Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.254 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0125 | 0.7773 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.254 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0313 | 0.1234 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0313 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0017 | 0.0313 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0313 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.254 | 1 |
Leishmania major | trypanothione reductase | 0.0049 | 0.254 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.254 | 1 |
Brugia malayi | glutathione reductase | 0.0049 | 0.254 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.254 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.254 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0017 | 0.0313 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0017 | 0.0313 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.254 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0.0313 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.254 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0112 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0112 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0112 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0125 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0112 | 0.6906 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0125 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0112 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.254 | 0.2985 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0112 | 0.6906 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0125 | 0.7773 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.254 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0.0313 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.254 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0017 | 0.0313 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.254 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.254 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0.0313 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
2-DG uptake stimulation (functional) | = 1.01 | In vitro stimulation of 2-Deoxyglucose uptake in L6 myocytes from rat skeletal myoblasts at a concentration of 3 microM | ChEMBL. | 1992133 |
2-DG uptake stimulation (functional) | = 1.33 | In vitro stimulation of 2-Deoxyglucose uptake in L6 myocytes from rat skeletal myoblasts at a concentration of 10 microM | ChEMBL. | 1992133 |
2-DG uptake stimulation (functional) | = 1.38 | In vitro stimulation of 2-Deoxyglucose uptake in L6 myocytes from rat skeletal myoblasts at a concentration of 30 microM | ChEMBL. | 1992133 |
Glucose normalisation (functional) | = 24 % | In vivo percent glucose normalization in mice at a concentration of 25 mg/kg | ChEMBL. | 1992133 |
Glucose normalisation (functional) | = 24 % | In vivo percent glucose normalization in mice at a concentration of 25 mg/kg | ChEMBL. | 1992133 |
GT fold stimulation (functional) | = 1.08 | In vitro fold stimulation of glucose trasportor protein in 3T3-L1 adipocytes at a concentration of 10 microM | ChEMBL. | 1992133 |
GT fold stimulation (functional) | = 1.21 | In vitro fold stimulation of glucose trasportor protein in 3T3-L1 adipocytes at a concentration of 30 microM | ChEMBL. | 1992133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.