TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.475 | Formula: C18H34N2O2
H donors: 1 H acceptors: 1 LogP: 4.81 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(CO/N=C/1\CCCCCCCCCCC(=O)NCC1)C
InChi: 1S/C18H34N2O2/c1-16(2)15-22-20-17-11-9-7-5-3-4-6-8-10-12-18(21)19-14-13-17/h16H,3-15H2,1-2H3,(H,19,21)/b20-17+
InChiKey: IRJGJCSITWOEBG-LVZFUZTISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0302	0.341	1
Mycobacterium ulcerans	thioesterase TesA	0.0132	0.1106	0.1106
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	hypothetical protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0117	0.0915	0.5
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0153	0.139	0.139
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0117	0.0915	0.0624
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Onchocerca volvulus		0.0275	0.3038	0.9414
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0117	0.0915	0.0624
Entamoeba histolytica	hypothetical protein, conserved	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0162	0.1522	0.1522
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0117	0.0915	0.5
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0153	0.139	0.139
Entamoeba histolytica	serine/threonine kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0153	0.139	0.139
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	cysteine surface protein, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0162	0.1522	0.1522
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0124	0.1002	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0117	0.0915	0.1689
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0231	0.2443	0.2443
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	ankyrin repeat protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Loa Loa (eye worm)	SRC-1	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0064	0.0192	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0117	0.0915	0.1689
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0132	0.1106	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Echinococcus granulosus	dihydrofolate reductase	0.0791	1	1
Entamoeba histolytica	hypothetical protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Mycobacterium ulcerans	polyketide synthase Pks13	0.0231	0.2443	0.2443
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.009	0.0542	0.0542
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0153	0.139	0.0523
Loa Loa (eye worm)	TK protein kinase	0.0117	0.0915	0.0624
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	hypothetical protein	0.0117	0.0915	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Toxoplasma gondii	type I fatty acid synthase, putative	0.0162	0.1522	0.3712
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Giardia lamblia	Kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0302	0.341	1
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0147	0.1321	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Entamoeba histolytica	serine/threonine kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0117	0.0915	0.5
Giardia lamblia	Kinase, NEK	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0162	0.1522	0.1522
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0231	0.2443	0.2443
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Entamoeba histolytica	hypothetical protein	0.0117	0.0915	0.5
Toxoplasma gondii	type I fatty acid synthase, putative	0.0112	0.0847	0.1464
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0791	1	1
Loa Loa (eye worm)	TK protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	receptor protein kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0153	0.139	0.139
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0117	0.0915	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.0915	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0122	0.0974	0.0974
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0294	0.3297	0.2622
Loa Loa (eye worm)	fatty acid synthase	0.0156	0.1433	0.1158
Entamoeba histolytica	serine/threonine kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0117	0.0915	0.5
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0102	0.0713	0.1017
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium ulcerans	thioesterase	0.0132	0.1106	0.1106
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Entamoeba histolytica	hypothetical protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	STE family protein kinase	0.0117	0.0915	0.5
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0162	0.1522	0.1522
Entamoeba histolytica	receptor protein kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	hypothetical protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TK family protein kinase	0.0117	0.0915	0.5
Chlamydia trachomatis	dihydrofolate reductase	0.0791	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Toxoplasma gondii	STE kinase	0.0117	0.0915	0.1689
Entamoeba histolytica	hypothetical protein	0.0117	0.0915	0.5
Giardia lamblia	Kinase, NEK	0.0117	0.0915	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK protein kinase	0.0117	0.0915	0.0624
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0791	1	1
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0117	0.0915	0.0624
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0153	0.139	0.139
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0153	0.1396	0.1396
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Toxoplasma gondii	protein kinase	0.0117	0.0915	0.1689
Mycobacterium ulcerans	polyketide synthase Pks9	0.0099	0.0668	0.0668
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0113	0.0861	0.0861
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0117	0.0915	0.1689
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0153	0.1396	0.1396
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Echinococcus multilocularis	dihydrofolate reductase	0.0791	1	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0162	0.1522	0.1522
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	serine/threonine kinase, putative	0.0117	0.0915	0.5
Giardia lamblia	Protein 21.1	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0117	0.0915	0.5
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0122	0.0974	0.0974
Loa Loa (eye worm)	TK protein kinase	0.0117	0.0915	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0099	0.0668	0.0668
Entamoeba histolytica	ankyrin repeat protein	0.0117	0.0915	0.5
Entamoeba histolytica	hypothetical protein	0.0117	0.0915	0.5
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0302	0.341	1
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Onchocerca volvulus	Fatty acid synthase homolog	0.0285	0.3171	1
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK protein kinase	0.0117	0.0915	0.0624
Loa Loa (eye worm)	TK/FAK protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0302	0.341	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0162	0.1522	0.1522
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	hypothetical protein	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0117	0.0915	0.5
Schistosoma mansoni	dihydrofolate reductase	0.0791	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium leprae	Polyketide synthase Pks13	0.0231	0.2443	0.2443
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0117	0.0915	0.0624
Loa Loa (eye worm)	dihydrofolate reductase	0.0791	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/Met protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0122	0.0974	0.0974
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0302	0.341	1
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0791	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Mycobacterium ulcerans	polyketide synthase	0.0162	0.1522	0.1522
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0132	0.1106	0.1106
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0153	0.139	0.139
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0147	0.1321	0.1321
Entamoeba histolytica	protein kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Mycobacterium ulcerans	polyketide synthase	0.0153	0.139	0.139
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Brugia malayi	Dihydrofolate reductase	0.0791	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0117	0.0915	0.0624
Entamoeba histolytica	hypothetical protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Entamoeba histolytica	serine/threonine kinase, putative	0.0117	0.0915	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0117	0.0915	0.1689
Brugia malayi	AMP-binding enzyme family protein	0.0147	0.1321	0.0447
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK protein kinase	0.0117	0.0915	0.0624
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0153	0.139	0.139
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0302	0.341	1
Entamoeba histolytica	tyrosin kinase, putative	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0117	0.0915	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0453	0.0147
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0117	0.0915	0.0624
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	hypothetical protein	0.026	0.2838	0.2609
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0915	0.0624
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0162	0.1522	0.1522
Loa Loa (eye worm)	TK/RYK protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0117	0.0915	0.0624
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0162	0.1522	0.1522
Onchocerca volvulus		0.0147	0.1321	0.1802
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0153	0.139	0.139
Loa Loa (eye worm)	TK/ALK protein kinase	0.0117	0.0915	0.0624
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.0915	0.5
Entamoeba histolytica	hypothetical protein	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Loa Loa (eye worm)	TK protein kinase	0.0117	0.0915	0.0624
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0153	0.139	0.139
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0117	0.0915	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0117	0.0915	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.0915	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0117	0.0915	0.0624
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0099	0.0668	0.0668
Trichomonas vaginalis	TKL family protein kinase	0.0117	0.0915	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2252674

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1812159