Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Arabidopsis thaliana | acetolactate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase 2, putative | 0.0321 | 0.62 | 0.4899 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0317 | 0.6116 | 0.977 |
Trypanosoma cruzi | Protein kinase B | 0.0321 | 0.62 | 0.5 |
Brugia malayi | Hr1 repeat family protein | 0.0165 | 0.255 | 0.0932 |
Echinococcus granulosus | nervana 2 | 0.0317 | 0.6116 | 0.977 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0165 | 0.255 | 0.2196 |
Trichomonas vaginalis | AGC family protein kinase | 0.0165 | 0.255 | 0.0111 |
Schistosoma mansoni | serine/threonine kinase | 0.0165 | 0.255 | 0.2504 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0321 | 0.62 | 0.4899 |
Echinococcus multilocularis | nervana 2 | 0.0317 | 0.6116 | 0.977 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0165 | 0.255 | 0.2504 |
Brugia malayi | Protein kinase domain containing protein | 0.0483 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 0.1785 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0321 | 0.62 | 0.5 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0165 | 0.255 | 0.2196 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 0.1785 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.0554 | 0.0105 |
Trichomonas vaginalis | AGC family protein kinase | 0.0165 | 0.255 | 0.0111 |
Trichomonas vaginalis | AGC family protein kinase | 0.0483 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0165 | 0.255 | 0.2196 |
Trichomonas vaginalis | AGC family protein kinase | 0.0483 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.0317 | 0.6116 | 0.977 |
Brugia malayi | Protein kinase domain containing protein | 0.0165 | 0.255 | 0.0932 |
Entamoeba histolytica | protein kinase, putative | 0.0483 | 1 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0321 | 0.62 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.1785 | 1 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.0451 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0165 | 0.255 | 0.0932 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0321 | 0.62 | 0.4899 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0321 | 0.62 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0317 | 0.6116 | 0.977 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0483 | 1 | 0.5 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0165 | 0.255 | 0.2196 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0483 | 1 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0317 | 0.6116 | 0.977 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0321 | 0.62 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0321 | 0.62 | 0.5 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0165 | 0.255 | 0.2196 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0165 | 0.255 | 0.2504 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0165 | 0.255 | 0.2504 |
Trichomonas vaginalis | AGC family protein kinase | 0.0165 | 0.255 | 0.0111 |
Trichomonas vaginalis | AGC family protein kinase | 0.0483 | 1 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0321 | 0.62 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0321 | 0.62 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.255 | 0.2196 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 0.1785 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0483 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0483 | 1 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.1785 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0165 | 0.255 | 0.2504 |
Echinococcus multilocularis | nervana 2 | 0.0317 | 0.6116 | 0.977 |
Schistosoma mansoni | atypical protein kinase C | 0.0165 | 0.255 | 0.2504 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0133 | 0.1785 | 0.5 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0483 | 1 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.0321 | 0.62 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0483 | 1 | 1 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0321 | 0.62 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0321 | 0.62 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0165 | 0.255 | 0.2504 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0321 | 0.62 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0483 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0165 | 0.255 | 0.0111 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0165 | 0.255 | 0.2504 |
Brugia malayi | protein kinase C II. | 0.0165 | 0.255 | 0.0932 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0165 | 0.255 | 0.2504 |
Trichomonas vaginalis | AGC family protein kinase | 0.0483 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0483 | 1 | 1 |
Toxoplasma gondii | AGC kinase | 0.0483 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.1785 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0165 | 0.255 | 0.2196 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0317 | 0.6116 | 0.977 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0321 | 0.62 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.02 uM | Inhibition of wild type Arabidopsis thaliana acetolactate synthase by colorimetry | ChEMBL. | 20598554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.