Detailed information for compound 1812706

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 517.527 | Formula: C29H27NO8
  • H donors: 0 H acceptors: 1 LogP: 4.39 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1c(OC)cc(cc1OC)[C@H]1[C@@H](C(=O)OCc2ccccc2)[C@@H]2CON=C2c2c1cc1OCOc1c2
  • InChi: 1S/C29H27NO8/c1-32-23-9-17(10-24(33-2)28(23)34-3)25-18-11-21-22(37-15-36-21)12-19(18)27-20(14-38-30-27)26(25)29(31)35-13-16-7-5-4-6-8-16/h4-12,20,25-26H,13-15H2,1-3H3/t20-,25+,26-/m0/s1
  • InChiKey: COKXRBLODMNSCQ-LZYPDUGYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase eta 0.0021 0.0008 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.014 0.0143
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0077 0.0077
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0242 0.0329 0.086
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0242 0.0329 0.0338
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0006
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0595 0.0841 0.1476
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0008 0.0006
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0375 0.0522 0.3064
Plasmodium falciparum carbamoyl phosphate synthetase 0.0595 0.0841 0.116
Echinococcus granulosus geminin 0.0197 0.0264 0.0261
Schistosoma mansoni hypothetical protein 0.0197 0.0264 0.0261
Schistosoma mansoni hypothetical protein 0.0197 0.0264 0.0261
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.0035 0.0029 0.0027
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0242 0.0329 0.0528
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0029 0.0027
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.2632 0.3795 0.6137
Loa Loa (eye worm) hypothetical protein 0.0242 0.0329 0.0338
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0595 0.0841 0.2198
Leishmania major DNA polymerase eta, putative 0.0021 0.0008 0.0005
Schistosoma mansoni hypothetical protein 0.0052 0.0053 0.0051
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.1178 0.1687 1
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0242 0.0329 0.0528
Echinococcus multilocularis short transient receptor potential channel 6 0.0144 0.0187 0.0184
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0242 0.0329 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0008 0.0005
Schistosoma mansoni hypothetical protein 0.0035 0.0029 0.0027
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0936 0.1336 0.2905
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0242 0.0329 0.0326
Echinococcus granulosus transient receptor potential ion channel A 0.0211 0.0283 0.0281
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0242 0.0329 0.0329
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.2632 0.3795 1
Echinococcus granulosus dna polymerase eta 0.0021 0.0008 0.0005
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0936 0.1336 0.3506
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0242 0.0329 0.0329
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0242 0.0329 0.0338
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.691 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0008 0.0005
Schistosoma mansoni pyruvate carboxylase 0.2632 0.3795 0.3794
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0011 1
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0242 0.0329 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0008 0.0005
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0242 0.0329 0.0329
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0936 0.1336 0.1334
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0074 0.0085 0.0085
Echinococcus multilocularis transient receptor potential ion channel A 0.0211 0.0283 0.0281
Leishmania major carboxylase, putative 0.2632 0.3795 0.3794
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0008 0.0005
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0002 0.0002
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0077 0.0074
Echinococcus granulosus Biotin lipoyl attachment 0.0242 0.0329 0.0326
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0242 0.0329 0.0326
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0242 0.0329 0.0326
Chlamydia trachomatis biotin carboxylase 0.239 0.3444 1
Echinococcus granulosus bloom syndrome protein 0.0023 0.0011 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0077 0.0074
Entamoeba histolytica hypothetical protein 0.0107 0.0133 0.0743
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0011 0.0009
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.0348 0.0346
Loa Loa (eye worm) RecQ helicase 0.0023 0.0011 0.0009
Echinococcus granulosus tar DNA binding protein 0.0068 0.0077 0.0074
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0002
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0242 0.0329 0.0326
Trypanosoma cruzi acetyl-CoA carboxylase 0.4278 0.6182 1
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.2632 0.3795 0.3794
Brugia malayi TAR-binding protein 0.0068 0.0077 0.0077
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.2632 0.3795 0.3794
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0008 0.0005
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.2632 0.3795 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0008 0.0005
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0011 1
Echinococcus granulosus short transient receptor potential channel 6 0.0144 0.0187 0.0184
Leishmania major acetyl-CoA carboxylase, putative 0.691 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0008 0.0005
Giardia lamblia DNA repair protein RAD52 0.0375 0.0522 0.3064
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0242 0.0329 0.086
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0936 0.1336 0.3516
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0008 0.0005
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0936 0.1336 0.3506
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0008 0.0009
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.2632 0.3795 1
Brugia malayi Transient-receptor-potential like protein 0.0081 0.0095 0.0096
Schistosoma mansoni hypothetical protein 0.0035 0.0029 0.0027
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0029 0.0027
Brugia malayi RNA binding protein 0.0068 0.0077 0.0077
Echinococcus multilocularis GPCR, family 2 0.0035 0.0029 0.0027
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0077 0.0077
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.2632 0.3795 0.3794
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0029 0.0028
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0936 0.1336 0.1336
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0077 0.0077
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0089 0.0089
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0595 0.0841 0.0838
Echinococcus granulosus GPCR family 2 0.0035 0.0029 0.0027
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.691 1 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.0294 0.0302
Schistosoma mansoni survival motor neuron protein 0.0052 0.0053 0.0051
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0595 0.0841 0.1356
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0936 0.1336 0.3506
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0242 0.0329 0.0326
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0242 0.0329 0.0326
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0242 0.0329 0.0847
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0008 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0077 0.0074
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.2632 0.3795 0.3794
Trypanosoma brucei unspecified product 0.173 0.2487 0.2486
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0242 0.0329 0.0326
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0936 0.1336 0.2158
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0008 0.0005
Schistosoma mansoni acetyl-CoA carboxylase 0.691 1 1
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0936 0.1336 0.2158
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.2632 0.3795 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0002 0.0003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0008 0.0014
Trypanosoma brucei unspecified product 0.0021 0.0008 0.0005
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0242 0.0329 0.0528
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.2632 0.3795 0.3794
Echinococcus granulosus transient receptor potential gamma protein 0.0218 0.0294 0.0291
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0242 0.0329 0.0451
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.014 0.0143
Schistosoma mansoni transient receptor potential channel 4 0.0218 0.0294 0.0291
Echinococcus multilocularis transient receptor potential gamma protein 0.0218 0.0294 0.0291
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0876 0.1248 0.1246
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0242 0.0329 0.0326
Leishmania major carbamoyl-phosphate synthase, putative 0.0595 0.0841 0.0838
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0242 0.0329 0.0847
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0008 0.0014
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0936 0.1336 0.1334
Brugia malayi Carboxyl transferase domain containing protein 0.6668 0.9649 1
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0242 0.0329 0.0326
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.2632 0.3795 0.3794
Loa Loa (eye worm) hypothetical protein 0.0081 0.0095 0.0096
Schistosoma mansoni hypothetical protein 0.0076 0.0089 0.0086
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0242 0.0329 0.0528
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0137 0.0176 0.018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0242 0.0329 0.0338
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0595 0.0841 0.1356
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0936 0.1336 0.3516
Echinococcus granulosus dna polymerase kappa 0.0021 0.0008 0.0005
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0242 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0255 0.0348 0.0358
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0242 0.0329 0.0454
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0595 0.0841 0.0838
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0936 0.1336 0.2905
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0008 0.0005
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0936 0.1336 0.1334
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.691 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0008 0.0006
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.5 0.723 1
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0242 0.0329 0.0326
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0004 0.0002
Treponema pallidum pyruvate carboxylase subunit B 0.0242 0.0329 0.5
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0008 0.0005
Entamoeba histolytica acetyl-coA carboxylase, putative 0.1178 0.1687 1
Schistosoma mansoni transient receptor potential channel 0.0144 0.0187 0.0184
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0936 0.1336 0.2158
Schistosoma mansoni transient receptor potential channel 0.0218 0.0294 0.0291
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0242 0.0329 0.0326
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0936 0.1336 0.3506
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0008 0.0005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0053 0.0053
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0936 0.1336 0.1334
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0081 0.0095 0.0093
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0242 0.0329 0.086
Echinococcus multilocularis Biotin lipoyl attachment 0.0242 0.0329 0.0326
Loa Loa (eye worm) hypothetical protein 0.0112 0.014 0.0143
Schistosoma mansoni transient receptor potential channel 0.0144 0.0187 0.0184
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0242 0.0329 0.0326
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0008 0.0009
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.0348 0.0346
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0029 0.0028
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0242 0.0329 0.0451
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0242 0.0329 0.0338
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0008 0.0009
Toxoplasma gondii carbamoylphosphate synthetase 0.0595 0.0841 0.0841
Onchocerca volvulus 0.0052 0.0053 0.5
Loa Loa (eye worm) hypothetical protein 0.0242 0.0329 0.0338
Loa Loa (eye worm) RNA binding protein 0.0068 0.0077 0.0077
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0242 0.0329 0.0528
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0242 0.0329 0.0528
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0029 0.0027
Mycobacterium ulcerans pyruvate carboxylase 0.2632 0.3795 1
Echinococcus granulosus short transient receptor potential channel 6 0.0144 0.0187 0.0184
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0595 0.0841 0.0838
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.014 0.0143
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0936 0.1336 0.1334
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0008 0.0005
Echinococcus multilocularis short transient receptor potential channel 6 0.0144 0.0187 0.0184
Schistosoma mansoni hypothetical protein 0.0035 0.0029 0.0027
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0242 0.0329 0.0326
Mycobacterium ulcerans hypothetical protein 0.0242 0.0329 0.0847
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0002 0.0002
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.2632 0.3795 0.3794
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0008 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0077 0.0074
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.6668 0.9649 1
Toxoplasma gondii pyruvate carboxylase 0.2632 0.3795 0.3795
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0936 0.1336 0.3506
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0107 0.0133 0.0743
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0936 0.1336 0.2905
Schistosoma mansoni DNA polymerase eta 0.0021 0.0008 0.0005
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0242 0.0329 0.0326
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0077 0.0074
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0008 0.0009
Trypanosoma brucei acetyl-CoA carboxylase 0.691 1 1
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0936 0.1336 0.3233
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0008 0.0006
Echinococcus multilocularis geminin 0.0197 0.0264 0.0261
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0008 0.0005
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.2632 0.3795 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0089 0.0089
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0242 0.0329 0.0454
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0242 0.0329 0.0329
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.2632 0.3795 1
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0242 0.0329 0.0528
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0029 0.0028
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.5 0.723 1
Brugia malayi hypothetical protein 0.0255 0.0348 0.0358
Schistosoma mansoni aspartate carbamoyltransferase 0.0595 0.0841 0.0838
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0936 0.1336 0.3506
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0008 0.0005
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0595 0.0841 0.1162
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0008 0.0005
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.2632 0.3795 0.6137
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.2632 0.3795 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0077 0.0074
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0242 0.0329 0.0451
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0936 0.1336 0.1334
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0008 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0008 0.0005
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0936 0.1336 0.2905
Leishmania major DNA polymerase kappa, putative 0.0021 0.0008 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0008 0.0005
Echinococcus granulosus TRP transient receptor potential channel 0.0081 0.0095 0.0093

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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