Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | threonyl-tRNA synthetase | 0.003 | 0.0015 | 0.0015 |
Brugia malayi | Dihydrofolate reductase | 1.0323 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.0323 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 1.0323 | 1 | 1 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0038 | 0.0022 | 0.0059 |
Schistosoma mansoni | dihydrofolate reductase | 1.0323 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 1.0323 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.0323 | 1 | 1 |
Trichomonas vaginalis | threonyl-tRNA synthetase, putative | 0.0033 | 0.0018 | 0.5 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0038 | 0.0022 | 0.0059 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0026 | 0.001 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0157 | 0.0138 | 0.0138 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.0323 | 1 | 1 |
Echinococcus multilocularis | Threonyl tRNA synthetase, C | 0.0038 | 0.0022 | 0.0022 |
Wolbachia endosymbiont of Brugia malayi | threonyl-tRNA synthetase | 0.0033 | 0.0018 | 0.5 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0026 | 0.001 | 1 |
Entamoeba histolytica | threonyl-tRNA synthetase, putative | 0.0033 | 0.0018 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3947 | 0.3815 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.0323 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0062 | 0.0046 | 0.0046 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3947 | 0.3815 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0077 | 0.006 | 0.006 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3947 | 0.3815 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3947 | 0.3815 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0193 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.004 | 0.0025 | 0.0025 |
Brugia malayi | threonyl-tRNA synthetase, cytoplasmic | 0.0038 | 0.0022 | 0.0022 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0077 | 0.006 | 0.006 |
Giardia lamblia | Threonyl-tRNA synthetase | 0.0033 | 0.0018 | 0.5 |
Echinococcus granulosus | Threonyl tRNA synthetase C | 0.0038 | 0.0022 | 0.0022 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0157 | 0.0138 | 0.0138 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0026 | 0.001 | 0.001 |
Chlamydia trachomatis | dihydrofolate reductase | 1.0323 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3947 | 0.3815 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0132 | 0.0113 | 0.0113 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0193 | 0.0173 | 0.0173 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0026 | 0.001 | 0.001 |
Leishmania major | threonyl-tRNA synthetase, putative | 0.0038 | 0.0022 | 0.0059 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.001 | 0.001 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0142 | 0.0124 | 0.0124 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0179 | 0.0159 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.004 | 0.0025 | 0.0025 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0132 | 0.0113 | 0.0113 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0026 | 0.001 | 0.001 |
Loa Loa (eye worm) | threonyl-tRNA synthetase | 0.0038 | 0.0022 | 0.0022 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0132 | 0.0113 | 0.0113 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3947 | 0.3815 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.004 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0025 | 0.0025 |
Treponema pallidum | threonyl-tRNA synthetase | 0.0033 | 0.0018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.001 | 0.001 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.