TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 430.459 | Formula: C23H22N6O3
H donors: 1 H acceptors: 4 LogP: 3.69 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)c1nc(nc(n1)Nc1ccccc1)Oc1cc(=O)oc2c1cccc2
InChi: 1S/C23H22N6O3/c1-28-11-13-29(14-12-28)22-25-21(24-16-7-3-2-4-8-16)26-23(27-22)32-19-15-20(30)31-18-10-6-5-9-17(18)19/h2-10,15H,11-14H2,1H3,(H,24,25,26,27)
InChiKey: LAPOUAYUXJEMOU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0105	0.5849	0.5935
Trichomonas vaginalis	CMGC family protein kinase	0.0158	0.9161	0.5
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	neuropeptide FF receptor 2	0.0105	0.5849	0.5935
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0105	0.5849	0.5849
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0105	0.5849	0.5935
Brugia malayi	Dopamine receptor	0.0105	0.5849	0.5849
Brugia malayi	neuropeptide F receptor	0.0105	0.5849	0.5849
Echinococcus granulosus	g protein coupled receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0169	0.9856	0.9856
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Brugia malayi	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	neuroglian	0.0013	0.0166	0.0169
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0158	0.9161	0.9161
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	somatostatin receptor	0.0105	0.5849	0.5935
Brugia malayi	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0158	0.9161	0.9296
Schistosoma mansoni	hypothetical protein	0.0105	0.5849	0.5935
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	tyrosine kinase	0.009	0.4903	0.4974
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0105	0.5849	0.5849
Echinococcus granulosus	biogenic amine 5HT receptor	0.0105	0.5849	0.5935
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0158	0.9161	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0213	0.0213
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0105	0.5849	0.5849
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0055	0.2746	0.2786
Echinococcus multilocularis	allatostatin A receptor	0.0105	0.5849	0.5935
Trichomonas vaginalis	CMGC family protein kinase	0.0158	0.9161	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	neuropeptide receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.5849	0.5935
Brugia malayi	GnHR receptor homolog	0.0105	0.5849	0.5849
Schistosoma mansoni	tyrosine kinase	0.0091	0.5021	0.5095
Schistosoma mansoni	tyrosine kinase	0.009	0.4903	0.4974
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Echinococcus granulosus	mitogen activated protein kinase	0.0158	0.9161	0.9296
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0105	0.5849	0.5849
Echinococcus multilocularis	g protein coupled receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	g-protein coupled receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	fmrfamide receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	histamine h1 receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	biogenic amine receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	neuropeptide receptor A26	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	roundabout 2	0.0017	0.0379	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	neuropeptides capa receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.5849	0.5935
Loa Loa (eye worm)	TK/INSR protein kinase	0.0055	0.2746	0.2746
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Brugia malayi	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0105	0.5849	0.5935
Echinococcus multilocularis	neuropeptide receptor A26	0.0105	0.5849	0.5935
Echinococcus granulosus	7TM GPCR rhodopsin	0.0105	0.5849	0.5935
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0105	0.5849	0.5849
Brugia malayi	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	neuropeptide receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	epidermal growth factor receptor	0.0091	0.5021	0.5095
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0105	0.5849	0.5935
Schistosoma mansoni	hypothetical protein	0.0105	0.5849	0.5935
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0105	0.5849	0.5935
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0158	0.9161	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0105	0.5849	0.5849
Echinococcus multilocularis	orexin receptor type 2	0.0105	0.5849	0.5935
Echinococcus granulosus	orexin receptor type 2	0.0105	0.5849	0.5935
Echinococcus granulosus	neuropeptide Y receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	neuropeptide Y receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0105	0.5849	0.5935
Schistosoma mansoni	neuropeptide F-like receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	insulin receptor	0.0055	0.2746	0.2786
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0055	0.2746	0.2786
Schistosoma mansoni	hypothetical protein	0.0105	0.5849	0.5935
Trichomonas vaginalis	CMGC family protein kinase	0.0158	0.9161	0.5
Schistosoma mansoni	opsin-like receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	hypothetical protein	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Giardia lamblia	Kinase, CMGC MAPK	0.0158	0.9161	0.5
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.5849	0.5935
Brugia malayi	sulfakinin receptor protein	0.0105	0.5849	0.5849
Echinococcus granulosus	epidermal growth factor receptor	0.0169	0.9856	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0158	0.9161	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0105	0.5849	0.5849
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	tm gpcr rhodopsin	0.0105	0.5849	0.5935
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0105	0.5849	0.5935
Brugia malayi	larval opioid receptor	0.0105	0.5849	0.5849
Echinococcus granulosus	g protein coupled receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	neuropeptide Y receptor	0.0105	0.5849	0.5935
Brugia malayi	G-protein coupled receptor	0.0105	0.5849	0.5849
Loa Loa (eye worm)	neuropeptide F receptor	0.0105	0.5849	0.5849
Echinococcus multilocularis	neuropeptides capa receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0105	0.5849	0.5935
Loa Loa (eye worm)	melatonin receptor type 1A	0.0105	0.5849	0.5849
Echinococcus granulosus	dro:myosuppressin receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	serotonin receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0014	0.0213	0.0216
Loa Loa (eye worm)	G-protein coupled receptor	0.0105	0.5849	0.5849
Echinococcus granulosus	g protein coupled receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0105	0.5849	0.5935
Schistosoma mansoni	tyrosine kinase	0.0091	0.5021	0.5095
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0105	0.5849	0.5935
Brugia malayi	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	neuropeptide F receptor	0.0105	0.5849	0.5849
Schistosoma mansoni	opsin-like receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0105	0.5849	0.5935
Brugia malayi	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	tyrosine kinase	0.0055	0.2746	0.2786
Echinococcus multilocularis	G protein coupled receptor 139	0.0105	0.5849	0.5935
Echinococcus multilocularis	fmrfamide receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Brugia malayi	Melatonin receptor type 1A	0.0105	0.5849	0.5849
Schistosoma mansoni	serine/threonine protein kinase	0.0158	0.9161	0.9296
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0105	0.5849	0.5935
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0105	0.5849	0.5935
Brugia malayi	Dopamine receptor protein 2	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	G-protein coupled receptor	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0379	0.0379
Brugia malayi	Serotonin receptor	0.0105	0.5849	0.5849
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0091	0.5021	0.5095
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Onchocerca volvulus	Tyrosine kinase homolog	0.0161	0.9302	1
Brugia malayi	MAP kinase sur-1	0.0158	0.9161	0.9161
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Brugia malayi	hypothetical protein	0.0105	0.5849	0.5849
Brugia malayi	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	mitogen activated protein kinase 3	0.0158	0.9161	0.9296
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	biogenic amine receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	growth hormone secretagogue receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	neuropeptide receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	dro:myosuppressin receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0105	0.5849	0.5935
Brugia malayi	neuropeptide F receptor	0.0105	0.5849	0.5849
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	tyrosine kinase	0.009	0.4903	0.4974
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0158	0.9161	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	roundabout 2	0.0017	0.0379	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	epidermal growth factor receptor	0.0169	0.9856	1
Echinococcus granulosus	allatostatin A receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	neuropeptide s receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	biogenic amine 5HT receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	neuropeptide receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	amine GPCR	0.0105	0.5849	0.5935
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	neuropeptide receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.5849	0.5935
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0105	0.5849	0.5935
Echinococcus multilocularis	g protein coupled receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0105	0.5849	0.5935
Brugia malayi	AKH receptor	0.0105	0.5849	0.5849
Echinococcus multilocularis	serotonin receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	opsin-like receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0105	0.5849	0.5935
Echinococcus granulosus	7tm_1 domain containing protein	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Brugia malayi	putative neuropeptide receptor NPR1	0.0105	0.5849	0.5849
Schistosoma mansoni	tyrosine kinase	0.0055	0.2746	0.2786
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.5849	0.5935
Echinococcus granulosus	tm gpcr rhodopsin	0.0105	0.5849	0.5935
Schistosoma mansoni	neuropeptide F-like receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	myosin xvIII	0.0105	0.5849	0.5935
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	adenoreceptor	0.0105	0.5849	0.5935
Brugia malayi	Serotonin receptor	0.0105	0.5849	0.5849
Schistosoma mansoni	neuropeptide receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	g-protein coupled receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0379	0.0379
Trichomonas vaginalis	CMGC family protein kinase	0.0158	0.9161	0.5
Brugia malayi	hypothetical protein	0.0105	0.5849	0.5849
Brugia malayi	G-protein coupled receptor	0.0105	0.5849	0.5849
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Brugia malayi	Furin-like cysteine rich region family protein	0.0169	0.9856	0.9856
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0105	0.5849	0.5935
Brugia malayi	G protein-coupled receptor	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.5849	0.5935
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0158	0.9161	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0105	0.5849	0.5849
Schistosoma mansoni	amine GPCR	0.0105	0.5849	0.5935
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0158	0.9161	0.5
Trypanosoma brucei	protein kinase, putative	0.0158	0.9161	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Brugia malayi	follicle stimulating hormone receptor	0.0105	0.5849	0.5849
Echinococcus granulosus	G protein coupled receptor 139	0.0105	0.5849	0.5935
Schistosoma mansoni	neuropeptide f receptor 76f	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	tyrosine kinase	0.0169	0.9856	1
Brugia malayi	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	hypothetical protein	0.0105	0.5849	0.5935
Echinococcus granulosus	twitchin	0.0015	0.0255	0.0259
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	insulin receptor	0.0055	0.2746	0.2786
Echinococcus granulosus	somatostatin receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0105	0.5849	0.5935
Echinococcus granulosus	epidermal growth factor receptor	0.0091	0.5021	0.5095
Onchocerca volvulus		0.0156	0.9017	0.9175
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0105	0.5849	0.5849
Loa Loa (eye worm)	TYRA-2 protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus granulosus	tm gpcr rhodopsin	0.0105	0.5849	0.5935
Echinococcus granulosus	neuropeptide s receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0105	0.5849	0.5849
Brugia malayi	Protein kinase domain containing protein	0.0055	0.2746	0.2746
Echinococcus multilocularis	neuropeptide Y receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	neuropeptides capa receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	nephrin	0.0013	0.0166	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Schistosoma mansoni	amine GPCR	0.0105	0.5849	0.5935
Schistosoma mansoni	biogenic amine receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.5849	0.5935
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	sex peptide receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	amine GPCR	0.0105	0.5849	0.5935
Echinococcus multilocularis	mitogen activated protein kinase	0.0158	0.9161	0.9296
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0105	0.5849	0.5935
Brugia malayi	RE15519p	0.0105	0.5849	0.5849
Brugia malayi	Dopamine receptor protein 1	0.0105	0.5849	0.5849
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0172	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.5849	0.5935
Echinococcus multilocularis	neuropeptide receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	serotonin receptor	0.0105	0.5849	0.5935
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0158	0.9161	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0105	0.5849	0.5935
Brugia malayi	putative neuropeptide receptor	0.0105	0.5849	0.5849
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0105	0.5849	0.5935
Schistosoma mansoni	cell adhesion molecule	0.0014	0.0213	0.0216
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0105	0.5849	0.5849
Echinococcus multilocularis	fmrfamide receptor	0.0105	0.5849	0.5935
Schistosoma mansoni	amine GPCR	0.0105	0.5849	0.5935
Echinococcus multilocularis	neuroglian	0.0013	0.0166	0.0169
Schistosoma mansoni	neuropeptide receptor	0.0105	0.5849	0.5935
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0105	0.5849	0.5935
Echinococcus multilocularis		0.0052	0.2582	0.262
Echinococcus multilocularis	sex peptide receptor	0.0105	0.5849	0.5935
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5849	0.5849
Brugia malayi	ORL1-like opioid receptor	0.0105	0.5849	0.5849
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0158	0.9161	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 16 mm	Antibacterial activity against Escherichia coli after 24 hr by disk diffusion test	ChEMBL.	No reference
IZ (functional)	= 17 mm	Antifungal activity against Candida albicans after 48 hr by disk diffusion test	ChEMBL.	No reference
MIC (functional)	= 100 ug ml-1	Antifungal activity against Candida albicans after 48 hr by agar plate method	ChEMBL.	No reference
MIC (functional)	= 100 ug ml-1	Antibacterial activity against Escherichia coli after 24 hr by agar plate method	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2237547

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1811563