Detailed information for compound 1812508

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 906.925 | Formula: C56H42O12
  • H donors: 9 H acceptors: 9 LogP: 9.96 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 3
  • SMILES: Oc1ccc(cc1)[C@@H]1Oc2c([C@H]1c1cc(O)cc3c1[C@H](c1cc(O)cc(c1)O)[C@H](O3)c1ccc(cc1)O)cc(cc2)/C=C/c1cc(O)cc2c1[C@H](c1cc(O)cc(c1)O)[C@H](O2)c1ccc(cc1)O
  • InChi: 1S/C56H42O12/c57-35-10-4-29(5-11-35)54-50(33-19-38(60)23-39(61)20-33)49-32(18-42(64)26-47(49)67-54)3-1-28-2-16-46-44(17-28)52(56(66-46)31-8-14-37(59)15-9-31)45-25-43(65)27-48-53(45)51(34-21-40(62)24-41(63)22-34)55(68-48)30-6-12-36(58)13-7-30/h1-27,50-52,54-65H/b3-1+/t50-,51-,52-,54+,55+,56-/m0/s1
  • InChiKey: WZKKRZSJTLGPHH-QGYUWUKLSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK protein kinase 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Entamoeba histolytica tyrosin kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Giardia lamblia Protein 21.1 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0217 0.0402
Brugia malayi hypothetical protein 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus multilocularis tyrosine kinase 0.0322 0.5401 0.5401
Loa Loa (eye worm) TK/EGFR protein kinase 0.0322 0.5401 1
Echinococcus multilocularis acetylcholinesterase 0.0073 0.0933 0.0933
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0322 0.5401 1
Schistosoma mansoni protein kinase 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Onchocerca volvulus 0.0322 0.5401 1
Toxoplasma gondii protein kinase 0.0322 0.5401 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0322 0.5401 1
Schistosoma mansoni hypothetical protein 0.0197 0.3158 0.5847
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Entamoeba histolytica ankyrin repeat protein 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0322 0.5401 1
Onchocerca volvulus 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0322 0.5401 0.5401
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0322 0.5401 1
Brugia malayi integrin-linked kinase 0.0322 0.5401 1
Plasmodium falciparum tyrosine kinase-like protein 0.0322 0.5401 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0322 0.5401 1
Echinococcus granulosus tyrosine kinase 0.0322 0.5401 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0026 0.009 0.0167
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0322 0.5401 1
Entamoeba histolytica tyrosin kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0073 0.0933 0.1727
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0322 0.5401 0.5401
Echinococcus granulosus tyrosine protein kinase shark 0.0322 0.5401 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0322 0.5401 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0322 0.5401 0.5401
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Entamoeba histolytica serine/threonine kinase, putative 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0322 0.5401 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0322 0.5401 0.5401
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Onchocerca volvulus 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Onchocerca volvulus 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0322 0.5401 1
Trichomonas vaginalis TK family protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0322 0.5401 0.5401
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0322 0.5401 0.5401
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0322 0.5401 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0322 0.5401 0.5401
Echinococcus granulosus c src tyrosine kinase 0.0322 0.5401 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0322 0.5401 1
Trichomonas vaginalis STE family protein kinase 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Echinococcus granulosus geminin 0.0197 0.3158 0.5847
Leishmania major protein kinase, putative 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0322 0.5401 0.5401
Entamoeba histolytica hypothetical protein, conserved 0.0322 0.5401 1
Echinococcus multilocularis protein kinase 0.0322 0.5401 0.5401
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Brugia malayi Receptor family ligand binding region containing protein 0.0322 0.5401 1
Echinococcus granulosus protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Schistosoma mansoni ephrin receptor 0.0322 0.5401 1
Schistosoma mansoni protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Trypanosoma brucei Pseudokinase, putative 0.0322 0.5401 1
Echinococcus multilocularis protein tyrosine kinase 0.0322 0.5401 0.5401
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0196 0.0362
Echinococcus granulosus retinal guanylyl cyclase 2 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Brugia malayi C-terminal src kinase protein 1 0.0322 0.5401 1
Giardia lamblia Kinase, NEK 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Brugia malayi protein-tyrosine kinase 0.0322 0.5401 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0322 0.5401 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0217 0.0402
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Schistosoma mansoni protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0933 0.1727
Onchocerca volvulus Tyrosine kinase homolog 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0322 0.5401 0.5401
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0322 0.5401 0.5401
Trypanosoma brucei PAB1-binding protein , putative 0.0038 0.0307 0.0568
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0322 0.5401 0.5401
Echinococcus multilocularis tyrosine protein kinase pr2 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Loa Loa (eye worm) TK protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK protein kinase 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0322 0.5401 0.5401
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0322 0.5401 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Plasmodium falciparum protein kinase, putative 0.0322 0.5401 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Echinococcus granulosus insulin receptor 0.0322 0.5401 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0322 0.5401 1
Trichomonas vaginalis protein kinase atn1, putative 0.0322 0.5401 1
Onchocerca volvulus 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0026 0.009 0.0167
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase csk 0.0322 0.5401 1
Schistosoma mansoni ephrin receptor 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi Raf kinase 0.0322 0.5401 1
Schistosoma mansoni protein kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus granulosus acetylcholinesterase 0.0073 0.0933 0.1727
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Schistosoma mansoni serine/threonine RGC 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Entamoeba histolytica receptor protein kinase, putative 0.0322 0.5401 1
Echinococcus granulosus epidermal growth factor receptor 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Schistosoma mansoni hypothetical protein 0.0197 0.3158 0.5847
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0217 0.0217
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0322 0.5401 0.5401
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Loa Loa (eye worm) TK protein kinase 0.0322 0.5401 1
Trypanosoma brucei protein kinase, putative 0.0322 0.5401 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Onchocerca volvulus 0.0322 0.5401 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0322 0.5401 1
Echinococcus multilocularis tyrosine kinase 0.0322 0.5401 0.5401
Echinococcus granulosus tyrosine protein kinase Fyn 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.3725 0.6897
Trichomonas vaginalis protein tyrosine kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0322 0.5401 0.5401
Echinococcus granulosus tyrosine protein kinase csk 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Schistosoma mansoni protein kinase 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0307 0.0568
Brugia malayi Tyrosine-protein kinase abl-1 0.0322 0.5401 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0322 0.5401 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi SH2 domain containing protein 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0038 0.0307 0.0568
Loa Loa (eye worm) carboxylesterase 0.0073 0.0933 0.1727
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0322 0.5401 0.5401
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0026 0.009 0.0167
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0038 0.0307 0.0568
Onchocerca volvulus 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase 0.0322 0.5401 1
Entamoeba histolytica receptor protein kinase, putative 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0933 0.1727
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Toxoplasma gondii LsmAD domain-containing protein 0.0038 0.0307 0.0568
Loa Loa (eye worm) TK/ROR protein kinase 0.0322 0.5401 1
Onchocerca volvulus 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0322 0.5401 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0322 0.5401 1
Echinococcus multilocularis insulin receptor 0.0322 0.5401 0.5401
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi hypothetical protein 0.0026 0.009 0.0167
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0322 0.5401 1
Schistosoma mansoni protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK protein kinase 0.0322 0.5401 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0322 0.5401 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0322 0.5401 1
Leishmania major hypothetical protein, conserved 0.0038 0.0307 0.0568
Brugia malayi bone morphogenetic protein type 1 receptor 0.0322 0.5401 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0322 0.5401 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.0933 0.1727
Brugia malayi Tyrosine-protein kinase PR2 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0322 0.5401 0.5401
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0322 0.5401 0.5401
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0322 0.5401 1
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Brugia malayi Furin-like cysteine rich region family protein 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0322 0.5401 1
Entamoeba histolytica serine/threonine kinase, putative 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Schistosoma mansoni protein kinase 0.0322 0.5401 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0217 0.0402
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.5401 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0322 0.5401 1
Echinococcus multilocularis protein kinase 0.0322 0.5401 0.5401
Onchocerca volvulus 0.0322 0.5401 1
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0322 0.5401 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0038 0.0307 0.0568
Echinococcus granulosus tyrosine kinase 0.0322 0.5401 1
Echinococcus multilocularis geminin 0.0197 0.3158 0.3158
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Plasmodium falciparum tyrosine kinase-like protein 0.0322 0.5401 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0038 0.0307 0.0568
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0322 0.5401 1
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Entamoeba histolytica serine/threonine kinase, putative 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Onchocerca volvulus 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0322 0.5401 1
Toxoplasma gondii STE kinase 0.0322 0.5401 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0322 0.5401 1
Trichomonas vaginalis AGC family protein kinase 0.0322 0.5401 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0322 0.5401 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0322 0.5401 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0322 0.5401 1
Plasmodium vivax protein kinase, putative 0.0322 0.5401 1
Echinococcus granulosus protein tyrosine kinase 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0322 0.5401 0.5401
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0322 0.5401 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0322 0.5401 1
Echinococcus granulosus activated cdc42 kinase 1 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Plasmodium vivax SET domain protein, putative 0.0033 0.0217 0.0402
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Giardia lamblia Kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0322 0.5401 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Trypanosoma cruzi protein kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0322 0.5401 0.5401
Echinococcus granulosus activated cdc42 kinase 1 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0322 0.5401 0.5401
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0322 0.5401 0.5401
Onchocerca volvulus 0.0322 0.5401 1
Echinococcus multilocularis FL cytokine receptor 0.0322 0.5401 0.5401
Entamoeba histolytica hypothetical protein 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0322 0.5401 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0026 0.009 0.0167
Toxoplasma gondii protein kinase domain-containing protein 0.0322 0.5401 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0322 0.5401 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0322 0.5401 1
Entamoeba histolytica serine/threonine kinase, putative 0.0322 0.5401 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0322 0.5401 0.5401
Echinococcus multilocularis epidermal growth factor receptor 0.0322 0.5401 0.5401
Entamoeba histolytica hypothetical protein 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0322 0.5401 0.5401
Entamoeba histolytica ankyrin repeat protein 0.0322 0.5401 1
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus multilocularis transfer RNA-Thr 0.0322 0.5401 0.5401
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Loa Loa (eye worm) TK protein kinase 0.0322 0.5401 1
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0322 0.5401 1
Trypanosoma cruzi protein kinase, putative 0.0322 0.5401 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0322 0.5401 0.5401
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0322 0.5401 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0322 0.5401 0.5401
Echinococcus multilocularis activated cdc42 kinase 1 0.0322 0.5401 0.5401
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0322 0.5401 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0322 0.5401 1
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Brugia malayi SH2 domain containing protein 0.0322 0.5401 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0322 0.5401 1
Plasmodium falciparum protein kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.5401 1
Loa Loa (eye worm) TK protein kinase 0.0322 0.5401 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0322 0.5401 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0322 0.5401 1
Loa Loa (eye worm) TK protein kinase 0.0322 0.5401 1
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.5401 1
Brugia malayi hypothetical protein 0.0322 0.5401 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0217 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi hypothetical protein 0.0024 0.0067 0.0124
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Plasmodium falciparum protein kinase, putative 0.0322 0.5401 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0322 0.5401 0.5401
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0322 0.5401 1
Echinococcus granulosus integrin linked protein kinase 0.0322 0.5401 1
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.5401 1
Brugia malayi SRC-1 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Schistosoma mansoni hypothetical protein 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase csk 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Echinococcus multilocularis carboxylesterase 5A 0.0073 0.0933 0.0933
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Schistosoma mansoni protein kinase 0.0322 0.5401 1
Echinococcus granulosus activin receptor type 0.0322 0.5401 1
Echinococcus multilocularis heat shock protein 70 0.0322 0.5401 0.5401
Brugia malayi Guanylyl cyclase protein 23 0.0322 0.5401 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0217 0.0402
Onchocerca volvulus 0.0322 0.5401 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0322 0.5401 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.0322 0.5401 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0322 0.5401 0.5401
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Brugia malayi Pre-SET motif family protein 0.0228 0.3725 0.6897
Schistosoma mansoni hypothetical protein 0.0026 0.009 0.0167
Schistosoma mansoni transcription factor LCR-F1 0.0026 0.009 0.0167
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0322 0.5401 0.5401
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Giardia lamblia Kinase, NEK 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Trichomonas vaginalis CAMK family protein kinase 0.0322 0.5401 1
Schistosoma mansoni protein kinase 0.0322 0.5401 1
Schistosoma mansoni protein tyrosine kinase 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Entamoeba histolytica serine/threonine kinase, putative 0.0322 0.5401 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0322 0.5401 1
Entamoeba histolytica serine/threonine kinase, putative 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Leishmania major protein kinase, putative 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0217 0.0402
Schistosoma mansoni protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0026 0.009 0.009
Echinococcus granulosus tyrosine protein kinase Fyn 0.0322 0.5401 1
Echinococcus multilocularis c src tyrosine kinase 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK/ACK protein kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Brugia malayi Carboxylesterase family protein 0.0073 0.0933 0.1727
Brugia malayi ephrin receptor 1 precursor 0.0322 0.5401 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus multilocularis epidermal growth factor receptor 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Echinococcus granulosus acetylcholinesterase 0.0073 0.0933 0.1727
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0322 0.5401 1
Onchocerca volvulus 0.026 0.4291 0.7858
Loa Loa (eye worm) hypothetical protein 0.0033 0.0217 0.0402
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0217 0.0402
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus multilocularis acetylcholinesterase 0.0073 0.0933 0.0933
Trichomonas vaginalis set domain proteins, putative 0.026 0.4291 0.7944
Loa Loa (eye worm) TK/INSR protein kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0322 0.5401 0.5401
Brugia malayi Carboxylesterase family protein 0.0073 0.0933 0.1727
Brugia malayi hypothetical protein 0.0322 0.5401 1
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Onchocerca volvulus 0.0322 0.5401 1
Onchocerca volvulus 0.0322 0.5401 1
Loa Loa (eye worm) SRC-1 0.0322 0.5401 1
Entamoeba histolytica cysteine surface protein, putative 0.0322 0.5401 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0322 0.5401 0.5401
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0322 0.5401 1
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Leishmania major hypothetical protein, conserved 0.0322 0.5401 1
Brugia malayi hypothetical protein 0.0038 0.0307 0.0568
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.5401 1
Entamoeba histolytica tyrosine kinase, putative 0.0322 0.5401 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0322 0.5401 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0322 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0322 0.5401 1
Entamoeba histolytica protein kinase, putative 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0322 0.5401 0.5401
Echinococcus granulosus tyrosine protein kinase Blk 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Schistosoma mansoni protein kinase 0.0322 0.5401 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0322 0.5401 0.5401
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0322 0.5401 0.5401
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0322 0.5401 0.5401
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Echinococcus multilocularis integrin linked protein kinase 0.0322 0.5401 0.5401
Loa Loa (eye worm) hypothetical protein 0.0322 0.5401 1
Loa Loa (eye worm) TK/FER protein kinase 0.0322 0.5401 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0322 0.5401 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0322 0.5401 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0322 0.5401 1
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0026 0.009 0.0167
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Entamoeba histolytica tyrosin kinase, putative 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Schistosoma mansoni tyrosine protein kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein kinase domain containing protein 0.0322 0.5401 1
Schistosoma mansoni tyrosine kinase 0.0322 0.5401 1
Plasmodium vivax ataxin-2 like protein, putative 0.0038 0.0307 0.0568
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Echinococcus granulosus tyrosine kinase 0.0322 0.5401 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0217 0.0402
Loa Loa (eye worm) TK/Met protein kinase 0.0322 0.5401 1
Trichomonas vaginalis TKL family protein kinase 0.0322 0.5401 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0322 0.5401 1
Entamoeba histolytica hypothetical protein 0.0322 0.5401 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.5401 1
Loa Loa (eye worm) TK protein kinase 0.0322 0.5401 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0322 0.5401 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0322 0.5401 1
Echinococcus multilocularis activin receptor type 0.0322 0.5401 0.5401
Echinococcus granulosus carboxylesterase 5A 0.0073 0.0933 0.1727
Onchocerca volvulus 0.0322 0.5401 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0322 0.5401 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgD expression at 20 ug/ml after 5 hrs by qRT-PCR analysis ChEMBL. 24456071
Activity (ADMET) Antimicrobial activity against Escherichia coli O157:H7 assessed as growth inhibition up to 50 ug/ml by spectrophotometry ChEMBL. 24456071
Activity (functional) Antibiofilm activity against Escherichia coli O157:H7 assessed as induction of fliA gene expression at 20 ug/ml after 5 hrs by qRT-PCR analysis ChEMBL. 24456071
Activity (functional) Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgB expression at 20 ug/ml after 5 hrs by qRT-PCR analysis ChEMBL. 24456071
Activity (functional) Antibiofilm activity against Escherichia coli O157:H7 assessed as induction of motB gene expression at 20 ug/ml after 5 hrs by qRT-PCR analysis ChEMBL. 24456071
Activity (functional) Antibiofilm activity against Escherichia coli O157:H7 assessed as effect on rrsG expression at 20 ug/ml after 5 hrs by qRT-PCR analysis ChEMBL. 24456071
Activity (functional) Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgF expression at 20 ug/ml after 5 hrs by qRT-PCR analysis ChEMBL. 24456071
Activity (functional) Antibiofilm activity against Escherichia coli O157:H7 assessed as induction of flhD gene expression at 20 ug/ml after 5 hrs by qRT-PCR analysis ChEMBL. 24456071
Activity (functional) Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgA expression at 20 ug/ml after 5 hrs by qRT-PCR analysis ChEMBL. 24456071
Activity (functional) Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgG expression at 20 ug/ml after 5 hrs by qRT-PCR analysis ChEMBL. 24456071
Activity (functional) Antibiofilm activity against Escherichia coli O157:H7 assessed as induction of qseB gene expression at 20 ug/ml after 5 hrs by qRT-PCR analysis ChEMBL. 24456071
Activity (functional) Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgC expression at 20 ug/ml after 5 hrs by qRT-PCR analysis ChEMBL. 24456071
Activity (functional) Reduction in fimbriae production in Escherichia coli O157:H7 biofilm grown on nylon filter at 20 ug/ml after 24 hrs by scanning electron microscopy ChEMBL. 24456071
Inhibition (functional) Antibiofilm activity against Escherichia coli O157:H7 after 24 hrs by spectrophotometry ChEMBL. 24456071
Inhibition (functional) Antibiofilm activity against Escherichia coli O157:H7 after 24 hrs by GFP-based confocal laser microscopy ChEMBL. 24456071
Inhibition (functional) > 90 % Antibiofilm activity against Escherichia coli O157:H7 at 5 ug/ml after 24 hrs by spectrophotometry ChEMBL. 24456071

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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