas vaginalis	histone deacetylase, putative	0.0099	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0039	0.339	0.3381
Brugia malayi	AKH receptor	0.0039	0.339	0.339
Brugia malayi	hypothetical protein	0.0039	0.339	0.339
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.339	0.3381
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0015	0.0699	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0699	0.0687
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0039	0.339	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus multilocularis	histone deacetylase	0.0044	0.3904	0.3896
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0057	0.5318	0.5312
Brugia malayi	ORL1-like opioid receptor	0.0039	0.339	0.339
Schistosoma mansoni	biogenic amine receptor	0.0039	0.339	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Brugia malayi	hypothetical protein	0.0039	0.339	0.339
Echinococcus multilocularis	somatostatin receptor	0.0039	0.339	0.3381
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0039	0.339	0.3381
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0039	0.339	0.3381
Loa Loa (eye worm)	TYRA-2 protein	0.0039	0.339	0.3381
Onchocerca volvulus		0.0039	0.339	0.8395
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Toxoplasma gondii	histone deacetylase HDAC5	0.0044	0.3904	0.3446
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.339	0.2893
Schistosoma mansoni	histone deacetylase hda2	0.0044	0.3904	0.3446
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0039	0.339	0.3381
Giardia lamblia	Rrm3p helicase	0.0057	0.5318	0.4966
Schistosoma mansoni	hypothetical protein	0.0039	0.339	0.2893
Trypanosoma cruzi	histone deacetylase, putative	0.0044	0.3904	0.3446
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Schistosoma mansoni	biogenic amine receptor	0.0039	0.339	0.2893
Echinococcus granulosus	neuropeptide receptor	0.0039	0.339	0.3381
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0039	0.339	0.2893
Onchocerca volvulus		0.0039	0.339	0.8395
Schistosoma mansoni	amine GPCR	0.0039	0.339	0.2893
Brugia malayi	Melatonin receptor type 1A	0.0039	0.339	0.339
Echinococcus granulosus	fmrfamide receptor	0.0039	0.339	0.3381
Echinococcus multilocularis	G protein coupled receptor 139	0.0039	0.339	0.3381
Echinococcus multilocularis	allatostatin A receptor	0.0039	0.339	0.3381
Echinococcus granulosus	g protein coupled receptor	0.0039	0.339	0.3381
Plasmodium falciparum	histone deacetylase 2	0.0044	0.3904	0.3446
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.339	0.3381
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0039	0.339	0.3381
Loa Loa (eye worm)	melatonin receptor type 1A	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Trypanosoma cruzi	histone deacetylase, putative	0.0044	0.3904	0.3446
Onchocerca volvulus		0.0039	0.339	0.8395
Schistosoma mansoni	histamine h1 receptor	0.0039	0.339	0.2893
Schistosoma mansoni	cpg binding protein	0.003	0.2368	0.1795
Schistosoma mansoni	histone deacetylase 4 5	0.0044	0.3904	0.3446
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.339	0.3381
Echinococcus multilocularis	histone deacetylase 8	0.0044	0.3904	0.3896
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0039	0.339	0.339
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0039	0.339	0.339
Schistosoma mansoni	histone deacetylase	0.0099	1	1
Echinococcus granulosus	neuropeptide receptor	0.0039	0.339	0.3381
Brugia malayi	Serotonin receptor	0.0039	0.339	0.339
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0057	0.5318	0.4966
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0039	0.339	0.339
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.339	0.2893
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0039	0.339	0.2893
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0039	0.339	0.2893
Trypanosoma cruzi	histone deacetylase, putative	0.0044	0.3904	0.3446
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.5318	0.4966
Onchocerca volvulus		0.0039	0.339	0.8395
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0039	0.339	0.3381
Brugia malayi	G protein-coupled receptor F59B2.13	0.0039	0.339	0.339
Leishmania major	histone deacetylase, putative	0.0044	0.3904	0.3446
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Toxoplasma gondii	histone deacetylase HDAC2	0.0099	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0039	0.339	0.3381
Onchocerca volvulus		0.0039	0.339	0.8395
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus multilocularis	musashi	0.0027	0.1996	0.1986
Onchocerca volvulus		0.0039	0.339	0.8395
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.339	0.3381
Brugia malayi	follicle stimulating hormone receptor	0.0039	0.339	0.339
Trypanosoma cruzi	histone deacetylase 1, putative	0.0099	1	1
Echinococcus granulosus	histone deacetylase	0.0044	0.3904	0.3896
Echinococcus multilocularis	histone deacetylase 6	0.0044	0.3904	0.3896
Toxoplasma gondii	histone deacetylase HDAC1	0.0044	0.3904	0.3446
Echinococcus granulosus	histone deacetylase 1	0.0099	1	1
Schistosoma mansoni	cpg binding protein	0.003	0.2368	0.1795
Trypanosoma brucei	histone deacetylase 4	0.0044	0.3904	0.3446
Trypanosoma cruzi	histone deacetylase, putative	0.0044	0.3904	0.3446
Echinococcus granulosus	7tm_1 domain containing protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.339	0.3381
Brugia malayi	hypothetical protein	0.0039	0.339	0.339
Echinococcus multilocularis	serotonin receptor	0.0039	0.339	0.3381
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.339	0.3381
Echinococcus granulosus	dro:myosuppressin receptor	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1996	0.1986
Brugia malayi	G-protein coupled receptor	0.0039	0.339	0.339
Trichomonas vaginalis	histone deacetylase, putative	0.0099	1	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.5721	0.54
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus multilocularis	g-protein coupled receptor	0.0039	0.339	0.3381
Brugia malayi	hypothetical protein	0.0039	0.339	0.339
Schistosoma mansoni	hypothetical protein	0.0039	0.339	0.2893
Brugia malayi	Serotonin receptor	0.0039	0.339	0.339
Echinococcus multilocularis	lamin	0.0027	0.1996	0.1986
Echinococcus multilocularis	histone deacetylase 6	0.0044	0.3904	0.3896
Brugia malayi	histone deacetylase 1 (HD1)	0.0099	1	1
Trypanosoma cruzi	histone deacetylase 1, putative	0.0099	1	1
Trypanosoma brucei	histone deacetylase 3	0.0044	0.3904	0.3446
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.339	0.3381
Plasmodium falciparum	histone deacetylase 1	0.0099	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.339	0.2893
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.339	0.3381
Trypanosoma cruzi	histone deacetylase, putative	0.0044	0.3904	0.3446
Echinococcus granulosus	cpg binding protein	0.003	0.2368	0.2359
Schistosoma mansoni	amine GPCR	0.0039	0.339	0.2893
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0039	0.339	0.2893
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0039	0.339	0.3381
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0057	0.5318	0.4966
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0039	0.339	0.2893
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0039	0.339	0.3381
Echinococcus granulosus	G protein coupled receptor 139	0.0039	0.339	0.3381
Echinococcus granulosus	allatostatin A receptor	0.0039	0.339	0.3381
Schistosoma mansoni	amine GPCR	0.0039	0.339	0.2893
Leishmania major	histone deacetylase, putative	0.0099	1	1
Trichomonas vaginalis	histone deacetylase, putative	0.0099	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.339	0.3381
Onchocerca volvulus		0.0039	0.339	0.8395
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0466	0.0454
Trichomonas vaginalis	histone deacetylase, putative	0.0099	1	1
Echinococcus granulosus	sex peptide receptor	0.0039	0.339	0.3381
Schistosoma mansoni	intermediate filament proteins	0.0027	0.1996	0.1395
Trypanosoma brucei	histone deacetylase, putative	0.0044	0.3904	0.3446
Schistosoma mansoni	neuropeptide receptor	0.0039	0.339	0.2893
Toxoplasma gondii	histone deacetylase HDAC4	0.0044	0.3904	0.3446
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0039	0.339	0.8395
Entamoeba histolytica	histone deacetylase, putative	0.0099	1	1
Brugia malayi	hypothetical protein	0.0039	0.339	0.339
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.339	0.3381
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.339	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Brugia malayi	Histone deacetylase family protein	0.0044	0.3904	0.3904
Brugia malayi	hypothetical protein	0.0039	0.339	0.339
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0015	0.0699	0.0687
Brugia malayi	eukaryotic initiation factor 4A	0.0015	0.0699	0.0699
Trypanosoma brucei	histone deacetylase 2	0.0044	0.3904	0.3446
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.339	0.2893
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0099	1	1
Entamoeba histolytica	hypothetical protein, conserved	0.0057	0.5318	0.4966
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Echinococcus granulosus	7TM GPCR rhodopsin	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.339	0.2893
Brugia malayi	RE15519p	0.0039	0.339	0.339
Brugia malayi	sulfakinin receptor protein	0.0039	0.339	0.339
Leishmania major	histone deacetylase, putative	0.0099	1	1
Echinococcus granulosus	histone deacetylase 7	0.0044	0.3904	0.3896
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.5007	0.4632
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0039	0.339	0.2893
Echinococcus multilocularis	sex peptide receptor	0.0039	0.339	0.3381
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus multilocularis	histone deacetylase 7	0.0044	0.3904	0.3896
Echinococcus multilocularis	neuropeptide receptor A26	0.0039	0.339	0.3381
Schistosoma mansoni	lamin	0.0027	0.1996	0.1395
Loa Loa (eye worm)	histone deacetylase 7A	0.0044	0.3904	0.3896
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.339	0.2893
Brugia malayi	hypothetical protein	0.0039	0.339	0.339
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Trichomonas vaginalis	histone deacetylase, putative	0.0099	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0015	0.0699	0.0687
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0039	0.339	0.2893
Echinococcus multilocularis	cpg binding protein	0.003	0.2368	0.2359
Schistosoma mansoni	myosin xvIII	0.0039	0.339	0.2893
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.339	0.2893
Trypanosoma brucei	histone deacetylase 1	0.0099	1	1
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0044	0.3904	1
Brugia malayi	neuropeptide F receptor	0.0039	0.339	0.339
Onchocerca volvulus		0.0028	0.2189	0.4648
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.339	0.3381
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.339	0.3381
Schistosoma mansoni	cpg binding protein	0.0028	0.2189	0.1601
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.339	0.2893
Schistosoma mansoni	histone deacetylase 1 2 3	0.0044	0.3904	0.3446
Echinococcus granulosus	orexin receptor type 2	0.0039	0.339	0.3381
Schistosoma mansoni	growth hormone secretagogue receptor	0.0039	0.339	0.2893
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.2189	0.2179
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0039	0.339	0.3381
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0057	0.5318	0.4966
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.339	0.2893
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.339	0.2893
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.339	0.3381
Echinococcus multilocularis	histone deacetylase 6	0.0044	0.3904	0.3896
Echinococcus multilocularis	histone deacetylase 3	0.0099	1	1
Plasmodium vivax	histone deacetylase, putative	0.0044	0.3904	0.3446
Trichomonas vaginalis	histone deacetylase, putative	0.0099	1	1
Schistosoma mansoni	amine GPCR	0.0039	0.339	0.2893
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0015	0.0699	0.5
Brugia malayi	Dopamine receptor	0.0039	0.339	0.339
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0039	0.339	0.2893
Loa Loa (eye worm)	histone deacetylase 3	0.0099	1	1
Plasmodium falciparum	histone deacetylase, putative	0.0044	0.3904	0.3446
Leishmania major	histone deacetylase, putative	0.0044	0.3904	0.3446
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Brugia malayi	Dopamine receptor protein 2	0.0039	0.339	0.339
Echinococcus granulosus	histone deacetylase 6	0.0044	0.3904	0.3896
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0057	0.5318	0.4966
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0466	0.0454
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0039	0.339	0.3381
Onchocerca volvulus		0.0039	0.339	0.8395
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0099	1	1
Brugia malayi	G protein-coupled receptor	0.0039	0.339	0.339
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.339	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0039	0.339	0.3381
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.339	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0411	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus granulosus	g protein coupled receptor	0.0039	0.339	0.3381
Echinococcus granulosus	neuropeptide FF receptor 2	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Echinococcus granulosus	lamin dm0	0.0027	0.1996	0.1986
Schistosoma mansoni	adenoreceptor	0.0039	0.339	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0623	0.0611
Echinococcus multilocularis	neuropeptide s receptor	0.0039	0.339	0.3381
Brugia malayi	intermediate filament protein	0.0027	0.1996	0.1996
Onchocerca volvulus		0.0039	0.339	0.8395
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Onchocerca volvulus		0.0039	0.339	0.8395
Plasmodium vivax	histone deacetylase 1, putative	0.0099	1	1
Onchocerca volvulus		0.0039	0.339	0.8395
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.339	0.3381
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0039	0.339	0.3381
Onchocerca volvulus		0.0039	0.339	0.8395
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0039	0.339	0.3381
Loa Loa (eye worm)	histone deacetylase 1	0.0099	1	1
Onchocerca volvulus		0.0039	0.339	0.8395
Giardia lamblia	Histone deacetylase	0.0099	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Schistosoma mansoni	histone deacetylase hda2	0.0044	0.3904	0.3446
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.339	0.3381
Echinococcus granulosus	neuropeptide receptor A26	0.0039	0.339	0.3381
Brugia malayi	Histone deacetylase 1	0.0099	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0039	0.339	0.339
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0039	0.339	0.3381
Brugia malayi	putative neuropeptide receptor	0.0039	0.339	0.339
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Schistosoma mansoni	neuropeptide receptor	0.0039	0.339	0.2893
Schistosoma mansoni	amine GPCR	0.0039	0.339	0.2893
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0039	0.339	0.3381
Schistosoma mansoni	lamin	0.0027	0.1996	0.1395
Loa Loa (eye worm)	histone deacetylase 11	0.0044	0.3904	0.3896
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0411	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0039	0.339	0.3381
Schistosoma mansoni	opsin-like receptor	0.0039	0.339	0.2893

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.0045 uM	Inhibition of Homo sapiens (human) HDAC8	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2235266

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1810925