Detailed information for compound 1812193

Basic information

Technical information
  • TDR Targets ID: 1812193
  • Name: N-(2,4-dichlorophenyl)naphthalene-2-carboxami de
  • MW: 316.181 | Formula: C17H11Cl2NO
  • H donors: 1 H acceptors: 1 LogP: 5.26 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)NC(=O)c1ccc2c(c1)cccc2
  • InChi: 1S/C17H11Cl2NO/c18-14-7-8-16(15(19)10-14)20-17(21)13-6-5-11-3-1-2-4-12(11)9-13/h1-10H,(H,20,21)
  • InChiKey: WZYJDNGSKRVUPE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dichlorophenyl)-2-naphthalenecarboxamide
  • N-(2,4-dichlorophenyl)-2-naphthamide
  • AO-548/10420003
  • ZINC00826232
  • STK201230
  • Oprea1_167598
  • Oprea1_679225

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum dihydroorotate dehydrogenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Neospora caninum dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania braziliensis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania mexicana dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei gambiense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma japonicum ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania donovani dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma congolense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma mansoni dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium knowlesi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Babesia bovis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania major dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium yoelii dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania infantum dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530 Get druggable targets OG5_127289 All targets in OG5_127289
Theileria parva dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium falciparum dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium berghei dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) steroid hormone receptor 0.0871 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0871 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0871 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0871 1 1
Brugia malayi hypothetical protein 0.046 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.046 0.1071 0.1071
Brugia malayi Nuclear hormone receptor-like 1 0.046 0.1071 0.1071
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0871 1 1
Brugia malayi steroid hormone receptor 0.0871 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0871 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0871 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0871 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0871 1 1
Brugia malayi hypothetical protein 0.046 0.1071 0.1071
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0871 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0871 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0871 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0871 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0871 1 1
Schistosoma mansoni coup transcription factor 0.0871 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0871 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0871 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.046 0.1071 0.1071
Onchocerca volvulus Protein ultraspiracle homolog 0.0871 1 1
Loa Loa (eye worm) hypothetical protein 0.046 0.1071 0.1071
Brugia malayi photoreceptor-specific nuclear receptor 0.0871 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0871 1 1
Loa Loa (eye worm) hypothetical protein 0.0871 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0871 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0871 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0871 1 1
Loa Loa (eye worm) hypothetical protein 0.046 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0871 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0871 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0871 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0871 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0871 1 1
Loa Loa (eye worm) hypothetical protein 0.0871 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.046 0.1071 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0871 1 1
Brugia malayi nuclear receptor NHR-88 0.0871 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0871 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0871 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0871 1 1
Loa Loa (eye worm) hypothetical protein 0.0871 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.046 0.1071 0.1071
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0871 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0871 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0871 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0871 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.046 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0871 1 1
Schistosoma mansoni nuclear hormone receptor 0.0871 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0871 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0871 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0871 1 1
Brugia malayi nuclear hormone receptor 0.0871 1 1
Loa Loa (eye worm) hypothetical protein 0.046 0.1071 0.1071
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0871 1 1
Brugia malayi nuclear receptor RXR 0.046 0.1071 0.1071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0871 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0871 1 1
Loa Loa (eye worm) hypothetical protein 0.0871 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0871 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0871 1 1
Loa Loa (eye worm) hypothetical protein 0.0871 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0871 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0871 1 1
Loa Loa (eye worm) hypothetical protein 0.046 0.1071 0.1071
Echinococcus multilocularis thyroid hormone receptor alpha 0.0871 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0871 1 1
Schistosoma mansoni thyroid hormone receptor 0.0871 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0871 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0871 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0871 1 1
Schistosoma mansoni thyroid hormone receptor 0.0871 1 1
Loa Loa (eye worm) hypothetical protein 0.0871 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0871 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0871 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.046 0.1071 0.1071
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.046 0.1071 0.1071
Onchocerca volvulus 0.0871 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0871 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0871 1 1
Echinococcus granulosus FTZ F1 alpha 0.0871 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7 Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectrophotometric analysis ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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