Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Histone deacetylase family protein | 0.0177 | 0.0819 | 0.0819 |
Echinococcus granulosus | histone deacetylase | 0.0177 | 0.0819 | 0.0819 |
Schistosoma mansoni | tyrosine kinase | 0.1211 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0196 | 0.0992 | 0.0992 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1211 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0892 | 0.7171 | 0.7171 |
Trypanosoma brucei | histone deacetylase 3 | 0.0177 | 0.0819 | 0.1142 |
Schistosoma mansoni | tyrosine kinase | 0.0643 | 0.4957 | 0.4957 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0177 | 0.0819 | 0.1142 |
Echinococcus granulosus | histone deacetylase 1 | 0.0196 | 0.0992 | 0.0992 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0332 | 0.2197 | 0.3064 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0196 | 0.0992 | 0.0992 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0196 | 0.0992 | 0.1384 |
Echinococcus granulosus | histone deacetylase 6 | 0.0177 | 0.0819 | 0.0819 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0892 | 0.7171 | 0.7171 |
Schistosoma mansoni | tyrosine kinase | 0.0651 | 0.5035 | 0.5035 |
Trypanosoma brucei | histone deacetylase, putative | 0.0177 | 0.0819 | 0.1142 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0177 | 0.0819 | 0.0819 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0332 | 0.2197 | 0.3064 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0196 | 0.0992 | 0.0992 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0651 | 0.5035 | 0.5035 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0335 | 0.2222 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0388 | 0.2698 | 0.2698 |
Schistosoma mansoni | tyrosine kinase | 0.0388 | 0.2698 | 0.2698 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0892 | 0.7171 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0196 | 0.0992 | 0.0992 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0177 | 0.0819 | 0.1142 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.0992 | 0.0992 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0177 | 0.0819 | 0.0819 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0196 | 0.0992 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0651 | 0.5035 | 0.5035 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0196 | 0.0992 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0177 | 0.0819 | 0.0819 |
Schistosoma mansoni | tyrosine kinase | 0.0388 | 0.2698 | 0.2698 |
Schistosoma mansoni | tyrosine kinase | 0.0643 | 0.4957 | 0.4957 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0196 | 0.0992 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0643 | 0.4957 | 0.4957 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0177 | 0.0819 | 0.0819 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0892 | 0.7171 | 0.7171 |
Onchocerca volvulus | 0.032 | 0.2095 | 0.9428 | |
Plasmodium vivax | histone deacetylase, putative | 0.0177 | 0.0819 | 0.8254 |
Brugia malayi | Protein kinase domain containing protein | 0.0388 | 0.2698 | 0.2698 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1211 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0196 | 0.0992 | 0.0992 |
Schistosoma mansoni | histone deacetylase | 0.0196 | 0.0992 | 0.0992 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0177 | 0.0819 | 0.8254 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0388 | 0.2698 | 0.2698 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0182 | 0.0864 | 0.0864 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0358 | 0.2427 | 0.2427 |
Echinococcus granulosus | insulin receptor | 0.0388 | 0.2698 | 0.2698 |
Echinococcus multilocularis | histone deacetylase | 0.0177 | 0.0819 | 0.0819 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0177 | 0.0819 | 0.1142 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0332 | 0.2197 | 0.3064 |
Entamoeba histolytica | histone deacetylase, putative | 0.0196 | 0.0992 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0892 | 0.7171 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0196 | 0.0992 | 0.0992 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0177 | 0.0819 | 0.0819 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1211 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0651 | 0.5035 | 0.5035 |
Echinococcus granulosus | histone deacetylase 6 | 0.0182 | 0.0864 | 0.0864 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0182 | 0.0864 | 0.0864 |
Leishmania major | histone deacetylase, putative | 0.0196 | 0.0992 | 0.0273 |
Trypanosoma brucei | histone deacetylase 1 | 0.0196 | 0.0992 | 0.1384 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0196 | 0.0992 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0651 | 0.5035 | 0.5035 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0892 | 0.7171 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0196 | 0.0992 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0196 | 0.0992 | 0.1384 |
Plasmodium falciparum | histone deacetylase 1 | 0.0196 | 0.0992 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0196 | 0.0992 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0196 | 0.0992 | 0.1384 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0071 | 0.0071 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0358 | 0.2427 | 0.2427 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0332 | 0.2197 | 0.3064 |
Loa Loa (eye worm) | histone deacetylase | 0.0177 | 0.0819 | 0.0819 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0892 | 0.7171 | 1 |
Leishmania major | histone deacetylase, putative | 0.0196 | 0.0992 | 0.0273 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0196 | 0.0992 | 0.0992 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0196 | 0.0992 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0116 | 0.0116 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0196 | 0.0992 | 0.1384 |
Leishmania major | 0.0892 | 0.7171 | 1 | |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0388 | 0.2698 | 0.2698 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0177 | 0.0819 | 0.0819 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0196 | 0.0992 | 0.5 |
Echinococcus granulosus | histone deacetylase 7 | 0.0177 | 0.0819 | 0.0819 |
Echinococcus multilocularis | insulin receptor | 0.0388 | 0.2698 | 0.2698 |
Schistosoma mansoni | histone deacetylase | 0.0196 | 0.0992 | 0.0992 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0177 | 0.0819 | 0.0819 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0177 | 0.0819 | 0.1142 |
Giardia lamblia | Histone deacetylase | 0.0196 | 0.0992 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0196 | 0.0992 | 0.5 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0892 | 0.7171 | 0.7171 |
Brugia malayi | Histone deacetylase family protein | 0.0177 | 0.0819 | 0.0819 |
Echinococcus multilocularis | 0.0374 | 0.2573 | 0.2573 | |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0892 | 0.7171 | 0.7171 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0332 | 0.2197 | 0.3064 |
Brugia malayi | Histone deacetylase 1 | 0.0196 | 0.0992 | 0.0992 |
Trypanosoma brucei | histone deacetylase 4 | 0.0177 | 0.0819 | 0.1142 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0196 | 0.0992 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 242.13 uM | Antimicrobial activity against Candida albicans ATCC 90028 by serial plate dilution method | ChEMBL. | No reference |
MIC (functional) | = 242.13 uM | Antimicrobial activity against Escherichia coli ATCC 25922 by serial plate dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.